Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor

Planta Medica

Volumn 69, Issue 2, 2003, Pages 113-117

  Kavvadias, Dominique ^a   Monschein, Vanessa ^a   Sand, Philipp ^b   Riederer, Peter ^b   Schreier, Peter ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

7 methoxyrosmanol; Apigenin; Benzodiazepine receptor; Cirsimaritin; Galdosol; Hispidulin; Lamiaceae; Salvia officinalis L.

Indexed keywords

7 METHOXYROSMANOL; APIGENIN; BENZODIAZEPINE RECEPTOR; CIRSIMARITIN; GALDOSOL; HISPIDULIN; SALVIA OFFICINALIS EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; FLAVONOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RECEPTORS, GABA-A; SALVIA OFFICINALIS; STRUCTURE-ACTIVITY RELATIONSHIP;

LAMIACEAE; SALVIA; SALVIA OFFICINALIS;

EID: 0037302165     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-37712     Document Type: Article

References (22)

1. Wang M, Li J, Rangarajan M, Shao Y, LaVoie EJ, Huang T-Oh, Ho Ch-T. Anti-oxidative phenolic compounds from sage (Salvia officinalis). J Agric Food Chem 1998; 46: 4869-73
2. Wu J, Wang J, Zhang J. Protective effect of total salvianolic acids against cerebral ischemia-reperfusion injuries in mice and rats. Zhongcaoyao 2001; 32: 227-9
3. Perry N, Howes M-J, Houghton P, Perry E. Why sage may be a wise remedy: Effects of Salvia on the nervous system. Medicinal and Aromatic Plants - Industrial Profiles 2000; 14: 207-23
4. Zupko I, Hohmann J, Redei D, Falkay G, Janicsak G, Mathe I. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent-systems of lipid peroxidation and their phenolic constituents. Planta Medica 2001; 67: 366-8
5. Zanoli P, Avallone R, Baraldi M. Behavioral characterization of the flavonoids apigenin and chrysin. Fitoterapia 2000; 71 Suppl 1: 117-23
6. Soulimani R, Younos Ch, Jarmouni S, Bousta D, Misslin R, Mortier F. Behavioral effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J of Ethnopharmacol 1997; 57: 11-20
7. Medina JH, Viola H, Wolfman C, Marder M, Wasowski C, Calvo D, et al. Overview-Flavonoids: A new family of benzodiazepine receptor ligands. Neurochem Res 1997; 22: 419-25
8. 35S]thionate binding to chloride channel of rat cerebra-cortical membranes in vitro. Neurosci Lett 1992; 135: 224-6
9. Lee ChM, Wong HNC, Chui KY, Choang TF, Hon PM, Chang HM. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett 1991; 127: 237-41
10. Medina JH, Viola H, Wolfman C, Marder M, Wasowski C, Calvo D et al. Neuroactive flavonoids. New ligands for the benzodiazepine receptors. Phytomedicine 1998; 5: 235-43
11. Möhler H, Okada T. Benzodiazepine receptors: demonstration in the central nervous system. Science 1977; 198: 849-51
12. Wisden W, David N. Pharmacology: Towards better benzodiazepines. Nature 1999; 401: 751-2
13. Nakasugi T, Komai K. Antimutagens in the Brazilian folk medicinal plant Carqueja (Baccharis trimera Less.). J Agric Food Chem 1998; 46: 2560-4
14. Takenaka M, Watanabe T, Sugahara K, Harada Y, Yoshida S, Sugawara F. New antimicrobial substances against Streptomyces scabies from rosemary (Rosmarinus officinalis L.). Biosci Biotech Biochem 1997; 61: 1440-4
15. Marrero JG, Andres LS, Luis JG. Semisynthesis of rosmanol and its derivatives. Easy access to abietatriene diterpenes isolated from the genus Salvia with biological activities. J Nat Prod 2002; 65: 986-9
16. Paladini AC, Marder M, Viola H, Wolfman C, Wasowski C, Medina JH. Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds. J Pharm Pharmcol 1999; 51: 519-26
17. Ma QG, Liu WZ, Wu XY, Zhou TX, Qin G. Diterpenoids from Euphorbia fischeriana. Phytochemistry 1997; 44: 663-6
18. 3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein. Chung Kuo Yao Li Hsueh Pao 1994; 15: 385-8
19. A receptors in vitro. Drug Dev Res 1997; 41: 99-106
20. Salgueiro JB, Ardenghi P, Dias M, Ferreira MBC, Izquierdo I, Medina JH. Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats. Pharmacology, Biochem Behavior 1997; 58: 887-91
21. Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000; 59: 1387-94
22. Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptor-ligand with anxiolytic effects. Planta Medica 1995; 61: 213-6