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Volumn 13, Issue 6, 2016, Pages 333-349

Induced pluripotent stem cells: At the heart of cardiovascular precision medicine

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2;

EID: 84961391762     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2016.36     Document Type: Review
Times cited : (151)

References (180)
  • 1
    • 84923762812 scopus 로고    scopus 로고
    • A new initiative on precision medicine
    • Collins F. S, & Varmus H. A new initiative on precision medicine. N. Engl. J. Med. 372, 793-795 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 793-795
    • Collins, F.S.1    Varmus, H.2
  • 2
    • 84931427223 scopus 로고    scopus 로고
    • Planning for US Precision Medicine Initiative underway
    • Jaffe S. Planning for US Precision Medicine Initiative underway. Lancet. 385, 2448-2449 (2015).
    • (2015) Lancet , vol.385 , pp. 2448-2449
    • Jaffe, S.1
  • 3
    • 84903196154 scopus 로고    scopus 로고
    • Human stem cells for modeling heart disease and for drug discovery
    • Matsa E, Burridge P. W, & Wu J. C. Human stem cells for modeling heart disease and for drug discovery. Sci. Transl. Med. 6, 239ps6 (2014).
    • (2014) Sci. Transl. Med , vol.6 , pp. 239ps6
    • Matsa, E.1    Burridge, P.W.2    Wu, J.C.3
  • 4
    • 84940033414 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived cardiomyocytes: Insights into molecular, cellular, and functional phenotypes
    • Karakikes I, Ameen M, Termglinchan V, & Wu J. C. Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes. Circ. Res. 117, 80-88 (2015).
    • (2015) Circ. Res , vol.117 , pp. 80-88
    • Karakikes, I.1    Ameen, M.2    Termglinchan, V.3    Wu, J.C.4
  • 5
    • 84928727557 scopus 로고    scopus 로고
    • Induced pluripotent stem cells
    • Wilson K. D, & Wu J. C. Induced pluripotent stem cells. JAMA. 313, 1613-1614 (2015).
    • (2015) JAMA , vol.313 , pp. 1613-1614
    • Wilson, K.D.1    Wu, J.C.2
  • 6
    • 84926624275 scopus 로고    scopus 로고
    • Modelling sarcomeric cardiomyopathies in the dish: From human heart samples to iPSC cardiomyocytes
    • Eschenhagen T, Mummery C, & Knollmann B. C. Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes. Cardiovasc. Res. 105, 424-438 (2015).
    • (2015) Cardiovasc. Res , vol.105 , pp. 424-438
    • Eschenhagen, T.1    Mummery, C.2    Knollmann, B.C.3
  • 7
    • 84862528505 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: Past, present, and future
    • Yamanaka S. Induced pluripotent stem cells: past, present, and future. Cell Stem Cell. 10, 678-684 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 678-684
    • Yamanaka, S.1
  • 8
    • 84873353816 scopus 로고    scopus 로고
    • Induced pluripotent stem cells in cardiovascular drug discovery
    • Mercola M, Colas A, & Willems E. Induced pluripotent stem cells in cardiovascular drug discovery. Circ. Res. 112, 534-548 (2013).
    • (2013) Circ. Res , vol.112 , pp. 534-548
    • Mercola, M.1    Colas, A.2    Willems, E.3
  • 9
    • 84876526111 scopus 로고    scopus 로고
    • Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
    • Liang P, et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation. 127, 1677-1691 (2013).
    • (2013) Circulation , vol.127 , pp. 1677-1691
    • Liang, P.1
  • 10
    • 84878878364 scopus 로고    scopus 로고
    • Integrating human pluripotent stem cells into drug development
    • Engle S. J, & Puppala D. Integrating human pluripotent stem cells into drug development. Cell Stem Cell. 12, 669-677 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 669-677
    • Engle, S.J.1    Puppala, D.2
  • 11
    • 84877280221 scopus 로고    scopus 로고
    • Momentum grows to make 'personalized' medicine more 'precise
    • Katsnelson A. Momentum grows to make 'personalized' medicine more 'precise'. Nat. Med. 19, 249 (2013).
    • (2013) Nat. Med , vol.19 , pp. 249
    • Katsnelson, A.1
  • 12
    • 84897908258 scopus 로고    scopus 로고
    • Technology: The dollar;1, 000 genome
    • Hayden E. C. Technology: the dollar;1, 000 genome. Nature. 507, 294-295 (2014).
    • (2014) Nature , vol.507 , pp. 294-295
    • Hayden, E.C.1
  • 13
    • 17444403604 scopus 로고    scopus 로고
    • Phenotypic differences in genetically identical organisms: The epigenetic perspective
    • Wong A. H, Gottesman I. I, & Petronis A. Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum. Mol. Genet. 14, R11-R18 (2005).
    • (2005) Hum. Mol. Genet , vol.14 , pp. R11-R18
    • Wong, A.H.1    Gottesman, I.I.2    Petronis, A.3
  • 14
    • 57649243614 scopus 로고    scopus 로고
    • Genome-based prediction of common diseases: Advances and prospects
    • Janssens A. C, & van Duijn C. M. Genome-based prediction of common diseases: advances and prospects. Hum. Mol. Genet. 17, R166-R173 (2008).
    • (2008) Hum. Mol. Genet , vol.17 , pp. R166-R173
    • Janssens, A.C.1    Van Duijn, C.M.2
  • 15
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors DNA variants, and the development of type 2 diabetes
    • Lyssenko V, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N. Engl. J. Med. 359, 2220-2232 (2008).
    • (2008) N. Engl. J. Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1
  • 16
    • 56749101779 scopus 로고    scopus 로고
    • Genotype score in addition to common risk factors for prediction of type 2 diabetes
    • Meigs J. B, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N. Engl. J. Med. 359, 2208-2219 (2008).
    • (2008) N. Engl. J. Med , vol.359 , pp. 2208-2219
    • Meigs, J.B.1
  • 17
    • 82755175640 scopus 로고    scopus 로고
    • Genetic risk prediction in complex disease
    • Jostins L, & Barrett J. C. Genetic risk prediction in complex disease. Hum. Mol. Genet. 20, R182-R188 (2011).
    • (2011) Hum. Mol. Genet , vol.20 , pp. R182-R188
    • Jostins, L.1    Barrett, J.C.2
  • 18
    • 85026338471 scopus 로고    scopus 로고
    • Epigenetic modifications: Basic mechanisms and role in cardiovascular disease (2013 Grover Conference series
    • Loscalzo J, & Handy D. E. Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series). Pulm. Circ. 4, 169-174 (2014).
    • (2014) Pulm. Circ , vol.4 , pp. 169-174
    • Loscalzo, J.1    Handy, D.E.2
  • 19
    • 84906058450 scopus 로고    scopus 로고
    • The role of post-Translational modifications in acute and chronic cardiovascular disease
    • Smith L. E, & White M. Y. The role of post-Translational modifications in acute and chronic cardiovascular disease. Proteomics Clin. Appl. 8, 506-521 (2014).
    • (2014) Proteomics Clin. Appl , vol.8 , pp. 506-521
    • Smith, L.E.1    White, M.Y.2
  • 20
    • 84864243791 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: A methods overview
    • Mummery C. L, et al. Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview. Circ. Res. 111, 344-358 (2012).
