-
1
-
-
34249736779
-
Caenorhabditis elegans: a versatile platform for drug discovery
-
Artal-Sanz M., de Jong L., Tavernarakis N. Caenorhabditis elegans: a versatile platform for drug discovery. Biotech. J. 2006, 1:1405-1418.
-
(2006)
Biotech. J.
, vol.1
, pp. 1405-1418
-
-
Artal-Sanz, M.1
de Jong, L.2
Tavernarakis, N.3
-
2
-
-
0028364672
-
Replacement of animal procedures: alternatives in research, education and testing
-
Balls M. Replacement of animal procedures: alternatives in research, education and testing. Lab. Anim. 1994, 28:193-211.
-
(1994)
Lab. Anim.
, vol.28
, pp. 193-211
-
-
Balls, M.1
-
3
-
-
0036053326
-
Future improvements: replacement in vitro methods
-
Balls M. Future improvements: replacement in vitro methods. ILAR J. 2002, 43:S69-S73.
-
(2002)
ILAR J.
, vol.43
, pp. S69-S73
-
-
Balls, M.1
-
5
-
-
27944488794
-
Science-based assessment of animal welfare: laboratory animals
-
Baumans V. Science-based assessment of animal welfare: laboratory animals. Revue Scientifique et Tech. 2005, 24:503.
-
(2005)
Revue Scientifique et Tech.
, vol.24
, pp. 503
-
-
Baumans, V.1
-
6
-
-
26944444354
-
Drosophila melanogaster: The model organism of choice for the complex biology of multi-cellular organisms
-
Beckingham K.M., Armstrong J.D., Texada M.J., Munjaal R., Baker D.A. Drosophila melanogaster: The model organism of choice for the complex biology of multi-cellular organisms. Gravit. Space Biol. Bull. 2005, 18:17-29.
-
(2005)
Gravit. Space Biol. Bull.
, vol.18
, pp. 17-29
-
-
Beckingham, K.M.1
Armstrong, J.D.2
Texada, M.J.3
Munjaal, R.4
Baker, D.A.5
-
7
-
-
0042035602
-
Human neurodegenerative disease modeling using Drosophila
-
Bonini N.M., Fortini M.E. Human neurodegenerative disease modeling using Drosophila. Ann. Rev. Neurosci. 2003, 26:627-656.
-
(2003)
Ann. Rev. Neurosci.
, vol.26
, pp. 627-656
-
-
Bonini, N.M.1
Fortini, M.E.2
-
8
-
-
0004306751
-
-
National Academy Press, Washington, DC
-
Committee on use of laboratory animals in biomedical and behavioral research, national research council and institute of medicine, 1988. Use of laboratory animals in biomedical and behavioral research. National Academy Press, Washington, DC.
-
(1988)
Use of laboratory animals in biomedical and behavioral research
-
-
-
9
-
-
3042859635
-
Alternative methods for skin sensitization testing
-
De Silva O., Basketter D.A., Barratt M.D., Corsini E., Cronin M.T., Das P.K., Ponec M. Alternative methods for skin sensitization testing. Atla Nottingham 1996, 24:683-706.
-
(1996)
Atla Nottingham
, vol.24
, pp. 683-706
-
-
De Silva, O.1
Basketter, D.A.2
Barratt, M.D.3
Corsini, E.4
Cronin, M.T.5
Das, P.K.6
Ponec, M.7
-
10
-
-
0028691777
-
Comparison of a computer simulation program and a traditional laboratory practical class for teaching the principles of intestinal absorption
-
Dewhurst D.G., Hardcastle J., Hardcastle P.T., Stuart E. Comparison of a computer simulation program and a traditional laboratory practical class for teaching the principles of intestinal absorption. Am. J. Physiol. 1994, 267:S95-S104.
-
(1994)
Am. J. Physiol.
, vol.267
, pp. S95-S104
-
-
Dewhurst, D.G.1
Hardcastle, J.2
Hardcastle, P.T.3
Stuart, E.4
-
11
-
-
0033524413
-
Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron
-
Faber P.W., Alter J.R., MacDonald M.E., Hart A.C. Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc. Natl. Acad. Sci. 1999, 96:179-184.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 179-184
-
-
Faber, P.W.1
Alter, J.R.2
MacDonald, M.E.3
Hart, A.C.4
-
12
-
-
0029975458
-
A simple organ culture model for assessing the effects of growth factor on corneal re-epitheliazation
-
Foreman D.M., Pancholi S., Jarvis-Evans J., McLeod D., Boulton M.E. A simple organ culture model for assessing the effects of growth factor on corneal re-epitheliazation. Exp. Eye Res. 1996, 62:555-564.
