Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet

Life Sciences

Volumn 81, Issue 17-18, 2007, Pages 1339-1345

  Fang, Zhi yuan ^a   Lin, Rong ^a,b   Yuan, Bing xiang ^a   Liu, Yu ^a   Zhang, Hui ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

IL 1 ; MMP 2; MMP 9; Tanshinone IIA; VCAM 1

Indexed keywords

GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE IIA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; EXPERIMENTAL RABBIT; IMAGE ANALYSIS; LIPID DIET; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; WESTERN BLOTTING; ZYMOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AORTA; CORONARY ARTERY DISEASE; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUGS, CHINESE HERBAL; FEMALE; INTERLEUKIN-1BETA; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MOLECULAR STRUCTURE; PHENANTHRENES; RABBITS; VASCULAR CELL ADHESION MOLECULE-1;

ANIMALIA; ORYCTOLAGUS CUNICULUS; SALVIA MILTIORRHIZA;

EID: 35348951539     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.08.043     Document Type: Article

References (37)

1. Bendeck M.P., Conte M., Zhang M., Nili N., Strauss B.H., and Farwell S.M. Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury. American Journal of Pathology 160 (2002) 1089-1095
2. Chattopadhyay S., Myers R.R., Janes J., and Shubayev V. Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve. Brain, Behavior, and Immunity 21 (2007) 561-568
3. Chen Y.L., Yang S.P., Shiao M.S., Chen J.W., and Lin S.J. Salvia miltiorrhiza inhibits intimal hyperplasia and monocyte chemotactic protein-1 expression after balloon injury in cholesterol-fed rabbits. Journal of Cellular Biochemistry 83 (2001) 484-493
4. Cho A., and Reidy M.A. Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circulation Research 91 (2002) 845-851
5. Du J.R., Li X., Zhang R., and Qian Z.M. Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice. Journal of Ethnopharmacology 98 (2005) 319-322
6. Fujisaki K., Tanabe N., Suzuki N., Mitsui N., Oka H., Ito K., and Maeno M. The effect of IL-1α on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in osteoblastic ROS 17/2.8 cells. Life Sciences 78 (2006) 1975-1982
7. Galis Z.S., Johnson C., Godin D., Magid R., Shipley J.M., Senior R.M., and Ivan E. Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circulation Research 91 (2002) 852-859
8. Islam M.M., Franco C.D., Courtman D.W., and Bendeck M.P. A nonantibiotic chemically modified tetracycline (CMT-3) inhibits intimal thickening. American Journal of Pathology 163 (2003) 1557-1566
9. Jang S.I., Jeong S.I., Kim K.J., Kim H.J., Yu H.H., Park R., Kim H.M., and You Y.O. Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-α, IL-1β and IL-6 in activated RAW 264.7 cells. Planta Medica 69 (2003) 1057-1059
10. Jin U.H., Kang S.K., Suh S.J., Hong S.Y., Park S.D., Kim D.W., Chang H.W., Son J.K., Lee S.H., Son K.H., and Kim C.H. Inhibitory effect of Salvia miltiorrhiza BGE on matrix metalloproteinase-9 activity and migration of TNF-α-induced human aortic smooth muscle cells. Vascular Pharmacology 44 (2006) 345-353
11. Johnson C., and Galis Z.S. Matrix metalloproteinase-2 and-9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization. Arteriosclerosis Thrombosis and Vascular Biology 24 (2004) 54-60
12. Kang H.S., Chung H.Y., Jung J.H., Kang S.S., and Choi J.S. Antioxidant effect of Salvia miltiorrhiza. Archives of Pharmacal Research 20 (1997) 496-500
13. Kerrie L.F., Wendell P.D., Adele J.M., and Thomas L.F. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in hamster aortic atherosclerosis: correlation with in-situ zymography. Atherosclerosis 160 (2002) 325-337
14. Kim H.H., Kim J.H., Kwak H.B., Huang H., Han S.H., Ha H., Lee S.W., Woo E.R., and Lee Z.H. Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge. Biochemical Pharmacology 67 (2004) 1647-1656
15. Kuzuya M., Kanda S., Sasaki T., Tamaya-Mori N., Cheng X.W., Itoh T., Itohara S., and Iguchi A. Deficiency of gelatinase A suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia. Circulation 108 (2003) 1375-1381
