Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells

International Journal of Cardiology

Volumn 168, Issue 6, 2013, Pages 5277-5286

  Ma, Dongrui ^a   Wei, Heming ^a,b   Zhao, Yongxing ^a   Lu, Jun ^a   Li, Guang ^a   Sahib, Norliza Binte Esmail ^a   Tan, Teng Hong ^c   Wong, Keng Yean ^c   Shim, Winston ^a,b   Wong, Philip ^a,b   Cook, Stuart A ^a,b,d   Liew, Reginald ^a,b  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Cardiomyocytes; Induced pluripotent stem cells; Long QT syndrome; SCN5A; Sodium channel

Indexed keywords

KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MEXILETINE; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; SODIUM CHANNEL NAV1.5; SODIUM ION; SUPPRESSOR OF CYTOKINE SIGNALING 2; TETRODOTOXIN;

ARTICLE; CELL DIFFERENTIATION; CELL SPECIFICITY; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; LONG QT SYNDROME; MOLECULAR PATHOLOGY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SKIN FIBROBLAST; SODIUM CURRENT;

CARDIOMYOCYTES; INDUCED PLURIPOTENT STEM CELLS; LONG QT SYNDROME; SCN5A; SODIUM CHANNEL;

ACTION POTENTIALS; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 3; DERMIS; ELECTROCARDIOGRAPHY; FEMALE; FIBROBLASTS; GENOTYPE; HEART ARREST; HUMANS; LONG QT SYNDROME; MEMBRANE POTENTIALS; MEXILETINE; MYOCYTES, CARDIAC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PATCH-CLAMP TECHNIQUES; PLURIPOTENT STEM CELLS; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84887150722     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.08.015     Document Type: Article

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