Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension

Phytomedicine

Volumn 18, Issue 1, 2010, Pages 58-64

  Fang, Jian ^a,b   Xu, Suo Wen ^a   Wang, Ping ^a   Tang, Fu Tian ^a,c   Zhou, Si Gui ^a,c   Gao, Jie ^a   Chen, Jian Wen ^a   Huang, He Qing ^a   Liu, Pei Qing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangdong Provincial Lung Cancer Research Institute   (China)

^c GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Collagen; Left ventricular fibrosis; Matrix metalloproteinases; Renovascular hypertensive rat; Salvia miltiorrhiza; Tanshinone II A

Indexed keywords

COLLAGEN; DRUG VEHICLE; GELATINASE A; GELATINASE B; HYDROXYPROLINE; MESSENGER RNA; TANSHINONE IIA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VALSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN METABOLISM; CONTROLLED STUDY; DRUG MEGADOSE; GENE EXPRESSION; HEART DISEASE; HEART FUNCTION; HEART LEFT VENTRICLE; HEART MUSCLE FIBROSIS; HYPOTENSION; LOW DRUG DOSE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RENOVASCULAR HYPERTENSION; SHAM PROCEDURE; SYSTOLIC BLOOD PRESSURE; TRANSCRIPTION REGULATION;

ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR AGENTS; COLLAGEN; DITERPENES, ABIETANE; DRUGS, CHINESE HERBAL; FIBROSIS; GENE EXPRESSION; HEART; HYPERTENSION, RENOVASCULAR; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MYOCARDIUM; PHYTOTHERAPY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SALVIA MILTIORRHIZA; TETRAZOLES; TISSUE INHIBITOR OF METALLOPROTEINASE-1; VALINE;

RATTUS; SALVIA MILTIORRHIZA;

EID: 78649789528     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.06.002     Document Type: Article

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