16. Liang J.Y., Liu E.Q., Yu Y., Kitajima S.J., Koike T., Jin Y.J., Morimoto M.S., Hatakeyama K., Asada Y.J., Watanabe T., Sasaguri Y., Watanabe S., and Fan J.L. Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. Circulation 113 (2006) 1993-2001
17. Lijnen H.R., Soloway P., and Collen D. Tissue inhibitor of matrix metalloproteinases-1 impairs arterial neointima formation after vascular injury in mice. Circulation Research 85 (1999) 1186-1191
18. Limin Z., Zhong Z., and Moses S.S.C. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. Journal of Clinical Pharmacology 45 (2005) 1345-1359
19. Lin R., Liu J.T., Gan W.J., Yang G.D., and Wang W.R. C-reactive protein-induced expression of CD40-CD40L and the effect of lovastatin and fenofibrate on it in human vascular endothelial cells. Biological and Pharmaceutical Bulletin 27 (2004) 1537-1543
20. Lin R., Yang G.D., Wang W.R., Liu J.T., He L.C., Peng N., and Han C.J. Screening the active components of Salvia miltiorrhiza for atherosclerosis with chromatography of CD40 highly expressed cell membrane. Journal of Chinese Medicinal Materials 29 (2006) 1325-1327
21. Lv B.Q., Fan Y.C., and Sun L.S. The influence of salvianolic acid B and tanshinone IIA on the nitric oxide and triglyceride in sera of atherosclerosis rabbit. Journal of Tianjin University of Traditional Chinese Medicine 25 (2006) 32-34
22. Mason D.P., Kenagy R.D., Hasenstab D., Bowen-Pope D.F., Seifert R.A., Coats S., Hawkins S.M., and Clowes A.W. Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery. Circulation Research 85 (1999) 1179-1185
23. May A.E., Kalsch T., Massberg S., Herouy Y., Schmidt R., and Gawaz M. Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation 106 (2002) 2111-2117
24. Newby A.C. Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiological Reviews 85 (2005) 1-31
25. Niu X.L., Ichimori K., Yang X., Hirota Y., Hoshiai K., Li M., and Nakazawa H. Tanshinone IIA inhibits low density lipoprotein oxidation in vitro. Free Radical Research 33 (2000) 305-312
26. Romanic A.M., and Madri J.A. The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. Journal of Cell Biology 125 (1994) 1165-1178
27. Ross R. Atherosclerosis-an inflammatory disease. The New England Journal of Medicine 340 (1999) 115-126
28. Sarén P., Welgus H.G., and Kovanen P.T. TNF-α and IL-1β selectively induce expression of 92-kDa gelatinase by human macrophages. Journal of Immunology 157 (1996) 4159-4165
29. Wang H., Gao X.M., and Zhang B.L. Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells. Journal of Ethnopharmacology 99 (2005) 93-98
30. Wang W.R., Lin R., Peng N., and Han C.J. The protective effects of tanshinone IIA on vascular endothelial cells injury induced by hydrogen peroxide. Journal of Chinese Medicinal Materials 29 (2006) 53-55
31. Wang X.H., Morris-Natschke S.L., and Lee K.H. New developments in the chemistry and biology of the bioactive constituents of tanshen. Medicinal Research Reviews 27 (2007) 133-148
32. Xu J.W., and Fu C.M. Progress of Salvia miltiorrhiza in pharmaceutical action. Medical Recapitulate 12 (2006) 1467-1469
33. 1 mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Experimental Cell Research 260 (2000) 73-84
34. Zhan C., Tao X., Tian C., Xiong W., and Zheng Z. Expression of intercellular adhesion molecule-1 in the development of hypertensive left hypertrophy and inhibitory effect of tanshinone IIA. Chinese Journal of Clinical Rehabilitation 9 (2005) 254-256
35. Zhang M., Zhang B.L., Gao X.M., Guo L.P., and Du R. Effect of different proportions of salvianolic acid B and tanshinone IIA on rat cardiac microvascular endothelial cells injured by tumor necrosis factor in vitro. Chinese Traditional and Herbal Drugs 35 (2004) 63-65
36. Zhou G.T., Zhao G.F., and Fan Y.C. Effect of tanshinone IIA on expression of MCP-1 and IL-1β in injured smooth muscle cell induced buy TNF-α. Tianjin Journal of Traditional Chinese Medicine 23 (2006) 189-191
37. Zorina S.G., and Jaikirshan J.K. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circulation Research 90 (2002) 251-262