Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease

Molecular Medicine Reports

Volumn 10, Issue 2, 2014, Pages 689-694

  Jiang, Ping ^a   Li, Chunbo ^a   Xiang, Zhenghua ^b   Jiao, Binghua ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; iNOS; Mechanism; MMP 2; NF Bp65; Tanshinone IIA

Indexed keywords

AMYLOID BETA PROTEIN; GELATINASE A; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; TANSHINONE IIA; TRANSCRIPTION FACTOR RELA; ABIETANE DERIVATIVE; NEUROPROTECTIVE AGENT; TANSHINONE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; LEARNING; MALE; MEMORY; MOLECULAR BIOLOGY; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; RNA TRANSLATION; SHAM PROCEDURE; TEMPORAL LOBE; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; MAZE TEST; MEDICINAL PLANT; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DISEASE MODELS, ANIMAL; DITERPENES, ABIETANE; MALE; MATRIX METALLOPROTEINASE 2; MAZE LEARNING; MEMORY; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE II; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; TEMPORAL LOBE; TRANSCRIPTION FACTOR RELA;

EID: 84903316609     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2254     Document Type: Article

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