Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

Journal of Clinical Investigation

Volumn 108, Issue 3, 2001, Pages 407-414

  Kehat, Izhak ^a   Kenyagin Karsenti, Dorit ^a   Snir, Mirit ^a   Segev, Hana ^a   Amit, Michal ^a   Gepstein, Amira ^a   Livne, Erella ^a   Binah, Ofer ^a   Itskovitz Eldor, Joseph ^a,b   Gepstein, Lior ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; CALCIUM ION; CARBACHOL; DESMIN; ISOPRENALINE; MONOCLONAL ANTIBODY; MYOSIN HEAVY CHAIN; TRANSCRIPTION FACTOR; TROPONIN I;

ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; CHRONOTROPISM; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MUSCLE DEVELOPMENT; NORMAL HUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; TRANSMISSION ELECTRON MICROSCOPY;

ACTININ; ATRIAL NATRIURETIC FACTOR; BASE SEQUENCE; CALCIUM; CELL AGGREGATION; CELL DIFFERENTIATION; CELLS, CULTURED; DESMIN; DNA PRIMERS; EMBRYO; GENE EXPRESSION; HUMANS; MICROSCOPY, ELECTRON; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOSIN HEAVY CHAINS; STEM CELLS; TROPONIN I;

EID: 0034904645     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200112131     Document Type: Article

References (30)

1. Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium
2. Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium?
3. Establishment in culture of pluripotential cells from mouse embryos
4. Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study
5. Myosin heavy chain expression in contracting myocytes isolated during embryonic stem cell cardiogenesis
6. Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents
7. Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis
8. 2- current in the early stages of cardiomyocyte development
9. 2- oscillations drive spontaneous contractions in cardiomyocytes during early development
10. Embryonic stem cell lines derived from human blastocysts
11. Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
12. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers
13. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
14. Clonally derived human embryonic stem cell lines maintain plutipotency and proliferative potential for prolonged periods of culture
15. Expression of transcription regulating genes in human preimplantation embryos
16. Molecular cloning and characterization of human cardiac homeobox gene CSX1
17. RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle
18. Action potential propagation failures in longterm recordings from embryonic stem cell-derived cardiomyocytes in tissue culture
19. Fas (CD95/Apo-1)-mediated damage to ventricular myocytes induced by cytotoxic T lymphocytes from per forin-deficient mice. A major role for inositol 1,4,5-triphosphate
20. Differentiation of muscle-specific proteins in chicken somites as studied by immunofluorescence microscopy
21. Histogenesis of the embryonic myocardium
22. Observations on the ultrastructure of developing myocardium of rat embryos
23. Zebrafish genetics and vertebrate heart formation
24. 2+ transients in the human heart
25. Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types
26. Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent protein
27. Transmembrane electrical characteristics of cultured human skeletal muscle cells
28. 2+ channel blockers
29. Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation
30. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts