In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors

Environmental Toxicology and Pharmacology

Volumn 31, Issue 3, 2011, Pages 443-452

  Zhou, Yongqiang ^a   Li, Weize ^b   Xu, Lei ^a   Chen, Lvyi ^c  

^a New Medicine R and D Center   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Acetylcholinesterase; Amyloid ; Radix Salvia miltiorrhiza

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; ACETYLCHOLINESTERASE; ALCOHOL; AMYLOID BETA PROTEIN[25-35]; CALCIUM ION; CHOLINESTERASE INHIBITOR; CRYPTOTANSHINONE; DIHYDROTANSHINONE; GALANTAMINE; LACTATE DEHYDROGENASE; POLYPHENOL DERIVATIVE; PROTOCATECHUALDEHYDE; SALVIA MILTIORRHIZA EXTRACT; SALVIANOLIC ACID B; TANSHINONE; TANSHINONE I; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; BRAIN HOMOGENATE; CALCIUM INTAKE; CELL PROTECTION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SALVIA MILTIORRHIZA;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BENZOFURANS; CALCIUM; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; DITERPENES, ABIETANE; HYDROXYBENZOIC ACIDS; L-LACTATE DEHYDROGENASE; MALE; NEUROPROTECTIVE AGENTS; PC12 CELLS; PHOSPHATIDYLINOSITOLS; PLANT EXTRACTS; POLYPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; TETRAZOLIUM SALTS; THIAZOLES;

RATTUS; SALVIA MILTIORRHIZA;

EID: 79954743977     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2011.02.006     Document Type: Article

References (56)

1. Andreasen N., Blennow K. β-Amyloid (Aβ) protein in cerebrospinal fluid as a biomarker for Alzheimer's disease. Peptides 2002, 23:1205-1214.
2. 2+ signaling: direct interactions with fura-2. Eur. J. Pharmacol. 2000, 389:35-40.
3. Brunetti G., Serra S., Vacca G., Lobina C., Morazzoni P., Bombardelli E., et al. IDN 5082, a standardized extract of Salvia miltiorrhiza, delays acquisition of alcohol drinking behavior in rats. J. Ethnopharmacol. 2003, 85:93-97.
4. Chan K., Chui S.H., Wong D.Y.L., Ha W.Y., Chan C.L., Wong R.N.S. Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sci. 2004, 75:315-3171.
5. Chen Y.Z., Xu S.Y., Wang S.S., She X.B., Wu Q.M. Studies on the constituents of Dan Shen. J. Jinan Univ. (Natural Science) 1993, 14:55-60.
6. Colombres M., Sagal J.P., Inestrosa N.C. An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds. Curr. Pharm. Des. 2004, 10:3121-3130.
7. Colombo G., Agabio R., Lobina C., Reali R., Morazzoni P., Bombardelli E., et al. Salvia miltiorriza extract inhibits alcohol absorption, preference, and discrimination in sP rats. Alcohol 1999, 18:65-70.
8. Don M.J., Shen C.C., Syu W.J., Ding Y.H., Sun C.M. Cytotoxic and aromatic constituents from Salvia miltiorrhiza. Phytochemistry 2006, 67:497-503.
9. Durairajan S.S.K., Yuan Q., Xie L., Chan W.S., Kum W.F., Koo I., et al. Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicity. Neurochem. Int. 2008, 52:741-750.
10. Gu M., Wang X., Su Z., Ouyang F. One-step separation and purification of 3,4-dihydroxyphenyllactic acid, salvianolic acid B and protocatechualdehyde from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography. J. Chromatogr. A 2007, 1140:107-111.
11. Han J.Y., Fan J.Y., Horie Y., Miura S., Cui D.H., Ishii H., et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol. Therapeut. 2008, 117:280-295.
12. Han B., Tang R.H., Wang F., Han S.Y., Wu D. Effects of Chinese herb Danshen-Dahuang on learning memory ability and hippocampal gene expression of APP and PS1 in rats with Alzheimer disease. Chin. J. Clinicians 2008, 2:912-917.
13. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 1997, 20:154-159.
14. Harigaya Y., Saido T.C., Eckman C.B., Prada C.M., Shoji M., Younkin S.G. Amyloid β protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's Disease brain. Biochem. Biophys. Res. Commun. 2000, 276:422-427.
15. Irie K., Murakami K., Masuda Y., Morioto A., Ohigashi H., Ohashi R., et al. Structure of β-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's Disease. J. Biosci. Bioeng. 2005, 99:437-447.
16. Iwatsubo T. Amyloid β protein in plasma as a diagnostic maker for Alzheimer's disease. Neurobiol. Aging 1998, 19:161-163.
17. Ji W., Gong B.Q. Hypolipidemic activity and mechanism of purified herbal extract of Salvia miltiorrhiza in hyperlipidemic rats. J. Ethnopharmacol. 2008, 119:291-298.
18. Joshua K.S., Leung W.C., Ho W.K., Chiu P. Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. Eur. J. Pharmacol. 2007, 559:1-13.
19. Kang B.Y., Chung S.W., Kim S.H., Ryu S.Y., Kim T.S. Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhiza. Immunopharmacology 2000, 49:355-361.
20. Kang D.G., Oh H., Sohn E.J., Hur T.Y., Lee K.C., Kim K.J., et al. Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats. Life Sci. 2004, 75:1801-1806.
21. Kawahara M., Kuroda Y. Molecular mechanism of neurodegeneration induced by Alzheimer's β-amyloid protein: channel formation and disruption of calcium homeostasis. Brain Res. Bull. 2000, 4:389-397.
22. Kim D.H., Hung T.M., Bae K.H., Jung J.W., Lee S., Yoon B.H., et al. Gomisin A improves scopolamine-induced memory impairment in mice. Eur. J. Pharmacol. 2006, 542:129-135.
23. Kim D.H., Jeon S.J., Jung J.W., Lee S., Yoon B.H., Shin B.Y., et al. Tanshinones congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Eur. J. Pharmacol. 2007, 574:140-147.
24. Kong D.Y. Chemical constituents of Salvia miltiorrhiza (Dan-Shen). Chin. J. Pharm. 1989, 20:279-285.
25. Lam F.F.Y., Yeung J.H.K., Chan K.M., Or P.M.Y. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vasc. Pharmacol. 2007, 46:271-277.
26. Lam F.F.Y., Yeung J.H.K., Chan K.M., Or P.M.Y. Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J. Ethnopharmacol. 2008, 119:318-321.
27. 25-35-induced reduction in BPRP in PC12 cells. Biochem. Biophys. Res. Commun. 2006, 348:593-599.
28. 2 cells. Cancer Lett. 2000, 153:85-93.
29. Liu A.H., Li L., Xu M., Lin Y.H., Guo H.Z., Guo D.A. Simultaneous quantification of six major phenolic acids in the roots of Salvia miltiorrhiza and four related traditional Chinese medicinal preparations by HPLC-DAD method. J. Pharmaceut. Biomed. 2006, 41:48-56.