-
(1996)
Exp. Eye Res.
, vol.62
, pp. 555-564
-
-
Foreman, D.M.1
Pancholi, S.2
Jarvis-Evans, J.3
McLeod, D.4
Boulton, M.E.5
-
13
-
-
77951672406
-
High-throughput screening and small animal models, where are we?
-
Giacomotto J., Segalat L. High-throughput screening and small animal models, where are we?. Br. J. Pharmacol. 2010, 160:204-216.
-
(2010)
Br. J. Pharmacol.
, vol.160
, pp. 204-216
-
-
Giacomotto, J.1
Segalat, L.2
-
14
-
-
51249103626
-
Drosophila is an inclusive model for human diseases, growth and development
-
Gilbert L.I. Drosophila is an inclusive model for human diseases, growth and development. Mol. Cell Endocrinol. 2008, 293:25-31.
-
(2008)
Mol. Cell Endocrinol.
, vol.293
, pp. 25-31
-
-
Gilbert, L.I.1
-
15
-
-
0000638543
-
Cell biology of the corneal epithelium
-
Saunders WB, Philadelphia, D. Albert, F. Jakobiec (Eds.)
-
Gipson I., Sugrue S. Cell biology of the corneal epithelium. Principles and Practice of Ophthalmology 1994, 4-16. Saunders WB, Philadelphia. D. Albert, F. Jakobiec (Eds.).
-
(1994)
Principles and Practice of Ophthalmology
, pp. 4-16
-
-
Gipson, I.1
Sugrue, S.2
-
16
-
-
64949104542
-
Three Rs achievements in vaccinology
-
Hendriksen C.F. Three Rs achievements in vaccinology. AATEX 2007, 14:575-579.
-
(2007)
AATEX
, vol.14
, pp. 575-579
-
-
Hendriksen, C.F.1
-
17
-
-
63849201560
-
Replacement, reduction and refinement alternatives to animal use in vaccine potency measurement
-
Hendriksen C.F. Replacement, reduction and refinement alternatives to animal use in vaccine potency measurement. Expert Rev. Vaccines 2009, 8:313-322.
-
(2009)
Expert Rev. Vaccines
, vol.8
, pp. 313-322
-
-
Hendriksen, C.F.1
-
18
-
-
26944441684
-
Zebra fish as a model vertebrate for investigating chemical toxicity
-
Hill A.J., Teraoka H., Heideman W., Peterson R.E. Zebra fish as a model vertebrate for investigating chemical toxicity. Toxicol. Sci. 2005, 86:6-19.
-
(2005)
Toxicol. Sci.
, vol.86
, pp. 6-19
-
-
Hill, A.J.1
Teraoka, H.2
Heideman, W.3
Peterson, R.E.4
-
19
-
-
58149380019
-
Drosophila models of Alzheimer's amyloidosis: The challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42
-
Iijima K., Iijima-Ando K. Drosophila models of Alzheimer's amyloidosis: The challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42. J. Alzheimers Dis. 2008, 15:523-540.
-
(2008)
J. Alzheimers Dis.
, vol.15
, pp. 523-540
-
-
Iijima, K.1
Iijima-Ando, K.2
-
20
-
-
2342473791
-
Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease
-
Iijima K., Liu H.P., Chiang A.S., Hearn S.A., Konsolaki M., Zhong Y. Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc. Natl. Acad. Sci. 2004, 101:6623-6628.
-
(2004)
Proc. Natl. Acad. Sci.
, vol.101
, pp. 6623-6628
-
-
Iijima, K.1
Liu, H.P.2
Chiang, A.S.3
Hearn, S.A.4
Konsolaki, M.5
Zhong, Y.6
-
21
-
-
0034836544
-
Alternative approaches to the identification and characterization of chemical allergens
-
Kimber I., Pichowski J.S., Betts C.J., Cumberbatch M., Basketter D.A., Dearman R.J. Alternative approaches to the identification and characterization of chemical allergens. Toxicol. In Vitro 2001, 15:307-312.
-
(2001)
Toxicol. In Vitro
, vol.15
, pp. 307-312
-
-
Kimber, I.1
Pichowski, J.S.2
Betts, C.J.3
Cumberbatch, M.4
Basketter, D.A.5
Dearman, R.J.6
-
22
-
-
33644861285
-
Animal carcinogenicity studies: alternatives to the bioassay
-
Knight A., Bailey J., Balcombe J. Animal carcinogenicity studies: alternatives to the bioassay. Atla Nottingham 2006, 34:39.
