메뉴 건너뛰기




Volumn 61, Issue 2, 2012, Pages 227-235

The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons

Author keywords

Amyloid protein; Cdk5; p35 p25; Tanshinone IIA; Tau protein

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; CALPAIN; CYCLIN DEPENDENT KINASE 5; PROTEIN P35; TANSHINONE IIA; TAU PROTEIN;

EID: 84863424370     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.04.019     Document Type: Article
Times cited : (64)

References (49)
  • 1
    • 0032859938 scopus 로고    scopus 로고
    • Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death
    • A. Alvarez, R. Toro, A. Cáceres, and R.B. Maccioni Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death FEBS Lett. 459 1999 421 426
    • (1999) FEBS Lett. , vol.459 , pp. 421-426
    • Alvarez, A.1    Toro, R.2    Cáceres, A.3    MacCioni, R.B.4
  • 2
    • 77954621167 scopus 로고    scopus 로고
    • Agmatine protects against beta-amyloid25-35-induced memory impairments in the rat
    • D.H. Bergin, and P. Liu Agmatine protects against beta-amyloid25-35- induced memory impairments in the rat Neuroscience 169 2010 794 811
    • (2010) Neuroscience , vol.169 , pp. 794-811
    • Bergin, D.H.1    Liu, P.2
  • 3
    • 0031007546 scopus 로고    scopus 로고
    • Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
    • M.L. Billingsley, and R.L. Kincaid Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration Biochem. J. 323 1997 577 591
    • (1997) Biochem. J. , vol.323 , pp. 577-591
    • Billingsley, M.L.1    Kincaid, R.L.2
  • 4
    • 0028986916 scopus 로고
    • Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
    • J. Busciglio, A. Lorenzo, J. Yeh, and B.A. Yankner Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding Neuron 14 1995 879 888
    • (1995) Neuron , vol.14 , pp. 879-888
    • Busciglio, J.1    Lorenzo, A.2    Yeh, J.3    Yankner, B.A.4
  • 5
    • 40849125462 scopus 로고    scopus 로고
    • Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
    • X. Chen, T. Huang, J. Zhang, J. Song, L. Chen, and Y. Zhu Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons Brain Res. 1200 2008 99 106
    • (2008) Brain Res. , vol.1200 , pp. 99-106
    • Chen, X.1    Huang, T.2    Zhang, J.3    Song, J.4    Chen, L.5    Zhu, Y.6
  • 6
    • 61349154148 scopus 로고    scopus 로고
    • The anti-inflammatory activities of tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS
    • G.W. Fan, X.M. Gao, H. Wang, Y. Zhu, J. Zhang, L.M. Hu, Y.F. Su, L.Y. Kang, and B.L. Zhang The anti-inflammatory activities of tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS J. Steroid Biochem. Mol. Biol. 113 2009 275 280
    • (2009) J. Steroid Biochem. Mol. Biol. , vol.113 , pp. 275-280
    • Fan, G.W.1    Gao, X.M.2    Wang, H.3    Zhu, Y.4    Zhang, J.5    Hu, L.M.6    Su, Y.F.7    Kang, L.Y.8    Zhang, B.L.9
  • 7
    • 0035659377 scopus 로고    scopus 로고
    • Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies
    • I. Ferrer, R. Blanco, M. Carmona, and B. Puig Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies J. Neural. Transm. 108 2001 1397 1415
    • (2001) J. Neural. Transm. , vol.108 , pp. 1397-1415
    • Ferrer, I.1    Blanco, R.2    Carmona, M.3    Puig, B.4
  • 8
    • 0027420369 scopus 로고
    • Tau protein and the neurofibrillary pathology of Alzheimer's disease
    • M. Goedert Tau protein and the neurofibrillary pathology of Alzheimer's disease Trends Neurosci. 16 1993 460 465
    • (1993) Trends Neurosci. , vol.16 , pp. 460-465
    • Goedert, M.1
  • 9
    • 0031796883 scopus 로고    scopus 로고
    • Neurofibrillary pathology of Alzheimer's disease and other tauopathies
    • M. Goedert Neurofibrillary pathology of Alzheimer's disease and other tauopathies Prog. Brain Res. 117 1998 287 306
    • (1998) Prog. Brain Res. , vol.117 , pp. 287-306
    • Goedert, M.1
  • 10
    • 1942472491 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: Involvement of protein kinase C
    • Y.S. Han, W.H. Zheng, S. Bastianetto, J.G. Chabot, and R. Quirion Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C Br. J. Pharmacol. 141 2004 997 1005
