메뉴 건너뛰기




Volumn 35, Issue 8, 2016, Pages 939-951

Targeting JAK kinase in solid tumors: Emerging opportunities and challenges

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 22 RECEPTOR; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN RECEPTOR; JANUS KINASE; JANUS KINASE INHIBITOR; STAT PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 84959319525     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.150     Document Type: Review
Times cited : (181)

References (229)
  • 2
    • 0028301958 scopus 로고
    • Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes
    • Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, et al. Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci USA 1994; 91: 6374-6378.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6374-6378
    • Kawamura, M.1    McVicar, D.W.2    Johnston, J.A.3    Blake, T.B.4    Chen, Y.Q.5    Lal, B.K.6
  • 3
    • 0026081302 scopus 로고
    • Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
    • Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol 1991; 11: 2057-2065.
    • (1991) Mol Cell Biol , vol.11 , pp. 2057-2065
    • Wilks, A.F.1    Harpur, A.G.2    Kurban, R.R.3    Ralph, S.J.4    Zurcher, G.5    Ziemiecki, A.6
  • 5
    • 21344467318 scopus 로고    scopus 로고
    • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
    • Jones AV, Kreil S, Zoi K, Waghorn K, Curtis C, Zhang L, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 2005; 106: 2162-2168.
    • (2005) Blood , vol.106 , pp. 2162-2168
    • Jones, A.V.1    Kreil, S.2    Zoi, K.3    Waghorn, K.4    Curtis, C.5    Zhang, L.6
  • 7
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes
    • Steensma DP, Dewald GW, Lasho TL, Powell HL, McClure RF, Levine RL, et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes. Blood 2005; 106: 1207-1209.
    • (2005) Blood , vol.106 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3    Powell, H.L.4    McClure, R.F.5    Levine, R.L.6
  • 9
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 10
    • 84896491618 scopus 로고    scopus 로고
    • The IL-6 feed-forward loop: A driver of tumorigenesis
    • Chang Q, Daly L, Bromberg J. The IL-6 feed-forward loop: a driver of tumorigenesis. Semin Immunol 2014; 26: 48-53.
    • (2014) Semin Immunol , vol.26 , pp. 48-53
    • Chang, Q.1    Daly, L.2    Bromberg, J.3
  • 11
    • 36849017497 scopus 로고    scopus 로고
    • IL-6 involvement in epithelial cancers
    • Schafer ZT, Brugge JS. IL-6 involvement in epithelial cancers. J Clin Invest 2007; 117: 3660-3663.
    • (2007) J Clin Invest , vol.117 , pp. 3660-3663
    • Schafer, Z.T.1    Brugge, J.S.2
  • 12
    • 78649741783 scopus 로고    scopus 로고
    • Gp130 at the nexus of inflammation, autoimmunity, and cancer
    • Silver JS, Hunter CA. gp130 at the nexus of inflammation, autoimmunity, and cancer. J Leuk Biol 2010; 88: 1145-1156.
    • (2010) J Leuk Biol , vol.88 , pp. 1145-1156
    • Silver, J.S.1    Hunter, C.A.2
  • 13
    • 84896494013 scopus 로고    scopus 로고
    • IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
    • Taniguchi K, Karin M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol 2014; 26: 54-74.
    • (2014) Semin Immunol , vol.26 , pp. 54-74
    • Taniguchi, K.1    Karin, M.2
  • 14
    • 84881534116 scopus 로고    scopus 로고
    • Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically
    • Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, et al. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 2013; 24: 257-271.
    • (2013) Cancer Cell , vol.24 , pp. 257-271
    • Putoczki, T.L.1    Thiem, S.2    Loving, A.3    Busuttil, R.A.4    Wilson, N.J.5    Ziegler, P.K.6
  • 15
    • 84875837868 scopus 로고    scopus 로고
    • Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells
    • Onnis B, Fer N, Rapisarda A, Perez VS, Melillo G. Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. J Clin Invest 2013; 123: 1615-1629.
