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Volumn 6, Issue SEP, 2015, Pages

Salvinorin A, a kappa-opioid receptor agonist hallucinogen: Pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders

Author keywords

Addiction; Depression; Dynorphins; Kappa opioid receptor; Salvia divinorum; Salvinorin A

Indexed keywords

BETA ARRESTIN; DYNORPHIN; KAPPA OPIATE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; SALVINORIN A;

EID: 84944723037     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00190     Document Type: Short Survey
Times cited : (60)

References (87)
  • 1
    • 0037269383 scopus 로고    scopus 로고
    • Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix
    • Adams, D. H., Hanson, G. R., and Keefe, K. A. (2003). Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. J. Neurochem. 84, 87-93. doi: 10.1046/j.1471-4159.2003.01507.x
    • (2003) J. Neurochem , vol.84 , pp. 87-93
    • Adams, D.H.1    Hanson, G.R.2    Keefe, K.A.3
  • 2
    • 0026076879 scopus 로고
    • Ontogeny of μ-and κ-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats
    • Adamson, W. T., Windh, R. T., Blackford, S., and Kuhn, C. M. (1991). Ontogeny of μ-and κ-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats. Endocrinology 129, 959-964. doi: 10.1210/endo-129-2-959
    • (1991) Endocrinology , vol.129 , pp. 959-964
    • Adamson, W.T.1    Windh, R.T.2    Blackford, S.3    Kuhn, C.M.4
  • 3
    • 84858444030 scopus 로고    scopus 로고
    • Acute and post-acute behavioral and psychological effects of salvinorin A in humans
    • Addy, P. H. (2012). Acute and post-acute behavioral and psychological effects of salvinorin A in humans. Psychopharmacology (Berl.) 220, 195-204. doi: 10.1007/s00213-011-2470-6
    • (2012) Psychopharmacology (Berl.) , vol.220 , pp. 195-204
    • Addy, P.H.1
  • 4
    • 84875437470 scopus 로고    scopus 로고
    • The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior
    • Aldrich, J. V., Senadheera, S. N., Ross, N. C., Ganno, M. L., Eans, S. O., and Mclaughlin, J. P. (2013). The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior. J. Nat. Prod. 76, 433-438. doi: 10.1021/np300697k
    • (2013) J. Nat. Prod , vol.76 , pp. 433-438
    • Aldrich, J.V.1    Senadheera, S.N.2    Ross, N.C.3    Ganno, M.L.4    Eans, S.O.5    Mclaughlin, J.P.6
  • 5
    • 77957310716 scopus 로고    scopus 로고
    • Use patterns and self-reported effects of Salvia divinorum: an internet-based survey
    • Baggott, M. J., Erowid, E., Erowid, F., Galloway, G. P., and Mendelson, J. (2010). Use patterns and self-reported effects of Salvia divinorum: an internet-based survey. Drug Alcohol. Depend. 111, 250-256. doi: 10.1016/j.drugalcdep.2010.05.003
    • (2010) Drug Alcohol. Depend , vol.111 , pp. 250-256
    • Baggott, M.J.1    Erowid, E.2    Erowid, F.3    Galloway, G.P.4    Mendelson, J.5
  • 6
    • 62449248169 scopus 로고    scopus 로고
    • Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats
    • Baker, L. E., Panos, J. J., Killinger, B. A., Peet, M. M., Bell, L. M., Haliw, L. A., et al. (2009). Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats. Psychopharmacology (Berl.) 203, 203-211. doi: 10.1007/s00213-008-1458-3
    • (2009) Psychopharmacology (Berl.) , vol.203 , pp. 203-211
    • Baker, L.E.1    Panos, J.J.2    Killinger, B.A.3    Peet, M.M.4    Bell, L.M.5    Haliw, L.A.6
  • 7
    • 27844519330 scopus 로고    scopus 로고
    • Nalmefene induced elevation in serum prolactin in normal human volunteers: partial κ-opioid agonist activity?
    • Bart, G., Schluger, J. H., Borg, L., Ho, A., Bidlack, J. M., and Kreek, M. J. (2005). Nalmefene induced elevation in serum prolactin in normal human volunteers: partial κ-opioid agonist activity? Neuropsychopharmacology 30, 2254-2262. doi: 10.1038/sj.npp.1300811
    • (2005) Neuropsychopharmacology , vol.30 , pp. 2254-2262
    • Bart, G.1    Schluger, J.H.2    Borg, L.3    Ho, A.4    Bidlack, J.M.5    Kreek, M.J.6
  • 8
    • 26944494536 scopus 로고    scopus 로고
    • Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
    • Beardsley, P. M., Howard, J. L., Shelton, K. L., and Carroll, F. I. (2005). Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats. Psychopharmacology (Berl.) 183, 118-126. doi: 10.1007/s00213-005-0167-4
    • (2005) Psychopharmacology (Berl.) , vol.183 , pp. 118-126
    • Beardsley, P.M.1    Howard, J.L.2    Shelton, K.L.3    Carroll, F.I.4
  • 9
