Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency

Cell

Volumn 160, Issue 6, 2015, Pages 1072-1086

  Theodoris, Christina V ^a,b,c   Li, Molong ^a,b   White, Mark P ^a,b   Liu, Lei ^a,b   He, Daniel ^a,b   Pollard, Katherine S ^a,d   Bruneau, Benoit G ^a,b,c,d   Srivastava, Deepak ^a,b,c,d  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b Roddenberry Center for Stem Cell Biology and Medicine at Gladstone   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR; UNTRANSLATED RNA; NOTCH1 PROTEIN, HUMAN;

AORTA VALVE; AORTA VALVE DISEASE; ARTICLE; CALCIFICATION; CELL DIFFERENTIATION; CHROMATIN; CLINICAL ARTICLE; CONGENITAL HEART DISEASE; DISEASE MODEL; ENDOTHELIUM CELL; EPIGENETICS; FEMALE; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; HAPLOINSUFFICIENCY; HEMODYNAMICS; HISTONE MODIFICATION; HUMAN; HUMAN CELL; MALE; NONSENSE MUTATION; PEDIGREE ANALYSIS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SHEAR STRESS; VALVULAR HEART DISEASE; BONE DEVELOPMENT; GENETIC EPIGENESIS; GENETICS; HISTONE CODE; INDUCED PLURIPOTENT STEM CELL; INFLAMMATION; MECHANICAL STRESS; METABOLISM; PEDIGREE;

ENDOTHELIAL CELLS; EPIGENESIS, GENETIC; FEMALE; GENE REGULATORY NETWORKS; HAPLOINSUFFICIENCY; HISTONE CODE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INFLAMMATION; MALE; OSTEOGENESIS; PEDIGREE; RECEPTOR, NOTCH1; STRESS, MECHANICAL; TRANSCRIPTION, GENETIC;

EID: 84924561757     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.02.035     Document Type: Article

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