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Volumn 30, Issue 6, 2016, Pages 878-893

Molecular Signaling Pathways behind the Biological Effects of Salvia Species Diterpenes in Neuropharmacology and Cardiology

Author keywords

cell signaling pathway; miltirone; Salvia; salvinorin A; tanshinone

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 7 METHOXYROSMANOL; AMYLOID BETA PROTEIN; BENZODIAZEPINE RECEPTOR; CARNOSIC ACID; CARNOSOL; CRYPTOTANSHINONE; DIHYDROTANSHINONE; DITERPENE; DIVINATORIN D; DIVINATORIN E; GALDOSOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAPPA OPIATE RECEPTOR; MILTIRONE; MITOGEN ACTIVATED PROTEIN KINASE; PLACEBO; SALVINICIN B; SALVINORIN A; SALVINORIN G; SCLAREOL; TANSHINOATE B; TANSHINONE; TANSHINONE I; TANSHINONE IIA; TANSHINONE SULFONATE; TAU PROTEIN; TAXODIONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; PHENANTHRENE DERIVATIVE;

EID: 84961263132     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5599     Document Type: Review
Times cited : (35)

References (163)
  • 1
    • 0032859938 scopus 로고    scopus 로고
    • Inhibition of tau phosphorylating protein kinase Cdk5 prevents beta-amyloid-induced neuronal death
    • Alvarez A, Toro R, Caceres A, Maccioni RB,. 1999. Inhibition of tau phosphorylating protein kinase Cdk5 prevents beta-amyloid-induced neuronal death. FEBS Lett 459: 421-426.
    • (1999) FEBS Lett , vol.459 , pp. 421-426
    • Alvarez, A.1    Toro, R.2    Caceres, A.3    Maccioni, R.B.4
  • 2
    • 0026584825 scopus 로고
    • Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and carnosic acid
    • Aruoma OI, Halliwell B, Aeschbach R, Lolingers J,. 1992. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. Xenobiotica 22: 257-268.
    • (1992) Xenobiotica , vol.22 , pp. 257-268
    • Aruoma, O.I.1    Halliwell, B.2    Aeschbach, R.3    Lolingers, J.4
  • 3
    • 53849146695 scopus 로고    scopus 로고
    • Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole
    • Beerepoot P, Lam V, Luu A, Tsoi B, Siebert D, Szechtman H,. 2008. Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole. Neurosci Lett 446: 101-104.
    • (2008) Neurosci Lett , vol.446 , pp. 101-104
    • Beerepoot, P.1    Lam, V.2    Luu, A.3    Tsoi, B.4    Siebert, D.5    Szechtman, H.6
  • 4
    • 0033982996 scopus 로고    scopus 로고
    • The 'ABC' of GABA receptors
    • Bormann J,. 2000. The 'ABC' of GABA receptors. Trends Pharmacol Sci 21: 16-19.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 16-19
    • Bormann, J.1
  • 5
    • 38049032934 scopus 로고    scopus 로고
    • Involvement of kappa-opioid and endocannabinoid system on salvinorin A-induced reward
    • Braida D, Limonta V, Capurro V, et al., 2008. Involvement of kappa-opioid and endocannabinoid system on salvinorin A-induced reward. Biol Psychiatry 63: 286-292.
    • (2008) Biol Psychiatry , vol.63 , pp. 286-292
    • Braida, D.1    Limonta, V.2    Capurro, V.3
  • 6
    • 70350166693 scopus 로고    scopus 로고
    • Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents
    • Braida D, Capurro V, Zani A, et al., 2009. Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents. Br J Pharmacol 157: 844-853.
    • (2009) Br J Pharmacol , vol.157 , pp. 844-853
    • Braida, D.1    Capurro, V.2    Zani, A.3
  • 7
    • 84944723037 scopus 로고    scopus 로고
    • Salvinorin A, a kappa-opioid receptor agonist hallucinogen: Pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders
    • Butelman ER, Kreek MJ,. 2015. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol 6: 190.
    • (2015) Front Pharmacol , vol.6 , pp. 190
    • Butelman, E.R.1    Kreek, M.J.2
  • 8
    • 0029911616 scopus 로고    scopus 로고
    • Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells
    • Cao EH, Liu XQ, Wang JJ, Xu NF,. 1996. Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells. Free Radic Biol Med 20: 801-806.
    • (1996) Free Radic Biol Med , vol.20 , pp. 801-806
    • Cao, E.H.1    Liu, X.Q.2    Wang, J.J.3    Xu, N.F.4
  • 9
    • 33644947581 scopus 로고    scopus 로고
    • The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the Guinea-pig ileum
    • Capasso R, Borrelli F, Capasso F, et al., 2006. The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea-pig ileum. Neurogastroenterol Motil 18: 69-75.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 69-75
    • Capasso, R.1    Borrelli, F.2    Capasso, F.3
  • 10
    • 54949096945 scopus 로고    scopus 로고
    • Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: Cross-talk between kappa-opioid and cannabinoid CB(1) receptors
    • Capasso R, Borrelli F, Cascio MG, et al., 2008. Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors. Br J Pharmacol 155: 681-689.
    • (2008) Br J Pharmacol , vol.155 , pp. 681-689
    • Capasso, R.1    Borrelli, F.2    Cascio, M.G.3
  • 11
    • 38149069125 scopus 로고    scopus 로고
    • The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice
    • Capasso R, Borrelli F, Zjawiony J, et al., 2008. The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice. Neurogastroenterol Motil 20: 142-148.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 142-148
    • Capasso, R.1    Borrelli, F.2    Zjawiony, J.3
  • 12
    • 79953661402 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits angiotensin II-induced cell proliferation in rat cardiac fibroblasts
    • Chan P, Liu JC, Lin LJ, et al., 2011. Tanshinone IIA inhibits angiotensin II-induced cell proliferation in rat cardiac fibroblasts. Am J Chin Med 39: 381-394.
    • (2011) Am J Chin Med , vol.39 , pp. 381-394
    • Chan, P.1    Liu, J.C.2    Lin, L.J.3
  • 13
    • 1342265861 scopus 로고    scopus 로고
    • Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious kappa-opioid receptor agonist: Structural and functional considerations
    • Chavkin C, Sud S, Jin W, et al., 2004. Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. J Pharmacol Exp Ther 308: 1197-1203.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1197-1203
    • Chavkin, C.1    Sud, S.2    Jin, W.3
  • 14
    • 33847684809 scopus 로고    scopus 로고
    • Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells
    • Chen TH, Hsu YT, Chen CH, Kao SH, Lee HM,. 2007. Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells. Mitochondrion 7: 101-105.
    • (2007) Mitochondrion , vol.7 , pp. 101-105
    • Chen, T.H.1    Hsu, Y.T.2    Chen, C.H.3    Kao, S.H.4    Lee, H.M.5
  • 16
    • 77953892400 scopus 로고    scopus 로고
    • Molecular mechanisms of neurodegeneration in Alzheimer's disease
    • Crews L, Masliah E,. 2010. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet 19: R12-R20.
    • (2010) Hum Mol Genet , vol.19 , pp. R12-R20
    • Crews, L.1    Masliah, E.2
  • 19
    • 23944445343 scopus 로고    scopus 로고
    • New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human k opioid receptors
    • David YW, Lee ZM, Lee-Yuan LC, et al., 2005. New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human k opioid receptors. Bioorg Med Chem 13: 5635-5639.
    • (2005) Bioorg Med Chem , vol.13 , pp. 5635-5639
    • David, Y.W.1    Lee, Z.M.2    Lee-Yuan, L.C.3
  • 20
    • 1442276958 scopus 로고    scopus 로고
    • Peripherally restricted opioid agonists as novel analgesic agents
    • DeHaven-Hudkins DL, Dolle RE,. 2004. Peripherally restricted opioid agonists as novel analgesic agents. Curr Pharm Des 10: 743-757.
    • (2004) Curr Pharm des , vol.10 , pp. 743-757
    • DeHaven-Hudkins, D.L.1    Dolle, R.E.2
  • 21
    • 33745268224 scopus 로고    scopus 로고
    • Different conformations of amyloid β induce neurotoxicity by distinct mechanisms inhumancorticalneurons
    • Deshpande A, Mina E, Glabe C, Busciglio J,. 2006. Different conformations of amyloid β induce neurotoxicity by distinct mechanisms inhumancorticalneurons. J Neurosci 26: 6011-6018.
    • (2006) J Neurosci , vol.26 , pp. 6011-6018
    • Deshpande, A.1    Mina, E.2    Glabe, C.3    Busciglio, J.4
  • 22
    • 84922231744 scopus 로고    scopus 로고
    • Salvinorin a and related compounds as therapeutic drugs for psychostimulant-related disorders
    • dos Santos RG, Crippa JA, Machado-de-Sousa JP, Hallak JE,. 2014. Salvinorin a and related compounds as therapeutic drugs for psychostimulant-related disorders. Curr Drug Abuse Rev 7: 128-132.
    • (2014) Curr Drug Abuse Rev , vol.7 , pp. 128-132
    • Dos Santos, R.G.1    Crippa, J.A.2    Machado-De-Sousa, J.P.3    Hallak, J.E.4
  • 23
    • 16244391149 scopus 로고    scopus 로고
    • Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice
    • Du JR, Li X, Zhang R, Qian ZM,. 2005. Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice. J Ethnopharmacol 98: 319-322.
    • (2005) J Ethnopharmacol , vol.98 , pp. 319-322
    • Du, J.R.1    Li, X.2    Zhang, R.3    Qian, Z.M.4
  • 24
    • 24344447078 scopus 로고    scopus 로고
    • The folklore and cosmetics use of various Salvia species
    • In, Kintzios S.E. (ed). Harwood Academic Publishers: Amsterdam, the Netherlands
    • Dweck AC,. 2000. The folklore and cosmetics use of various Salvia species. In The genus Salvia, Kintzios SE, (ed). Harwood Academic Publishers: Amsterdam, the Netherlands; 1-25.
    • (2000) The Genus Salvia , pp. 1-25
    • Dweck, A.C.1
  • 25
    • 0036178388 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases in hamster aortic atherosclerosis: Correlation with in-situ zymography
    • Faia KL, Davis WP, Marone AJ, Foxall TL,. 2002. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in hamster aortic atherosclerosis: correlation with in-situ zymography. Atherosclerosis 160: 325-337.
    • (2002) Atherosclerosis , vol.160 , pp. 325-337
    • Faia, K.L.1    Davis, W.P.2    Marone, A.J.3    Foxall, T.L.4
  • 26
    • 61349154148 scopus 로고    scopus 로고
    • The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS
    • Fan GW, Gao XM, Wang H, et al., 2009. The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS. J Steroid Biochem Mol Biol 113: 275-280.
    • (2009) J Steroid Biochem Mol Biol , vol.113 , pp. 275-280
    • Fan, G.W.1    Gao, X.M.2    Wang, H.3
  • 27
    • 78649789528 scopus 로고    scopus 로고
    • Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension
    • Fang J, Xu SW, Wang P, et al., 2010. Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension. Phytomedicine 18: 58-64.
    • (2010) Phytomedicine , vol.18 , pp. 58-64
    • Fang, J.1    Xu, S.W.2    Wang, P.3
  • 28
    • 35348951539 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet
    • Fang ZY, Lin R, Yuan BX, Liu Y, Zhang H,. 2007. Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet. Life Sci 81: 1339-1345.
    • (2007) Life Sci , vol.81 , pp. 1339-1345
    • Fang, Z.Y.1    Lin, R.2    Yuan, B.X.3    Liu, Y.4    Zhang, H.5
  • 29
    • 37249061594 scopus 로고    scopus 로고
    • Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit
    • Fang ZY, Lin R, Yuan BX, Yang GD, Liu Y, Zhang H,. 2008. Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit. J Ethnopharmacol 115: 217-222.
    • (2008) J Ethnopharmacol , vol.115 , pp. 217-222
    • Fang, Z.Y.1    Lin, R.2    Yuan, B.X.3    Yang, G.D.4    Liu, Y.5    Zhang, H.6
  • 30
    • 79955904766 scopus 로고    scopus 로고
    • Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum
    • Fichna J, Dicay M, Hirota SA, et al., 2011. Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum. Neurogastroenterol Motil 23: 583-e212.
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 583-612
    • Fichna, J.1    Dicay, M.2    Hirota, S.A.3
  • 31
    • 84861334183 scopus 로고    scopus 로고
    • Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors
    • Fichna J, Dicay M, Lewellyn K, et al., 2012. Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors. Inflamm Bowel Dis 18: 1137-1145.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1137-1145
    • Fichna, J.1    Dicay, M.2    Lewellyn, K.3
  • 32
    • 72449196776 scopus 로고    scopus 로고
    • Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating κ-opioid and cannabinoid receptors
    • Fichna J, Schicho R, Andrews CN, et al., 2009. Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating κ-opioid and cannabinoid receptors. Neurogastroenterol Motil 21: 1326-e128.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 1326-2128
    • Fichna, J.1    Schicho, R.2    Andrews, C.N.3
  • 33
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB,. 2003. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63: 1256-1272.
    • (2003) Mol Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 34
    • 34250814485 scopus 로고    scopus 로고
    • Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis
    • Fu J, Huang H, Liu J, Pi R, Chen J, Liu P,. 2007. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmacol 568: 213-221.
    • (2007) Eur J Pharmacol , vol.568 , pp. 213-221
    • Fu, J.1    Huang, H.2    Liu, J.3    Pi, R.4    Chen, J.5    Liu, P.6
  • 35
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis
    • Galkina E, Ley K,. 2009. Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol 27: 165-197.
    • (2009) Annu Rev Immunol , vol.27 , pp. 165-197
    • Galkina, E.1    Ley, K.2
  • 36
    • 38049051048 scopus 로고    scopus 로고
    • Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis
    • Gao J, Yang G, Pi R, et al., 2008. Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis. Transl Res 151: 79-87.
    • (2008) Transl Res , vol.151 , pp. 79-87
    • Gao, J.1    Yang, G.2    Pi, R.3
  • 37
    • 84155164808 scopus 로고    scopus 로고
    • Cardiovascular actions and therapeutic potential of tanshinone IIA
    • Gao S, Liu Z, Li H, Little PJ, Liu P, Xu S,. 2012. Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis 220: 3-10.
    • (2012) Atherosclerosis , vol.220 , pp. 3-10
    • Gao, S.1    Liu, Z.2    Li, H.3    Little, P.J.4    Liu, P.5    Xu, S.6
  • 39
    • 0030005625 scopus 로고    scopus 로고
    • Tau protein and the neurofibrillary pathology of Alzheimer's disease
    • Goedert M,. 1996. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Ann N Y Acad Sci 777: 121-131.
    • (1996) Ann N y Acad Sci , vol.777 , pp. 121-131
    • Goedert, M.1
  • 40
    • 0031796883 scopus 로고    scopus 로고
    • Neurofibrillary pathology of Alzheimer's disease and other tauopathies
    • Goedert M,. 1998. Neurofibrillary pathology of Alzheimer's disease and other tauopathies. Prog Brain Res 117: 287-306.
    • (1998) Prog Brain Res , vol.117 , pp. 287-306
    • Goedert, M.1
  • 41
    • 58149471235 scopus 로고    scopus 로고
    • The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism
    • Gong Z, Huang C, Sheng X, et al., 2009. The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism. Endocrinology 150: 104-113.
    • (2009) Endocrinology , vol.150 , pp. 104-113
    • Gong, Z.1    Huang, C.2    Sheng, X.3
  • 42
    • 22244466770 scopus 로고    scopus 로고
    • Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum
    • Harding WW, Tidgewell K, Schmidt M, et al., 2005. Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum. Org Lett 7: 3017-3020.
    • (2005) Org Lett , vol.7 , pp. 3017-3020
    • Harding, W.W.1    Tidgewell, K.2    Schmidt, M.3
  • 44
    • 78651269781 scopus 로고    scopus 로고
    • Anti-inflammatory, anticholinesterase and antioxidative constituents from the roots and the leaves of Salvia nipponica Miq
    • Chan H-H, Hwang T-L, Su CR, Reddy MVB, Wu T-S,. 2011. Anti-inflammatory, anticholinesterase and antioxidative constituents from the roots and the leaves of Salvia nipponica Miq. Var formosana Phytomedicine 18: 148-150.
    • (2011) Var Formosana Phytomedicine , vol.18 , pp. 148-150
    • Chan, H.-H.1    Hwang, T.-L.2    Su, C.R.3    Reddy, M.V.B.4    Wu, T.-S.5
  • 45
    • 34447133157 scopus 로고    scopus 로고
    • Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging
    • Huang KJ, Wang H, Xie WZ, Zhang HS,. 2007. Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging. Spectrochim Acta A Mol Biomol Spectrosc 68: 1180-1186.
    • (2007) Spectrochim Acta A Mol Biomol Spectrosc , vol.68 , pp. 1180-1186
    • Huang, K.J.1    Wang, H.2    Xie, W.Z.3    Zhang, H.S.4
  • 46
    • 77952802551 scopus 로고    scopus 로고
    • Neuroprotective herbs and foods from different traditional medicines and diets
    • Iriti M, Vitalini S, Fico G, Faoro F,. 2010. Neuroprotective herbs and foods from different traditional medicines and diets. Molecules 15: 3517-3555.
    • (2010) Molecules , vol.15 , pp. 3517-3555
    • Iriti, M.1    Vitalini, S.2    Fico, G.3    Faoro, F.4
  • 47
    • 1942455887 scopus 로고    scopus 로고
    • Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles
    • Itoh K, Tong KI, Yamamoto M,. 2004. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36: 1208-1213.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1208-1213
    • Itoh, K.1    Tong, K.I.2    Yamamoto, M.3
  • 48
    • 0346059348 scopus 로고    scopus 로고
    • Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells
    • Jang SI, Jeong SI, Kim KJ, et al., 2003. Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells. Planta Med 69: 1057-1059.
    • (2003) Planta Med , vol.69 , pp. 1057-1059
    • Jang, S.I.1    Jeong, S.I.2    Kim, K.J.3
  • 49
    • 33745997334 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: Possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways
    • Jang SI, Kim HJ, Kim YJ, Jeong SI, You YO,. 2006. Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways. Eur J Pharmacol 542: 1-7.
    • (2006) Eur J Pharmacol , vol.542 , pp. 1-7
    • Jang, S.I.1    Kim, H.J.2    Kim, Y.J.3    Jeong, S.I.4    You, Y.O.5
  • 50
    • 33646027023 scopus 로고    scopus 로고
    • Effect of tanshinone IIA on myocardial cell apoptosis protein of spontaneously hypertensive rats with left ventricular hypertrophy
    • Jiang FL, Leo S, Wang XG, et al., 2006. Effect of tanshinone IIA on myocardial cell apoptosis protein of spontaneously hypertensive rats with left ventricular hypertrophy. Chin J Clin Rehabil 10: 58-60.
    • (2006) Chin J Clin Rehabil , vol.10 , pp. 58-60
    • Jiang, F.L.1    Leo, S.2    Wang, X.G.3
  • 51
    • 77952491633 scopus 로고    scopus 로고
    • Effect of tanshinone II A on MMP-2 and iNOS expression and free radical release in hippocampus of rat Alzheimer's disease model
    • Jiang P, Chen M, Lu J, Chen C, Jiao BH,. 2010. Effect of tanshinone II A on MMP-2 and iNOS expression and free radical release in hippocampus of rat Alzheimer's disease model. Acad J Sec Milit Med Univ 31: 380-384.
    • (2010) Acad J Sec Milit Med Univ , vol.31 , pp. 380-384
    • Jiang, P.1    Chen, M.2    Lu, J.3    Chen, C.4    Jiao, B.H.5
  • 52
    • 84903316609 scopus 로고    scopus 로고
    • Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP-2 and NF-kappa Bp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease
    • Jiang P, Li C, Xiang Z, Jiao B,. 2014. Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP-2 and NF-kappa Bp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. Mol Med Rep 10: 689-694.
    • (2014) Mol Med Rep , vol.10 , pp. 689-694
    • Jiang, P.1    Li, C.2    Xiang, Z.3    Jiao, B.4
  • 53
    • 0019405088 scopus 로고
    • Effects of sodium tanshinone II-A sulfonate and propranolol on coronary collaterals in acutely infarcted dogs
    • Jiang WD, Yu YZ, Liu WW, Chen YH, Wang YP, Huang TC,. 1981. Effects of sodium tanshinone II-A sulfonate and propranolol on coronary collaterals in acutely infarcted dogs. Zhongguo Yao Li Xue Bao 2: 29-33.
    • (1981) Zhongguo Yao Li Xue Bao , vol.2 , pp. 29-33
    • Jiang, W.D.1    Yu, Y.Z.2    Liu, W.W.3    Chen, Y.H.4    Wang, Y.P.5    Huang, T.C.6
  • 54
    • 46449089508 scopus 로고    scopus 로고
    • Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway
    • Jin UH, Suh SJ, Chang HW, et al., 2008. Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J Cell Biochem 104: 15-26.
    • (2008) J Cell Biochem , vol.104 , pp. 15-26
    • Jin, U.H.1    Suh, S.J.2    Chang, H.W.3
  • 55
    • 79955531128 scopus 로고    scopus 로고
    • Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum
    • Johnson MW, MacLean KA, Reissig CJ, Prisinzano TE, Griffiths RR,. 2011. Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum. Drug Alcohol Depend 115: 150-155.
    • (2011) Drug Alcohol Depend , vol.115 , pp. 150-155
    • Johnson, M.W.1    MacLean, K.A.2    Reissig, C.J.3    Prisinzano, T.E.4    Griffiths, R.R.5
  • 57
    • 57549112591 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells
    • Kang YJ, Jin UH, Chang HW, et al., 2008. Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells. Phytother Res 22: 1640-1645.
    • (2008) Phytother Res , vol.22 , pp. 1640-1645
    • Kang, Y.J.1    Jin, U.H.2    Chang, H.W.3
  • 58
    • 0343237727 scopus 로고    scopus 로고
    • Effect of magnesium tanshinoate B on the production of nitric oxide in endothelial cells
    • Karmin O, Cheung F, Sung FL, Zhu DY, Siow YL,. 2000. Effect of magnesium tanshinoate B on the production of nitric oxide in endothelial cells. Mol Cell Biochem 207: 35-39.
    • (2000) Mol Cell Biochem , vol.207 , pp. 35-39
    • Karmin, O.1    Cheung, F.2    Sung, F.L.3    Zhu, D.Y.4    Siow, Y.L.5
  • 59
    • 0037302165 scopus 로고    scopus 로고
    • Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor
    • Kavvadias D, Monschein V, Sand P, Riederer P, Schreier P,. 2003. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med 69: 113-117.
    • (2003) Planta Med , vol.69 , pp. 113-117
    • Kavvadias, D.1    Monschein, V.2    Sand, P.3    Riederer, P.4    Schreier, P.5
  • 60
    • 34548480683 scopus 로고    scopus 로고
    • Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5
    • Kesavapany S, Zheng YL, Amin N, Pant HC,. 2007. Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5. Biotechnol J 2: 978-987.
    • (2007) Biotechnol J , vol.2 , pp. 978-987
    • Kesavapany, S.1    Zheng, Y.L.2    Amin, N.3    Pant, H.C.4
  • 61
    • 12744274953 scopus 로고    scopus 로고
    • Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98g human glioblastoma cells
    • Kosaka K, Yokoi T,. 2003. Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98g human glioblastoma cells. Biol Pharm Bull 26: 1620-1622.
    • (2003) Biol Pharm Bull , vol.26 , pp. 1620-1622
    • Kosaka, K.1    Yokoi, T.2
  • 62
    • 0346882649 scopus 로고    scopus 로고
    • G-protein coupled receptors at a glance
    • Kroeze WK, Sheffler DJ, Roth BL,. 2003. G-protein coupled receptors at a glance. J Cell Sci 116: 4867-4869.
    • (2003) J Cell Sci , vol.116 , pp. 4867-4869
    • Kroeze, W.K.1    Sheffler, D.J.2    Roth, B.L.3
  • 63
    • 84866668465 scopus 로고    scopus 로고
    • Neuroprotective potential of phytochemicals
    • Kumar GP, Khanum F,. 2012. Neuroprotective potential of phytochemicals. Pharmacogn Rev 6: 81-90.
