Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation

Translational Research

Volumn 160, Issue 2, 2012, Pages 114-124

  Xu, Suowen ^a   Liu, Zhiping ^a   Huang, Yan ^a   Le, Kang ^a   Tang, Futian ^b   Huang, Heqing ^a   Ogura, Sayoko ^c   Little, Peter J ^d   Shen, Xiaoyan ^a   Liu, Peiqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^c NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; APOLIPOPROTEIN E; HISTONE H1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NEUTRALIZING ANTIBODY; NUCLEAR PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR; SUPEROXIDE; TANSHINONE IIA; TRANSCRIPTION FACTOR RELA; TUBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG MECHANISM; FOAM CELL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; MACROPHAGE; MALE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RABBIT; RHIZOME; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION;

EID: 84863957609     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2012.01.008     Document Type: Article

References (41)

1. D. Steinberg Low density lipoprotein oxidation and its pathobiological significance J Biol Chem 272 1997 20963 20966 (Pubitemid 27373946)
2. F. Robbesyn, R. Salvayre, and A. Negre-Salvayre Dual role of oxidized LDL on the NF-κB signaling pathway Free Radic Res 38 2004 541 551 (Pubitemid 38697088)
3. J. Scott The liver X receptor and atherosclerosis N Engl J Med 357 2007 2195 2197
4. T. Sawamura, N. Kume, and T. Aoyama An endothelial receptor for oxidized low-density lipoprotein Nature 386 1997 73 77 (Pubitemid 27130922)
5. T. Aoyama, M. Chen, H. Fujiwara, T. Masaki, and T. Sawamura LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells FEBS Lett 467 2000 217 220 (Pubitemid 30081737)
6. L. Li, T. Sawamura, and G. Renier Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation Circ Res 94 7 2004 892 901 (Pubitemid 38490066)
7. D. Li, and J.L. Mehta Intracellular signaling of LOX-1 in endothelial cell apoptosis Circ Res 104 2009 566 568
8. D.Y. Li, H.J. Chen, and J.L. Mehta Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation Cardiovasc Res 52 2001 130 135 (Pubitemid 32835246)
9. K. Oka, T. Sawamura, and K. Kikuta Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells Proc Natl Acad Sci U S A 95 1998 9535 9540 (Pubitemid 28506266)
10. L. Cominacini, A.F. Pasini, and U. Garbin Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species J Biol Chem 275 2000 12633 12638 (Pubitemid 30241412)
11. D.F. Schaeffer, M. Riazy, and K.S. Parhar LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma J Lipid Res 50 2009 1676 1684
12. S. Stein, C. Lohmann, and N. Schafer SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis Eur Heart J 31 2010 2301 2309
13. C. Hu, A. Dandapat, and L. Sun LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet Cardiovasc Res 79 2008 287 293 (Pubitemid 351951615)
14. H. Kataoka, N. Kume, and S. Miyamoto Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions Circulation 99 1999 3110 3117 (Pubitemid 29289075)
15. M. Chen, T. Masaki, and T. Sawamura LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis Pharmacol Ther 95 2002 89 100
16. S. Ogura, A. Kakino, Y. Sato, Y. Fujita, S. Iwamoto, and K. Otsui LOX-1: the multifunctional receptor underlying cardiovascular dysfunction Circ J 73 2009 1993 1999
17. O. Hofnagel, B. Luechtenborg, H. Eschert, G. Weissen-Plenz, N.J. Severs, and H. Robenek Pravastatin inhibits expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in Watanabe heritable hyperlipidemic rabbits: a new pleiotropic effect of statins Arterioscler Thromb Vasc Biol 26 2006 604 610
18. J. Ishiyama, R. Taguchi, A. Yamamoto, and K. Murakami Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells Atherosclerosis 209 2010 118 124
19. S. Gao, Z. Liu, H. Li, P.J. Little, P. Liu, and S. Xu Cardiovascular actions and therapeutic potential of tanshinone IIA Atherosclerosis 220 2012 3 10
20. W. Chen, F. Tang, B. Xie, S. Chen, H. Huang, and P. Liu Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress Eur J Pharmacol 674 2012 359 364
21. F. Tang, X. Wu, and T. Wang Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress Vasc Pharmacol 46 2007 427 438 (Pubitemid 46552282)
22. F.T. Tang, Y. Cao, and T.Q. Wang Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression Eur J Pharmacol 650 2011 275 284
23. S. Xu, P.J. Little, and T. Lan Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet Arch Biochem Biophys 515 2011 72 79
24. M. Xia, M. Hou, and H. Zhu Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor γ-liver X receptor α-ABCA1 pathway J Biol Chem 280 2005 36792 36801 (Pubitemid 41587759)
25. S. Xu, J. Fu, and J. Chen Development of an optimized protocol for primary culture of smooth muscle cells from rat thoracic aortas Cytotechnology 61 2009 65 72
26. T. Thum, and J. Borlak Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism? Circ Res 94 2004 e1 e13
27. S. Xu, Y. Huang, and Y. Xie Evaluation of foam cell formation in cultured macrophages: an improved method with oil red O staining and DiI-oxLDL uptake Cytotechnology 62 2010 473 481
28. A. Jones, R. Deb, and E. Torsney Rosiglitazone reduces the development and rupture of experimental aortic aneurysms Circulation 119 2009 3125 3132
29. Y.S. Bae, J.H. Lee, and S.H. Choi Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2 Circ Res 104 2009 210 218
30. X. Wu, H. Huang, F. Tang, K. Le, S. Xu, and P. Liu Regulated expression of endothelial lipase in atherosclerosis Mol Cell Endocrinol 315 2010 233 238
31. S. Ghosh, and D. Baltimore Activation in vitro of NF-κ B by phosphorylation of its inhibitor I κB Nature 344 1990 678 682
32. L. Li, T. Sawamura, and G. Renier Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium Diabetes 52 2003 1843 1850 (Pubitemid 36792477)
33. M. Nagase, J. Abe, K. Takahashi, J. Ando, S. Hirose, and T. Fujita Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene J Biol Chem 273 1998 33702 33707 (Pubitemid 29005759)
34. S.J. White, G.B. Sala-Newby, and A.C. Newby Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE(-/-) mouse model Cardiovasc Pathol 20 2011 369 373
35. K. Inoue, Y. Arai, H. Kurihara, T. Kita, and T. Sawamura Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice Circ Res 97 2005 176 184 (Pubitemid 41033474)
36. C. Pan, L. Lou, and Y. Huo Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways Ther Adv Cardiovasc Dis 5 2011 99 111
37. G. Fan, Y. Zhu, H. Guo, X. Wang, H. Wang, and X. Gao Direct Vasorelaxation by a novel phytoestrogen tanshinone IIA is mediated by nongenomic action of estrogen receptor through endothelial nitric oxide synthase activation and calcium mobilization J Cardiovasc Pharmacol 57 2011 340 347
38. X. Li, J.R. Du, Y. Yu, B. Bai, and X.Y. Zheng Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway J Ethnopharmacol 129 2010 273 279
39. X.L. Niu, K. Ichimori, and X. Yang Tanshinone II-A inhibits low density lipoprotein oxidation in vitro Free Radic Res 33 2000 305 312
40. A. Taye, A.H. Saad, A.H. Kumar, and H. Morawietz Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose Eur J Pharmacol 627 2010 42 48
41. S. Stein, and C.M. Matter Protective roles of SIRT1 in atherosclerosis Cell Cycle 10 2011 640 647