Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 5, 2012, Pages

  O'Hara, Thomas ^a   Rudy, Yoram ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Cardiac action potential; Delayed rectifier current; Drug effects; Human cardiac model

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM);

ARTICLE; CONTROLLED STUDY; DOG; GUINEA PIG; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE; HUMAN; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RABBIT; SPECIES DIFFERENCE;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIAC ELECTROPHYSIOLOGY; COMPUTER SIMULATION; DELAYED RECTIFIER POTASSIUM CHANNELS; DOGS; GUINEA PIGS; HUMANS; ISOPROTERENOL; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; SODIUM; SODIUM-POTASSIUM-EXCHANGING ATPASE; VENTRICULAR FUNCTION;

EID: 84857282827     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00785.2011     Document Type: Article

References (38)

1. Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V, 3rd Houser SR, Tomaselli GF. Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. Am J Physiol Heart Circ Physiol 286: H602-H609, 2004.
2. Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110: 904-910, 2004.
3. + channel transcript patterns in the mammalian heart are species-dependent. Prog Biophys Mol Biol 98: 309-318, 2008.
4. 2+ handling in a model of mouse ventricular tissue. Am J Physiol Heart Circ Physiol 299: H454-H469, 2010.
5. Brown AM. Drugs, hERG and sudden death. Cell Calcium 35: 543-547, 2004.
6. Davey PP, Barlow C, Hart G. Prolongation of the QT interval in heart failure occurs at low but not at high heart rates. Clin Sci (Lond) 98: 603-610, 2000.
7. Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y. Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. Am J Physiol Heart Circ Physiol 296: H1017-H1026, 2009.
8. Faber GM, Rudy Y. Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophys J 78: 2392-2404, 2000.
9. Faber GM, Rudy Y. Calsequestrin mutation and catecholaminergic polymorphic ventricular tachycardia: a simulation study of cellular mechanism. Cardiovasc Res 75: 79-88, 2007.
10. 2+ channel and its role in myocyte electrophysiology: a theoretical investigation. Biophys J 92: 1522-1543, 2007.
11. Feldman DS, Carnes CA, Abraham WT, Bristow MR. Mechanisms of disease: beta-adrenergic receptors-alterations in signal transduction and pharmacogenomics in heart failure. Nat Clin Pract Cardiovasc Med 2: 475-483, 2005.
12. Grandi E, Pasqualini FS, Bers DM. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol 48: 112-121, 2010.
13. Guo D, Liu Q, Liu T, Elliott G, Gingras M, Kowey PR, Yan GX. Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol 57: 79-85, 2011.
14. Heijman J, Volders PG, Westra RL, Rudy Y. Local control of betaadrenergic stimulation: effects on ventricular myocyte electrophysiology and Ca(2+)-transient. J Mol Cell Cardiol 50: 863-871, 2011.
15. Hund TJ, Rudy Y. Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 110: 3168-3174, 2004.
16. Iyer V, Mazhari R, Winslow RL. A computational model of the human left-ventricular epicardial myocyte. Biophys J 87: 1507-1525, 2004.
17. Jost N, Acsai K, Horvath B, Banyasz T, Baczko I, Bitay M, Bogats G, Nanasi PP. Contribution of I Kr and I K1 to ventricular repolarization in canine and human myocytes: is there any influence of action potential duration? Basic Res Cardiol 104: 33-41, 2009.
18. Jost N, Virag L, Belati B, Lengyel C, Nemeth M, Bitay M, Bogats G, Varro A, Papp JG. A kesoi egyeniranyito kaliumaram gyors (IKr) es lassu komponensenek (IKs) osszehasonlito vizsgalata egeszseges emberi, kutya, nyul es tengerimalac kamrai szivizomsejteken. Cardiologia Hungarica 34: 103-113, 2004.
19. Liu DW, Gintant GA, Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res 72: 671-687, 1993.
20. O'Hara T, Rudy Y. Arrhythmia formation in subclinical ("silent") long QT syndrome requires multiple insults: quantitative mechanistic atudy using the KCNQ1 mutation Q357R as example. Heart Rhythm 2011 Sep 25 [Epub ahead of print].
21. O'Hara T, Virag L, Varro A, Rudy Y. Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. PLoS Comput Biol 7: e1002061, 2011.
22. Pandit SV, Clark RB, Giles WR, Demir SS. A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes. Biophys J 81: 3029-3051, 2001.
23. Pieske B, Maier LS, Piacentino V, 3rd Weisser J, Hasenfuss G, Houser S. Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium. Circulation 106: 447-453, 2002.
24. Rocchetti M, Besana A, Gurrola GB, Possani LD, Zaza A. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol 534: 721-732, 2001.
25. Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med 350: 1013-1022, 2004.
26. Rudy Y, Silva JR. Computational biology in the study of cardiac ion channels and cell electrophysiology. Q Rev Biophys 39: 57-116, 2006.
27. Schwartz PJ, Stramba-Badiale M, Crotti L, Pedrazzini M, Besana A, Bosi G, Gabbarini F, Goulene K, Insolia R, Mannarino S, Mosca F, Nespoli L, Rimini A, Rosati E, Salice P, Spazzolini C. Prevalence of the congenital long-QT syndrome. Circulation 120: 1761-1767, 2009.
28. Shannon TR, Wang F, Puglisi J, Weber C, Bers DM. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J 87: 3351-3371, 2004.
29. Silva J, Rudy Y. Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation 112: 1384-1391, 2005.
30. Silva JR, Pan H, Wu D, Nekouzadeh A, Decker KF, Cui J, Baker NA, Sept D, Rudy Y. A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proc Natl Acad Sci USA 106: 11102-11106, 2009.
31. Stengl M, Volders PG, Thomsen MB, Spatjens RL, Sipido KR, Vos MA. Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes. J Physiol 551: 777-786, 2003.
32. Szabo G, Szentandrassy N, Biro T, Toth BI, Czifra G, Magyar J, Banyasz T, Varro A, Kovacs L, Nanasi PP. Asymmetrical distribution of ion channels in canine and human left-ventricular wall: epicardium vs. midmyocardium. Pflügers Arch 450: 307-316, 2005.
33. ten Tusscher KH, Noble D, Noble PJ, Panfilov AV. A model for human ventricular tissue. Am J Physiol Heart Circ Physiol 286: H1573-H1589, 2004.
34. Ten Tusscher KH, Panfilov AV. Alternans and spiral breakup in a human ventricular tissue model. Am J Physiol Heart Circ Physiol 291: H1088-H1100, 2006.
35. Viswanathan PC, Shaw RM, Rudy Y. Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation 99: 2466-2474, 1999.
36. Volders PG, Stengl M, van Opstal JM, Gerlach U, Spatjens RL, Beekman JD, Sipido KR, Vos MA. Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation. Circulation 107: 2753-2760, 2003.
37. Wang ZG, Pelletier LC, Talajic M, Nattel S. Effects of flecainide and quinidine on human atrial action potentials. Role of rate-dependence and comparison with guinea pig, rabbit, and dog tissues. Circulation 82: 274-283, 1990.
38. + currents in the heart. Am J Physiol Heart Circ Physiol 285: H1641-H1649, 2003.