    • 84855677697 scopus 로고    scopus 로고
    • Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues
    • Beguin, C., Potuzak, J., Xu, W., Liu-Chen, L. Y., Streicher, J. M., Groer, C. E., et al. (2012). Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. Bioorg. Med. Chem. Lett. 22, 1023-1026. doi: 10.1016/j.bmcl.2011.11.128
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , pp. 1023-1026
    • Beguin, C.1    Potuzak, J.2    Xu, W.3    Liu-Chen, L.Y.4    Streicher, J.M.5    Groer, C.E.6
  • 10
    • 84893168612 scopus 로고    scopus 로고
    • Mixed κ-/μ partial opioid agonists as potential treatments for cocaine dependence
    • Bidlack, J. M. (2014). Mixed κ-/μ partial opioid agonists as potential treatments for cocaine dependence. Adv. Pharmacol. 69, 387-418. doi: 10.1016/b978-0-12-420118-7.00010-x
    • (2014) Adv. Pharmacol , vol.69 , pp. 387-418
    • Bidlack, J.M.1
  • 11
    • 38049032934 scopus 로고    scopus 로고
    • Involvement of κ-opioid and endocannabinoid system on Salvinorin A-induced reward
    • Braida, D., Limonta, V., Capurro, V., Fadda, P., Rubino, T., Mascia, P., et al. (2008). Involvement of κ-opioid and endocannabinoid system on Salvinorin A-induced reward. Biol. Psychiatry 63, 286-292. doi: 10.1016/j.biopsych.2007.07.020
    • (2008) Biol. Psychiatry , vol.63 , pp. 286-292
    • Braida, D.1    Limonta, V.2    Capurro, V.3    Fadda, P.4    Rubino, T.5    Mascia, P.6
  • 12
    • 77951855896 scopus 로고    scopus 로고
    • Kinase cascades and ligand-directed signaling at the kappa opioid receptor
    • Bruchas, M. R., and Chavkin, C. (2010). Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology (Berl.) 210, 137-147. doi: 10.1007/s00213-010-1806-y
    • (2010) Psychopharmacology (Berl.) , vol.210 , pp. 137-147
    • Bruchas, M.R.1    Chavkin, C.2
  • 13
    • 75149183092 scopus 로고    scopus 로고
    • The dynorphin/κ-opioid system as a modulator of stress-induced and pro-addictive behaviors
    • Bruchas, M. R., Land, B. B., and Chavkin, C. (2010). The dynorphin/κ-opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res. 1314, 44-55. doi: 10.1016/j.brainres.2009.08.062
    • (2010) Brain Res , vol.1314 , pp. 44-55
    • Bruchas, M.R.1    Land, B.B.2    Chavkin, C.3
  • 14
    • 0345276453 scopus 로고    scopus 로고
    • Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic κ-opioid agonists in rhesus monkeys
    • Butelman, E. R., Ball, J. W., and Kreek, M. J. (2004a). Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic κ-opioid agonists in rhesus monkeys. Psychoneuroendocrinology 29, 307-326. doi: 10.1016/S0306-4530(03)00030-1
    • (2004) Psychoneuroendocrinology , vol.29 , pp. 307-326
    • Butelman, E.R.1    Ball, J.W.2    Kreek, M.J.3
  • 15
    • 1642340346 scopus 로고    scopus 로고
    • The plant-derived hallucinogen, salvinorin A, produces κ-opioid agonist-like discriminative effects in rhesus monkeys
    • Butelman, E. R., Harris, T. J., and Kreek, M. J. (2004b). The plant-derived hallucinogen, salvinorin A, produces κ-opioid agonist-like discriminative effects in rhesus monkeys. Psychopharmacology (Berl.) 172, 220-224. doi: 10.1007/s00213-003-1638-0
    • (2004) Psychopharmacology (Berl.) , vol.172 , pp. 220-224
    • Butelman, E.R.1    Harris, T.J.2    Kreek, M.J.3
  • 16
    • 84861569915 scopus 로고    scopus 로고
    • Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo
    • Butelman, E. R., Caspers, M., Lovell, K. M., Kreek, M. J., and Prisinzano, T. E. (2012a). Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo. J. Pharmacol. Exp. Ther. 341, 802-808. doi: 10.1124/jpet.112.193227
    • (2012) J. Pharmacol. Exp. Ther , vol.341 , pp. 802-808
    • Butelman, E.R.1    Caspers, M.2    Lovell, K.M.3    Kreek, M.J.4    Prisinzano, T.E.5
  • 17
    • 84866770393 scopus 로고    scopus 로고
    • kappa opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction
    • Butelman, E. R., Yuferov, V., and Kreek, M. J. (2012b). kappa opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends Neurosci. 35, 587-596. doi: 10.1016/j.tins.2012.05.005
    • (2012) Trends Neurosci , vol.35 , pp. 587-596
    • Butelman, E.R.1    Yuferov, V.2    Kreek, M.J.3
  • 18
    • 0032764055 scopus 로고    scopus 로고
    • Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeys
    • Butelman, E. R., Harris, T. J., and Kreek, M. (1999). Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeys. Eur. J. Pharmacol. 383, 305-309.