    • (2013) J Clin Invest , vol.123 , pp. 1615-1629
    • Onnis, B.1    Fer, N.2    Rapisarda, A.3    Perez, V.S.4    Melillo, G.5
  • 16
    • 84869021181 scopus 로고    scopus 로고
    • Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation
    • Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Cespedes MV, et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell 2012; 22: 571-584.
    • (2012) Cancer Cell , vol.22 , pp. 571-584
    • Calon, A.1    Espinet, E.2    Palomo-Ponce, S.3    Tauriello, D.V.4    Iglesias, M.5    Cespedes, M.V.6
  • 17
    • 58649119388 scopus 로고    scopus 로고
    • Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment
    • Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, Harris T, et al. Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell 2009; 15: 114-123.
    • (2009) Cancer Cell , vol.15 , pp. 114-123
    • Kortylewski, M.1    Xin, H.2    Kujawski, M.3    Lee, H.4    Liu, Y.5    Harris, T.6
  • 18
    • 84868613705 scopus 로고    scopus 로고
    • Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
    • Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 2012; 491: 254-258.
    • (2012) Nature , vol.491 , pp. 254-258
    • Grivennikov, S.I.1    Wang, K.2    Mucida, D.3    Stewart, C.A.4    Schnabl, B.5    Jauch, D.6
  • 19
    • 67651097885 scopus 로고    scopus 로고
    • Impaired development of human Th1 cells in patients with deficient expression of STAT4
    • Chang HC, Han L, Goswami R, Nguyen ET, Pelloso D, Robertson MJ, et al. Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood 2009; 113: 5887-5890.
    • (2009) Blood , vol.113 , pp. 5887-5890
    • Chang, H.C.1    Han, L.2    Goswami, R.3    Nguyen, E.T.4    Pelloso, D.5    Robertson, M.J.6
  • 20
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: From interferons to cytokines
    • Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem 2007; 282: 20059-20063.
    • (2007) J Biol Chem , vol.282 , pp. 20059-20063
    • Schindler, C.1    Levy, D.E.2    Decker, T.3
  • 22
    • 33745700364 scopus 로고    scopus 로고
    • Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response
    • Murray PJ. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr Opin Pharmacol 2006; 6: 379-386.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 379-386
    • Murray, P.J.1
  • 23
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon RK, Tonkonogy S, Schultz M, Dieleman LA, Grenther W, Balish E, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 1998; 66: 5224-5231.
    • (1998) Infect Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3    Dieleman, L.A.4    Grenther, W.5    Balish, E.6
  • 24
    • 0026645911 scopus 로고
    • Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies
    • Pisa P, Halapi E, Pisa EK, Gerdin E, Hising C, Bucht A, et al. Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies. Proc Natl Acad Sci USA 1992; 89: 7708-7712.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7708-7712
    • Pisa, P.1    Halapi, E.2    Pisa, E.K.3    Gerdin, E.4    Hising, C.5    Bucht, A.6
  • 25
    • 0031006224 scopus 로고    scopus 로고
    • High incidence of interleukin 10 mRNA but not interleukin 2 mRNA detected in human breast tumours
    • Venetsanakos E, Beckman I, Bradley J, Skinner JM. High incidence of interleukin 10 mRNA but not interleukin 2 mRNA detected in human breast tumours. Br J Cancer 1997; 75: 1826-1830.
    • (1997) Br J Cancer , vol.75 , pp. 1826-1830
    • Venetsanakos, E.1    Beckman, I.2    Bradley, J.3    Skinner, J.M.4
  • 26
    • 0029124129 scopus 로고
    • Human non-small cell lung cancer cells express a type 2 cytokine pattern
    • Huang M, Wang J, Lee P, Sharma S, Mao JT, Meissner H, et al. Human non-small cell lung cancer cells express a type 2 cytokine pattern. Cancer Res 1995; 55: 3847-3853.