    • (2012) Circ. Res , vol.111 , pp. 344-358
    • Mummery, C.L.1
  • 21
    • 84928478759 scopus 로고    scopus 로고
    • Differentiation of pluripotent stem cells into endothelial cells
    • Yoder M. C. Differentiation of pluripotent stem cells into endothelial cells. Curr. Opin. Hematol. 22, 252-257 (2015).
    • (2015) Curr. Opin. Hematol , vol.22 , pp. 252-257
    • Yoder, M.C.1
  • 22
    • 84920622506 scopus 로고    scopus 로고
    • Induced pluripotent stem cell-derived vascular smooth muscle cells: Methods and application
    • Dash B. C, Jiang Z, Suh C, & Qyang Y. Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application. Biochem. J. 465, 185-194 (2015).
    • (2015) Biochem. J , vol.465 , pp. 185-194
    • Dash, B.C.1    Jiang, Z.2    Suh, C.3    Qyang, Y.4
  • 23
    • 84936791706 scopus 로고    scopus 로고
    • Hurdles to clinical translation of human induced pluripotent stem cells
    • Neofytou E, O'Brien C. G, Couture L. A, & Wu J. C. Hurdles to clinical translation of human induced pluripotent stem cells. J. Clin. Invest. 125, 2551-2557 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 2551-2557
    • Neofytou, E.1    O'Brien, C.G.2    Couture, L.A.3    Wu, J.C.4
  • 24
    • 84898927707 scopus 로고    scopus 로고
    • Induced pluripotent stem cells for post-myocardial infarction repair: Remarkable opportunities and challenges
    • Lalit P. A, Hei D. J, Raval A. N, Kamp T. J. Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges. Circ. Res. 114, 1328-1345 (2014).
    • (2014) Circ. Res , vol.114 , pp. 1328-1345
    • Lalit, P.A.1    Hei, D.J.2    Raval, A.N.3    Kamp, T.J.4
  • 25
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 131, 861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 26
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 318, 1917-1920 (2007).
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1
  • 27
    • 50249098740 scopus 로고    scopus 로고
    • Generation of human-induced pluripotent stem cells
    • Park I. H, Lerou P. H, Zhao R, Huo H, & Daley G. Q. Generation of human-induced pluripotent stem cells. Nat. Protoc. 3, 1180-1186 (2008).
    • (2008) Nat. Protoc , vol.3 , pp. 1180-1186
    • Park, I.H.1    Lerou, P.H.2    Zhao, R.3    Huo, H.4    Daley, G.Q.5
  • 28
    • 41349090105 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells from dermal fibroblasts
    • Lowry W. E, et al. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc. Natl Acad. Sci. USA. 105, 2883-2888 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2883-2888
    • Lowry, W.E.1
  • 29
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, & Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 126, 663-676 (2006).
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 30
    • 48249117043 scopus 로고    scopus 로고
    • Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells?
    • Hawley R. G. Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells?. Mol. Ther. 16, 1354-1355 (2008).
    • (2008) Mol. Ther , vol.16 , pp. 1354-1355
    • Hawley, R.G.1
  • 31
    • 84882239370 scopus 로고    scopus 로고
    • Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
    • Lee A. S, Tang C, Rao M. S, Weissman I. L, & Wu J. C. Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies. Nat. Med. 19, 998-1004 (2013).
    • (2013) Nat. Med , vol.19 , pp. 998-1004
    • Lee, A.S.1    Tang, C.2    Rao, M.S.3    Weissman, I.L.4    Wu, J.C.5
  • 32
    • 80052157957 scopus 로고    scopus 로고
    • Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors
    • Ban H, et al. Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors. Proc. Natl Acad. Sci. USA. 108, 14234-14239 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 14234-14239
    • Ban, H.1
  • 33
    • 55849115999 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated without viral integration
    • Stadtfeld M, Nagaya M, Utikal J, Weir G, & Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science. 322, 945-949 (2008).
    • (2008) Science , vol.322 , pp. 945-949
    • Stadtfeld, M.1    Nagaya, M.2    Utikal, J.3    Weir, G.4    Hochedlinger, K.5
  • 34
    • 79955634826 scopus 로고    scopus 로고
    • A more efficient method to generate integration-free human iPS cells
    • Okita K, et al. A more efficient method to generate integration-free human iPS cells. Nat. Methods. 8, 409-412 (2011).
    • (2011) Nat Methods , vol.8 , pp. 409-412
    • Okita, K.1
  • 35
    • 77649275936 scopus 로고    scopus 로고
    • A nonviral minicircle vector for deriving human iPS cells
    • Jia F, et al. A nonviral minicircle vector for deriving human iPS cells. Nat. Methods. 7, 197-199 (2010).
    • (2010) Nat Methods , vol.7 , pp. 197-199
    • Jia, F.1
  • 36
    • 84940786435 scopus 로고    scopus 로고
    • Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency
    • Diecke S, et al. Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Sci. Rep. 5, 8081 (2015).
    • (2015) Sci. Rep , vol.5 , pp. 8081
    • Diecke, S.1
  • 37
    • 61349100729 scopus 로고    scopus 로고
    • Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    • Soldner F, et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 136, 964-977 (2009).
    • (2009) Cell , vol.136 , pp. 964-977
    • Soldner, F.1
  • 38
    • 64749083939 scopus 로고    scopus 로고
    • PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
    • Woltjen K, et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 458, 766-770 (2009).
    • (2009) Nature , vol.458 , pp. 766-770
    • Woltjen, K.1
  • 39
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 7, 618-630 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1
  • 40
    • 66049143859 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
    • Kim D, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell. 4, 472-476 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 472-476
    • Kim, D.1
  • 41
    • 84925341709 scopus 로고    scopus 로고
    • A comparison of non-integrating reprogramming methods
    • Schlaeger T. M, et al. A comparison of non-integrating reprogramming methods. Nat. Biotechnol. 33, 58-63 (2015).
    • (2015) Nat Biotechnol , vol.33 , pp. 58-63
    • Schlaeger, T.M.1
  • 42
    • 84881186856 scopus 로고    scopus 로고
    • Genetic and epigenetic variations in iPSCs: Potential causes and implications for application
    • Liang G, & Zhang Y. Genetic and epigenetic variations in iPSCs: potential causes and implications for application. Cell Stem Cell. 13, 149-159 (2013).
    • (2013) Cell Stem Cell , vol.13 , pp. 149-159
    • Liang, G.1    Zhang, Y.2
  • 43
    • 84947252379 scopus 로고    scopus 로고
    • A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
    • Choi J, et al. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs. Nat. Biotechnol. 33, 1173-1181 (2015).
    • (2015) Nat Biotechnol , vol.33 , pp. 1173-1181
    • Choi, J.1
  • 44
    • 0038210217 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to cardiomyocytes: Role of coculture with visceral endoderm-like cells
    • Mummery C, et al. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation. 107, 2733-2740 (2003).
    • (2003) Circulation , vol.107 , pp. 2733-2740
    • Mummery, C.1
  • 45
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • Kehat I, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest. 108, 407-414 (2001).
    • (2001) J. Clin. Invest , vol.108 , pp. 407-414
    • Kehat, I.1
  • 46
    • 70350135472 scopus 로고    scopus 로고
    • Cardiomyocyte differentiation of human induced pluripotent stem cells
    • Zwi L, et al. Cardiomyocyte differentiation of human induced pluripotent stem cells. Circulation. 120, 1513-1523 (2009).
    • (2009) Circulation , vol.120 , pp. 1513-1523
    • Zwi, L.1
  • 47
    • 61949300076 scopus 로고    scopus 로고
    • Functional cardiomyocytes derived from human induced pluripotent stem cells
    • Zhang J, et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ. Res. 104, e30-e41 (2009).
    • (2009) Circ. Res , vol.104 , pp. e30-e41
    • Zhang, J.1
  • 48
    • 34147124971 scopus 로고    scopus 로고
    • Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability
    • Burridge P. W, et al. Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells. 25, 929-938 (2007).
    • (2007) Stem Cells , vol.25 , pp. 929-938
    • Burridge, P.W.1
  • 49
    • 80755142726 scopus 로고    scopus 로고
    • SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells
    • Dubois N. C, et al. SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nat. Biotechnol. 29, 1011-1018 (2011).
    • (2011) Nat. Biotechnol , vol.29 , pp. 1011-1018
    • Dubois, N.C.1
  • 50
    • 34948891467 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    • Laflamme M. A, et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat. Biotechnol. 25, 1015-1024 (2007).
    • (2007) Nat. Biotechnol , vol.25 , pp. 1015-1024
    • Laflamme, M.A.1
  • 51
    • 79954418253 scopus 로고    scopus 로고
    • Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals
    • Zhang Q, et al. Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res. 21, 579-587 (2011).
    • (2011) Cell Res , vol.21 , pp. 579-587
    • Zhang, Q.1
  • 52
    • 82355175128 scopus 로고    scopus 로고
    • NKX2 5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes
    • Elliott D. A, et al. NKX2 5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat. Methods. 8, 1037-1040 (2011).
    • (2011) Nat. Methods , vol.8 , pp. 1037-1040
    • Elliott, D.A.1
  • 54
    • 84863560929 scopus 로고    scopus 로고
    • Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
    • Lian X, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc. Natl Acad. Sci. USA. 109, E1848-E1857 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. E1848-E1857
    • Lian, X.1
  • 55
    • 84905242471 scopus 로고    scopus 로고
    • Chemically defined generation of human cardiomyocytes
    • Burridge P. W, et al. Chemically defined generation of human cardiomyocytes. Nat. Methods. 11, 855-860 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 855-860
    • Burridge, P.W.1
  • 56
    • 77956696064 scopus 로고    scopus 로고
    • Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells
    • Levenberg S, Ferreira L. S, Chen-Konak L, Kraehenbuehl T. P, & Langer R. Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells. Nat. Protoc. 5, 1115-1126 (2010).
    • (2010) Nat. Protoc , vol.5 , pp. 1115-1126
    • Levenberg, S.1    Ferreira, L.S.2    Chen-Konak, L.3    Kraehenbuehl, T.P.4    Langer, R.5
  • 57
    • 84901847622 scopus 로고    scopus 로고
    • Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells
    • Orlova V. V, et al. Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells. Nat. Protoc. 9, 1514-1531 (2014).
    • (2014) Nat. Protoc , vol.9 , pp. 1514-1531
    • Orlova, V.V.1
  • 58
    • 34548335261 scopus 로고    scopus 로고
    • Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo
    • Ferreira L. S, et al. Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo. Circ. Res. 101, 286-294 (2007).
    • (2007) Circ. Res , vol.101 , pp. 286-294
    • Ferreira, L.S.1
  • 59
    • 84892754233 scopus 로고    scopus 로고
    • Concurrent generation of functional smooth muscle and endothelial cells via a vascular progenitor
    • Marchand M, et al. Concurrent generation of functional smooth muscle and endothelial cells via a vascular progenitor. Stem Cells Transl. Med. 3, 91-97 (2014).
    • (2014) Stem Cells Transl. Med , vol.3 , pp. 91-97
    • Marchand, M.1
  • 60
    • 77957729169 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell models for long QT syndrome
    • Moretti A, et al. Patient-specific induced pluripotent stem-cell models for long QT syndrome. N. Engl. J. Med. 363, 1397-1409 (2010).
    • (2010) N. Engl. J. Med , vol.363 , pp. 1397-1409
    • Moretti, A.1
  • 61
    • 84865254838 scopus 로고    scopus 로고
    • Disease characterization using LQTS-specific induced pluripotent stem cells
    • Egashira T, et al. Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc. Res. 95, 419-429 (2012).
    • (2012) Cardiovasc. Res , vol.95 , pp. 419-429
    • Egashira, T.1
  • 62
    • 84927556371 scopus 로고    scopus 로고
    • Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes
    • Ma D, et al. Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Res. Ther. 6, 39 (2015).
    • (2015) Stem Cell Res. Ther , vol.6 , pp. 39
    • Ma, D.1
  • 63
    • 84918553552 scopus 로고    scopus 로고
    • Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue
    • Zhang M, et al. Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc. Natl Acad. Sci. USA. 111, E5383-E5392 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E5383-E5392
    • Zhang, M.1
  • 64
    • 79954523845 scopus 로고    scopus 로고
    • Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
    • Matsa E, et al. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur. Heart J. 32, 952-962 (2011).
    • (2011) Eur. Heart J , vol.32 , pp. 952-962
    • Matsa, E.1
  • 65
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • Itzhaki I, et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature. 471, 225-229 (2011).
    • (2011) Nature , vol.471 , pp. 225-229
    • Itzhaki, I.1
  • 66
    • 84858040591 scopus 로고    scopus 로고
    • Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
    • Lahti A. L, et al. Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. Dis. Model. Mech. 5, 220-230 (2012).
    • (2012) Dis. Model. Mech , vol.5 , pp. 220-230
    • Lahti, A.L.1
  • 67
    • 84901452339 scopus 로고    scopus 로고
    • Re trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes
    • Mehta A, et al. Re trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes. Cardiovasc. Res. 102, 497-506 (2014).
    • (2014) Cardiovasc Res , vol.102 , pp. 497-506
    • Mehta, A.1
  • 68
    • 85006201984 scopus 로고    scopus 로고
    • Toward personalized medicine: Using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome
    • Jouni M, et al. Toward personalized medicine: using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome. J. Am. Heart Assoc. 4, e002159 (2015).
    • (2015) J. Am. Heart Assoc , vol.4 , pp. e002159
    • Jouni, M.1
  • 69
    • 84872238836 scopus 로고    scopus 로고
    • Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
    • Terrenoire C, et al. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. J. Gen. Physiol. 141, 61-72 (2013).
    • (2013) J. Gen. Physiol , vol.141 , pp. 61-72
    • Terrenoire, C.1
  • 70
    • 84887150722 scopus 로고    scopus 로고
    • Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells
    • Ma D, et al. Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells. Int. J. Cardiol. 168, 5277-5286 (2013).
    • (2013) Int. J. Cardiol , vol.168 , pp. 5277-5286
    • Ma, D.1
  • 71
    • 84892429611 scopus 로고    scopus 로고
    • The disease-specific phenotype in cardiomyocytes derived from induced pluripotent stem cells of two long QT syndrome type 3 patients
    • Fatima A, et al. The disease-specific phenotype in cardiomyocytes derived from induced pluripotent stem cells of two long QT syndrome type 3 patients. PLoS ONE. 8, e83005 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e83005
    • Fatima, A.1
  • 72
    • 83755195408 scopus 로고    scopus 로고
    • In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells
    • Fatima A, et al. In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell. Physiol. Biochem. 28, 579-592 (2011).
