Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway

Journal of Cellular Biochemistry

Volumn 104, Issue 1, 2008, Pages 15-26

  Jin, Un Ho ^a   Suh, Seok Jong ^a   Hyen, Wook Chang ^b   Son, Jong Keun ^b   Seung, Ho Lee ^b   Son, Kun Ho ^c   Chang, Young Chae ^d   Kim, Cheorl Ho ^a  

^a Sungkyunkwan University   (South Korea)

^b Yeungnam University   (South Korea)

^c Andong National University   (South Korea)

^d Catholic University of Daegu   (South Korea)

Author keywords

Human aortic smooth muscle cells; Matrix metalloproteinase 9; Salviae miltiorrahizae (Salvia miltiorrhiza bunge); Tanshinone IIA; Tumor necrosis factor

Indexed keywords

GELATINASE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TANSHINONE; TANSHINONE IIA; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HERBACEOUS AGENT; PHENANTHRENE DERIVATIVE;

ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MIGRATION INHIBITION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEINASE INHIBITION; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; AORTA; CELL MOTION; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; METABOLISM;

SALVIA MILTIORRHIZA;

AORTA; CELL MOVEMENT; DRUGS, CHINESE HERBAL; HUMANS; MATRIX METALLOPROTEINASE 9; MYOCYTES, SMOOTH MUSCLE; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-AKT; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION;

EID: 46449089508     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21599     Document Type: Article

References (50)