    • (1999) Eur. J. Pharmacol , vol.383 , pp. 305-309
    • Butelman, E.R.1    Harris, T.J.2    Kreek, M.3
  • 19
    • 33845912189 scopus 로고    scopus 로고
    • Effects of salvinorin A, a κ-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high κ-receptor homology to humans
    • Butelman, E. R., Mandau, M., Tidgewell, K., Prisinzano, T. E., Yuferov, V., and Kreek, M. J. (2007). Effects of salvinorin A, a κ-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high κ-receptor homology to humans. J. Pharmacol. Exp. Ther. 320, 300-306. doi: 10.1124/jpet.106.112417
    • (2007) J. Pharmacol. Exp. Ther , vol.320 , pp. 300-306
    • Butelman, E.R.1    Mandau, M.2    Tidgewell, K.3    Prisinzano, T.E.4    Yuferov, V.5    Kreek, M.J.6
  • 20
    • 59649116688 scopus 로고    scopus 로고
    • Unconditioned behavioral effects of the powerful κ-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid
    • Butelman, E. R., Prisinzano, T. E., Deng, H., Rus, S., and Kreek, M. J. (2009). Unconditioned behavioral effects of the powerful κ-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid. J. Pharmacol. Exp. Ther. 328, 588-597. doi: 10.1124/jpet.108.145342
    • (2009) J. Pharmacol. Exp. Ther , vol.328 , pp. 588-597
    • Butelman, E.R.1    Prisinzano, T.E.2    Deng, H.3    Rus, S.4    Kreek, M.J.5
  • 21
    • 77953286927 scopus 로고    scopus 로고
    • The discriminative effects of the κ-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects
    • Butelman, E. R., Rus, S., Prisinzano, T. E., and Kreek, M. J. (2010). The discriminative effects of the κ-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl.) 210, 253-262. doi: 10.1007/s00213-009-1771-5
    • (2010) Psychopharmacology (Berl.) , vol.210 , pp. 253-262
    • Butelman, E.R.1    Rus, S.2    Prisinzano, T.E.3    Kreek, M.J.4
  • 22
    • 29244488204 scopus 로고    scopus 로고
    • Depressive-like effects of the κ-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats
    • Carlezon, W. A. Jr., Beguin, C., Dinieri, J. A., Baumann, M. H., Richards, M. R., Todtenkopf, M. S., et al. (2006). Depressive-like effects of the κ-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J. Pharmacol. Exp. Ther. 316, 440-447. doi: 10.1124/jpet.105.092304
    • (2006) J. Pharmacol. Exp. Ther , vol.316 , pp. 440-447
    • Carlezon, W.A.1    Beguin, C.2    Dinieri, J.A.3    Baumann, M.H.4    Richards, M.R.5    Todtenkopf, M.S.6
  • 23
    • 83555166044 scopus 로고    scopus 로고
    • Quantitative PK-PD model-based translational pharmacology of a novel kappa opioid receptor antagonist between rats and humans
    • Chang, C., Byon, W., Lu, Y., Jacobsen, L. K., Badura, L. L., Sawant-Basak, A., et al. (2011). Quantitative PK-PD model-based translational pharmacology of a novel kappa opioid receptor antagonist between rats and humans. AAPS J. 13, 565-575. doi: 10.1208/s12248-011-9296-3
    • (2011) AAPS J , vol.13 , pp. 565-575
    • Chang, C.1    Byon, W.2    Lu, Y.3    Jacobsen, L.K.4    Badura, L.L.5    Sawant-Basak, A.6
  • 24
    • 78649666302 scopus 로고    scopus 로고
    • The therapeutic potential of κ-opioids for treatment of pain and addiction
    • Chavkin, C. (2011). The therapeutic potential of κ-opioids for treatment of pain and addiction. Neuropsychopharmacology 36, 369-370. doi: 10.1038/npp.2010.137
    • (2011) Neuropsychopharmacology , vol.36 , pp. 369-370
    • Chavkin, C.1
  • 25
    • 84876920223 scopus 로고    scopus 로고
    • Dynorphin-still an extraordinarily potent opioid peptide
    • Chavkin, C. (2012). Dynorphin-still an extraordinarily potent opioid peptide. Mol. Pharmacol. 83, 729-736. doi: 10.1124/mol.112.083337
    • (2012) Mol. Pharmacol , vol.83 , pp. 729-736
    • Chavkin, C.1
  • 26
    • 0345158331 scopus 로고
    • Specific receptor for the opioid peptide dynorphin: structure-activity relationships
    • Chavkin, C., and Goldstein, A. (1981). Specific receptor for the opioid peptide dynorphin: structure-activity relationships. Proc. Natl. Acad. Sci. U.S.A. 78, 6543-6547.
    • (1981) Proc. Natl. Acad. Sci. U.S.A , vol.78 , pp. 6543-6547
    • Chavkin, C.1    Goldstein, A.2
  • 27
    • 1342265861 scopus 로고    scopus 로고
    • Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations
    • Chavkin, C., Sud, S., Jin, W., Stewart, J., Zjawiony, J. K., Siebert, D. J., et al. (2004). Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. J. Pharmacol. Exp. Ther. 308, 1197-1203. doi: 10.1124/jpet.103.059394
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , pp. 1197-1203
    • Chavkin, C.1    Sud, S.2    Jin, W.3    Stewart, J.4    Zjawiony, J.K.5    Siebert, D.J.6
  • 28
    • 84901217949 scopus 로고    scopus 로고
    • Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization
    • Cohen, A., Whitfield, T. W., Kreifeldt, M., Koebel, P., Kieffer, B. L., Contet, C., et al. (2014). Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PLoS ONE 9:e97216. doi: 10.1371/journal.pone.0097216
    • (2014) PLoS ONE , vol.9
    • Cohen, A.1    Whitfield, T.W.2    Kreifeldt, M.3    Koebel, P.4    Kieffer, B.L.5    Contet, C.6
  • 29
    • 0027294728 scopus 로고
    • Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum
    • Daunais, J. B., Roberts, D. C., and Mcginty, J. F. (1993). Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum. Neuroreport 4, 543-546.
    • (1993) Neuroreport , vol.4 , pp. 543-546
    • Daunais, J.B.1    Roberts, D.C.2    Mcginty, J.F.3
  • 31
    • 0023836656 scopus 로고
    • Opposite effects of μ and κ-opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats
    • Di Chiara, G., and Imperato, A. (1988). Opposite effects of μ and κ-opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J. Pharmacol. Exp. Ther. 244, 1067-1080.