    • (2012) Pharmacogn Rev , vol.6 , pp. 81-90
    • Kumar, G.P.1    Khanum, F.2
  • 64
    • 50949129144 scopus 로고    scopus 로고
    • Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels
    • Lam FF, Yeung JH, Chan KM, Or PM,. 2008. Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J Ethnopharmacol 119: 318-321.
    • (2008) J Ethnopharmacol , vol.119 , pp. 318-321
    • Lam, F.F.1    Yeung, J.H.2    Chan, K.M.3    Or, P.M.4
  • 65
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander ES, Linton LM, Birren B, et al., 2001. Initial sequencing and analysis of the human genome. Nature 409: 860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 66
    • 30344485665 scopus 로고    scopus 로고
    • Targeting acetylcholinesterase and butyrylcholinesterase in dementia
    • Lane RM, Potkin SG, Enz A,. 2006. Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int J Neuropsychopharmacol 9: 101-124.
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 101-124
    • Lane, R.M.1    Potkin, S.G.2    Enz, A.3
  • 67
    • 0025915236 scopus 로고
    • Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza
    • Lee CM, Wong HN, Chui KY, Choang TF, Hon PM, Chang HM,. 1991. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett 127: 237-241.
    • (1991) Neurosci Lett , vol.127 , pp. 237-241
    • Lee, C.M.1    Wong, H.N.2    Chui, K.Y.3    Choang, T.F.4    Hon, P.M.5    Chang, H.M.6
  • 69
    • 46749119468 scopus 로고    scopus 로고
    • Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1/2 in angiotensin II-induced hypertrophy of myocardial cells
    • Li SS, Feng J, Zheng Z, Liang QS,. 2008. Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1/2 in angiotensin II-induced hypertrophy of myocardial cells. Chin J Integr Med 14: 123-127.
    • (2008) Chin J Integr Med , vol.14 , pp. 123-127
    • Li, S.S.1    Feng, J.2    Zheng, Z.3    Liang, Q.S.4
  • 70
    • 56049111397 scopus 로고    scopus 로고
    • Inhibitory effects and mechanism of tanshinone II A on proliferation of rat aortic smooth muscle cells
    • Li X, Du JR, Bo B, et al., 2008. Inhibitory effects and mechanism of tanshinone II A on proliferation of rat aortic smooth muscle cells. Zhongguo Zhongyao Zazhi 33: 2146-2150.
    • (2008) Zhongguo Zhongyao Zazhi , vol.33 , pp. 2146-2150
    • Li, X.1    Du, J.R.2    Bo, B.3
  • 71
    • 77952891072 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway
    • Li X, Du JR YY, Bai B, Zheng XY,. 2010. Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway. J Ethnopharmacol 129: 273-279.
    • (2010) J Ethnopharmacol , vol.129 , pp. 273-279
    • Li, X.1    Du, J.R.Y.Y.2    Bai, B.3    Zheng, X.Y.4
  • 72
    • 68949135051 scopus 로고    scopus 로고
    • The effect of tanshinone IIA upon the TGF-beta1/SMADS signaling pathway in hypertrophic myocardium of hypertensive rats
    • Li Y, Yang Y, Yu D, Liang Q,. 2009. The effect of tanshinone IIA upon the TGF-beta1/SMADS signaling pathway in hypertrophic myocardium of hypertensive rats. J Huazhong Univ Sci Technolog Med Sci 29: 476-480.
    • (2009) J Huazhong Univ Sci Technolog Med Sci , vol.29 , pp. 476-480
    • Li, Y.1    Yang, Y.2    Yu, D.3    Liang, Q.4
  • 73
    • 52149112511 scopus 로고    scopus 로고
    • Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase
    • Li YI, Elmer G, Leboeuf RC,. 2008. Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase. Life Sci 83: 557-562.
    • (2008) Life Sci , vol.83 , pp. 557-562
    • Li, Y.I.1    Elmer, G.2    Leboeuf, R.C.3
  • 74
    • 77953467123 scopus 로고    scopus 로고
    • Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading
    • Li YS, Wang ZH, Wang J,. 2008a. Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading. Zhongguo Zhong xi yi jie he za zhi 28: 632-636.
    • (2008) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.28 , pp. 632-636
    • Li, Y.S.1    Wang, Z.H.2    Wang, J.3
  • 75
    • 53549084606 scopus 로고    scopus 로고
    • Effect and molecular mechanism of tashinon IIA on the hypertrophic cadiocyte due to abdominal aorta stenosis in rats
    • Li YS, Wang ZH, Wang J, et al., 2008b. Effect and molecular mechanism of tashinon IIA on the hypertrophic cadiocyte due to abdominal aorta stenosis in rats. Chin Pharm J 43: 1313-1316+1317.
    • (2008) Chin Pharm J , vol.43
    • Li, Y.S.1    Wang, Z.H.2    Wang, J.3
  • 76
    • 50249178084 scopus 로고    scopus 로고
    • Effect of tashinone on nitric oxide synthase in hypertrophic cardiomyocyte of rats suffered abdominal aorta constriction
    • Li YS, Wang ZH, Yan L, et al., 2008c. Effect of tashinone on nitric oxide synthase in hypertrophic cardiomyocyte of rats suffered abdominal aorta constriction. Zhongguo Zhong Yao Za Zhi 33: 1446-1450.
    • (2008) Zhongguo Zhong Yao Za Zhi , vol.33 , pp. 1446-1450
    • Li, Y.S.1    Wang, Z.H.2    Yan, L.3
  • 77
    • 48149106680 scopus 로고    scopus 로고
    • Effects of four medicinal herbs on human vascular endothelial cells in culture
    • Ling S, Nheu L, Dai A, Guo Z, Komesaroff P,. 2008. Effects of four medicinal herbs on human vascular endothelial cells in culture. Int J Cardiol 128: 350-358.
    • (2008) Int J Cardiol , vol.128 , pp. 350-358
    • Ling, S.1    Nheu, L.2    Dai, A.3    Guo, Z.4    Komesaroff, P.5
  • 78
    • 53549119130 scopus 로고    scopus 로고
    • Hyperelongated biglycan: The surreptitious initiator of atherosclerosis
    • Little PJ, Osman N, O'Brien KD,. 2008. Hyperelongated biglycan: the surreptitious initiator of atherosclerosis. Curr Opin Lipidol 19: 448-454.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 448-454
    • Little, P.J.1    Osman, N.2    O'Brien, K.D.3
  • 79
    • 84874298451 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via Akt/Skp2/ p27-associated pathway
    • Luo Y, Xu DQ, Dong HY, et al., 2013. Tanshinone IIA inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via Akt/Skp2/ p27-associated pathway. PLoS One 8 (2): e56774.
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e56774
    • Luo, Y.1    Xu, D.Q.2    Dong, H.Y.3
  • 80
    • 84960133390 scopus 로고    scopus 로고
    • Salvinorin-A induces intense dissociative effects, blocking external sensory perception and modulating interoception and sense of body ownership in humans
    • pii
    • Maqueda AE, Valle M, Addy PH, et al., 2015. Salvinorin-A induces intense dissociative effects, blocking external sensory perception and modulating interoception and sense of body ownership in humans. Int J Neuropsychopharmacol 8 (12): pii: pyv065.
    • (2015) Int J Neuropsychopharmacol , vol.8 , Issue.12 , pp. pyv065
    • Maqueda, A.E.1    Valle, M.2    Addy, P.H.3
  • 81
    • 1542335553 scopus 로고    scopus 로고
    • Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
    • Martin D, Rojo AI, Salinas M, et al., 2004. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 279: 8919-8929.
    • (2004) J Biol Chem , vol.279 , pp. 8919-8929
    • Martin, D.1    Rojo, A.I.2    Salinas, M.3
  • 82
    • 0025230509 scopus 로고
    • Metalloproteinases and their inhibitors in matrix remodeling
    • Matrisian LM,. 1990. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6: 121-125.