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 997-1005
    • Han, Y.S.1    Zheng, W.H.2    Bastianetto, S.3    Chabot, J.G.4    Quirion, R.5
  • 11
    • 57049099718 scopus 로고    scopus 로고
    • N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons
    • Y.H. Hsiao, P.S. Chen, S.H. Yeh, C.H. Lin, and P.W. Gean N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons J. Neurosci. Res. 86 2008 2685 2695
    • (2008) J. Neurosci. Res. , vol.86 , pp. 2685-2695
    • Hsiao, Y.H.1    Chen, P.S.2    Yeh, S.H.3    Lin, C.H.4    Gean, P.W.5
  • 12
    • 33644873928 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis by tanshinone IIA in NCI-H460 cell
    • H. Hu, Y. Zhang, F. Huang, and H. Deng Inhibition of proliferation and induction of apoptosis by tanshinone IIA in NCI-H460 cell Zhong Yao Cai 28 2005 301 304
    • (2005) Zhong Yao Cai , vol.28 , pp. 301-304
    • Hu, H.1    Zhang, Y.2    Huang, F.3    Deng, H.4
  • 13
    • 0038030381 scopus 로고    scopus 로고
    • P39 activates cdk5 in neurons, and is associated with the actin cytoskeleton
    • S. Humbert, R. Dhavan, and L. Tsai P39 activates cdk5 in neurons, and is associated with the actin cytoskeleton J. Cell Sci. 113 2000 975 983
    • (2000) J. Cell Sci. , vol.113 , pp. 975-983
    • Humbert, S.1    Dhavan, R.2    Tsai, L.3
  • 14
    • 13244296826 scopus 로고    scopus 로고
    • Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats
    • K.S. Hung, S.L. Hwang, C.L. Liang, Y.J. Chen, T.H. Lee, J.K. Liu, S.L. Howng, and C.H. Wang Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats J. Neuropathol. Exp. Neurol. 64 2005 15 26
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 15-26
    • Hung, K.S.1    Hwang, S.L.2    Liang, C.L.3    Chen, Y.J.4    Lee, T.H.5    Liu, J.K.6    Howng, S.L.7    Wang, C.H.8
  • 16
    • 0035031502 scopus 로고    scopus 로고
    • Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone II A
    • Z.N. Ji, and G.Q. Liu Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone II A Acta Pharmacol. Sin. 22 2001 459 462
    • (2001) Acta Pharmacol. Sin. , vol.22 , pp. 459-462
    • Ji, Z.N.1    Liu, G.Q.2
  • 18
    • 34548480683 scopus 로고    scopus 로고
    • Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5
    • S. Kesavapany, Y.L. Zheng, N. Amin, and H.C. Pant Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5 Biotechnol. J. 2 2007 978 987
    • (2007) Biotechnol. J. , vol.2 , pp. 978-987
    • Kesavapany, S.1    Zheng, Y.L.2    Amin, N.3    Pant, H.C.4
  • 19
    • 0035808457 scopus 로고    scopus 로고
    • Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
    • S. Leclerc, M. Garnier, R. Hoessel, D. Marko, J.A. Bibb, G.L. Snyder, P. Greengard, J. Biernat, Y.Z. Wu, E.M. Mandelkow, G. Eisenbrand, and L. Meijer Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J. Biol. Chem. 276 2001 251 260
    • (2001) J. Biol. Chem. , vol.276 , pp. 251-260
    • Leclerc, S.1    Garnier, M.2    Hoessel, R.3    Marko, D.4    Bibb, J.A.5    Snyder, G.L.6    Greengard, P.7    Biernat, J.8    Wu, Y.Z.9    Mandelkow, E.M.10    Eisenbrand, G.11    Meijer, L.12
  • 22
    • 1542681205 scopus 로고    scopus 로고
    • Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4
    • Y. Liu, X. Wang, and Y. Liu Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4 Zhong Yao Cai 26 2003 415 417
    • (2003) Zhong Yao Cai , vol.26 , pp. 415-417
    • Liu, Y.1    Wang, X.2    Liu, Y.3
  • 25
    • 37549015597 scopus 로고    scopus 로고
    • Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies
    • J.P. Lopes, C.R. Oliveira, and P. Agostinho Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies Cell Mol. Neurobiol. 27 2007 943 957
    • (2007) Cell Mol. Neurobiol. , vol.27 , pp. 943-957
    • Lopes, J.P.1    Oliveira, C.R.2    Agostinho, P.3
  • 26
    • 67349280677 scopus 로고    scopus 로고
    • Erythropoietin protects PC12 cells from beta-amyloid (25-35)-induced apoptosis via PI3K/Akt signaling pathway
    • R. Ma, N. Xiong, C. Huang, Q. Tang, B. Hu, J. Xiang, and G. Li Erythropoietin protects PC12 cells from beta-amyloid (25-35)-induced apoptosis via PI3K/Akt signaling pathway Neuropharmacology 56 2009 1027 1034