    • (1988) J. Pharmacol. Exp. Ther , vol.244 , pp. 1067-1080
    • Di Chiara, G.1    Imperato, A.2
  • 32
    • 27944491908 scopus 로고    scopus 로고
    • kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse
    • Fantegrossi, W. E., Kugle, K. M., Valdes, L. J. III., Koreeda, M., and Woods, J. H. (2005). kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse. Behav. Pharmacol. 16, 627-633. doi: 10.1097/00008877-200512000-00005
    • (2005) Behav. Pharmacol , vol.16 , pp. 627-633
    • Fantegrossi, W.E.1    Kugle, K.M.2    Valdes, L.J.3    Koreeda, M.4    Woods, J.H.5
  • 33
    • 2342469912 scopus 로고    scopus 로고
    • Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys
    • Fantegrossi, W. E., Woods, J. H., and Winger, G. (2004). Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys. Behav. Pharmacol. 15, 149-157. doi: 10.1097/00008877-200403000-00007
    • (2004) Behav. Pharmacol , vol.15 , pp. 149-157
    • Fantegrossi, W.E.1    Woods, J.H.2    Winger, G.3
  • 34
    • 43149092465 scopus 로고    scopus 로고
    • Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum
    • Gehrke, B. J., Chefer, V. I., and Shippenberg, T. S. (2008). Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum. Psychopharmacology (Berl.) 197, 509-517. doi: 10.1007/s00213-007-1067-6
    • (2008) Psychopharmacology (Berl.) , vol.197 , pp. 509-517
    • Gehrke, B.J.1    Chefer, V.I.2    Shippenberg, T.S.3
  • 35
    • 44449102022 scopus 로고    scopus 로고
    • Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
    • Hooker, J. M., Xu, Y., Schiffer, W., Shea, C., Carter, P., and Fowler, J. S. (2008). Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans. Neuroimage 41, 1044-1050. doi: 10.1016/j.neuroimage.2008.03.003
    • (2008) Neuroimage , vol.41 , pp. 1044-1050
    • Hooker, J.M.1    Xu, Y.2    Schiffer, W.3    Shea, C.4    Carter, P.5    Fowler, J.S.6
  • 36
    • 79955531128 scopus 로고    scopus 로고
    • Human psychopharmacology and dose-effects of salvinorin A, a κ-opioid agonist hallucinogen present in the plant Salvia divinorum
    • Johnson, M. W., Maclean, K. A., Reissig, C. J., Prisinzano, T. E., and Griffiths, R. R. (2011). Human psychopharmacology and dose-effects of salvinorin A, a κ-opioid agonist hallucinogen present in the plant Salvia divinorum. Drug Alcohol. Depend. 115, 150-155. doi: 10.1016/j.drugalcdep.2010.11.005
    • (2011) Drug Alcohol. Depend , vol.115 , pp. 150-155
    • Johnson, M.W.1    Maclean, K.A.2    Reissig, C.J.3    Prisinzano, T.E.4    Griffiths, R.R.5
  • 37
    • 77954758120 scopus 로고    scopus 로고
    • Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats
    • Killinger, B. A., Peet, M. M., and Baker, L. E. (2010). Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats. Pharmacol. Biochem. Behav. 96, 260-265. doi: 10.1016/j.pbb.2010.05.014
    • (2010) Pharmacol. Biochem. Behav , vol.96 , pp. 260-265
    • Killinger, B.A.1    Peet, M.M.2    Baker, L.E.3
  • 38
    • 84907359962 scopus 로고    scopus 로고
    • Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism
    • Kivell, B., Uzelac, Z., Sundaramurthy, S., Rajamanickam, J., Ewald, A., Chefer, V., et al. (2014). Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology 86, 228-240. doi: 10.1016/j.neuropharm.2014.07.016
    • (2014) Neuropharmacology , vol.86 , pp. 228-240
    • Kivell, B.1    Uzelac, Z.2    Sundaramurthy, S.3    Rajamanickam, J.4    Ewald, A.5    Chefer, V.6
  • 39
    • 0031809173 scopus 로고    scopus 로고
    • Differentiation of κ-opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys
    • Ko, M. C., Butelman, E. R., Traynor, J. R., and Woods, J. H. (1998). Differentiation of κ-opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys. J. Pharmacol. Exp. Ther. 285, 518-526.
    • (1998) J. Pharmacol. Exp. Ther , vol.285 , pp. 518-526
    • Ko, M.C.1    Butelman, E.R.2    Traynor, J.R.3    Woods, J.H.4
  • 40
    • 0032589934 scopus 로고    scopus 로고
    • Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions
    • Kreek, M. J., Schluger, J., Borg, L., Gunduz, M., and Ho, A. (1999). Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. J. Pharmacol. Exp. Ther. 288, 260-269.
    • (1999) J. Pharmacol. Exp. Ther , vol.288 , pp. 260-269
    • Kreek, M.J.1    Schluger, J.2    Borg, L.3    Gunduz, M.4    Ho, A.5
  • 41
    • 0023028721 scopus 로고
    • Human psychopharmacology of ketocyclazocine as compared with cyclazocine, morphine and placebo
    • Kumor, K. M., Haertzen, C. A., Johnson, R. E., Kocher, T., and Jasinski, D. (1986). Human psychopharmacology of ketocyclazocine as compared with cyclazocine, morphine and placebo. J. Pharmacol. Exp. Ther. 238, 960-968.