    • (1990) Trends Genet , vol.6 , pp. 121-125
    • Matrisian, L.M.1
  • 84
    • 77955717406 scopus 로고    scopus 로고
    • Cryptotanshinione upregulates α-secretase by activation PI3K pathway in cortical neurons
    • Mei Z, Situ B, Tan X, et al., 2010. Cryptotanshinione upregulates α-secretase by activation PI3K pathway in cortical neurons. Brain Res 1348: 165-173.
    • (2010) Brain Res , vol.1348 , pp. 165-173
    • Mei, Z.1    Situ, B.2    Tan, X.3
  • 85
    • 2942720613 scopus 로고    scopus 로고
    • Inhibition by miltirone of up-regulation of GABAA receptor α4 subunit mRNA by ethanol withdrawal in hippocampal neurons
    • Mostallino MC, Mascia MP, Pisu MG, Busonero F, Talani G, Biggio G,. 2004. Inhibition by miltirone of up-regulation of GABAA receptor α4 subunit mRNA by ethanol withdrawal in hippocampal neurons. Eur J Pharmacol 494: 83-90.
    • (2004) Eur J Pharmacol , vol.494 , pp. 83-90
    • Mostallino, M.C.1    Mascia, M.P.2    Pisu, M.G.3    Busonero, F.4    Talani, G.5    Biggio, G.6
  • 86
    • 0032502337 scopus 로고    scopus 로고
    • Aortocoronary saphenous vein graft disease: Pathogenesis, predisposition, and prevention
    • Motwani JG, Topol EJ,. 1998. Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention. Circulation 97: 916-931.
    • (1998) Circulation , vol.97 , pp. 916-931
    • Motwani, J.G.1    Topol, E.J.2
  • 88
    • 0033832406 scopus 로고    scopus 로고
    • Tanshinone II-A inhibits low density lipoprotein oxidation in vitro
    • Niu XL, Ichimori K, Yang X, et al., 2000. Tanshinone II-A inhibits low density lipoprotein oxidation in vitro. Free Radic Res 33: 305-312.
    • (2000) Free Radic Res , vol.33 , pp. 305-312
    • Niu, X.L.1    Ichimori, K.2    Yang, X.3
  • 89
    • 33745209915 scopus 로고    scopus 로고
    • ADAM10 activation is required for green tea(-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein
    • Obregon DF, Rezai-Zadeh K, Bai Y, et al., 2006. ADAM10 activation is required for green tea(-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. J Biol Chem 281: 16419-16427.
    • (2006) J Biol Chem , vol.281 , pp. 16419-16427
    • Obregon, D.F.1    Rezai-Zadeh, K.2    Bai, Y.3
  • 90
    • 13344267870 scopus 로고
    • Salvinorin, a new trans-neoclerodane diterpene from Salvia divinorum (Labiatae)
    • Ortega A, Blount JF, Manchand PS,. 1982. Salvinorin, a new trans-neoclerodane diterpene from Salvia divinorum (Labiatae). J Chem Soc 1: 2505-2508.
    • (1982) J Chem Soc , vol.1 , pp. 2505-2508
    • Ortega, A.1    Blount, J.F.2    Manchand, P.S.3
  • 91
    • 77953035521 scopus 로고    scopus 로고
    • Effect of tanshinone II A on the calcineurin activity in proliferating vascular smooth muscle cells of rats
    • Pan YJ, Li XY, Yang GT,. 2009. Effect of tanshinone II A on the calcineurin activity in proliferating vascular smooth muscle cells of rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 29: 133-135.
    • (2009) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.29 , pp. 133-135
    • Pan, Y.J.1    Li, X.Y.2    Yang, G.T.3
  • 92
    • 84904545571 scopus 로고    scopus 로고
    • Anti-inflammatory effect of tanshinone i in neuroprotection against cerebral ischemia-reperfusion injury in the gerbil hippocampus
    • Park JH, Park OK, Cho JH, et al., 2014. Anti-inflammatory effect of tanshinone I in neuroprotection against cerebral ischemia-reperfusion injury in the gerbil hippocampus. Neurochem Res 39: 1300-1312.
    • (2014) Neurochem Res , vol.39 , pp. 1300-1312
    • Park, J.H.1    Park, O.K.2    Cho, J.H.3
  • 93
  • 94
    • 0022494591 scopus 로고
    • Psychotomimesis mediated by kappa opiate receptors
    • Pfeiffer A, Brantl V, Herz A, Emrich HM,. 1986. Psychotomimesis mediated by kappa opiate receptors. Science 233: 774-776.
    • (1986) Science , vol.233 , pp. 774-776
    • Pfeiffer, A.1    Brantl, V.2    Herz, A.3    Emrich, H.M.4
  • 95
    • 77953030300 scopus 로고    scopus 로고
    • Alzheimer's disease: A molecular mechanism, new hypotheses, and therapeutic strategies
    • Pleckaityte M,. 2010. Alzheimer's disease: a molecular mechanism, new hypotheses, and therapeutic strategies. Medicina 46: 70-76.
    • (2010) Medicina , vol.46 , pp. 70-76
    • Pleckaityte, M.1
  • 96
    • 84862215711 scopus 로고    scopus 로고
    • The protective effects of tanshinone IIA on β-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron
    • Qian YH, Xiao Q, Xu J,. 2012. The protective effects of tanshinone IIA on β-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron. Brain Res Bull 88: 354-358.
    • (2012) Brain Res Bull , vol.88 , pp. 354-358
    • Qian, Y.H.1    Xiao, Q.2    Xu, J.3
  • 97
    • 84867746318 scopus 로고    scopus 로고
    • Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the kappa opioid agonist Salvinorin A in humans
    • Ranganathan M, Schnakenberg A, Skosnik PD, et al., 2012. Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the kappa opioid agonist Salvinorin A in humans. Biol Psychiatry 72: 871-879.
    • (2012) Biol Psychiatry , vol.72 , pp. 871-879
    • Ranganathan, M.1    Schnakenberg, A.2    Skosnik, P.D.3
  • 98
    • 33748588914 scopus 로고    scopus 로고
    • Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma
    • Rau O, Wurglics M, Paulke A, et al., 2006. Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma. Planta Med 72: 881-887.
    • (2006) Planta Med , vol.72 , pp. 881-887
    • Rau, O.1    Wurglics, M.2    Paulke, A.3
  • 99
    • 21244496428 scopus 로고    scopus 로고
    • Current pharmacologic options for patients with Alzheimer's disease
    • Reichman WE,. 2003. Current pharmacologic options for patients with Alzheimer's disease. Ann Gen Hosp Psychiatry 2: 1.
    • (2003) Ann Gen Hosp Psychiatry , vol.2 , pp. 1
    • Reichman, W.E.1
  • 100
    • 1842588815 scopus 로고    scopus 로고
    • Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza
    • Ren Y, Houghton PJ, Hider RC, Howes MJR,. 2004. Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza. Planta Med 70: 201-204.
    • (2004) Planta Med , vol.70 , pp. 201-204
    • Ren, Y.1    Houghton, P.J.2    Hider, R.C.3    Howes, M.J.R.4
  • 101
    • 75249095628 scopus 로고    scopus 로고
    • Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression
    • Ren ZH, Tong YH, Xu W, Ma J, Chen Y,. 2010. Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression. Phytomedicine 17: 212-218.
    • (2010) Phytomedicine , vol.17 , pp. 212-218
    • Ren, Z.H.1    Tong, Y.H.2    Xu, W.3    Ma, J.4    Chen, Y.5
  • 102
    • 0028297606 scopus 로고
    • The cardiovascular and central nervous system effects in the human of U-62066E. A selective opioid receptor agonist
    • Rimoy GH, Wright DM, Bhaskar NK, Rubin PC,. 1994. The cardiovascular and central nervous system effects in the human of U-62066E. A selective opioid receptor agonist. Eur Clin Pharmacol 46: 203-207.