    • (1995) Cancer Res , vol.55 , pp. 3847-3853
    • Huang, M.1    Wang, J.2    Lee, P.3    Sharma, S.4    Mao, J.T.5    Meissner, H.6
  • 27
    • 84919890714 scopus 로고    scopus 로고
    • Significance of -1082 A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression
    • Miteva LD, Stanilov NS, Deliysky TS, Stanilova SA. Significance of -1082 A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression. Tumour Biol 2014; 35: 12655-12664.
    • (2014) Tumour Biol , vol.35 , pp. 12655-12664
    • Miteva, L.D.1    Stanilov, N.S.2    Deliysky, T.S.3    Stanilova, S.A.4
  • 28
  • 29
    • 0029121415 scopus 로고
    • IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response
    • Kim J, Modlin RL, Moy RL, Dubinett SM, McHugh T, Nickoloff BJ, et al. IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response. J Immunol 1995; 155: 2240-2247.
    • (1995) J Immunol , vol.155 , pp. 2240-2247
    • Kim, J.1    Modlin, R.L.2    Moy, R.L.3    Dubinett, S.M.4    McHugh, T.5    Nickoloff, B.J.6
  • 31
    • 84863973465 scopus 로고    scopus 로고
    • IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs
    • Emmerich J, Mumm JB, Chan IH, LaFace D, Truong H, McClanahan T, et al. IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs. Cancer Res 2012; 72: 3570-3581.
    • (2012) Cancer Res , vol.72 , pp. 3570-3581
    • Emmerich, J.1    Mumm, J.B.2    Chan, I.H.3    LaFace, D.4    Truong, H.5    McClanahan, T.6
  • 32
  • 33
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006; 203: 2271-2279.
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6
  • 35
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 2009; 206: 1465-1472.
    • (2009) J Exp Med , vol.206 , pp. 1465-1472
    • Pickert, G.1    Neufert, C.2    Leppkes, M.3    Zheng, Y.4    Wittkopf, N.5    Warntjen, M.6
  • 36
    • 84863507522 scopus 로고    scopus 로고
    • Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity
    • da Rocha Jr LF, Duarte AL, Dantas AT, Mariz HA, Pitta Ida R, Galdino SL, et al. Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity. J Rheumatol 2012; 39: 1320-1325.
    • (2012) J Rheumatol , vol.39 , pp. 1320-1325
    • Da Rocha, L.F.1    Duarte, A.L.2    Dantas, A.T.3    Mariz, H.A.4    Pitta Ida, R.5    Galdino, S.L.6
  • 37
    • 84899835126 scopus 로고    scopus 로고
    • Endogenous IL-22 plays a dual role in arthritis: Regulation of established arthritis via IFN-gamma responses
    • Justa S, Zhou X, Sarkar S. Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN-gamma responses. PLoS One 2014; 9: e93279.
    • (2014) PLoS One , vol.9 , pp. e93279
    • Justa, S.1    Zhou, X.2    Sarkar, S.3
  • 38
    • 79959811817 scopus 로고    scopus 로고
    • Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis
    • Leipe J, Schramm MA, Grunke M, Baeuerle M, Dechant C, Nigg AP, et al. Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis. Ann Rheum Dis 2011; 70: 1453-1457.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1453-1457
    • Leipe, J.1    Schramm, M.A.2    Grunke, M.3    Baeuerle, M.4    Dechant, C.5    Nigg, A.P.6
  • 39
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008; 118: 534-544.
    • (2008) J Clin Invest , vol.118 , pp. 534-544
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3    Shimomura, Y.4    Andoh, A.5    Bhan, A.K.6
  • 40
    • 67349195975 scopus 로고    scopus 로고
    • IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFNgamma are not
    • Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M, et al. IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFNgamma are not. J Mol Med 2009; 87: 523-536.
    • (2009) J Mol Med , vol.87 , pp. 523-536
    • Wolk, K.1    Haugen, H.S.2    Xu, W.3    Witte, E.4    Waggie, K.5    Anderson, M.6
  • 42
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 2012; 491: 259-263.