    • (1986) J. Pharmacol. Exp. Ther , vol.238 , pp. 960-968
    • Kumor, K.M.1    Haertzen, C.A.2    Johnson, R.E.3    Kocher, T.4    Jasinski, D.5
  • 42
    • 39149109153 scopus 로고    scopus 로고
    • College student use of Salvia divinorum
    • Lange, J. E., Reed, M. B., Croff, J. M., and Clapp, J. D. (2008). College student use of Salvia divinorum. Drug Alcohol. Depend. 94, 263-266. doi: 10.1016/j.drugalcdep.2007.10.018
    • (2008) Drug Alcohol. Depend , vol.94 , pp. 263-266
    • Lange, J.E.1    Reed, M.B.2    Croff, J.M.3    Clapp, J.D.4
  • 43
    • 38749134465 scopus 로고    scopus 로고
    • Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys
    • Li, J. X., Rice, K. C., and France, C. P. (2008). Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys. J. Pharmacol. Exp. Ther. 324, 827-833. doi: 10.1124/jpet.107.130625
    • (2008) J. Pharmacol. Exp. Ther , vol.324 , pp. 827-833
    • Li, J.X.1    Rice, K.C.2    France, C.P.3
  • 44
    • 84939787218 scopus 로고    scopus 로고
    • Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over β-arrestin2 signaling bias
    • Lovell, K. M., Frankowski, K. J., Stahl, E. L., Slauson, S. R., Yoo, E., Prisinzano, T. E., et al. (2015). Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over β-arrestin2 signaling bias. ACS Chem. Neurosci. 19, 1411-1419. doi: 10.1021/acschemneuro.5b00092
    • (2015) ACS Chem. Neurosci , vol.19 , pp. 1411-1419
    • Lovell, K.M.1    Frankowski, K.J.2    Stahl, E.L.3    Slauson, S.R.4    Yoo, E.5    Prisinzano, T.E.6
  • 45
    • 84877148871 scopus 로고    scopus 로고
    • Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects
    • MacLean, K. A., Johnson, M. W., Reissig, C. J., Prisinzano, T. E., and Griffiths, R. R. (2013). Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects. Psychopharmacology (Berl.) 226, 381-392. doi: 10.1007/s00213-012-2912-9
    • (2013) Psychopharmacology (Berl.) , vol.226 , pp. 381-392
    • MacLean, K.A.1    Johnson, M.W.2    Reissig, C.J.3    Prisinzano, T.E.4    Griffiths, R.R.5
  • 47
    • 0035793936 scopus 로고    scopus 로고
    • μ-, δ-and κ-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients
    • Mathieu-Kia, A. M., Fan, L. Q., Kreek, M. J., Simon, E. J., and Hiller, J. M. (2001). μ-, δ-and κ-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients. Brain Res. 893, 121-134. doi: 10.1016/S0006-8993(00)03302-3
    • (2001) Brain Res , vol.893 , pp. 121-134
    • Mathieu-Kia, A.M.1    Fan, L.Q.2    Kreek, M.J.3    Simon, E.J.4    Hiller, J.M.5
  • 48
    • 79953661182 scopus 로고    scopus 로고
    • Lack of effect of sublingual salvinorin A, a naturally occurring κ-opioid, in humans: a placebo-controlled trial
    • Mendelson, J. E., Coyle, J. R., Lopez, J. C., Baggott, M. J., Flower, K., Everhart, E. T., et al. (2011). Lack of effect of sublingual salvinorin A, a naturally occurring κ-opioid, in humans: a placebo-controlled trial. Psychopharmacology (Berl.) 214, 933-939. doi: 10.1007/s00213-010-2103-5
    • (2011) Psychopharmacology (Berl.) , vol.214 , pp. 933-939
    • Mendelson, J.E.1    Coyle, J.R.2    Lopez, J.C.3    Baggott, M.J.4    Flower, K.5    Everhart, E.T.6
  • 49
    • 84857281021 scopus 로고    scopus 로고
    • Effects of peripherally restricted kappa opioid receptor agonists on pain-related stimulation and depression of behavior in rats
    • Negus, S. S., O'connell, R., Morrissey, E., Cheng, K., and Rice, K. C. (2012). Effects of peripherally restricted kappa opioid receptor agonists on pain-related stimulation and depression of behavior in rats. J. Pharmacol. Exp. Ther. 340, 501-509. doi: 10.1124/jpet.111.186783
    • (2012) J. Pharmacol. Exp. Ther , vol.340 , pp. 501-509
    • Negus, S.S.1    O'connell, R.2    Morrissey, E.3    Cheng, K.4    Rice, K.C.5
  • 50
    • 33746900423 scopus 로고    scopus 로고
    • The mesolimbic dopamine reward circuit in depression
    • Nestler, E. J., and Carlezon, W. A. Jr. (2006). The mesolimbic dopamine reward circuit in depression. Biol. Psychiatry 59, 1151-1159. doi: 10.1016/j.biopsych.2005.09.018
    • (2006) Biol. Psychiatry , vol.59 , pp. 1151-1159
    • Nestler, E.J.1    Carlezon, W.A.2
  • 51
    • 0035935189 scopus 로고    scopus 로고
    • Mixed κ-agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan
    • Neumeyer, J. L., Gu, X. H., Van Vliet, L. A., Denunzio, N. J., Rusovici, D. E., Cohen, D. J., et al. (2001). Mixed κ-agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. Bioorg. Med. Chem. Lett. 11, 2735-2740. doi: 10.1016/S0960-894X(01)00543-1
    • (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 2735-2740
    • Neumeyer, J.L.1    Gu, X.H.2    Van Vliet, L.A.3    Denunzio, N.J.4    Rusovici, D.E.5    Cohen, D.J.6
  • 53
    • 41849151395 scopus 로고    scopus 로고
    • Effects of μ, κ, and δ opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys
    • Pascoe, J. E., Williams, K. L., Mukhopadhyay, P., Rice, K. C., Woods, J. H., and Ko, M. C. (2008). Effects of μ, κ, and δ opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys. Psychoneuroendocrinology 33, 478-486. doi: 10.1016/j.psyneuen.2008.01.006
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 478-486
    • Pascoe, J.E.1    Williams, K.L.2    Mukhopadhyay, P.3    Rice, K.C.4    Woods, J.H.5    Ko, M.C.6
  • 55
    • 0022494591 scopus 로고
    • Psychotomimesis mediated by κ-opiate receptors
    • Pfeiffer, A., Brantl, V., Herz, A., and Emrich, H. M. (1986). Psychotomimesis mediated by κ-opiate receptors. Science 233, 774-776.
