Tanshinone IIA inhibits LPS-induced NF-κB activation in RAW 264.7 cells: Possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways

European Journal of Pharmacology

Volumn 542, Issue 1-3, 2006, Pages 1-7

  Il Jang, Seon ^a   Jin Kim, Hyung ^b   Kim, Young Jun ^a   Jeong, Seung Il ^b   You, Yong Ouk ^b  

^a Seojeong College University   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

I B kinase; Lipopolysaccharide; Mitogen activated protein kinase; NF B inducing kinase; Nuclear factor B; Tanshinone IIA

Indexed keywords

DITERPENE; DNA; I KAPPA B ALPHA; I KAPPA B ALPHA KINASE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEAR FACTOR KAPPA B INDUCING KINASE; PHOSPHOTRANSFERASE; SALVIA MILTIORRHIZA EXTRACT; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL STIMULATION; CELL STRAIN; CONTROLLED STUDY; CYTOSOL; DNA PROTEIN COMPLEX; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SALVIA MILTIORRHIZA; TANSHINONE IIA;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; I-KAPPA B KINASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENANTHRENES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 33745997334     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.04.044     Document Type: Article

References (34)

1. Ajizian S.J., English B.K., and Meals E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J. Infect. Dis. 179 (1999) 939-944
2. Bhat N.R., Zhang P., Lee J.C., and Hogan E.L. Extracellular signal regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18 (1998) 1633-1641
3. Bian Z.M., Elner S.G., Yoshida A., and Elner V.M. Human RPE-monocyte co-culture induces chemokine gene expression through activation of MAPK and NIK cascade. Exp. Eye Res. 76 (2003) 573-583
4. Birkenkamp K.U., Tuyt L.M., Lummen C., Wierenga A.T., Kruijer W., and Vellenga E. The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. Br. J. Pharmacol. 131 (2000) 99-107
5. Cavaillon J.M., and Haeffner-Cavaillon N. Signals involved in interleukin 1 synthesis and release by lipopolysaccharide-stimulated monocytes/macrophages. Cytokine 2 (1990) 313-329
6. Chakravortty D., Kato Y., Sugiyama T., Koide N., Mu M.M., Yoshida T., and Yokochi T. The inhibitory action of sodium arsenite on lipopolysaccharide-induced nitric oxide production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signaling. J. Immunol. 166 (2001) 2011-2017
7. Chaturvedi M.M., Mukhopadhyay A., and Aggarwal B.B. Assay for redox-sensitive transcription factor. Methods Enzymol. 319 (2000) 585-602
8. Chen C.C., and Wang J.K. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol. Pharmacol. 55 (1999) 481-488
9. Chen J.C., Ho F.M., Chao P.D.L., Chen C.P., Jeng K.C., Hsu H.B., Lee S.T., Wu W.T., and Lin W.W. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur. J. Pharmacol. 521 (2005) 9-20
10. Christman J.W., Lancaster L.H., and Blackwell T.S. Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med. 24 (1998) 1131-1138
11. Dumitru C.D., Ceci J.D., Tsatsanis C., Kontoyiannis D., Stamatakis K., Lin J.H., Patriotis C., Jenkins N.A., Copeland N.G., Kollias G., and Tsichlis P.N. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103 (2000) 1071-1083
12. Garrington T.P., and Johnson G.L. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 11 (1999) 211-218
13. Guha M., and Mackman N. LPS induction of gene expression in human monocytes. Cell. Signal. 13 (2001) 85-94
14. Hambleton J., Weinstein S.L., Lem L., and DeFranco A.L. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 2774-2778
15. Hirose M., Ishihara K., Saito A., Nakagawa T., Yamada S., and Okuda K. Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue. J. Periodontol. 72 (2001) 590-597
16. Irie T., Muta T., and Takeshige K. TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages. FEBS Lett. 467 (2000) 160-164
17. Jang S.I., Jeong S.I., Kim K.J., Kim H.J., Yu H.H., Park R., and You Y.O. Tanshinone IIA from Salvia miltiorrhiza inhibits expression of inducible nitric oxide synthase and production of TNF-α, IL-1β and IL-6 in activated RAW 264.7 cells. Planta Med. 69 (2003) 1057-1059
18. Karin M., and Delhase M. JNK or IKK, AP-1 or NF-κB, which are targets for MEK kinase 1 action?. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 9067-9069
19. Kim J.K. Illustrated Natural Drugs Encyclopedia (1989), Namsandan Publishers, Seoul 160
20. Kwon K.H., Kim K.I., Jun W.J., Shin D.H., Cho H.Y., and Hong B.S. In vitro and in vivo effects of macrophage-stimulatory polysaccharide from leaves of Perilla frutescens var. crispa. Biol. Pharm. Bull. 25 (2002) 367-371
21. Lee H.W., Ahn D.H., Crawley S.C., Li J.D., Gum Jr. JR., Basbaum C.B., Fan N.Q., Szymkowski D.E., Han S.Y., Lee B.H., Sleisenger M.H., and Kim Y.S. Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B. J. Biol. Chem. 277 (2002) 32624-32631
22. Li Q., and Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev., Immunol. 2 (2002) 725-734
23. Majumdar S., and Aggarwal B.B. Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J. Immunol. 167 (2001) 2911-2920
24. Mancuso G., Midiri A., Beninati C., Piraino G., Valenti A., Nicocia G., Teti D., Cook J., and Teti G. Mitogen-activated protein kinases and NF-kappa B are involved in TNF-alpha responses to group B streptococci. J. Immunol. 169 (2002) 1401-1409
25. Muzio M., Natoli G., Saccani S., Levrero M., and Mantovani A. The human toll signaling pathway: divergence of nuclear factor kappa-b and JNK/SAPK activation upstream of tumour necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187 (1998) 2097-2101
26. Niu X.L., Ichimori K., Yang X., Hirota Y., Hoshiai K., Li M., and Nakazawa H. Tanshinone II-A inhibits low density lipoprotein oxidation in vitro. Free Radic. Res. 33 (2000) 305-312
27. Ruland J., and Mak T.W. Transducing signals from antigen receptors to nuclear factor kappaB. Immunol. Rev. 193 (2003) 93-100
28. Ryu S.Y., No Z., Kim S.H., and Ahn J.W. Two novel abietane diterpenes from Salvia miltiorrhiza. Planta Med. 63 (1997) 44-46
29. Sha W.C., Liou H.C., Tuomanen E.I., and Baltimore D. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell 80 (1995) 321-330
30. Song Y.S., Park E.H., Hur G.M., Ryu Y.S., Lee Y.S., Lee J.Y., Kim Y.M., and Jin C. Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett. 175 (2002) 53-61
31. Wang X.C., Jobin C., Allen J.B., Roberts W.L., and Jaffe G.J. Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. Invest. Ophthalmol. Vis. Sci. 40 (1999) 477-486
32. Watanabe K., Jinnouchi K., Hess A., Michel O., and Yagi T. Detection of apoptotic change in the lipopolysaccharide (LPS)-treated cochlea of guinea pigs. Hear. Res. 158 (2001) 116-122
33. Zhou G.Y., Zhao B.L., Hou J.W., Ma G.E., and Xin W.J. Protective effects of sodium tanshinone IIA sulphonate against adriamycin-induced lipid peroxidation in mice hearts in vivo and in vitro. Pharmacol. Res. 40 (1999) 487-491
34. Zhou G., Jiang W., Zhao Y., Ma G., Xin W., Yin J., and Zhao B. Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria. Biochem. Pharmacol. 65 (2003) 51-57