    • (1994) Eur Clin Pharmacol , vol.46 , pp. 203-207
    • Rimoy, G.H.1    Wright, D.M.2    Bhaskar, N.K.3    Rubin, P.C.4
  • 103
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R,. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 104
    • 0037015067 scopus 로고    scopus 로고
    • Salvinorin A: A potent naturally occurring nonnitrogenous kappa opioid selective agonist
    • Roth BL, Baner K, Westkaemper R, et al., 2002. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proc Natl Acad Sci U S A 99: 11934-11939.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11934-11939
    • Roth, B.L.1    Baner, K.2    Westkaemper, R.3
  • 105
    • 2542477991 scopus 로고    scopus 로고
    • Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: A novel approach for CNS drug discovery
    • Roth BL, Lopez E, Beischel S, Westkaemper RB, Evans JM,. 2004. Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery. Pharmacol Ther 102: 99-110.
    • (2004) Pharmacol Ther , vol.102 , pp. 99-110
    • Roth, B.L.1    Lopez, E.2    Beischel, S.3    Westkaemper, R.B.4    Evans, J.M.5
  • 106
    • 0031595265 scopus 로고    scopus 로고
    • 5-hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): Where structure meets function
    • Roth BL, Willins DL, Kristiansen K, Kroeze WK,. 1998. 5-hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacol Ther 79: 231-257.
    • (1998) Pharmacol Ther , vol.79 , pp. 231-257
    • Roth, B.L.1    Willins, D.L.2    Kristiansen, K.3    Kroeze, W.K.4
  • 107
    • 0026613007 scopus 로고
    • Isolation and identification from Salvia officinalis of two diterpenes which inhibit t-butylbicyclophosphoro[35S]thionate binding to chloride channel of rat cerebrocortical membranes in vitro
    • Rutherford DM, Nielsen MP, Hansen SK, Witt MR, Bergendorff O, Sterner O,. 1992. Isolation and identification from Salvia officinalis of two diterpenes which inhibit t-butylbicyclophosphoro[35S]thionate binding to chloride channel of rat cerebrocortical membranes in vitro. Neurosci Lett 135: 224-226.
    • (1992) Neurosci Lett , vol.135 , pp. 224-226
    • Rutherford, D.M.1    Nielsen, M.P.2    Hansen, S.K.3    Witt, M.R.4    Bergendorff, O.5    Sterner, O.6
  • 108
    • 0027969012 scopus 로고
    • Development-related changes in matrix metalloproteinase expression in human aortic smooth muscle cells
    • Sasaguri Y, Murahashi N, Sugama K, et al., 1994. Development-related changes in matrix metalloproteinase expression in human aortic smooth muscle cells. Lab Invest 71: 261-269.
    • (1994) Lab Invest , vol.71 , pp. 261-269
    • Sasaguri, Y.1    Murahashi, N.2    Sugama, K.3
  • 109
    • 33845648094 scopus 로고    scopus 로고
    • Redox regulation of neuronal survival mediated by electrophilic compounds
    • Satoh T, Lipton SA,. 2007. Redox regulation of neuronal survival mediated by electrophilic compounds. Trends Neurosci 30: 37-45.
    • (2007) Trends Neurosci , vol.30 , pp. 37-45
    • Satoh, T.1    Lipton, S.A.2
  • 110
    • 40849145272 scopus 로고    scopus 로고
    • Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners
    • Satoh T, Izumi M, Inukai Y, et al., 2008. Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners. Neurosci Lett 434: 260-265.
    • (2008) Neurosci Lett , vol.434 , pp. 260-265
    • Satoh, T.1    Izumi, M.2    Inukai, Y.3
  • 111
    • 38449111059 scopus 로고    scopus 로고
    • Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
    • Satoh T, Kosaka K, Itoh K, et al., 2008. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem 104: 1116-1131.
    • (2008) J Neurochem , vol.104 , pp. 1116-1131
    • Satoh, T.1    Kosaka, K.2    Itoh, K.3
  • 112
    • 31444447800 scopus 로고    scopus 로고
    • Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic phase II inducers
    • Satoh T, Okamoto SI, Cui J, et al., 2006. Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic phase II inducers. Proc Natl Acad Sci U S A 103: 768-773.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 768-773
    • Satoh, T.1    Okamoto, S.I.2    Cui, J.3
  • 113
    • 10044250982 scopus 로고    scopus 로고
    • Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis
    • Satoi H, Tomimoto H, Ohtani R, et al., 2005. Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis. Neuroscience 130: 657-666.
    • (2005) Neuroscience , vol.130 , pp. 657-666
    • Satoi, H.1    Tomimoto, H.2    Ohtani, R.3
  • 114
    • 0029098078 scopus 로고
    • The intima. Soil for atherosclerosis and restenosis
    • Schwartz SM, deBlois D, O'Brien ER,. 1995. The intima. Soil for atherosclerosis and restenosis. Circ Res 77: 445-465.
    • (1995) Circ Res , vol.77 , pp. 445-465
    • Schwartz, S.M.1    DeBlois, D.2    O'Brien, E.R.3
  • 115
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe DJ,. 1999. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399: A23-A31.
    • (1999) Nature , vol.399 , pp. A23-A31
    • Selkoe, D.J.1
  • 116
    • 70849102208 scopus 로고    scopus 로고
    • Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1
    • Shan H, Li X, Pan Z, et al., 2009. Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1. Br J Pharmacol 168: 1227-1235.
    • (2009) Br J Pharmacol , vol.168 , pp. 1227-1235
    • Shan, H.1    Li, X.2    Pan, Z.3
  • 117
    • 0037333260 scopus 로고    scopus 로고
    • Salvinorin A: The "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor
    • Sheffler DJ, Roth BL,. 2003. Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor. Trends Pharmacol Sci 24: 107-109.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 107-109
    • Sheffler, D.J.1    Roth, B.L.2
  • 118
    • 84863424370 scopus 로고    scopus 로고
    • The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons
    • Shi LL, Yang WN, Chen XL, et al., 2012. The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons. Neurochem Int 61: 227-235.
    • (2012) Neurochem Int , vol.61 , pp. 227-235
    • Shi, L.L.1    Yang, W.N.2    Chen, X.L.3
  • 119
    • 0028305754 scopus 로고
    • Salvia divinorum and salvinorin A: New pharmacologic findings
    • Siebert DJ,. 1994. Salvia divinorum and salvinorin A: new pharmacologic findings. J Ethnopharmacol 43: 53-56.
    • (1994) J Ethnopharmacol , vol.43 , pp. 53-56
    • Siebert, D.J.1
  • 120
    • 67349192920 scopus 로고    scopus 로고
    • Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices
    • Smith JP, Lal V, Bowser D, Cappai R, Masters CL, Ciccotosto GD,. 2009. Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices. Brain Res 7: 176-184.
    • (2009) Brain Res , vol.7 , pp. 176-184
    • Smith, J.P.1    Lal, V.2    Bowser, D.3    Cappai, R.4    Masters, C.L.5    Ciccotosto, G.D.6
  • 121
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimer's disease
    • Su JH, Anderson AJ, Cummings BJ, Cotman CW,. 1994. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport 5: 2529-2533.
    • (1994) Neuroreport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 122
    • 33751119071 scopus 로고    scopus 로고
    • Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1
    • Suh SJ, Jin UH, Choi HJ, et al., 2006. Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1. Biochem Pharmacol 72: 1680-1689.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1680-1689
    • Suh, S.J.1    Jin, U.H.2    Choi, H.J.3
  • 123
    • 48049120166 scopus 로고    scopus 로고
    • Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels
    • Sun DD, Wang HC, Wang XB, et al., 2008. Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels. Eur J Pharmacol 590: 317-321.
    • (2008) Eur J Pharmacol , vol.590 , pp. 317-321
    • Sun, D.D.1    Wang, H.C.2    Wang, X.B.3
  • 124
    • 0037103657 scopus 로고    scopus 로고
    • Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells
    • Takahashi K, Ouyang X, Komatsu K, et al., 2002. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol 64: 745-749.
    • (2002) Biochem Pharmacol , vol.64 , pp. 745-749
    • Takahashi, K.1    Ouyang, X.2    Komatsu, K.3
  • 125
    • 0034490852 scopus 로고    scopus 로고
    • Chemoprotection against cancer by induction of phase 2 enzymes
    • Talalay P,. 2000. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 12: 5-11.
    • (2000) Biofactors , vol.12 , pp. 5-11
    • Talalay, P.1
  • 126
    • 79955526513 scopus 로고    scopus 로고
    • Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/Nfatc3 pathway
    • Tan X, Li J, Wang X, et al., 2011. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/Nfatc3 pathway. Int J Biol Sci 7: 383-389.