-
(2006)
Atla Nottingham
, vol.34
, pp. 39
-
-
Knight, A.1
Bailey, J.2
Balcombe, J.3
-
23
-
-
0031804663
-
Invertebrates in testing of environmental chemicals: are they alternatives?
-
Lagadic L., Caquet T. Invertebrates in testing of environmental chemicals: are they alternatives?. Environ. Health Perspect. 1998, 106:593.
-
(1998)
Environ. Health Perspect.
, vol.106
, pp. 593
-
-
Lagadic, L.1
Caquet, T.2
-
24
-
-
0035109444
-
Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
-
Link C.D., Johnson C.J., Fonte V., Paupard M., Hall D.H., Styren S., Mathis C.A., Klunk W.E. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol. Aging 2001, 22:217-226.
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 217-226
-
-
Link, C.D.1
Johnson, C.J.2
Fonte, V.3
Paupard, M.4
Hall, D.H.5
Styren, S.6
Mathis, C.A.7
Klunk, W.E.8
-
25
-
-
0036935147
-
Apoptosis in yeast: a new model system with applications in cell biology and medicine
-
Madeo F., Engelhardt S., Herker E., Lehmann N., Maldener C., Proksch A., Frohlich K.U. Apoptosis in yeast: a new model system with applications in cell biology and medicine. Curr. Genet. 2002, 41:208-216.
-
(2002)
Curr. Genet.
, vol.41
, pp. 208-216
-
-
Madeo, F.1
Engelhardt, S.2
Herker, E.3
Lehmann, N.4
Maldener, C.5
Proksch, A.6
Frohlich, K.U.7
-
26
-
-
0032458218
-
A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software
-
Matthews E.J., Contrera J.F. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul. Toxicol. Pharmacol. 1998, 28:242-264.
-
(1998)
Regul. Toxicol. Pharmacol.
, vol.28
, pp. 242-264
-
-
Matthews, E.J.1
Contrera, J.F.2
-
28
-
-
58549095658
-
Caenorhabditis elegans in Parkinson's disease drug discovery: addressing an unmet medical need
-
Nass R., Merchant K.M., Ryan T. Caenorhabditis elegans in Parkinson's disease drug discovery: addressing an unmet medical need. Mol. Intervention 2008, 8:284-293.
-
(2008)
Mol. Intervention
, vol.8
, pp. 284-293
-
-
Nass, R.1
Merchant, K.M.2
Ryan, T.3
-
29
-
-
79955749505
-
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
-
Pandey U.B., Nichols C.D. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol. Rev. 2011, 63:411-436.
-
(2011)
Pharmacol. Rev.
, vol.63
, pp. 411-436
-
-
Pandey, U.B.1
Nichols, C.D.2
-
30
-
-
84864922051
-
Contribution of yeast models to neurodegeneration research
-
Pereira C., Bessa C., Soares J., Leão M., Saraiva L. Contribution of yeast models to neurodegeneration research. J. Biomed. Biotech. 2012, 10.1155/2012/ 941232.
-
(2012)
J. Biomed. Biotech.
-
-
Pereira, C.1
Bessa, C.2
Soares, J.3
Leão, M.4
Saraiva, L.5
-
31
-
-
44649196430
-
Use of non-mammalian alternative models for neurotoxicological study
-
Peterson R.T., Nass R., Boyd W.A., Freedman J.H., Dong K., Narahashi T. Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology 2008, 29:546-555.
-
(2008)
Neurotoxicology
, vol.29
, pp. 546-555
-
-
Peterson, R.T.1
Nass, R.2
Boyd, W.A.3
Freedman, J.H.4
Dong, K.5
Narahashi, T.6
-
32
-
-
41549104500
-
Distinct innate immune responses to infection and wounding in the C. elegans epidermis
-
Pujol N., Cypowyj S., Ziegler K., Millet A., Astrain A., Goncharov A., Jin Y., Chisholm A.D., Ewbank J.J. Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr. Biol. 2008, 18:481-489.
-
(2008)
Curr. Biol.
, vol.18
, pp. 481-489
-
-
Pujol, N.1
Cypowyj, S.2
Ziegler, K.3
Millet, A.4
Astrain, A.5
Goncharov, A.6
Jin, Y.7
Chisholm, A.D.8
Ewbank, J.J.9
-
33
-
-
84870732121
-
A review on alternatives to animal testing methods in drug development
-
Ranganatha N., Kuppast I.J. A review on alternatives to animal testing methods in drug development. Int. J. Pharm. Pharm. Sci. 2012, 4:28-32.
-
(2012)
Int. J. Pharm. Pharm. Sci.
, vol.4
, pp. 28-32
-
-
Ranganatha, N.1
Kuppast, I.J.2
-
34
-
-
0034837386
-
A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
-
Reiter L.T., Potocki L., Chien S., Gribskov M., Bier E. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 2001, 11:1114-1125.
-
(2001)
Genome Res.
, vol.11
, pp. 1114-1125
-
-
Reiter, L.T.1
Potocki, L.2
Chien, S.3
Gribskov, M.4
Bier, E.5
-
35
-
-
0037260329
-
Toxicology and new social ethics for animals
-
Rollin B.E. Toxicology and new social ethics for animals. Toxicol. Pathol. 2003, 31:128-131.
-
(2003)
Toxicol. Pathol.
, vol.31
, pp. 128-131
-
-
Rollin, B.E.1
-
36
-
-
0036903001
-
Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion
-
Rothenfluh A., Heberlein U. Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr. Opin. Neurobiol. 2002, 12:639-645.
-
(2002)
Curr. Opin. Neurobiol.
, vol.12
, pp. 639-645
-
-
Rothenfluh, A.1
Heberlein, U.2
-
37
-
-
1542758710
-
The 3 Rs and animal welfare-conflict or the way forward
-
Rusche B. The 3 Rs and animal welfare-conflict or the way forward. ALTEX 2003, 20:63-76.
-
(2003)
ALTEX
, vol.20
, pp. 63-76
-
-
Rusche, B.1
-
39
-
-
0033986708
-
The use of telomerized cells for tissue engineering
-
Shay J.W., Wright W.E. The use of telomerized cells for tissue engineering. Nat. Biotech. 2000, 18:22-23.
-
(2000)
Nat. Biotech.
, vol.18
, pp. 22-23
-
-
Shay, J.W.1
Wright, W.E.2
-
40
-
-
46749108855
-
The yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins
-
Siggers K.A., Lesser C.F. The yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins. Cell Host Microbe 2008, 4:8-15.
-
(2008)
Cell Host Microbe
, vol.4
, pp. 8-15
-
-
Siggers, K.A.1
Lesser, C.F.2
-
41
-
-
0034619381
-
Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits in vivo restoration of valve tissue
-
Steinhoff G., Stock U., Karim N., Mertschin H., Timke A., Meliss R.R., Bader A. Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits in vivo restoration of valve tissue. Circulation 2000, 102:Iii50-Iii55.
-
(2000)
Circulation
, vol.102
, pp. 350-355
-
-
Steinhoff, G.1
Stock, U.2
Karim, N.3
Mertschin, H.4
Timke, A.5
Meliss, R.R.6
Bader, A.7
-
42
-
-
34249672226
-
Revisiting the Krogh principle in the post-genome era: Caenorhabditis elegans as a model system for integrative physiology research
-
Strange K. Revisiting the Krogh principle in the post-genome era: Caenorhabditis elegans as a model system for integrative physiology research. J. Exp. Biol. 2007, 210:1622-1631.
-
(2007)
J. Exp. Biol.
, vol.210
, pp. 1622-1631
-
-
Strange, K.1
-
43
-
-
54949089175
-
Computer-aided drug design: an alternative to animal testing in the pharmacological screening
-
Vedani A. Computer-aided drug design: an alternative to animal testing in the pharmacological screening. ALTEX 1991, 8:39.
-
(1991)
ALTEX
, vol.8
, pp. 39
-
-
Vedani, A.1
-
44
-
-
80054023212
-
Invertebrate models for biomedical research, testing, and education
-
Wilson-Sanders S.E. Invertebrate models for biomedical research, testing, and education. ILAR J. 2011, 52:126-152.
-
(2011)
ILAR J.
, vol.52
, pp. 126-152
-
-
Wilson-Sanders, S.E.1
-
45
-
-
67651248265
-
Drosophila melanogaster as a model system for genetics of postnatal cardiac function
-
Wolf M.J., Rockman H.A. Drosophila melanogaster as a model system for genetics of postnatal cardiac function. Drug Dis. Today Dis. Models 2008, 5:117-123.
-
(2008)
Drug Dis. Today Dis. Models
, vol.5
, pp. 117-123
-
-
Wolf, M.J.1
Rockman, H.A.2
-
46
-
-
84930540811
-
-
www.rspca.org.uk/researchanimals.
-
-
-
-
47
-
-
0034521026
-
Corneal organ culture model for assessing epithelial responses to surfactants
-
Xu K.P., Li X.F., Fu-Shin X.Y. Corneal organ culture model for assessing epithelial responses to surfactants. Toxicol. Sci. 2000, 58:306-314.
-
(2000)
Toxicol. Sci.
, vol.58
, pp. 306-314
-
-
Xu, K.P.1
Li, X.F.2
Fu-Shin, X.Y.3
|