1. Abedi H, Zachary I. 1995. Signalling mechanisms in the regulation of vascular cell migration. Cardiovasc Res 30:544-556.
2. Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. 1994. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res 75:539-545.
3. Bendeck MP, Irvin C, Reidy MA. 1996. Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Circ Res 78:38-43.
4. Bharti AC, Aggarwal BB. 2002. Nuclear factor-kappa B and cancer: Its role in prevention and therapy. Biochem Pharmacol 64:883-888.
5. Bode AM, Dong Z. 2000. Signal transduction pathways: Targets for chemoprevention of skin cancer. Lancet Oncol 1:181-188.
6. Cha BY, Park CJ, Lee DG, Lee YC, Kim DW, Kim JD, Seo WG, Kim CH. 2003. inhibitory effect of methanol extract of Euonymus alatus on matrix metalloproteinase-9. J Ethnopharmacol 85:163-167.
7. Chen YL, Yang SP, Shiao MS, Chen JW, Lin SJ. 2001. Salvia miltiorrhiza inhibits intimal hyperplasia and monocyte chemotactic protein-1 expression after balloon injury in cholesterol-fed rabbits. J Cell Biochem 83:484-493.
8. Chung TW, Moon SK, Lee YC, Kim JG, Ko JH, Kim CH. 2002. Enhanced expression of matrix metalloproteinase-9 (MMP-9) by hepatitis B virus infection into liver cells. Arch Biochem Biophys 408:147-154.
9. Clausell N, De Lima VC, Molossi S. 1995. Expression of tumor necrosis factor-α and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy. Br Heart J 73:534-539.
10. Cowley S, Paterson H, Kemp P, Marshall CJ. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
11. Dua J, Li X, Zhang R, Qian Z. 2005. Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice. J Ethnopharmacol 98:319-322.
12. Fabunmi RP, Baker AH, Murray EJ, Booth RF, Newby AC. 1996. Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors or metalloproteinases-1, -2, and -3 in rabbit aortic smooth muscle cells. Biochem J 315:335-342.
13. Fanburg BL, Lee SL. 1997. A new role for an old molecule: Serotonin as a mitogen. Am J Physiol 272:L795-L806.
14. Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Unemori EN, Lark MW, Amento E, Libby P. 1994. Cytokine stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res 75:181-189.
15. Galis ZS, Johnson C, Godin D, Magid R, Shipley JM, Senior RM, Ivan E. 2002. Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circ Res 91:852-859.
16. Ghosh S, Baltimore D. 1990. Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature 344:678-682.
17. Heber D. 2001. Herbs and atherosclerosis. Curr Atheroscler Rep 3:93-96.
18. Henkel T, Machleidt T, Alkalay I, Kronke M, Ben Neriah Y, Baeuerle PA. 1993. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature 365:182-185.
19. Huang Q, Shen HM, Ong CN. 2004. Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kB. Biochem Pharmacol 68:361-371.
20. Jovinge S, Hultgardh-Nilsson A, Regnstrom J, Nilsson J. 1997. TNF-a activates smooth muscle cell migration in culture and is expressed in the balloon-injured rat aorta. Arterioscler Thromb Vasc Biol 17:490-497.
21. Karin M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270:16483-16486.
22. Kenagy RD, Hart CE, Stetler-Stevenson WG, Clowes AW. 1997. Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting through matrix metalloproteinases 2 and 9. Circulation 96:3555-3560.
23. Kim BJ, Kim YK, Park WH, Ko JH, Lee YC, Kim CH. 2003. A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterolfed rabbits. Int Immunopharmacol 3:723-734.
24. Li X, Du JR, Zhang R, Zhang LF, Qian ZM. 2004. The experimental study of the effect of tanshinone on artery restenosis in mouse. Zhongguo Zhong Yao Za Zhi 29:255-258.
25. Matrisian LM. 1990. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6:121-125.
26. Moon SK, Cha BY, Kim CH. 2003a. In vitro cellular aging is associated with enhanced proliferative capacity, G1 cell cycle modulation, and matrix metalloproteinase-9 regulation in mouse aortic smooth muscle cells. Arch Biochem Biophys 418:39-48.
27. Moon SK, Cha BY, Kim CH. 2003b. ERK1/2 mediates TNF-α induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-κB and AP-1: Involvement of the Ras dependent pathway. J Cell Physiol 198:417-427.
28. Moon SK, Cho GO, Jung SY, Gal SW, Kwon TK, Lee YC, Madamanchi NR, Kim CH. 2003c. Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: Role of ERK1/2, cell cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun 301:1069-1078.
29. Motwani JG, Topol EJ. 1998. Aortocoronary saphenous vein graft disease: Pathogenesis, predisposion, and prevention. Circulation 97:916-931.
30. Newby AC, Zaltsman AB. 2000. Molecular mechanisms in intimal hyperplasia. J Pathol 190:300-309.
31. Okada Y, Gonoji Y, Naka K, Tomita K, Nakanishi I, Iwata K, Yamashita K, Hayakawa T. 1992. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. J Biol Chem 267:21712-21719.
32. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. 1999. NF-kappaB activation by tumour necrosis factor requires the AKT serine-threonine kinase. Nature 401:82-85.
33. Pauly RR, Passaniti A, Bilato C, Monticone R, Cheng L, Papadopoulos N, Gluzband YA, Smith L, Weinstein C, Lakatta EG. 1994. Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation. Circ Res 75:41-54.
34. Ross R. 1993. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362:801-809.
35. Ross R. 1995. Cell biology of atherosclerosis. Annu Rev Physiol 57:791-804.
36. Sankar S, Mahooti-Brooks N, Bensen L, McCarthy TL, Centrella M, Madri JA. 1996. Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis. J Clin Invest 97:1436-1446.
37. Sasaguri Y, Murahashi N, Sugama K, Kato S, Hiraoka K, Satoh T, Isomoto H, Morimatsu M. 1994. Development-related changes in matrixmetalloproteinase expression in human aortic smooth muscle cells. Lab Invest 71:261-269.
38. Sato H, Seiki M. 1993. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8:395-405.
39. Schwartz SM. 1997. Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest 100:S87-S89.
40. Senior RM, Griffin GL, Fliszar CJ, Shapiro SD, Goldberg GI, Welgus HG. 1991. Human 92- and 72-kilodalton type IV collagenases are elastases. J Biol Chem 266:7870-7875.
41. Shia Z, He J, Yao T, Chang W, Zhao M. 2005. Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC. J Pharm Biomed Anal 37:481-486.
42. Stenmark KR, Mecham RP. 1997. Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol 59:89-144.
43. Strauss BH, Chisholm RJ, Keeley FW, Gotlieb AI, Logan RA, Amstrong PW. 1994. Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. Circ Res 75:650-658.
44. Tipping PG, Hancock WW. 1993. Production of tumor necrosis factor and interleukin-1 by macrophages from human atherosclerotic plaques. Am J Pathol 142:1721-1728.
45. Westermarck J, Kahari VM. 1999. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13:781-792.
46. Woessner JF, Jr. 1991. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145-2154.
47. Yao JS, Chen Y, Zhai W, Xu K, Young WL, Yang GY. 2004. Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration. The role of ERK1/2, PI3K, and matrix metalloproteinases. Circ Res 95:364-371.
48. Yong VW, Krekoski CA, Forsyth PA, Bell R, Edwards DR. 1998. Matrix metalloproteinases and diseases of the CN. Trends Neurosci 21:75-80.
49. Yoshie F, Iizuka A, Kubo M, Komatsu Y, Matsumoto A, Itakura H, Takeda H, Matsumiya T, Kondo K. 2001. Protective effects of Saiko-ka-ryukotsu-borei-to (Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) against atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic(KHC) rabbits. Pharmacol Res 43:481-488.
50. Yuan SL, Wang XJ, Wei YQ. 2003. Anticancer effect of tanshinone and its mechanisms. Ai Zheng 22:1363-1366.