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1    Gagliani, N.2    Zenewicz, L.A.3    Huber, F.J.4    Bosurgi, L.5    Hu, B.6
  • 43
    • 84879571464 scopus 로고    scopus 로고
    • Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    • Kirchberger S, Royston DJ, Boulard O, Thornton E, Franchini F, Szabady RL, et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med 2013; 210: 917-931.
    • (2013) J Exp Med , vol.210 , pp. 917-931
    • Kirchberger, S.1    Royston, D.J.2    Boulard, O.3    Thornton, E.4    Franchini, F.5    Szabady, R.L.6
  • 44
    • 8444223078 scopus 로고    scopus 로고
    • Expression of interleukin-22 in murine carcinoma cells did not influence tumour growth in vivo but did improve survival of the inoculated hosts
    • Nagakawa H, Shimozato O, Yu L, Takiguchi Y, Tatsumi K, Kuriyama T, et al. Expression of interleukin-22 in murine carcinoma cells did not influence tumour growth in vivo but did improve survival of the inoculated hosts. Scand J Immunol 2004; 60: 449-454.
    • (2004) Scand J Immunol , vol.60 , pp. 449-454
    • Nagakawa, H.1    Shimozato, O.2    Yu, L.3    Takiguchi, Y.4    Tatsumi, K.5    Kuriyama, T.6
  • 45
    • 80355147292 scopus 로고    scopus 로고
    • Type I interferon is selectively required by dendritic cells for immune rejection of tumors
    • Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, et al. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 2011; 208: 1989-2003.
    • (2011) J Exp Med , vol.208 , pp. 1989-2003
    • Diamond, M.S.1    Kinder, M.2    Matsushita, H.3    Mashayekhi, M.4    Dunn, G.P.5    Archambault, J.M.6
  • 46
    • 77953976583 scopus 로고    scopus 로고
    • Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer
    • Simpson JA, Al-Attar A, Watson NF, Scholefield JH, Ilyas M, Durrant LG. Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer. Gut 2010; 59: 926-933.
    • (2010) Gut , vol.59 , pp. 926-933
    • Simpson, J.A.1    Al-Attar, A.2    Watson, N.F.3    Scholefield, J.H.4    Ilyas, M.5    Durrant, L.G.6
  • 48
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice
    • Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 1998; 95: 7556-7561.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3    Stockert, E.4    Aguet, M.5    Old, L.J.6
  • 49
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001; 410: 1107-1111.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6
  • 50
    • 0036645530 scopus 로고    scopus 로고
    • Suppression of lymphoma and epithelial malignancies effected by interferon gamma
    • Street SE, Trapani JA, MacGregor D, Smyth MJ. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 2002; 196: 129-134.
    • (2002) J Exp Med , vol.196 , pp. 129-134
    • Street, S.E.1    Trapani, J.A.2    MacGregor, D.3    Smyth, M.J.4
  • 51
    • 0029799912 scopus 로고    scopus 로고
    • Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma
    • Bromberg JF, Horvath CM, Wen Z, Schreiber RD, Darnell Jr JE. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci USA 1996; 93: 7673-7678.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7673-7678
    • Bromberg, J.F.1    Horvath, C.M.2    Wen, Z.3    Schreiber, R.D.4    Darnell, J.E.5
  • 52
    • 0030788405 scopus 로고    scopus 로고
    • Activation of t he STAT signaling pathway can cause expression of caspase 1 and apoptosis
    • Chin YE, Kitagawa M, Kuida K, Flavell RA, Fu XY. Activation of t he STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol 1997; 17: 5328-5337.
    • (1997) Mol Cell Biol , vol.17 , pp. 5328-5337
    • Chin, Y.E.1    Kitagawa, M.2    Kuida, K.3    Flavell, R.A.4    Fu, X.Y.5
  • 53
    • 0029923780 scopus 로고    scopus 로고
    • Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
    • Chin YE, Kitagawa M, Su WC, You ZH, Iwamoto Y, Fu XY. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 1996; 272: 719-722.