    • (1986) Science , vol.233 , pp. 774-776
    • Pfeiffer, A.1    Brantl, V.2    Herz, A.3    Emrich, H.M.4
  • 56
    • 84877699573 scopus 로고    scopus 로고
    • Neoclerodanes as atypical opioid receptor ligands
    • Prisinzano, T. E. (2013). Neoclerodanes as atypical opioid receptor ligands. J. Med. Chem. 56, 3435-3443. doi: 10.1021/jm400388u
    • (2013) J. Med. Chem , vol.56 , pp. 3435-3443
    • Prisinzano, T.E.1
  • 57
    • 67649966316 scopus 로고    scopus 로고
    • Persistent psychosis associated with Salvia divinorum use
    • Przekop, P., and Lee, T. (2009). Persistent psychosis associated with Salvia divinorum use. Am. J. Psychiatry 166, 832. doi: 10.1176/appi.ajp.2009.08121759
    • (2009) Am. J. Psychiatry , vol.166 , pp. 832
    • Przekop, P.1    Lee, T.2
  • 58
    • 84867746318 scopus 로고    scopus 로고
    • Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ-opioid agonist Salvinorin A in humans
    • Ranganathan, M., Schnakenberg, A., Skosnik, P. D., Cohen, B. M., Pittman, B., Sewell, R. A., et al. (2012). Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ-opioid agonist Salvinorin A in humans. Biol. Psychiatry. 72, 871-879. doi: 10.1016/j.biopsych.2012.06.012
    • (2012) Biol. Psychiatry , vol.72 , pp. 871-879
    • Ranganathan, M.1    Schnakenberg, A.2    Skosnik, P.D.3    Cohen, B.M.4    Pittman, B.5    Sewell, R.A.6
  • 59
    • 84864761578 scopus 로고    scopus 로고
    • Chromatin alterations in response to forced swimming underlie increased prodynorphin transcription
    • Reed, B., Fang, N., Mayer-Blackwell, B., Chen, S., Yuferov, V., Zhou, Y., et al. (2012). Chromatin alterations in response to forced swimming underlie increased prodynorphin transcription. Neuroscience 220, 109-118. doi: 10.1016/j.neuroscience.2012.06.006
    • (2012) Neuroscience , vol.220 , pp. 109-118
    • Reed, B.1    Fang, N.2    Mayer-Blackwell, B.3    Chen, S.4    Yuferov, V.5    Zhou, Y.6
  • 60
    • 84920109429 scopus 로고    scopus 로고
    • Synthesis and kappa opioid receptor activity of furan-substituted Salvinorin A analogues
    • Riley, A. P., Groer, C. E., Young, D., Ewald, A. W., Kivell, B. M., and Prisinzano, T. E. (2014). Synthesis and kappa opioid receptor activity of furan-substituted Salvinorin A analogues. J. Med. Chem. 57, 10464-10475. doi: 10.1021/jm501521d
    • (2014) J. Med. Chem , vol.57 , pp. 10464-10475
    • Riley, A.P.1    Groer, C.E.2    Young, D.3    Ewald, A.W.4    Kivell, B.M.5    Prisinzano, T.E.6
  • 61
    • 84886305699 scopus 로고    scopus 로고
    • LY2456302 is a novel, potent, orally-bioavailable small molecule κ-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders
    • Rorick-Kehn, L. M., Witkin, J. M., Statnick, M. A., Eberle, E. L., Mckinzie, J. H., Kahl, S. D., et al. (2014). LY2456302 is a novel, potent, orally-bioavailable small molecule κ-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders. Neuropharmacology 77, 131-144. doi: 10.1016/j.neuropharm.2013.09.021
    • (2014) Neuropharmacology , vol.77 , pp. 131-144
    • Rorick-Kehn, L.M.1    Witkin, J.M.2    Statnick, M.A.3    Eberle, E.L.4    Mckinzie, J.H.5    Kahl, S.D.6
  • 62
    • 0037015067 scopus 로고    scopus 로고
    • Salvinorin A: a potent naturally occurring nonnitrogenous κ-opioid selective agonist
    • Roth, B. L., Baner, K., Westkaemper, R., Siebert, D., Rice, K. C., Steinberg, S., et al. (2002). Salvinorin A: a potent naturally occurring nonnitrogenous κ-opioid selective agonist. Proc. Natl. Acad. Sci. U.S.A. 99, 11934-11939. doi: 10.1073/pnas.182234399
    • (2002) Proc. Natl. Acad. Sci. U.S.A , vol.99 , pp. 11934-11939
    • Roth, B.L.1    Baner, K.2    Westkaemper, R.3    Siebert, D.4    Rice, K.C.5    Steinberg, S.6
  • 63
    • 84939892297 scopus 로고    scopus 로고
    • Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat
    • Serra, V., Fattore, L., Scherma, M., Collu, R., Spano, M. S., Fratta, W., et al. (2015). Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat. Psychopharmacology (Berl). 232, 91-100. doi: 10.1007/s00213-014-3641-z
    • (2015) Psychopharmacology (Berl) , vol.232 , pp. 91-100
    • Serra, V.1    Fattore, L.2    Scherma, M.3    Collu, R.4    Spano, M.S.5    Fratta, W.6
  • 64
    • 0028305754 scopus 로고
    • Salvia divinorum and salvinorin A: new pharmacologic findings
    • Siebert, D. (1994). Salvia divinorum and salvinorin A: new pharmacologic findings. J. Ethnopharmacol. 43, 53-56.
    • (1994) J. Ethnopharmacol , vol.43 , pp. 53-56
    • Siebert, D.1
  • 65
    • 0028983787 scopus 로고
    • kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system
    • Simonin, F., Gaveriaux-Ruff, C., Befort, K., Matthes, H., Lannes, B., Micheletti, G., et al. (1995). kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 92, 7006-7010.