    • (2011) Int J Biol Sci , vol.7 , pp. 383-389
    • Tan, X.1    Li, J.2    Wang, X.3
  • 127
    • 34047247883 scopus 로고    scopus 로고
    • Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress
    • Tang F, Wu X, Wang T, et al., 2007. Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress. Vascul Pharmacol 46: 427-438.
    • (2007) Vascul Pharmacol , vol.46 , pp. 427-438
    • Tang, F.1    Wu, X.2    Wang, T.3
  • 128
    • 78649725643 scopus 로고    scopus 로고
    • Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression
    • Tang FT, Cao Y, Wang TQ, et al., 2011. Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression. Eur J Pharmacol 650: 275-284.
    • (2011) Eur J Pharmacol , vol.650 , pp. 275-284
    • Tang, F.T.1    Cao, Y.2    Wang, T.Q.3
  • 129
    • 70350043938 scopus 로고    scopus 로고
    • Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats
    • Tu EY, Zhou YG, Wang ZH, Liang QS, Yang GT,. 2009. Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats. Chin J Integr Med 15: 365-370.
    • (2009) Chin J Integr Med , vol.15 , pp. 365-370
    • Tu, E.Y.1    Zhou, Y.G.2    Wang, Z.H.3    Liang, Q.S.4    Yang, G.T.5
  • 130
    • 0021746557 scopus 로고
    • Divinorin-A, a psychotropic terpenoid, and divinorin-B from the hallucinogenic Mexican mint Salvia divinorum
    • Valdes LJ, Butler WM, Hatfield GM, Paul AG, Koreeda M,. 1984. Divinorin-A, a psychotropic terpenoid, and divinorin-B from the hallucinogenic Mexican mint Salvia divinorum. J Org Chem 49: 4716-4720.
    • (1984) J Org Chem , vol.49 , pp. 4716-4720
    • Valdes, L.J.1    Butler, W.M.2    Hatfield, G.M.3    Paul, A.G.4    Koreeda, M.5
  • 131
    • 15944378214 scopus 로고    scopus 로고
    • Beta-Secretase, APP and Abeta in Alzheimer's disease
    • Vassar R,. 2005. beta-Secretase, APP and Abeta in Alzheimer's disease. Subcell Biochem 38: 79-103.
    • (2005) Subcell Biochem , vol.38 , pp. 79-103
    • Vassar, R.1
  • 132
    • 0037446894 scopus 로고    scopus 로고
    • The G-protein coupled receptor repertoires of human and mouse
    • Vassilatis DK, Hohmann JG, Zeng H, et al., 2003. The G-protein coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A 100: 4903-4908.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4903-4908
    • Vassilatis, D.K.1    Hohmann, J.G.2    Zeng, H.3
  • 133
    • 0034873586 scopus 로고    scopus 로고
    • Enadoline, a selective kappa opioid agonist: Comparison with butorphanol and hydromorphone in humans
    • Walsh SL, Strain EC, Abreu ME, Bigelow GE,. 2001. Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans. Psychopharmacology (Berl) 157: 151-162.
    • (2001) Psychopharmacology (Berl) , vol.157 , pp. 151-162
    • Walsh, S.L.1    Strain, E.C.2    Abreu, M.E.3    Bigelow, G.E.4
  • 134
    • 17244374864 scopus 로고    scopus 로고
    • Effects of tanshinon on VSMC proliferation and the expression of pp-ERK1/2 protein in rats
    • Wang H, Gao XM, Zhang BL, Chai LJ, Hu LM, Wang SX,. 2005. Effects of tanshinon on VSMC proliferation and the expression of pp-ERK1/2 protein in rats. Chin Pharm J 40: 106-108.
    • (2005) Chin Pharm J , vol.40 , pp. 106-108
    • Wang, H.1    Gao, X.M.2    Zhang, B.L.3    Chai, L.J.4    Hu, L.M.5    Wang, S.X.6
  • 135
    • 34447310482 scopus 로고    scopus 로고
    • The effect of tanshinone on L-type calcium current in hypertrophic myocardium
    • Wang ZH, Liang QS, Zheng Z,. 2006. The effect of tanshinone on L-type calcium current in hypertrophic myocardium. Chin J Hypertens 14: 450-454.
    • (2006) Chin J Hypertens , vol.14 , pp. 450-454
    • Wang, Z.H.1    Liang, Q.S.2    Zheng, Z.3
  • 136
    • 84864238294 scopus 로고    scopus 로고
    • Salvinorin a administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets
    • Wang Z, Ma N, Riley J, Armstead WM, Liu R,. 2012. Salvinorin a administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets. PLoS One 7 (7): e41724.
    • (2012) PLoS One , vol.7 , Issue.7 , pp. e41724
    • Wang, Z.1    Ma, N.2    Riley, J.3    Armstead, W.M.4    Liu, R.5
  • 137
    • 84881622003 scopus 로고    scopus 로고
    • Regulation of antioxidant system, lipids and fatty acid beta-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats
    • Wei B, You MG, Ling JJ, et al., 2013. Regulation of antioxidant system, lipids and fatty acid beta-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats. Atherosclerosis 230: 148-156.
    • (2013) Atherosclerosis , vol.230 , pp. 148-156
    • Wei, B.1    You, M.G.2    Ling, J.J.3
  • 138
    • 77049128277 scopus 로고    scopus 로고
    • Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task
    • Wong KK, Ho MT, Lin HQ, et al., 2010. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Planta Med 76: 228-234.
    • (2010) Planta Med , vol.76 , pp. 228-234
    • Wong, K.K.1    Ho, M.T.2    Lin, H.Q.3
  • 139
    • 77955511441 scopus 로고    scopus 로고
    • Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis
    • Wong KKK, Ngo JCK, Liu S, et al., 2010. Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Chem Biol Interact 187: 335-339.
    • (2010) Chem Biol Interact , vol.187 , pp. 335-339
    • Wong, K.K.K.1    Ngo, J.C.K.2    Liu, S.3
  • 140
    • 84869193062 scopus 로고    scopus 로고
    • Constituents from Salvia species and their biological activities
    • Wu YB, Ni ZY, Shi QW, et al., 2012. Constituents from Salvia species and their biological activities. Chem Rev 112: 5967-6026.
    • (2012) Chem Rev , vol.112 , pp. 5967-6026
    • Wu, Y.B.1    Ni, Z.Y.2    Shi, Q.W.3
  • 141
    • 68549085074 scopus 로고    scopus 로고
    • Tanshinone II(A) elicited vasodilation in rat coronary arteriole: Roles of nitric oxide and potassium channels
    • Wu GB, Zhou EX, Qing DX,. 2009. Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels. Eur J Pharmacol 617: 102-107.
    • (2009) Eur J Pharmacol , vol.617 , pp. 102-107
    • Wu, G.B.1    Zhou, E.X.2    Qing, D.X.3
  • 142
    • 0027131744 scopus 로고
    • Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells
    • Wu TW, Zeng LH, Fung KP,. 1993. Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells. Biochem Pharmacol 12: 2327-2332.
    • (1993) Biochem Pharmacol , vol.12 , pp. 2327-2332
    • Wu, T.W.1    Zeng, L.H.2    Fung, K.P.3
  • 143
    • 0031732694 scopus 로고    scopus 로고
    • Correlation analysis of tanshinone IIA's inhibition of L-type calcium current and its shortening of action potential duration in cardiomyocytes of Guinea pig
    • Xu CQ, Lou YP, Yang BF,. 1998. Correlation analysis of tanshinone IIA's inhibition of L-type calcium current and its shortening of action potential duration in cardiomyocytes of guinea pig. Chin Pharmacol Bull 14: 428-431.
    • (1998) Chin Pharmacol Bull , vol.14 , pp. 428-431
    • Xu, C.Q.1    Lou, Y.P.2    Yang, B.F.3
  • 144
    • 80053966275 scopus 로고    scopus 로고
    • Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet
    • Xu S, Little PJ, Lan T, et al., 2011. Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet. Arch Biochem Biophys 515: 72-79.