    • (1996) Science , vol.272 , pp. 719-722
    • Chin, Y.E.1    Kitagawa, M.2    Su, W.C.3    You, Z.H.4    Iwamoto, Y.5    Fu, X.Y.6
  • 55
    • 33745025705 scopus 로고    scopus 로고
    • IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
    • Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, et al. IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med 2006; 203: 1391-1397.
    • (2006) J Exp Med , vol.203 , pp. 1391-1397
    • Hanada, T.1    Kobayashi, T.2    Chinen, T.3    Saeki, K.4    Takaki, H.5    Koga, K.6
  • 56
    • 84861347783 scopus 로고    scopus 로고
    • Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer
    • Greenwood C, Metodieva G, Al-Janabi K, Lausen B, Alldridge L, Leng L, et al. Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. J Proteomics 2012; 75: 3031-3040.
    • (2012) J Proteomics , vol.75 , pp. 3031-3040
    • Greenwood, C.1    Metodieva, G.2    Al-Janabi, K.3    Lausen, B.4    Alldridge, L.5    Leng, L.6
  • 57
    • 84855368868 scopus 로고    scopus 로고
    • Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner
    • Duarte CW, Willey CD, Zhi D, Cui X, Harris JJ, Vaughan LK, et al. Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner. PLoS One 2012; 7: e29653.
    • (2012) PLoS One , vol.7 , pp. e29653
    • Duarte, C.W.1    Willey, C.D.2    Zhi, D.3    Cui, X.4    Harris, J.J.5    Vaughan, L.K.6
  • 58
    • 0024273530 scopus 로고
    • The role of interferon in cancer therapy: A current perspective
    • Goldstein D, Laszlo J. The role of interferon in cancer therapy: a current perspective. CA Cancer J Clin 1988; 38: 258-277.
    • (1988) CA Cancer J Clin , vol.38 , pp. 258-277
    • Goldstein, D.1    Laszlo, J.2
  • 59
    • 39749104201 scopus 로고    scopus 로고
    • Practical guidelines for the management of interferon-alpha-2b side effects in patients receiving adjuvant treatment for melanoma: Expert opinion
    • Hauschild A, Gogas H, Tarhini A, Middleton MR, Testori A, Dreno B, et al. Practical guidelines for the management of interferon-alpha-2b side effects in patients receiving adjuvant treatment for melanoma: expert opinion. Cancer 2008; 112: 982-994.
    • (2008) Cancer , vol.112 , pp. 982-994
    • Hauschild, A.1    Gogas, H.2    Tarhini, A.3    Middleton, M.R.4    Testori, A.5    Dreno, B.6
  • 60
    • 77958012775 scopus 로고    scopus 로고
    • Gene signature in melanoma associated with clinical activity: A potential clue to unlock cancer immunotherapy
    • Gajewski TF, Louahed J, Brichard VG. Gene signature in melanoma associated with clinical activity: a potential clue to unlock cancer immunotherapy. Cancer J 2010; 16: 399-403.
    • (2010) Cancer J , vol.16 , pp. 399-403
    • Gajewski, T.F.1    Louahed, J.2    Brichard, V.G.3
  • 61
    • 26844552926 scopus 로고    scopus 로고
    • IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells
    • Lee SK, Seo SH, Kim BS, Kim CD, Lee JH, Kang JS, et al. IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells. J Dermatol Sci 2005; 40: 95-103.
    • (2005) J Dermatol Sci , vol.40 , pp. 95-103
    • Lee, S.K.1    Seo, S.H.2    Kim, B.S.3    Kim, C.D.4    Lee, J.H.5    Kang, J.S.6
  • 63
    • 58149218143 scopus 로고    scopus 로고
    • Cross talk of signals between EGFR and IL-6 R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
    • Colomiere M, Ward AC, Riley C, Trenerry MK, Cameron-Smith D, Findlay J, et al. Cross talk of signals between EGFR and IL-6 R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br J Cancer 2009; 100: 134-144.
