Salvinorin A: The 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor

Trends in Pharmacological Sciences

Volumn 24, Issue 3, 2003, Pages 107-109

  Sheffler, Douglas J ^a   Roth, Bryan L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; LYSERGIDE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; NALTREXONE; PSYCHEDELIC AGENT; SALVINORIN A; UNCLASSIFIED DRUG;

BINDING AFFINITY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; HALLUCINATION; HUMAN; MENTAL DISEASE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0037333260     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(03)00027-0     Document Type: Short Survey

References (21)

1. Valdes L.J. III. Salvia divinorum and the unique diterpene hallucinogen, salvinorin (divinorin) A. J. Psychoactive Drugs. 26:1994;277-283.
2. Giroud C., et al. Salvia divinorum: an hallucinogenic mint which might become a new recreational drug in Switzerland. Forensic Sci. Int. 112:2000;143-150.
3. Siebert D.J. Salvia divinorum and salvinorin A: new pharmacologic findings. J. Ethnopharmacol. 43:1994;53-56.
4. Ortega A., et al. Salvinorin, a new trans-neoclerodane diterpene from Salvia divinorum (Labiatae). J. Chem. Soc. Perkins Trans. 1:1982;2505-2508.
5. Valdes L.J., et al. Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint Salvia divinorum. J. Org. Chem. 49:1984;4716-4720.
6. Koreeda M., et al. The absolute stereochemistry of salvinorins. Chem. Lett. 1990;2015-2018.
7. Abramov M.M., Yaparova S.A. J. Appl. Chem (USSR). 36:1963;2471.
8. Roth B.L., et al. Salvinorin A: a potent naturally occurring nonnitrogenous κ opioid selective agonist. Proc. Nat. Acad. Sci. U. S. A. 99:2002;11934-11939.
9. 2C): where structure meets function. Pharmacol. Ther. 79:1998;231-257.
10. Pfeiffer A., et al. Psychotomimesis mediated by κ opiate receptors. Science. 233:1986;774-776.
11. Ni Q., et al. Opioid peptide receptor studies. 3. Interaction of opioid peptides and other drugs with four subtypes of the κ2 receptor in guinea pig brain. Peptides. 16:1995;1083-1095.
12. Marchesi G.F., et al. The therapeutic role of naltrexone in negative symptom schizophrenia. Prog. Neuro-Psychopharmacol. Biol. Psychiat. 19:1995;1239-1249.
13. Mathieu-Kia A., et al. μ-, δ-, and κ-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients. Brain Res. 893:2001;121-134.
14. Bard J., et al. Opioid receptor density in Alzheimer amygdala and putamen. Brain Res. 632:1993;209-215.
15. 2A receptors in atypical antipsychotic drug actions. The Neuroscientist. 5:1999;254-262.
16. Valdes L.J., et al. Ethnopharmacology of Ska Maria Pastora (Salvia divinorum, Epling and Javita-M.). J. Ethnopharmacology. 7:1982;287-312.
17. Valdes, L.J. (2001) The early history of Salvia divinorum. The Entheogen Review X, pp. 73-75.
18. Valdes L.J., et al. Studies of Salvia divinorum (Lamiaceae), an hallucinogenic mint from the Sierra Mazateca in Oaxaca, Central Mexico. Economic Botany. 41:1987;283-291.
19. Wasson, W.G. (1962) A new Mexican psychotropic drug from the mint family. In Botanical Museum Leaflets, Harvard University Press 20, pp. 77-84.
20. Siebert D.J. Salvia divinorum and salvinorin A: new pharmacologic findings. J. Ethnopharmacol. 43:1994;53-56.
21. Valdes L.J. Salvia divinorum and the unique diterpine hallucinogen Salvinorin (Divinorin) A. J. Psychoactive Drugs. 26:1994;277-283.