    • (1995) Proc. Natl. Acad. Sci. U.S.A , vol.92 , pp. 7006-7010
    • Simonin, F.1    Gaveriaux-Ruff, C.2    Befort, K.3    Matthes, H.4    Lannes, B.5    Micheletti, G.6
  • 66
    • 84920140188 scopus 로고    scopus 로고
    • Pharmacology and anti-addiction effects of the novel kappa opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A
    • Simonson, B., Morani, A. S., Ewald, A. W., Walker, L., Kumar, N., Simpson, D., et al. (2014). Pharmacology and anti-addiction effects of the novel kappa opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. Br. J. Pharmacol. 172, 515-531. doi: 10.1111/bph.12692
    • (2014) Br. J. Pharmacol , vol.172 , pp. 515-531
    • Simonson, B.1    Morani, A.S.2    Ewald, A.W.3    Walker, L.4    Kumar, N.5    Simpson, D.6
  • 67
    • 34247331787 scopus 로고    scopus 로고
    • Adolescent salvia substance abuse
    • Singh, S. (2007). Adolescent salvia substance abuse. Addiction 102, 823-824. doi: 10.1111/j.1360-0443.2007.01810.x
    • (2007) Addiction , vol.102 , pp. 823-824
    • Singh, S.1
  • 68
    • 0025107375 scopus 로고
    • The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study
    • Spanagel, R., Herz, A., and Shippenberg, T. S. (1990). The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study. J. Neurochem. 55, 1734-1740.
    • (1990) J. Neurochem , vol.55 , pp. 1734-1740
    • Spanagel, R.1    Herz, A.2    Shippenberg, T.S.3
  • 69
    • 0027327238 scopus 로고
    • 'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen
    • Spangler, R., Unterwald, E. M., and Kreek, M. J. (1993). 'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Brain Res. Mol. Brain Res. 19, 323-327.
    • (1993) Brain Res. Mol. Brain Res , vol.19 , pp. 323-327
    • Spangler, R.1    Unterwald, E.M.2    Kreek, M.J.3
  • 70
    • 84857657943 scopus 로고    scopus 로고
    • The dynorphin/kappa-opioid receptor system and its role in psychiatric disorders
    • Tejeda, H. A., Shippenberg, T. S., and Henriksson, R. (2012). The dynorphin/kappa-opioid receptor system and its role in psychiatric disorders. Cell. Mol. Life. Sci. 69, 857-896. doi: 10.1007/s00018-011-0844-x
    • (2012) Cell. Mol. Life. Sci , vol.69 , pp. 857-896
    • Tejeda, H.A.1    Shippenberg, T.S.2    Henriksson, R.3
  • 71
    • 0028110978 scopus 로고
    • Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors
    • Unterwald, E. M., Rubenfeld, J. M., and Kreek, M. J. (1994). Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors. Neuroreport 5, 1613-1616.
    • (1994) Neuroreport , vol.5 , pp. 1613-1616
    • Unterwald, E.M.1    Rubenfeld, J.M.2    Kreek, M.J.3
  • 72
    • 0030972607 scopus 로고    scopus 로고
    • The effects of spiradoline (U-62066E), a kappa-opioid receptor agonist, on neuroendocrine function in man
    • Ur, E., Wright, D. M., Bouloux, P. M., and Grossman, A. (1997). The effects of spiradoline (U-62066E), a kappa-opioid receptor agonist, on neuroendocrine function in man. Br. J. Pharmacol. 120, 781-784. doi: 10.1038/sj.bjp.0700971
    • (1997) Br. J. Pharmacol , vol.120 , pp. 781-784
    • Ur, E.1    Wright, D.M.2    Bouloux, P.M.3    Grossman, A.4
  • 73
    • 0020972613 scopus 로고
    • Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.)
    • Valdes, L. J., 3rd, Diaz, J. L., and Paul, A. G. (1983). Ethnopharmacology of ska Maria Pastora (Salvia divinorum, Epling and Jativa-M.). J. Ethnopharmacol. 7, 287-312.
    • (1983) J. Ethnopharmacol , vol.7 , pp. 287-312
    • Valdes, L.J.1    Diaz, J.L.2    Paul, A.G.3
  • 75
    • 38149040085 scopus 로고    scopus 로고
    • Evaluation of the μ and κ-opioid actions of butorphanol in humans through differential naltrexone blockade
    • Walsh, S. L., Chausmer, A. E., Strain, E. C., and Bigelow, G. E. (2008). Evaluation of the μ and κ-opioid actions of butorphanol in humans through differential naltrexone blockade. Psychopharmacology (Berl.) 196, 143-155. doi: 10.1007/s00213-007-0948-z
    • (2008) Psychopharmacology (Berl.) , vol.196 , pp. 143-155
    • Walsh, S.L.1    Chausmer, A.E.2    Strain, E.C.3    Bigelow, G.E.4
  • 76
    • 0034807831 scopus 로고    scopus 로고
    • Enadoline and butorphanol: evaluation of κ-agonists on cocaine pharmacodynamics and cocaine self-administration in humans
    • Walsh, S. L., Geter-Douglas, B., Strain, E. C., and Bigelow, G. E. (2001). Enadoline and butorphanol: evaluation of κ-agonists on cocaine pharmacodynamics and cocaine self-administration in humans. J. Pharmacol. Exp. Ther. 299, 147-158.
    • (2001) J. Pharmacol. Exp. Ther , vol.299 , pp. 147-158
    • Walsh, S.L.1    Geter-Douglas, B.2    Strain, E.C.3    Bigelow, G.E.4
  • 77
    • 0033586358 scopus 로고    scopus 로고
    • Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain
    • Wang, X. M., Zhou, Y., Spangler, R., Ho, A., Han, J. S., and Kreek, M. J. (1999). Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain. Brain Res. Mol. Brain Res. 66, 184-187.