    • (2009) Br J Cancer , vol.100 , pp. 134-144
    • Colomiere, M.1    Ward, A.C.2    Riley, C.3    Trenerry, M.K.4    Cameron-Smith, D.5    Findlay, J.6
  • 64
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007; 117: 3846-3856.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3    Pao, W.4    Motoi, N.5    Gerald, W.L.6
  • 65
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman TJ. A renaissance for SRC. Nat Rev Cancer 2004; 4: 470-480.
    • (2004) Nat Rev Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 66
    • 84863727617 scopus 로고    scopus 로고
    • Prolactin promotes hepatocellular carcinoma through Janus kinase 2
    • Yeh YT, Lee KT, Tsai CJ, Chen YJ, Wang SN. Prolactin promotes hepatocellular carcinoma through Janus kinase 2. World J Surg 2012; 36: 1128-1135.
    • (2012) World J Surg , vol.36 , pp. 1128-1135
    • Yeh, Y.T.1    Lee, K.T.2    Tsai, C.J.3    Chen, Y.J.4    Wang, S.N.5
  • 67
    • 79953208248 scopus 로고    scopus 로고
    • STAT3 signaling: Anticancer strategies and challenges
    • Johnston PA, Grandis JR. STAT3 signaling: anticancer strategies and challenges. Molecular Interv 2011; 11: 18-26.
    • (2011) Molecular Interv , vol.11 , pp. 18-26
    • Johnston, P.A.1    Grandis, J.R.2
  • 68
    • 0036469065 scopus 로고    scopus 로고
    • Signal transduction and the control of gene expression
    • Brivanlou AH, Darnell Jr JE. Signal transduction and the control of gene expression. Science 2002; 295: 813-818.
    • (2002) Science , vol.295 , pp. 813-818
    • Brivanlou, A.H.1    Darnell, J.E.2
  • 69
    • 78650528780 scopus 로고    scopus 로고
    • The role of Stat5 transcription factors as tumor suppressors or oncogenes
    • Ferbeyre G, Moriggl R. The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 2011; 1815: 104-114.
    • (2011) Biochim Biophys Acta , vol.1815 , pp. 104-114
    • Ferbeyre, G.1    Moriggl, R.2
  • 70
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy DE, Darnell Jr JE. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002; 3: 651-662.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.E.2
  • 71
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002; 109: S121-S131.
    • (2002) Cell , vol.109 , pp. S121-S131
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 72
    • 0035952638 scopus 로고    scopus 로고
    • G protein coupled receptor signaling through the Src and Stat3 pathway: Role in proliferation and transformation
    • Ram PT, Iyengar R. G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation. Oncogene 2001; 20: 1601-1606.
    • (2001) Oncogene , vol.20 , pp. 1601-1606
    • Ram, P.T.1    Iyengar, R.2
  • 73
    • 7944233465 scopus 로고    scopus 로고
    • Role of STATs as downstream signal transducers in Src family kinasemediated tumorigenesis
    • Silva CM. Role of STATs as downstream signal transducers in Src family kinasemediated tumorigenesis. Oncogene 2004; 23: 8017-8023.
    • (2004) Oncogene , vol.23 , pp. 8017-8023
    • Silva, C.M.1
  • 74
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9: 798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 76
    • 0035141924 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 5B potentiates v-Src-mediated transformation of NIH-3T3 cells
    • Kazansky AV, Rosen JM. Signal transducers and activators of transcription 5B potentiates v-Src-mediated transformation of NIH-3T3 cells. Cell Growth Differ 2001; 12: 1-7.
    • (2001) Cell Growth Differ , vol.12 , pp. 1-7
    • Kazansky, A.V.1    Rosen, J.M.2
  • 77
    • 0034604653 scopus 로고    scopus 로고
    • Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival
    • Odajima J, Matsumura I, Sonoyama J, Daino H, Kawasaki A, Tanaka H, et al. Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival. J Biol Chem 2000; 275: 24096-24105.
