Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels

Journal of Ethnopharmacology

Volumn 119, Issue 2, 2008, Pages 318-321

  Lam, Francis F Y ^a   Yeung, John H K ^a   Chan, Kam M ^a   Or, Penelope M Y ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Calcium channel; Coronary artery; Dihydrotanshinone; Salvia miltiorrhiza

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; ATROPINE; BETA ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CALCIUM CHLORIDE; DIHYDROTANSHINONE; FLURBIPROFEN; GUANYLATE CYCLASE; MUSCARINIC RECEPTOR; N(G) NITROARGININE METHYL ESTER; PROPRANOLOL; SEROTONIN; TANSHINONE; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG MECHANISM; MALE; NONHUMAN; RAT; SALVIA MILTIORRHIZA; VASODILATATION;

ANIMALS; CALCIUM; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; INHIBITORY CONCENTRATION 50; MALE; MYOCYTES, SMOOTH MUSCLE; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; SEROTONIN; VASODILATION;

LAMIACEAE; RATTUS; SALVIA MILTIORRHIZA;

EID: 50949129144     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.07.011     Document Type: Article

References (27)

1. Adams J.D., Wang R., Yang J., and Lien E.J. Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chinese Medicine 1 (2006) 3
2. Cao C.M., Xia Q., Zhang X., Xu W.H., Jiang H.D., and Chen J.Z. Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes. Life Sciences 72 (2003) 2451-2463
3. Chan K., Chui S.H., Wong D.Y., Ha W.Y., Chan C.L., and Wong R.N. Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sciences 75 (2004) 3157-3171
4. Cheng Y.Y., Fong S.M., and Chang H.M. Protective action of Salvia miltiorrhiza aqueous extract on chemically induced acute myocardial ischemia in rats. Zhong Xi Yi Jie He Za Zhi 10 (1990) 609-611
5. Choi H.S., and Kim K.M. Tanshinones inhibit mast cell degranulation by interfering with IgE receptor-mediated tyrosine phosphorylation of PLCgamma2 and MAPK. Planta Medica 70 (2004) 178-180
6. Cui S.K., and Li G.H. Clinical effect of Fufang Danshen Dripping Pill on hyperlipemia. Xiandai Zhongxiyi Jiehe Zazhi 11 (2003) 1029-1030
7. Garthwaite J., Southam E., Boulton C.L., Nielsen E.B., Schmidt K., and Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4, 3-a]quinoxalin-1-one. Molecular Pharmacology 48 (1995) 184-188
8. Godfraind T., Miller R., and Wibo M. Calcium antagonism and calcium entry blockade. Pharmacological Reviews 38 (1986) 321-416
9. 2+ channels in the rat aorta. The Chinese Journal of Physiology 39 (1996) 1-8
10. Ji X.Y., Tan B.K., and Zhu Y.Z. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacologica Sinica 21 (2000) 1089-1094
11. Kamata K., Iizuka T., Nagai M., and Kasuya Y. Endothelium-dependent vasodilator effects of the extract from Salvia miltiorrhiza radix A study on the identification of lithospermic acid B in the extracts. General Pharmacology 24 (1993) 977-981
12. Kang B.Y., Chung S.W., Kim S.H., Ryu S.Y., and Kim T.S. Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. Immunopharmacology 49 (2000) 355-361
13. Kohda H., Takeda O., Tanaka S., Yamasaki K., Yamashita A., Kurokawa T., and Ishibashi S. Isolation of inhibitors of adenylate cyclase from dan-shen, the root of Salvia miltiorrhiza. Chemical & Pharmaceutical Bulletin 37 (1989) 1287-1290
14. Lam F.F.Y., Yeung J.H.K., and Cheung J.H. Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. Journal of Cardiovascular Pharmacology 46 (2005) 361-368
15. Lam F.F.Y., Yeung J.H.K., Kwan Y.W., Chan K.M., and Or P.M.Y. Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. European Journal of Pharmacology 553 (2006) 240-245
16. Lam F.F.Y., Yeung J.H.K., and Cheung J.H.Y. Pharmacological evidence for calcium channel inhibition by Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. Journal of Cardiovascular Pharmacology 47 (2006) 139-145
17. Lam F.F.Y., Yeung J.H.K., Chan K.M., and Or P.M.Y. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vascular Pharmacology 46 (2007) 271-277
18. Lam F.F.Y., Yeung J.H.K., Chan K.M., and Or P.M.Y. Mechanisms of the dilator action of cryptotanshinone on rat coronary artery. European Journal of Pharmacology 578 (2008) 253-260
19. Lee D.S., Lee S.H., Noh J.G., and Hong S.D. Antibacterial activities of cryptotanshinone and dihydrotanshinone I from a medicinal herb, Salvia miltiorrhiza Bunge. Bioscience, Biotechnology, and Biochemistry 63 (1999) 2236-2239
20. Lei X.L., and Chiou G.C. Studies on cardiovascular actions of Salvia miltiorrhiza. The American Journal of Chinese Medicine 14 (1986) 26-32
21. Li C.P., Yung K.H., and Chiu K.W. Hypotensive action of Salvia miltiorrhiza cell culture extract. The American Journal of Chinese Medicine 18 (1990) 157-166
22. Li Z.T., Yang B.J., and Ma G.E. Chemical studies of Salvia miltiorrhiza f. alba. Yao Xue Xue Bao 26 (1991) 209-213
23. Lippe C., and Ardizzone C. Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536. Comparative Biochemistry and Physiology C: Comparative Pharmacology 99 (1991) 209-211
24. Liu G.T., Zhang T.M., Wang B.E., and Wang Y.W. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochemical Pharmacology 43 (1992) 147-152
25. Mosaddik M.A. In vitro cytotoxicity of tanshinones isolated from Salvia miltiorrhiza Bunge against P388 lymphocytic leukemia cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 10 (2003) 682-685
26. Xu J.K., Hiroshi K., Zheng J.J., Jiang T., and Yao X.S. Protective effect of tanshinones against liver injury in mice loaded with restraint stress. Yao Xue Xue Bao 41 (2006) 631-635
27. Zhang J., Huang M., Guan S., Bi H.C., Pan Y., Duan W., Chan S.Y., Chen X., Hong Y.H., Bian J.S., Yang H.Y., and Zhou S. A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza. The Journal of Pharmacology and Experimental Therapeutics 317 (2006) 1285-1294