    • (1999) Brain Res. Mol. Brain Res , vol.66 , pp. 184-187
    • Wang, X.M.1    Zhou, Y.2    Spangler, R.3    Ho, A.4    Han, J.S.5    Kreek, M.J.6
  • 78
    • 40849124258 scopus 로고    scopus 로고
    • 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A
    • Wang, Y., Chen, Y., Xu, W., Lee, D. Y., Ma, Z., Rawls, S. M., et al. (2008). 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A. J. Pharmacol. Exp. Ther. 324, 1073-1083. doi: 10.1124/jpet.107.132142
    • (2008) J. Pharmacol. Exp. Ther , vol.324 , pp. 1073-1083
    • Wang, Y.1    Chen, Y.2    Xu, W.3    Lee, D.Y.4    Ma, Z.5    Rawls, S.M.6
  • 79
    • 84919770416 scopus 로고    scopus 로고
    • The G protein-biased kappa-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo
    • White, K. L., Robinson, J. E., Zhu, H., Diberto, J. F., Polepally, P. R., Zjawiony, J. K., et al. (2015). The G protein-biased kappa-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo. J. Pharmacol. Exp. Ther. 352, 98-109. doi: 10.1124/jpet.114.216820
    • (2015) J. Pharmacol. Exp. Ther , vol.352 , pp. 98-109
    • White, K.L.1    Robinson, J.E.2    Zhu, H.3    Diberto, J.F.4    Polepally, P.R.5    Zjawiony, J.K.6
  • 80
    • 84890635488 scopus 로고    scopus 로고
    • Identification of novel functionally selective kappa-opioid receptor scaffolds
    • White, K. L., Scopton, A. P., Rives, M. L., Bikbulatov, R. V., Polepally, P. R., Brown, P. J., et al. (2014). Identification of novel functionally selective kappa-opioid receptor scaffolds. Mol. Pharmacol. 85, 83-90. doi: 10.1124/mol.113.089649
    • (2014) Mol. Pharmacol , vol.85 , pp. 83-90
    • White, K.L.1    Scopton, A.P.2    Rives, M.L.3    Bikbulatov, R.V.4    Polepally, P.R.5    Brown, P.J.6
  • 81
    • 84924439937 scopus 로고    scopus 로고
    • kappa Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake
    • Whitfield, T. W. Jr., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., et al. (2015). kappa Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J. Neurosci. 35, 4296-4305. doi: 10.1523/jneurosci.1978-13.2015
    • (2015) J. Neurosci , vol.35 , pp. 4296-4305
    • Whitfield, T.W.1    Schlosburg, J.E.2    Wee, S.3    Gould, A.4    George, O.5    Grant, Y.6
  • 82
    • 84858446871 scopus 로고    scopus 로고
    • Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers
    • Wu, L. T., Woody, G. E., Yang, C., Li, J. H., and Blazer, D. G. (2011). Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers. Subst Abuse Rehabil 2011, 53-68. doi: 10.2147/sar.s17192
    • (2011) Subst Abuse Rehabil , vol.2011 , pp. 53-68
    • Wu, L.T.1    Woody, G.E.2    Yang, C.3    Li, J.H.4    Blazer, D.G.5
  • 83
    • 34547841507 scopus 로고    scopus 로고
    • Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies
    • Zhang, H., Shi, Y. G., Woods, J. H., Watson, S. J., and Ko, M. C. (2007). Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Eur. J. Pharmacol 570, 89-96. doi: 10.1016/j.ejphar.2007.05.045
    • (2007) Eur. J. Pharmacol , vol.570 , pp. 89-96
    • Zhang, H.1    Shi, Y.G.2    Woods, J.H.3    Watson, S.J.4    Ko, M.C.5
  • 84
    • 2442488532 scopus 로고    scopus 로고
    • Effect of the endogenous κ-opioid agonist dynorphin A (1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice
    • Zhang, Y., Butelman, E. R., Schlussman, S. D., Ho, A., and Kreek, M. J. (2004). Effect of the endogenous κ-opioid agonist dynorphin A (1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl.) 172, 422-429. doi: 10.1007/s00213-003-1688-3
    • (2004) Psychopharmacology (Berl.) , vol.172 , pp. 422-429
    • Zhang, Y.1    Butelman, E.R.2    Schlussman, S.D.3    Ho, A.4    Kreek, M.J.5
  • 85
    • 18744387407 scopus 로고    scopus 로고
    • Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors
    • Zhang, Y., Butelman, E. R., Schlussman, S. D., Ho, A., and Kreek, M. J. (2005). Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. Psychopharmacology (Berl.) 179, 551-558. doi: 10.1007/s00213-004-2087-0
    • (2005) Psychopharmacology (Berl.) , vol.179 , pp. 551-558
    • Zhang, Y.1    Butelman, E.R.2    Schlussman, S.D.3    Ho, A.4    Kreek, M.J.5
  • 86
    • 84891363547 scopus 로고    scopus 로고
    • Development of functionally selective, small molecule agonists at kappa opioid receptors
    • Zhou, L., Lovell, K. M., Frankowski, K. J., Slauson, S. R., Phillips, A. M., Streicher, J. M., et al. (2013a). Development of functionally selective, small molecule agonists at kappa opioid receptors. J. Biol. Chem. 288, 36703-36716. doi: 10.1074/jbc.M113.504381
    • (2013) J. Biol. Chem , vol.288 , pp. 36703-36716
    • Zhou, L.1    Lovell, K.M.2    Frankowski, K.J.3    Slauson, S.R.4    Phillips, A.M.5    Streicher, J.M.6
  • 87
    • 84876452130 scopus 로고    scopus 로고
    • Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats
    • Zhou, Y., Leri, F., Grella, S., Aldrich, J., and Kreek, M. J. (2013b). Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats. Synapse 67, 358-361. doi: 10.1002/syn.21638
    • (2013) Synapse , vol.67 , pp. 358-361
    • Zhou, Y.1    Leri, F.2    Grella, S.3    Aldrich, J.4    Kreek, M.J.5


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