    • (2011) Cell. Physiol. Biochem , vol.28 , pp. 579-592
    • Fatima, A.1
  • 73
    • 84880513096 scopus 로고    scopus 로고
    • Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-Afflicted subjects
    • Zhang X. H, et al. Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-Afflicted subjects. Cell Calcium 54 57-70 (2013).
    • (2013) Cell Calcium , vol.54 , pp. 57-70
    • Zhang, X.H.1
  • 74
    • 84858129398 scopus 로고    scopus 로고
    • Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
    • Jung C. B, et al. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol. Med. 4, 180-191 (2012).
    • (2012) EMBO Mol. Med , vol.4 , pp. 180-191
    • Jung, C.B.1
  • 75
    • 84865801030 scopus 로고    scopus 로고
    • Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells
    • Itzhaki I, et al. Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells. J. Am. Coll. Cardiol. 60, 990-1000 (2012).
    • (2012) J. Am. Coll. Cardiol , vol.60 , pp. 990-1000
    • Itzhaki, I.1
  • 76
    • 84866033059 scopus 로고    scopus 로고
    • Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations
    • Kujala K, et al. Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations. PLoS ONE. 7, e44660 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e44660
    • Kujala, K.1
  • 77
    • 84887454024 scopus 로고    scopus 로고
    • CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia
    • Di Pasquale E, et al. CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia. Cell Death Dis. 4, e843 (2013).
    • (2013) Cell Death Dis , vol.4 , pp. e843
    • Di Pasquale, E.1
  • 78
    • 84938206204 scopus 로고    scopus 로고
    • Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations
    • Novak A, et al. Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations. J. Cell. Mol. Med. 19, 2006-2018 (2015).
    • (2015) J. Cell. Mol. Med , vol.19 , pp. 2006-2018
    • Novak, A.1
  • 79
    • 84857547828 scopus 로고    scopus 로고
    • Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-Adrenergic stimulation
    • Novak A, et al. Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-Adrenergic stimulation. J. Cell. Mol. Med. 16, 468-482 (2012).
    • (2012) J. Cell. Mol. Med , vol.16 , pp. 468-482
    • Novak, A.1
  • 80
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
    • Yazawa M, et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature. 471, 230-234 (2011).
    • (2011) Nature , vol.471 , pp. 230-234
    • Yazawa, M.1
  • 81
    • 84860156650 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
    • Sun N, et al. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci. Transl. Med. 4, 130ra47 (2012).
    • (2012) Sci. Transl. Med , vol.4 , pp. 130ra47
    • Sun, N.1
  • 82
    • 84937022594 scopus 로고    scopus 로고
    • Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised β-Adrenergic signaling in an iPSC model of dilated cardiomyopathy
    • Wu H, et al. Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised β-Adrenergic signaling in an iPSC model of dilated cardiomyopathy. Cell Stem Cell. 17, 89-100 (2015).
    • (2015) Cell Stem Cell , vol.17 , pp. 89-100
    • Wu, H.1
  • 83
    • 84872506168 scopus 로고    scopus 로고
    • Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells
    • Siu C. W, et al. Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells. Aging. 4, 803-822 (2012).
    • (2012) Aging , vol.4 , pp. 803-822
    • Siu, C.W.1
  • 84
    • 84875276852 scopus 로고    scopus 로고
    • Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel des mutation identified by whole exome sequencing
    • Tse H. F, et al. Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing. Hum. Mol. Genet. 22, 1395-1403 (2013).
    • (2013) Hum. Mol. Genet , vol.22 , pp. 1395-1403
    • Tse, H.F.1
  • 85
    • 84872026086 scopus 로고    scopus 로고
    • Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells
    • Lan F, et al. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell. 12, 101-113 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 101-113
    • Lan, F.1
  • 86
    • 84913590117 scopus 로고    scopus 로고
    • Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells
    • Han L, et al. Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells. Cardiovasc. Res. 104, 258-269 (2014).
    • (2014) Cardiovasc. Res , vol.104 , pp. 258-269
    • Han, L.1
  • 87
    • 84925833680 scopus 로고    scopus 로고
    • Endothelin 1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes
    • Tanaka A, et al. Endothelin 1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes. J. Am. Heart Assoc. 3, e001263 (2014).
    • (2014) J. Am. Heart Assoc , vol.3 , pp. e001263
    • Tanaka, A.1
  • 88
    • 84892415382 scopus 로고    scopus 로고
    • Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells
    • Caspi O, et al. Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells. Circ. Cardiovasc. Genet. 6, 557-568 (2013).
    • (2013) Circ. Cardiovasc. Genet , vol.6 , pp. 557-568
    • Caspi, O.1
  • 89
    • 84874741888 scopus 로고    scopus 로고
    • Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
    • Kim C, et al. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature. 494, 105-110 (2013).
    • (2013) Nature , vol.494 , pp. 105-110
    • Kim, C.1
  • 90
    • 84876522952 scopus 로고    scopus 로고
    • Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy
    • Ma D, et al. Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur. Heart J. 34, 1122-1133 (2013).
    • (2013) Eur. Heart J , vol.34 , pp. 1122-1133
    • Ma, D.1
  • 91
    • 84885133772 scopus 로고    scopus 로고
    • Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells-cardiomyocytes harboring DMD mutations
    • Dick E, et al. Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells-cardiomyocytes harboring DMD mutations. Stem Cells Dev. 22, 2714-2724 (2013).
    • (2013) Stem Cells Dev , vol.22 , pp. 2714-2724
    • Dick, E.1
  • 92
    • 84928994904 scopus 로고    scopus 로고
    • Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy
    • Lin B, et al. Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Dis. Model. Mech. 8, 457-466 (2015).
    • (2015) Dis. Model. Mech , vol.8 , pp. 457-466
    • Lin, B.1
  • 93
    • 84919764228 scopus 로고    scopus 로고
    • Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells
    • Drawnel F. M, et al. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Rep. 9, 810-821 (2014).
    • (2014) Cell Rep , vol.9 , pp. 810-821
    • Drawnel, F.M.1
  • 94
    • 84908377652 scopus 로고    scopus 로고
    • Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system
    • 255ra130
    • Ebert A. D, et al. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci. Transl. Med. 6, 255ra130 (2014).
    • (2014) Sci. Transl. Med , vol.6
    • Ebert, A.D.1
  • 95
    • 84902087268 scopus 로고    scopus 로고
    • Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart on chip technologies
    • Wang G, et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart on chip technologies. Nat. Med. 20, 616-623 (2014).
    • (2014) Nat. Med , vol.20 , pp. 616-623
    • Wang, G.1
  • 96
    • 81855172517 scopus 로고    scopus 로고
    • Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification
    • Huang H. P, et al. Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification. Hum. Mol. Genet. 20, 4851-4864 (2011).
    • (2011) Hum. Mol. Genet , vol.20 , pp. 4851-4864
    • Huang, H.P.1
  • 97
    • 84921926095 scopus 로고    scopus 로고
    • Pompe disease results in a Golgi based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes
    • Raval K. K, et al. Pompe disease results in a Golgi based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. J. Biol. Chem. 290, 3121-3136 (2015).
    • (2015) J. Biol. Chem , vol.290 , pp. 3121-3136
    • Raval, K.K.1
  • 98
    • 84962932527 scopus 로고    scopus 로고
    • Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe disease patient
    • Sato Y, et al. Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe disease patient. Mol. Ther. Methods Clin. Dev. 2, 15023 (2015).