    • (2011) Arch Biochem Biophys , vol.515 , pp. 72-79
    • Xu, S.1    Little, P.J.2    Lan, T.3
  • 145
    • 84863957609 scopus 로고    scopus 로고
    • Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-kappaB activation
    • Xu S, Liu Z, Huang Y, et al., 2012. Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-kappaB activation. Transl Res 160: 114-124.
    • (2012) Transl Res , vol.160 , pp. 114-124
    • Xu, S.1    Liu, Z.2    Huang, Y.3
  • 146
    • 70349241906 scopus 로고    scopus 로고
    • Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats
    • Xu W, Yang J, Wu LM,. 2009. Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats. Pharmazie 64: 332-336.
    • (2009) Pharmazie , vol.64 , pp. 332-336
    • Xu, W.1    Yang, J.2    Wu, L.M.3
  • 147
    • 0036945860 scopus 로고    scopus 로고
    • Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis
    • Yagami T, Ueda K, Asakura K, et al., 2002. Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis. Neuropharmacology 43: 1289-1296.
    • (2002) Neuropharmacology , vol.43 , pp. 1289-1296
    • Yagami, T.1    Ueda, K.2    Asakura, K.3
  • 148
    • 0024502823 scopus 로고
    • Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements
    • Yagi A, Fujimoto K, Tanonaka K, Hirai K, Takeo S,. 1989. Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements. Planta Med 55: 51-54.
    • (1989) Planta Med , vol.55 , pp. 51-54
    • Yagi, A.1    Fujimoto, K.2    Tanonaka, K.3    Hirai, K.4    Takeo, S.5
  • 149
    • 4544381116 scopus 로고    scopus 로고
    • Salvinorin A: A novel and highly selective κ-opioid receptor agonist
    • Yan F, Roth BL,. 2004. Salvinorin A: a novel and highly selective κ-opioid receptor agonist. Life Sci 75: 2615-2619.
    • (2004) Life Sci , vol.75 , pp. 2615-2619
    • Yan, F.1    Roth, B.L.2
  • 150
    • 77952007757 scopus 로고    scopus 로고
    • Effects of sodium tanshinone IIA sulfonate on myocardial hypertrophy angiotensins receptor and STAT3 of rats
    • Yan L, Li YS, Liang QS, Yang GT,. 2010. Effects of sodium tanshinone IIA sulfonate on myocardial hypertrophy angiotensins receptor and STAT3 of rats. Chin Trad Herb Drug 41: 588-592.
    • (2010) Chin Trad Herb Drug , vol.41 , pp. 588-592
    • Yan, L.1    Li, Y.S.2    Liang, Q.S.3    Yang, G.T.4
  • 151
    • 33847670191 scopus 로고    scopus 로고
    • Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway
    • Yang L, Zou X, Liang Q, et al., 2007. Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway. Exp Mol Med 39: 65-73.
    • (2007) Exp Mol Med , vol.39 , pp. 65-73
    • Yang, L.1    Zou, X.2    Liang, Q.3
  • 152
    • 68049097297 scopus 로고    scopus 로고
    • Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type i expression in cardiac fibroblasts in vitro
    • Yang L, Zou XJ, Gao X, et al., 2009. Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro. Exp Mol Med 41: 508-516.
    • (2009) Exp Mol Med , vol.41 , pp. 508-516
    • Yang, L.1    Zou, X.J.2    Gao, X.3
  • 153
    • 42449089893 scopus 로고    scopus 로고
    • Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation
    • Yang R, Liu A, Ma X, Li L, Su D, Liu J,. 2008. Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation. J Cardiovasc Pharmacol 51: 396-401.
    • (2008) J Cardiovasc Pharmacol , vol.51 , pp. 396-401
    • Yang, R.1    Liu, A.2    Ma, X.3    Li, L.4    Su, D.5    Liu, J.6
  • 154
    • 54049145428 scopus 로고    scopus 로고
    • Activation of high conductance Ca2 + -activated K+ channels by sodium tanshinone II-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells
    • Yang Y, Cai F, Li PY, et al., 2008. Activation of high conductance Ca2 + -activated K+ channels by sodium tanshinone II-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells. Eur J Pharmacol 598: 9-15.
    • (2008) Eur J Pharmacol , vol.598 , pp. 9-15
    • Yang, Y.1    Cai, F.2    Li, P.Y.3
  • 155
    • 52949106839 scopus 로고    scopus 로고
    • Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model
    • Yin Y, Huang L, Liu Y, et al., 2008. Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model. Clin Invest Med 31: E248-E257.
    • (2008) Clin Invest Med , vol.31 , pp. E248-E257
    • Yin, Y.1    Huang, L.2    Liu, Y.3
  • 156
    • 33947503436 scopus 로고    scopus 로고
    • Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells
    • Zhang HS, Wang SQ,. 2007. Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells. Biochem Pharmacol 73: 1358-1366.
    • (2007) Biochem Pharmacol , vol.73 , pp. 1358-1366
    • Zhang, H.S.1    Wang, S.Q.2
  • 157
    • 33846913970 scopus 로고    scopus 로고
    • Inhibition of mitochondrial permeability transition pore: A possible mechanism for cardioprotection conferred by pretreatment with tanshinone IIA
    • Zhang SZ, Ye ZG, Xia Q, Zhang W, Bruce I,. 2005. Inhibition of mitochondrial permeability transition pore: a possible mechanism for cardioprotection conferred by pretreatment with tanshinone IIA. Conf Proc IEEE Eng Med Biol Soc 3: 2276-2279.
    • (2005) Conf Proc IEEE Eng Med Biol Soc , vol.3 , pp. 2276-2279
    • Zhang, S.Z.1    Ye, Z.G.2    Xia, Q.3    Zhang, W.4    Bruce, I.5
  • 158
    • 77954381757 scopus 로고    scopus 로고
    • Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats
    • Zhang Y, Wei L, Sun D, et al., 2010. Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats. Diabetes Obes Metab 12: 316-322.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 316-322
    • Zhang, Y.1    Wei, L.2    Sun, D.3
  • 159
    • 77949739128 scopus 로고    scopus 로고
    • Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats
    • Zhao N, Liu YY, Wang F, et al., 2010. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am J Physiol Heart Circ Physiol 298: H1166-H1176.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H1166-H1176
    • Zhao, N.1    Liu, Y.Y.2    Wang, F.3
  • 160
    • 47349100211 scopus 로고    scopus 로고
    • Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A
    • Zhou DX, Liang QS, He XX, Zhan CY,. 2008. Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A. Zhongguo Zhong Yao Za Zhi 33: 936-939.
    • (2008) Zhongguo Zhong Yao Za Zhi , vol.33 , pp. 936-939
    • Zhou, D.X.1    Liang, Q.S.2    He, X.X.3    Zhan, C.Y.4
  • 161
    • 0037212739 scopus 로고    scopus 로고
    • Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria
    • Zhou G, Jiang W, Zhao Y, et al., 2003. Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria. Biochem Pharmacol 65: 51-57.
    • (2003) Biochem Pharmacol , vol.65 , pp. 51-57
    • Zhou, G.1    Jiang, W.2    Zhao, Y.3
  • 162
    • 0032763156 scopus 로고    scopus 로고
    • Protective effects of sodium tanshinone IIA sulphonate against adriamycin-induced lipid peroxidation in mice hearts in vivo and in vitro
    • Zhou GY, Zhao BL, Hou JW, Ma GE, Xin WJ,. 1999. Protective effects of sodium tanshinone IIA sulphonate against adriamycin-induced lipid peroxidation in mice hearts in vivo and in vitro. Pharmacol Res 40: 487-491.
    • (1999) Pharmacol Res , vol.40 , pp. 487-491
    • Zhou, G.Y.1    Zhao, B.L.2    Hou, J.W.3    Ma, G.E.4    Xin, W.J.5
  • 163
    • 79954743977 scopus 로고    scopus 로고
    • In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid beta-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors
    • Zhou Y, Li W, Xu L, Chen L,. 2011. In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid beta-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors. Environ Toxicol Pharmacol 31: 443-452.
    • (2011) Environ Toxicol Pharmacol , vol.31 , pp. 443-452
    • Zhou, Y.1    Li, W.2    Xu, L.3    Chen, L.4


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