    • (2009) Neuropharmacology , vol.56 , pp. 1027-1034
    • Ma, R.1    Xiong, N.2    Huang, C.3    Tang, Q.4    Hu, B.5    Xiang, J.6    Li, G.7
  • 27
    • 0030048606 scopus 로고    scopus 로고
    • Amnesia induced in mice by centrally administered 13-amyloid peptides involves cholinergic dysfunction
    • T. Maurice, B.P. Lockhart, and A. Privat Amnesia induced in mice by centrally administered 13-amyloid peptides involves cholinergic dysfunction Brain Res. 706 1996 181 193
    • (1996) Brain Res. , vol.706 , pp. 181-193
    • Maurice, T.1    Lockhart, B.P.2    Privat, A.3
  • 29
    • 0029966469 scopus 로고    scopus 로고
    • The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
    • M. Nikolic, H. Dudek, Y.T. Kwon, Y.F. Ramos, and L.H. Tsai The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation Genes Dev. 10 1996 816 825
    • (1996) Genes Dev. , vol.10 , pp. 816-825
    • Nikolic, M.1    Dudek, H.2    Kwon, Y.T.3    Ramos, Y.F.4    Tsai, L.H.5
  • 30
    • 0032508698 scopus 로고    scopus 로고
    • P35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
    • G.N. Patrick, P. Zhou, Y.T. Kwon, P.M. Howley, and L.H. Tsai P35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway J. Biol. Chem. 273 1998 24057 24064
    • (1998) J. Biol. Chem. , vol.273 , pp. 24057-24064
    • Patrick, G.N.1    Zhou, P.2    Kwon, Y.T.3    Howley, P.M.4    Tsai, L.H.5
  • 31
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • G.N. Patrick, L. Zukerberg, M. Nikolic, S. de la Monte, P. Dikkes, and L.H. Tsai Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 402 1999 615 622
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    De La Monte, S.4    Dikkes, P.5    Tsai, L.H.6
  • 32
    • 0028981219 scopus 로고
    • Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity
    • C.J. Pike, A.J. Walencewicz-Wasserman, J. Kosmoski, D.H. Cribbs, C.G. Glabe, and C.W. Cotman Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity J. Neurochem. 64 1995 253 265
    • (1995) J. Neurochem. , vol.64 , pp. 253-265
    • Pike, C.J.1    Walencewicz-Wasserman, A.J.2    Kosmoski, J.3    Cribbs, D.H.4    Glabe, C.G.5    Cotman, C.W.6
  • 33
  • 34
    • 68849102989 scopus 로고    scopus 로고
    • Protective effect of ginsenoside Rb1 on amyloid protein(1-42)-induced neurotoxicity in cortical neurons
    • Y.H. Qian, H. Han, X.D. Hu, and L.L. Shi Protective effect of ginsenoside Rb1 on amyloid protein(1-42)-induced neurotoxicity in cortical neurons Neurol. Res. 31 2009 663 667
    • (2009) Neurol. Res. , vol.31 , pp. 663-667
    • Qian, Y.H.1    Han, H.2    Hu, X.D.3    Shi, L.L.4
  • 35
    • 67349162522 scopus 로고    scopus 로고
    • Dexamethasone inhibits camptothecin-induced apoptosis in C6-glioma via activation of Stat5/Bcl-xL pathway
    • Y.H. Qian, Q. Xiao, H. Chen, and J. Xu Dexamethasone inhibits camptothecin-induced apoptosis in C6-glioma via activation of Stat5/Bcl-xL pathway BBA-Mol. Cell Res. 1793 2009 764 771
    • (2009) BBA-Mol. Cell Res. , vol.1793 , pp. 764-771
    • Qian, Y.H.1    Xiao, Q.2    Chen, H.3    Xu, J.4
  • 36
    • 78650082396 scopus 로고    scopus 로고
    • A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model
    • S.N. Thompson, K.M. Carrico, A.G. Mustafa, M. Bains, and E.D. Hall A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model J. Neurotrauma. 27 2010 2233 2243
    • (2010) J. Neurotrauma. , vol.27 , pp. 2233-2243
    • Thompson, S.N.1    Carrico, K.M.2    Mustafa, A.G.3    Bains, M.4    Hall, E.D.5
  • 37
    • 0027978170 scopus 로고
    • P35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • L.H. Tsai, I. Delalle, V.S. Caviness Jr., T. Chae, and E. Harlow P35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Nature 371 1994 419 423
    • (1994) Nature , vol.371 , pp. 419-423
    • Tsai, L.H.1    Delalle, I.2    Caviness, Jr.V.S.3    Chae, T.4    Harlow, E.5
  • 38
    • 70349560581 scopus 로고    scopus 로고
    • Effects of tanshinone IIA on proliferation and apoptosis of the human gastric cancer cell line BGC-823