30. 1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved. Life Sci. 2001, 69:309-326.
31. Mosaddik M.A. In vitro cytotoxicity of tanshinones isolated from Salvia miltiorrhiza Bunge against p388 lymphocytic leukemia cells. Phytomedicine 2003, 10:682-685.
32. Muir J.L. Acetylcholine, aging, and Alzheimer's disease. Pharmacol. Biochem. Be. 1997, 56:687-696.
33. Nobili F., Vitali P., Canfora M., Girtler N., Leo C.D., Mariani G., et al. Effects of long-term Donepezil therapy on rCBF of Alzheimer's patients. Clin. Neurophysiol. 2002, 113:1241-1248.
34. Oddo S., Laferla F.M. The role of nicotinic acetylcholine receptors in Alzheimer's disease. J. Physiol. Paris 2006, 99:172-179.
35. Oh S.H., Nan J.X., Sohn D.H., Kim Y.C., Lee B.H. Salvia miltiorrhiza inhibits biliary obstruction-induced hepatocyte apotosis by cytoplasmic sequestration of P53. Toxicol. Appl. Pharm. 2002, 182:27-33.
36. Pan X., Niu G., Liu H. Comparison of microwave-assisted extraction and conventional extraction techniques for the extraction of tanshinones from Salvia miltiorrhiza bunge. Biochem. Eng. J. 2002, 12:71-77.
37. Park E.J., Zhao Y.Z., Kim Y.C., Sohn D.H. PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation. Food Chem. Toxicol. 2007, 45:1891-1898.
38. Pepeu G. Overview and perspective on the therapy of Alzheimer's disease from a preclinical viewpoint. Prog. Neuropsychopharmacol. 2001, 25:193-209.
39. Reale M., Iarlori C., Gambi F., Fliciani C., Isabella L., Gambi D. The acetylcholinesterase inhibitor Donepezil, regulates a Th2 bias in Alzheimer's disease patients. Neuropharmacology 2006, 50:606-613.
40. Ren Y., Houghton P.J., Hider R.C., Howes M.J. Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorrhiza. Planta Med. 2004, 70:201-204.
41. Selkoe D.J. Presenilins β-amyloid precursor protein and the molecular basis of Alzheimer's disease. Clin. Neurosci. Res. 2001, 1:91-103.
42. Shi Z., He J., Yao T., Chang W., Zhao M. Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC. J. Pharmaceut. Biomed. 2005, 37:481-486.
43. Song Y.H., Liu Q., Lv Z.P., Chen Y.Y., Zhou Y.C., Sun X.G. Protection of a polysaccharide from Salvia miltiorrhiza, a Chinese medicinal herb, against immunological liver injury in mice. Int. J. Biol. Macromol. 2008, 43:170-175.
44. Takatori Y.T., Kume T., Sugimoto M., Katsuki H., Sugimoto H., Akaike A. Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology 2006, 51:474-486.
45. Talesa V.N. Acetylcholinesterase in Alzheimer's disease. Mech. Ageing Dev. 2001, 122:1961-1969.
46. Tang M.K., Ren D.C., Zhang J.T., Du G.H. Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats. Phytomedicine 2002, 9:405-409.
47. Thomsen T., Kewitz H. Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo. Life Sci. 1990, 46:1553-1558.
48. Villarroya M., Garcia A.G., Marco J.L. New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease. Curr. Pharm. Des. 2004, 10:3177-3184.
49. Wan J.M., Sit W.H., Lee C.L., Fu K.H., Chan D.K. Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza Bunge is via reduction in tumor necrosis factor alpha release and liver injury. Int. Immunopharmacol. 2006, 6:750-758.
50. Wu L., Qiao H., Li Y., Li L. Protective roles of puerarin and danshensu on acute ischemic myocardial injury in rats. Phytomedicine 2007, 14:652-668.
51. Wu M.H., Tsai W.J., Don M.J., Chen Y.C., Chen I.S., Kuo Y.C. Tanshinlacton A from Salvia miltiorrhiza modulates interleukin-2 and interferon-γ gene expression. J. Ethnopharmacol. 2007, 113:210-217.
52. Yang Y., Yang S., Chen M., Zhang X., Zou Y., Zhang X. Compound Astragalus and Salvia miltiorrhiza extract exerts anti-fibrosis by mediating TGF-β/Smad signaling in myofibroblasts. J. Ethnopharmacol. 2008, 18:264-270.
53. Yoon Y., Kim Y.O., Jeon W.K., Park H.J., Sung H.J. Tanshinone IIA isolated from Salvia miltiorrhiza Bunge induced apoptosis in HL60 human premyelocytic leukemia cell line. J. Ethnopharmacol. 1999, 68:121-127.
54. Zhao L.G., Fang T.H., Yuan D.P. Effects of Fufang Danshen tablets on the disturbance in learning and memorizing of vascular dementia mice. Lishizhen Med. Mater. Med. Res. 2006, 17:959-960.
55. Zhao G.R., Xiang Z.J., Ye T.X., Yuan Y.J., Guo Z.X. Antioxidant activities of Salvia miltiorrhiza and Panax notoginseng. Food Chem. 2006, 99:767-774.
56. Zhao G.R., Zhang H.M., Ye T.X., Xiang Z.J., Yuan Y.J., Guo Z.X., et al. Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B. Food Chem. Toxicol. 2008, 46:73-81.