    • (2015) Mol. Ther. Methods Clin. Dev , vol.2 , pp. 15023
    • Sato, Y.1
  • 99
    • 84897546322 scopus 로고    scopus 로고
    • An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes
    • Jiang Y, et al. An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes. Stem Cells Transl. Med. 3, 416-423 (2014).
    • (2014) Stem Cells Transl Med , vol.3 , pp. 416-423
    • Jiang, Y.1
  • 100
    • 84907140891 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3 induced myocarditis and antiviral drug screening platform
    • Sharma A, et al. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3 induced myocarditis and antiviral drug screening platform. Circ. Res. 115, 556-566 (2014).
    • (2014) Circ. Res , vol.115 , pp. 556-566
    • Sharma, A.1
  • 101
    • 84938937843 scopus 로고    scopus 로고
    • Finding the rhythm of sudden cardiac death: New opportunities using induced pluripotent stem cell-derived cardiomyocytes
    • Sallam K, Li Y, Sager P. T, Houser S. R, & Wu J. C. Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ. Res. 116, 1989-2004 (2015).
    • (2015) Circ. Res , vol.116 , pp. 1989-2004
    • Sallam, K.1    Li, Y.2    Sager, P.T.3    Houser, S.R.4    Wu, J.C.5
  • 102
    • 84857282827 scopus 로고    scopus 로고
    • Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species
    • O'Hara T, & Rudy Y. Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species. Am. J. Physiol. Heart Circ. Physiol. 302, H1023-H1030 (2012).
    • (2012) Am. J. Physiol. Heart Circ. Physiol , vol.302 , pp. H1023-H1030
    • O'Hara, T.1    Rudy, Y.2
  • 103
    • 84867602223 scopus 로고    scopus 로고
    • Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes
    • Braam S. R, et al. Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Res. 10, 48-56 (2013).
    • (2013) Stem Cell Res , vol.10 , pp. 48-56
    • Braam, S.R.1
  • 104
    • 84876322089 scopus 로고    scopus 로고
    • Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes
    • Lieu D. K, et al. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ. Arrhythm. Electrophysiol. 6, 191-201 (2013).
    • (2013) Circ. Arrhythm. Electrophysiol , vol.6 , pp. 191-201
    • Lieu, D.K.1
  • 105
    • 84899514041 scopus 로고    scopus 로고
    • Allele-specific RNA interference rescues the long QT syndrome phenotype in human induced pluripotency stem cell cardiomyocytes
    • Matsa E, et al. Allele-specific RNA interference rescues the long QT syndrome phenotype in human induced pluripotency stem cell cardiomyocytes. Eur. Heart J. 35, 1078-1087 (2014).
    • (2014) Eur. Heart J , vol.35 , pp. 1078-1087
    • Matsa, E.1
  • 106
    • 61849154781 scopus 로고    scopus 로고
    • Genetic Na+ channelopathies and sinus node dysfunction
    • Lei M, Huang C. L, & Zhang Y. Genetic Na+ channelopathies and sinus node dysfunction. Prog. Biophys. Mol. Biol. 98, 171-178 (2008).
    • (2008) Prog. Biophys. Mol. Biol , vol.98 , pp. 171-178
    • Lei, M.1    Huang, C.L.2    Zhang, Y.3
  • 107
    • 84897864670 scopus 로고    scopus 로고
    • Modeling inherited cardiac disorders
    • Sallam K, Kodo K, & Wu J. C. Modeling inherited cardiac disorders. Circ. J. 78, 784-794 (2014).
    • (2014) Circ. J , vol.78 , pp. 784-794
    • Sallam, K.1    Kodo, K.2    Wu, J.C.3
  • 108
    • 84940491378 scopus 로고    scopus 로고
    • Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
    • Hinson J. T, et al. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science. 349, 982-986 (2015).
    • (2015) Science , vol.349 , pp. 982-986
    • Hinson, J.T.1
  • 109
    • 84903202996 scopus 로고    scopus 로고
    • Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy
    • Asimaki A, et al. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci. Transl. Med. 6, 240ra74 (2014).
    • (2014) Sci. Transl. Med , vol.6 , pp. 240ra74
    • Asimaki, A.1
  • 110
    • 84931574633 scopus 로고    scopus 로고
    • Brief report: Oxidative stress mediates cardiomyocyte apoptosis in a human model of Danon disease and heart failure
    • Hashem S. I, et al. Brief report: oxidative stress mediates cardiomyocyte apoptosis in a human model of Danon disease and heart failure. Stem Cells. 33, 2343-2350 (2015).
    • (2015) Stem Cells , vol.33 , pp. 2343-2350
    • Hashem, S.I.1
  • 112
    • 77955278689 scopus 로고    scopus 로고
    • The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels
    • Guo Y. J, et al. The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: relation with endothelial ADMA levels. Atherosclerosis. 211, 545-550 (2010).
    • (2010) Atherosclerosis , vol.211 , pp. 545-550
    • Guo, Y.J.1
  • 113
    • 74349109244 scopus 로고    scopus 로고
    • ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients
    • Xu F, et al. ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients. Hypertens. Res. 33, 49-55 (2010).
    • (2010) Hypertens. Res , vol.33 , pp. 49-55
    • Xu, F.1
  • 114
    • 84919936034 scopus 로고    scopus 로고
    • Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling
    • Dhingra R, et al. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proc. Natl Acad. Sci. USA. 111, E5537-E5544 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E5537-E5544
    • Dhingra, R.1
  • 115
    • 84938503232 scopus 로고    scopus 로고
    • Generating induced pluripotent stem cell derived endothelial cells and induced endothelial cells for cardiovascular disease modelling and therapeutic angiogenesis
    • Clayton Z. E, Sadeghipour S, & Patel S. Generating induced pluripotent stem cell derived endothelial cells and induced endothelial cells for cardiovascular disease modelling and therapeutic angiogenesis. Int. J. Cardiol. 197, 116-122 (2015).
    • (2015) Int. J. Cardiol , vol.197 , pp. 116-122
    • Clayton, Z.E.1    Sadeghipour, S.2    Patel, S.3
  • 116
    • 74849117906 scopus 로고    scopus 로고
    • Williams-Beuren syndrome
    • Pober B. R. Williams-Beuren syndrome. N. Engl. J. Med. 362, 239-252 (2010).
    • (2010) N. Engl. J. Med , vol.362 , pp. 239-252
    • Pober, B.R.1
  • 118
    • 84867007532 scopus 로고    scopus 로고
    • Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells
    • Ge X, et al. Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation. 126, 1695-1704 (2012).
    • (2012) Circulation , vol.126 , pp. 1695-1704
    • Ge, X.1
  • 119
    • 84873466364 scopus 로고    scopus 로고
    • Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells
    • Kinnear C, et al. Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells. Stem Cells Transl. Med. 2, 2-15 (2013).
    • (2013) Stem Cells Transl. Med , vol.2 , pp. 2-15
    • Kinnear, C.1
  • 120
    • 77957313772 scopus 로고    scopus 로고
    • Induced chromosome deletion in a Williams-Beuren syndrome mouse model causes cardiovascular abnormalities
    • Goergen C. J, Li H. H, Francke U, & Taylor C. A. Induced chromosome deletion in a Williams-Beuren syndrome mouse model causes cardiovascular abnormalities. J. Vasc. Res. 48, 119-129 (2011).
    • (2011) J. Vasc. Res , vol.48 , pp. 119-129
    • Goergen, C.J.1    Li, H.H.2    Francke, U.3    Taylor, C.A.4
  • 121
    • 4444280637 scopus 로고    scopus 로고
    • Targeted therapy to prevent progression of calcific aortic stenosis
    • Rajamannan N. M, & Otto C. M. Targeted therapy to prevent progression of calcific aortic stenosis. Circulation. 110, 1180-1182 (2004).
    • (2004) Circulation , vol.110 , pp. 1180-1182
    • Rajamannan, N.M.1    Otto, C.M.2
  • 122
    • 14044262240 scopus 로고    scopus 로고
    • Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation
    • Roberts W. C, & Ko J. M. Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation. Circulation. 111, 920-925 (2005).
    • (2005) Circulation , vol.111 , pp. 920-925
    • Roberts, W.C.1    Ko, J.M.2
  • 123
    • 77949655921 scopus 로고    scopus 로고
    • Hemodynamic environments from opposing sides of human aortic valve leaflets evoke distinct endothelial phenotypes in vitro
    • Weinberg E. J, Mack P. J, Schoen F. J, Garcia Cardena G, & Kaazempur Mofrad M. R. Hemodynamic environments from opposing sides of human aortic valve leaflets evoke distinct endothelial phenotypes in vitro. Cardiovasc. Eng. 10, 5-11 (2010).
    • (2010) Cardiovasc. Eng , vol.10 , pp. 5-11
    • Weinberg, E.J.1    Mack, P.J.2    Schoen, F.J.3    Garcia Cardena, G.4    Kaazempur Mofrad, M.R.5
  • 124
    • 70149088960 scopus 로고    scopus 로고
    • Heart valve development: Regulatory networks in development and disease
    • Combs M. D, & Yutzey K. E. Heart valve development: regulatory networks in development and disease. Circ. Res. 105, 408-421 (2009).
    • (2009) Circ. Res , vol.105 , pp. 408-421
    • Combs, M.D.1    Yutzey, K.E.2
  • 125
    • 73849114175 scopus 로고    scopus 로고
    • Shear stress increases expression of the arterial endothelial marker ephrinB2 in murine ES cells via the VEGF-Notch signaling pathways
    • Masumura T, Yamamoto K, Shimizu N, Obi S, & Ando J. Shear stress increases expression of the arterial endothelial marker ephrinB2 in murine ES cells via the VEGF-Notch signaling pathways. Arterioscler. Thromb. Vasc. Biol. 29, 2125-2131 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , pp. 2125-2131
    • Masumura, T.1    Yamamoto, K.2    Shimizu, N.3    Obi, S.4    Ando, J.5
  • 126
    • 84924561757 scopus 로고    scopus 로고
    • Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency
    • Theodoris C. V, et al. Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell. 160, 1072-1086 (2015).
    • (2015) Cell , vol.160 , pp. 1072-1086
    • Theodoris, C.V.1
  • 127
    • 7244239317 scopus 로고    scopus 로고
    • Hutchinson-Gilford progeria syndrome
    • Pollex R. L, & Hegele R. A. Hutchinson-Gilford progeria syndrome. Clin. Genet. 66, 375-381 (2004).
    • (2004) Clin. Genet , vol.66 , pp. 375-381
    • Pollex, R.L.1    Hegele, R.A.2
  • 128
    • 79954626173 scopus 로고    scopus 로고
    • Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
    • Liu G. H, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 472, 221-225 (2011).
    • (2011) Nature , vol.472 , pp. 221-225
    • Liu, G.H.1
  • 129
    • 78650995671 scopus 로고    scopus 로고
    • A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects
    • Zhang J, et al. A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell 8 31-45 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 31-45
    • Zhang, J.1
  • 130
    • 84898778301 scopus 로고    scopus 로고
    • A guide to genome engineering with programmable nucleases
    • Kim H, & Kim J. S. A guide to genome engineering with programmable nucleases. Nat. Rev. Genet. 15, 321-334 (2014).
    • (2014) Nat Rev. Genet , vol.15 , pp. 321-334
    • Kim, H.1    Kim, J.S.2
  • 131
    • 84902096048 scopus 로고    scopus 로고
    • Development and applications of CRISPR-Cas9 for genome engineering
    • Hsu P. D, Lander E. S, & Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell. 157, 1262-1278 (2014).
    • (2014) Cell , vol.157 , pp. 1262-1278
    • Hsu, P.D.1    Lander, E.S.2    Zhang, F.3
  • 132
    • 84928966984 scopus 로고    scopus 로고
    • Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
    • Karakikes I, et al. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nat. Commun. 6, 6955 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 6955
    • Karakikes, I.1
  • 133
    • 84905157663 scopus 로고    scopus 로고
    • Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing
    • Wang Y, et al. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. J. Am. Coll. Cardiol. 64, 451-459 (2014).
    • (2014) J. Am. Coll. Cardiol , vol.64 , pp. 451-459
    • Wang, Y.1
  • 134
    • 84951573634 scopus 로고    scopus 로고
    • Drug-induced proarrhythmia: Risk factors and electrophysiological mechanisms
    • Frommeyer G, & Eckardt L. Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms. Nat. Rev. Cardiol. 13, 36-47 (2016).
    • (2016) Nat. Rev. Cardiol , vol.13 , pp. 36-47
    • Frommeyer, G.1    Eckardt, L.2
  • 135
    • 84908504728 scopus 로고    scopus 로고
    • Cardiac Safety Research Consortium: Can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward
    • Darpo B, et al. Cardiac Safety Research Consortium: can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies?. Scientific update and a research proposal for a path forward. Am. Heart J. 168, 262-272 (2014).
    • (2014) Am. Heart J , vol.168 , pp. 262-272
    • Darpo, B.1
  • 136
    • 84896692500 scopus 로고    scopus 로고
    • Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
    • Sager P. T, Gintant G, Turner J. R, Pettit S, & Stockbridge N. Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium. Am. Heart J. 167, 292-300 (2014).
    • (2014) Am. Heart J , vol.167 , pp. 292-300
    • Sager, P.T.1    Gintant, G.2    Turner, J.R.3    Pettit, S.4    Stockbridge, N.5
  • 137
    • 79955419099 scopus 로고    scopus 로고
    • Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
    • Mirams G. R, et al. Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc. Res. 91, 53-61 (2011).
    • (2011) Cardiovasc. Res , vol.91 , pp. 53-61
    • Mirams, G.R.1
  • 138
    • 84883791986 scopus 로고    scopus 로고
    • Screening drug-induced arrhythmia using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays
    • Navarrete E. G, et al. Screening drug-induced arrhythmia using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 128 (Suppl. 1), S3-S13 (2013).
    • (2013) Circulation , vol.128 , pp. S3-S13
    • Navarrete, E.G.1
  • 139
    • 83055173972 scopus 로고    scopus 로고
    • Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes
    • Jonsson M. K, Wang Q. D, & Becker B. Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes. Assay Drug Dev. Technol. 9, 589-599 (2011).
    • (2011) Assay Drug Dev. Technol , vol.9 , pp. 589-599
    • Jonsson, M.K.1    Wang, Q.D.2    Becker, B.3
  • 140
    • 80052487012 scopus 로고    scopus 로고
    • Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes
    • Guo L, et al. Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol. Sci. 123, 281-289 (2011).