    • X. Wang, Y.X. Xie, and B.E. Shan Effects of tanshinone IIA on proliferation and apoptosis of the human gastric cancer cell line BGC-823 Carcin. Teratogen. Mutagen. 20 2008 56 59
    • (2008) Carcin. Teratogen. Mutagen. , vol.20 , pp. 56-59
    • Wang, X.1    Xie, Y.X.2    Shan, B.E.3
  • 40
    • 73449100486 scopus 로고    scopus 로고
    • Danshen extracts decrease blood C reactive protein and prevent ischemic stroke recurrence. A controlled pilot study
    • G. Xu, W. Zhao, Z. Zhou, R. Zhang, W. Zhu, and X. Liu Danshen extracts decrease blood C reactive protein and prevent ischemic stroke recurrence. A controlled pilot study Phytother. Res. 23 2009 1721 1725
    • (2009) Phytother. Res. , vol.23 , pp. 1721-1725
    • Xu, G.1    Zhao, W.2    Zhou, Z.3    Zhang, R.4    Zhu, W.5    Liu, X.6
  • 41
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • B.A. Yankner Mechanisms of neuronal degeneration in Alzheimer's disease Neuron 16 1996 921 932
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 42
    • 4043125279 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells
    • S. Yuan, Y. Wei, W. Wang, F. Xiao, S. Li, and J. Zhang Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells World J. Gastroenterol. 10 2004 2024 2028
    • (2004) World J. Gastroenterol. , vol.10 , pp. 2024-2028
    • Yuan, S.1    Wei, Y.2    Wang, W.3    Xiao, F.4    Li, S.5    Zhang, J.6
  • 44
    • 84861205146 scopus 로고    scopus 로고
    • The protection of tanshinone IIA on cellular damage induced by glutamate and Beta-amyloid protein
    • M.T. Zhang, Y.H. Qian, J. Yang, L.L. Shi, S.J. Zhu, and Z. Liu The protection of tanshinone IIA on cellular damage induced by glutamate and Beta-amyloid protein Chin. J. Gerontol. 29 2009 2465 2469
    • (2009) Chin. J. Gerontol. , vol.29 , pp. 2465-2469
    • Zhang, M.T.1    Qian, Y.H.2    Yang, J.3    Shi, L.L.4    Zhu, S.J.5    Liu, Z.6
  • 45
    • 70349567473 scopus 로고    scopus 로고
    • Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding
    • Z.C. Zhang, J. Gao, Y.Y. Wang, T. Song, J. Zhang, G. Wua, T.T. Zhang, and G.H. Du Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding Biochem. Pharmacol. 78 2009 1316 1322
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 1316-1322
    • Zhang, Z.C.1    Gao, J.2    Wang, Y.Y.3    Song, T.4    Zhang, J.5    Wua, G.6    Zhang, T.T.7    Du, G.H.8
  • 46
    • 77951592474 scopus 로고    scopus 로고
    • Cdk5 nuclear localization is p27-dependent in nerve cells
    • J. Zhang, H.F. Li, and K. Herrup Cdk5 nuclear localization is p27-dependent in nerve cells J. Biol. Chem. 285 2010 14052 14061
    • (2010) J. Biol. Chem. , vol.285 , pp. 14052-14061
    • Zhang, J.1    Li, H.F.2    Herrup, K.3
  • 47
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • L. Zhou, Z. Zuo, and M.S. Chow Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use J. Clin. Pharmacol. 45 2005 1345 1359
    • (2005) J. Clin. Pharmacol. , vol.45 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.3
  • 48
    • 50849129920 scopus 로고    scopus 로고
    • Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest
    • L. Zhou, W.K. Chan, N. Xu, K. Xiao, H. Luo, K.Q. Luo, and D.C. Chang Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest Life Sci. 83 2008 394 403
    • (2008) Life Sci. , vol.83 , pp. 394-403
    • Zhou, L.1    Chan, W.K.2    Xu, N.3    Xiao, K.4    Luo, H.5    Luo, K.Q.6    Chang, D.C.7
  • 49
    • 77956698507 scopus 로고    scopus 로고
    • The effects of tanIIA on the change of calcium current induced by beta-amyloid protein 25-35 in neurons of nucleus basalis of Meynert
    • S.J. Zhu, Y.H. Qian, L.L. Shi, W.N. Yang, X.Z. Feng, C.Q. Li, and Y. Liu The effects of tanIIA on the change of calcium current induced by beta-amyloid protein 25-35 in neurons of nucleus basalis of Meynert Zhong Nan Da Xue Xue Bao Yi Xue Ban 35 2010 840 846
    • (2010) Zhong Nan da Xue Xue Bao Yi Xue Ban , vol.35 , pp. 840-846
    • Zhu, S.J.1    Qian, Y.H.2    Shi, L.L.3    Yang, W.N.4    Feng, X.Z.5    Li, C.Q.6    Liu, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.