Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 51, 2014, Pages E5537-E5544

  Dhingra, Rimpy ^a   Margulets, Victoria ^a   Chowdhury, Subir Roy ^a   Thliveris, James ^a   Jassal, Davinder ^a   Fernyhough, Paul ^a   Dorn, Gerald W ^b   Kirshenbaum, Lorrie A ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bnip3; Cell death; Heart failure; Mitochondria; Ventricular myocytes

Indexed keywords

BH3 PROTEIN; COMPLEX IV SUBUNIT 1; CYTOCHROME C OXIDASE; DOXORUBICIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BCL 2; PROTEIN BNIP3; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; SYNAPSIN II; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 3; ANTINEOPLASTIC ANTIBIOTIC; BNIP3 PROTEIN, RAT; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER PATIENT; CARDIOTOXICITY; CARDIOVASCULAR MORTALITY; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; DEATH; EFFECTOR CELL; GENE ACTIVATION; HEART FAILURE; HEART FUNCTION; HEART MITOCHONDRION; HEART MUSCLE NECROSIS; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG EFFECTS; ELECTRON TRANSPORT; HEART MUSCLE CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

MUS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL DEATH; CELLS, CULTURED; DOXORUBICIN; ELECTRON TRANSPORT; MEMBRANE PROTEINS; MICE; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MYOCYTES, CARDIAC; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84919936034     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414665111     Document Type: Article

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