    • (2011) Toxicol. Sci , vol.123 , pp. 281-289
    • Guo, L.1
  • 141
    • 84890320017 scopus 로고    scopus 로고
    • Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model
    • Guo L, et al. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol. Sci. 136, 581-594 (2013).
    • (2013) Toxicol. Sci , vol.136 , pp. 581-594
    • Guo, L.1
  • 142
    • 84871600132 scopus 로고    scopus 로고
    • Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells
    • Sirenko O, et al. Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. J. Biomol. Screen. 18, 39-53 (2013).
    • (2013) J. Biomol. Screen , vol.18 , pp. 39-53
    • Sirenko, O.1
  • 143
    • 84888861133 scopus 로고    scopus 로고
    • Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity
    • Sirenko O, et al. Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicol. Appl. Pharmacol. 273, 500-507 (2013).
    • (2013) Toxicol. Appl. Pharmacol , vol.273 , pp. 500-507
    • Sirenko, O.1
  • 144
    • 84933672526 scopus 로고    scopus 로고
    • A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing
    • Maddah M, et al. A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing. Stem Cell Rep 4 621-631 (2015).
    • (2015) Stem Cell Rep , vol.4 , pp. 621-631
    • Maddah, M.1
  • 145
    • 84930543108 scopus 로고    scopus 로고
    • Alternatives to animal testing: A review
    • Doke S. K, & Dhawale S. C. Alternatives to animal testing: a review. Saudi Pharm. J. 23, 223-229 (2015).
    • (2015) Saudi Pharm. J , vol.23 , pp. 223-229
    • Doke, S.K.1    Dhawale, S.C.2
  • 146
    • 84921511195 scopus 로고    scopus 로고
    • A low-cost, high-quality new drug discovery process using patient-derived induced pluripotent stem cells
    • Giri S, & Bader A. A low-cost, high-quality new drug discovery process using patient-derived induced pluripotent stem cells. Drug Discov. Today. 20, 37-49 (2015).
    • (2015) Drug Discov Today , vol.20 , pp. 37-49
    • Giri, S.1    Bader, A.2
  • 147
    • 85021857725 scopus 로고    scopus 로고
    • Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells
    • Burridge P. W, Holmstrom A, & Wu J. C. Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells. Curr. Protoc. Hum. Genet. 87, 21.3.1-21.3.15 (2015).
    • (2015) Curr. Protoc. Hum. Genet , vol.87 , pp. 2131-21315
    • Burridge, P.W.1    Holmstrom, A.2    Wu, J.C.3
  • 148
    • 84969191704 scopus 로고    scopus 로고
    • Modeling drug-induced long QT syndrome with patient-specific induced pluripotent stem cell-derived cardiomyocytes [abstract
    • Stillitano F, et al. Modeling drug-induced long QT syndrome with patient-specific induced pluripotent stem cell-derived cardiomyocytes [abstract]. Circulation. 130, A18442 (2014).
    • (2014) Circulation , vol.130 , pp. A18442
    • Stillitano, F.1
  • 149
    • 84940871746 scopus 로고    scopus 로고
    • Stem-cell discovery platforms yield first clinical candidates
    • Mullard A. Stem-cell discovery platforms yield first clinical candidates. Nat. Rev. Drug Discov. 14, 589-591 (2015).
    • (2015) Nat. Rev. Drug Discov , vol.14 , pp. 589-591
    • Mullard, A.1
  • 150
    • 84922785301 scopus 로고    scopus 로고
    • Human secreted tau increases amyloid-beta production
    • Bright J, et al. Human secreted tau increases amyloid-beta production. Neurobiol. Aging. 36, 693-709 (2015).
    • (2015) Neurobiol. Aging , vol.36 , pp. 693-709
    • Bright, J.1
  • 151
    • 84898034713 scopus 로고    scopus 로고
    • Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
    • Wainger B. J, et al. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 7, 1-11 (2014).
    • (2014) Cell Rep , vol.7 , pp. 1-11
    • Wainger, B.J.1
  • 152
    • 0030853963 scopus 로고    scopus 로고
    • Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: A new heart muscle model system
    • Eschenhagen T, et al. Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system. FASEB J. 11, 683-694 (1997).
    • (1997) FASEB J , vol.11 , pp. 683-694
    • Eschenhagen, T.1
  • 153
    • 84951736187 scopus 로고    scopus 로고
    • Human engineered heart tissue as a model system for drug testing
    • Eder A, Vollert I, Hansen A, & Eschenhagen T. Human engineered heart tissue as a model system for drug testing. Adv. Drug Deliv. Rev. 96, 214-224 (2016).
    • (2016) Adv. Drug Deliv. Rev , vol.96 , pp. 214-224
    • Eder, A.1    Vollert, I.2    Hansen, A.3    Eschenhagen, T.4
  • 154
    • 80054783465 scopus 로고    scopus 로고
    • Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology
    • Schaaf S, et al. Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology. PLoS ONE. 6, e26397 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e26397
    • Schaaf, S.1
  • 155
    • 84900549462 scopus 로고    scopus 로고
    • Automated analysis of contractile force and Ca2+ transients in engineered heart tissue
    • Stoehr A, et al. Automated analysis of contractile force and Ca2+ transients in engineered heart tissue. Am. J. Physiol. Heart Circ. Physiol. 306, H1353-H1363 (2014).
    • (2014) Am. J. Physiol. Heart Circ. Physiol , vol.306 , pp. H1353-H1363
    • Stoehr, A.1
  • 156
    • 84877794737 scopus 로고    scopus 로고
    • Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes
    • Zhang D, et al. Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials. 34, 5813-5820 (2013).
    • (2013) Biomaterials , vol.34 , pp. 5813-5820
    • Zhang, D.1
  • 157
    • 84881480907 scopus 로고    scopus 로고
    • Biowire: A platform for maturation of human pluripotent stem cell-derived cardiomyocytes
    • Nunes S. S, et al. Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat. Methods. 10, 781-787 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 781-787
    • Nunes, S.S.1
  • 158
    • 84924405787 scopus 로고    scopus 로고
    • Human iPSC-based cardiac microphysiological system for drug screening applications
    • Mathur A, et al. Human iPSC-based cardiac microphysiological system for drug screening applications. Sci. Rep. 5, 8883 (2015).
    • (2015) Sci. Rep , vol.5 , pp. 8883
    • Mathur, A.1
  • 159
    • 84951784669 scopus 로고    scopus 로고
    • Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies
    • Tzatzalos E, Abilez O. J, Shukla P, & Wu J. C. Engineered heart tissues and induced pluripotent stem cells: macro- And microstructures for disease modeling, drug screening, and translational studies. Adv. Drug Deliv. Rev. 96, 234-244 (2016).
    • (2016) Adv. Drug Deliv. Rev , vol.96 , pp. 234-244
    • Tzatzalos, E.1    Abilez, O.J.2    Shukla, P.3    Wu, J.C.4
  • 160
    • 70049093343 scopus 로고    scopus 로고
    • Role of hERG potassium channel assays in drug development
    • Priest B. T, Bell I. M, & Garcia M. L. Role of hERG potassium channel assays in drug development. Channels. 2, 87-93 (2008).
    • (2008) Channels , vol.2 , pp. 87-93
    • Priest, B.T.1    Bell, I.M.2    Garcia, M.L.3
  • 161
    • 33644647859 scopus 로고    scopus 로고
    • Utility of hERG assays as surrogate markers of delayed cardiac repolarization and QT safety
    • Gintant G. A, Su Z, Martin R. L, & Cox B. F. Utility of hERG assays as surrogate markers of delayed cardiac repolarization and QT safety. Toxicol. Pathol. 34, 81-90 (2006).
    • (2006) Toxicol. Pathol , vol.34 , pp. 81-90
    • Gintant, G.A.1    Su, Z.2    Martin, R.L.3    Cox, B.F.4
  • 162
    • 33746283859 scopus 로고    scopus 로고
    • Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs
    • Chen X, Cordes J. S, Bradley J. A, Sun Z, & Zhou J. Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs. J. Pharmacol. Toxicol. Methods. 54, 261-272 (2006).
    • (2006) J. Pharmacol. Toxicol. Methods , vol.54 , pp. 261-272
    • Chen, X.1    Cordes, J.S.2    Bradley, J.A.3    Sun, Z.4    Zhou, J.5
  • 163
    • 11444263995 scopus 로고    scopus 로고
    • Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3
    • Milberg P, et al. Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3. Cardiovasc. Res. 65, 397-404 (2005).
    • (2005) Cardiovasc. Res , vol.65 , pp. 397-404
    • Milberg, P.1
  • 164
    • 33845194767 scopus 로고    scopus 로고
    • A rabbit Langendorff heart proarrhythmia model: Predictive value for clinical identification of Torsades de Pointes
    • Lawrence C. L, Bridgland-Taylor M. H, Pollard C. E, Hammond T. G, & Valentin J. P. A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes. Br. J. Pharmacol 149 845-860 (2006).
    • (2006) Br. J. Pharmacol , vol.149 , pp. 845-860
    • Lawrence, C.L.1    Bridgland-Taylor, M.H.2    Pollard, C.E.3    Hammond, T.G.4    Valentin, J.P.5
  • 165
    • 48149111313 scopus 로고    scopus 로고
    • Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts
    • Sugiyama A. Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. Br. J. Pharmacol. 154, 1528-1537 (2008).
    • (2008) Br. J. Pharmacol , vol.154 , pp. 1528-1537
    • Sugiyama, A.1
  • 166
    • 84880227000 scopus 로고    scopus 로고
    • Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells
    • Lundy S. D, Zhu W. Z, Regnier M, & Laflamme M. A. Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells Dev. 22, 1991-2002 (2013).
    • (2013) Stem Cells Dev , vol.22 , pp. 1991-2002
    • Lundy, S.D.1    Zhu, W.Z.2    Regnier, M.3    Laflamme, M.A.4
  • 167
    • 84876570848 scopus 로고    scopus 로고
    • Concise review: Maturation phases of human pluripotent stem cell-derived cardiomyocytes
    • Robertson C, Tran D. D, & George S. C. Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. Stem Cells. 31, 829-837 (2013).
    • (2013) Stem Cells , vol.31 , pp. 829-837
    • Robertson, C.1    Tran, D.D.2    George, S.C.3
  • 168
    • 70349868345 scopus 로고    scopus 로고
    • Global expression profile of highly enriched cardiomyocytes derived from human embryonic stem cells
    • Xu X. Q, Soo S. Y, Sun W, & Zweigerdt R. Global expression profile of highly enriched cardiomyocytes derived from human embryonic stem cells. Stem Cells. 27, 2163-2174 (2009).
    • (2009) Stem Cells , vol.27 , pp. 2163-2174
    • Xu, X.Q.1    Soo, S.Y.2    Sun, W.3    Zweigerdt, R.4
  • 169
    • 84930193991 scopus 로고    scopus 로고
    • Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories
    • Hwang H. S, et al. Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. J. Mol. Cell. Cardiol. 85, 79-88 (2015).
    • (2015) J. Mol. Cell. Cardiol , vol.85 , pp. 79-88
    • Hwang, H.S.1
  • 170
    • 67650022307 scopus 로고    scopus 로고
    • Absence of transverse tubules contributes to non-uniform Ca2+ wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes
    • Lieu D. K, et al. Absence of transverse tubules contributes to non-uniform Ca2+ wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes. Stem Cells Dev. 18, 1493-1500 (2009).
    • (2009) Stem Cells Dev , vol.18 , pp. 1493-1500
    • Lieu, D.K.1
  • 171
    • 84922559369 scopus 로고    scopus 로고
    • Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells
    • Kim J. J, et al. Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. J. Mol. Cell. Cardiol. 81, 81-93 (2015).
    • (2015) J. Mol. Cell. Cardiol , vol.81 , pp. 81-93
    • Kim, J.J.1
  • 172
    • 84872048038 scopus 로고    scopus 로고
    • Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes
    • Tohyama S, et al. Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell. 12, 127-137 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 127-137
    • Tohyama, S.1
  • 173
    • 84988599499 scopus 로고    scopus 로고
    • Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes
    • Zhu R, et al. Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res. Ther. 5, 117 (2014).
    • (2014) Stem Cell Res. Ther , vol.5 , pp. 117
    • Zhu, R.1
  • 174
    • 78649366701 scopus 로고    scopus 로고
    • Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: Role for MIR 499
    • Wilson K. D, et al. Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR 499. Circ. Cardiovasc. Genet. 3, 426-435 (2010).
    • (2010) Circ. Cardiovasc. Genet , vol.3 , pp. 426-435
    • Wilson, K.D.1
  • 175
    • 84926020257 scopus 로고    scopus 로고
    • Stem cells: Disease models that show and tell
    • Marx V. Stem cells: disease models that show and tell. Nat. Methods. 12, 111-114 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 111-114
    • Marx, V.1
  • 176
    • 84860355832 scopus 로고    scopus 로고
    • Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures
    • Fluri D. A, et al. Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures. Nat. Methods. 9, 509-516 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 509-516
    • Fluri, D.A.1
  • 177
    • 84940101302 scopus 로고    scopus 로고
    • Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells
    • Chen V. C, et al. Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells. Stem Cell Res. 15, 365-375 (2015).
    • (2015) Stem Cell Res , vol.15 , pp. 365-375
    • Chen, V.C.1
  • 178
    • 79955539044 scopus 로고    scopus 로고
    • Dynamic suspension culture for scalable expansion of undifferentiated human pluripotent stem cells
    • Amit M, et al. Dynamic suspension culture for scalable expansion of undifferentiated human pluripotent stem cells. Nat. Protoc. 6, 572-579 (2011).
    • (2011) Nat. Protoc , vol.6 , pp. 572-579
    • Amit, M.1
  • 179
    • 53049108615 scopus 로고    scopus 로고
    • The systematic production of cells for cell therapies
    • Kirouac D. C, & Zandstra P. W. The systematic production of cells for cell therapies. Cell Stem Cell. 3, 369-381 (2008).
    • (2008) Cell Stem Cell , vol.3 , pp. 369-381
    • Kirouac, D.C.1    Zandstra, P.W.2
  • 180
    • 84940601627 scopus 로고    scopus 로고
    • Automated, high-Throughput derivation, characterization and differentiation of induced pluripotent stem cells
    • Paull D, et al. Automated, high-Throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat. Methods. 12, 885-892 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 885-892
    • Paull, D.1


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