Salvinorin A, an Active Component of the Hallucinogenic Sage Salvia divinorum Is a Highly Efficacious κ-Opioid Receptor Agonist: Structural and Functional Considerations

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 1197-1203

  Chavkin, Charles ^a   Sud, Sumit ^a   Jin, Wenzhen ^a   Stewart, Jeremy ^c   Zjawiony, Jordan K ^c   Siebert, Daniel J ^b   Toth, Beth Ann ^d   Hufeisen, Sandra J ^d   Roth, Bryan L ^d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Salvia Divinorum Res and Info Ctr   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; CYCLIC AMP; DITERPENE; DYNORPHIN A; FORSKOLIN; KAPPA OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; POTASSIUM CHANNEL; SALVIA DIVINORUM EXTRACT; SALVINORIN A; SALVINORINYL 2 HEPTANOATE; SALVINORINYL 2 PROPIONATE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CHIMERA; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; SALVIA; SALVIA DIVINORUM; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

CELL LINE; DITERPENES; ELECTROPHYSIOLOGY; HALLUCINOGENS; HUMANS; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, KAPPA; SALVIA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 1342265861     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.059394     Document Type: Article

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