STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

Development

Volumn 128, Issue 11, 2001, Pages 2119-2129

  Sahni, M ^a   Raz, R ^a   Coffin, J D ^a   Levy, D ^a   Basilico, C ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bone development; Chondrodysplasia; FGF; Mouse; STAT1

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; STAT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE GROWTH; CALVARIA; CARTILAGE CELL; CELL GROWTH; CELL PROLIFERATION; CHONDRODYSPLASIA; CONTROLLED STUDY; EMBRYO; ENCHONDRAL OSSIFICATION; EPIPHYSIS PLATE; GENE FUNCTION; GENE OVEREXPRESSION; GROWTH PLATE; GROWTH RATE; GROWTH REGULATION; MACROCEPHALY; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKULL MALFORMATION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BONE DEVELOPMENT; CELL DIVISION; CHONDROCYTES; DNA-BINDING PROTEINS; DWARFISM; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OSTEOCHONDRODYSPLASIAS; PHENOTYPE; SIGNAL TRANSDUCTION; SKULL; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0034960254     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development
2. Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis
3. The parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation
4. Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice
5. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
6. STATs and gene regulation
7. Fibroblast growth factor receptor 3 is a negative regulator of bone growth
8. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
9. Active role of chondrocyte apoptosis in endochondral ossification
10. Osteogenesis, the development of bone
11. Functions of fibroblast growth factors in vertebrate development
12. Fibroblast growth factors, their receptors and receptor disorders
13. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene
14. Indian Hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein dependent and -independent pathways
15. Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
16. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development
17. STAT1 affects lymphocyte survival and proliferation partially independent of its role down-stream of IFN-gamma
18. Fibroblast growth factor receptor 3 mutation promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia
19. Physiological significance of STAT proteins, investigations through gene disruption in vivo
20. A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
21. Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGF2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts
22. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
23. FGF Signaling in skeletal development
24. Repression of hedgehogsignaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
25. 'Cell paralysis' as an intermediate stage in the programmed cell death of epiphyseal chondrocytes during development
26. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia
27. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
28. Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice
29. Transcriptional responses to peptide ligands. The Jak-STAT pathway
30. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
31. Thanatophoric dysplasia (types I and II), caused by distinct mutations in fibroblast growth factor receptor 3
32. MMP-9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
33. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation
34. FGFR activation in skeletal disorders, too much of a good thing
35. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation