Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes

Stem Cell Research and Therapy

Volumn 6, Issue 1, 2015, Pages

  Ma, Dongrui ^a   Wei, Heming ^a,b   Lu, Jun ^a   Huang, Dou ^a   Liu, Zhenfeng ^a   Loh, Li Jun ^a   Islam, Omedul ^a   Liew, Reginald ^b   Shim, Winston ^a,b   Cook, Stuart A ^a,b,c  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; DELAYED RECTIFIER POTASSIUM CHANNEL; MESSENGER RNA; N [4 [4 METHOXYPHENYL]THIAZOL-2 YL] 1 TOSYLPIPERIDINE 2 CARBOXAMIDE; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; (R)-N-(4-(4-METHOXYPHENYL)THIAZOL-2-YL)-1-TOSYLPIPERIDINE-2-CARBOXAMIDE; KCNQ1 PROTEIN, HUMAN; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL PROTEIN I(SK); THIAZOLE DERIVATIVE; TOLUENESULFONIC ACID DERIVATIVE; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL DURATION; ADULT; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE MODEL; EXON; EXON SKIPPING; FEMALE; GENE DELETION; GENE IDENTIFICATION; HAPLOINSUFFICIENCY; HEART MUSCLE CELL; HETEROZYGOSITY; HUMAN; LONG QT SYNDROME 1; MISSENSE MUTATION; PLURIPOTENT STEM CELL; PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN TRANSPORT; SKIN FIBROBLAST; YOUNG ADULT; ACTION POTENTIAL; BIOSYNTHESIS; CARDIAC MUSCLE CELL; CELL LINE; CELL REPROGRAMMING TECHNIQUE; CYTOLOGY; DRUG EFFECTS; ELECTROCARDIOGRAPHY; GENETICS; INDUCED PLURIPOTENT STEM CELL; MALE; MIDDLE AGED; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; ROMANO-WARD SYNDROME;

ACTION POTENTIALS; ADULT; CELL DIFFERENTIATION; CELL LINE; CELLULAR REPROGRAMMING TECHNIQUES; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KCNQ1 POTASSIUM CHANNEL; MALE; MIDDLE AGED; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POTASSIUM CHANNELS, VOLTAGE-GATED; RNA, MESSENGER; ROMANO-WARD SYNDROME; SEQUENCE DELETION; THIAZOLES; TOSYL COMPOUNDS; YOUNG ADULT;

EID: 84927556371     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/s13287-015-0027-z     Document Type: Article

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