    • (2000) J Biol Chem , vol.275 , pp. 24096-24105
    • Odajima, J.1    Matsumura, I.2    Sonoyama, J.3    Daino, H.4    Kawasaki, A.5    Tanaka, H.6
  • 78
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    • Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998; 18: 2545-2552.
    • (1998) Mol Cell Biol , vol.18 , pp. 2545-2552
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhoven, E.4    De Groot, R.P.5    Jove, R.6
  • 79
    • 0033546315 scopus 로고    scopus 로고
    • ERBB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
    • Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem 1999; 274: 17209-17218.
    • (1999) J Biol Chem , vol.274 , pp. 17209-17218
    • Olayioye, M.A.1    Beuvink, I.2    Horsch, K.3    Daly, J.M.4    Hynes, N.E.5
  • 80
    • 0032933797 scopus 로고    scopus 로고
    • C-Src receptor tyrosine kinases, and human cancer
    • Biscardi JS, Tice DA, Parsons SJ. c-Src receptor tyrosine kinases, and human cancer. Adv Cancer Res 1999; 76: 61-119.
    • (1999) Adv Cancer Res , vol.76 , pp. 61-119
    • Biscardi, J.S.1    Tice, D.A.2    Parsons, S.J.3
  • 81
    • 0042357187 scopus 로고    scopus 로고
    • Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck
    • Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, et al. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem 2003; 278: 31574-31583.
    • (2003) J Biol Chem , vol.278 , pp. 31574-31583
    • Xi, S.1    Zhang, Q.2    Dyer, K.F.3    Lerner, E.C.4    Smithgall, T.E.5    Gooding, W.E.6
  • 82
    • 0142219889 scopus 로고    scopus 로고
    • Constitutive activation of Stat5b contributes to carcinogenesis in vivo
    • Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR. Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res 2003; 63: 6763-6771.
    • (2003) Cancer Res , vol.63 , pp. 6763-6771
    • Xi, S.1    Zhang, Q.2    Gooding, W.E.3    Smithgall, T.E.4    Grandis, J.R.5
  • 84
    • 15244350510 scopus 로고    scopus 로고
    • Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line
    • Melzner I, Bucur AJ, Bruderlein S, Dorsch K, Hasel C, Barth TF, et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood 2005; 105: 2535-2542.
    • (2005) Blood , vol.105 , pp. 2535-2542
    • Melzner, I.1    Bucur, A.J.2    Bruderlein, S.3    Dorsch, K.4    Hasel, C.5    Barth, T.F.6
  • 85
    • 33645233157 scopus 로고    scopus 로고
    • Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein
    • Melzner I, Weniger MA, Bucur AJ, Bruderlein S, Dorsch K, Hasel C, et al. Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein. Int J Cancer 2006; 118: 1941-1944.
    • (2006) Int J Cancer , vol.118 , pp. 1941-1944
    • Melzner, I.1    Weniger, M.A.2    Bucur, A.J.3    Bruderlein, S.4    Dorsch, K.5    Hasel, C.6
  • 86
    • 0038278866 scopus 로고    scopus 로고
    • Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
    • Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34: 148-150.
    • (2003) Nat Genet , vol.34 , pp. 148-150
    • Tartaglia, M.1    Niemeyer, C.M.2    Fragale, A.3    Song, X.4    Buechner, J.5    Jung, A.6
  • 87
    • 0142215552 scopus 로고    scopus 로고
    • DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome
    • Ueda M, Ota J, Yamashita Y, Choi YL, Ohki R, Wada T, et al. DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome. Br J Haematol 2003; 123: 288-296.
    • (2003) Br J Haematol , vol.123 , pp. 288-296
    • Ueda, M.1    Ota, J.2    Yamashita, Y.3    Choi, Y.L.4    Ohki, R.5    Wada, T.6
  • 88
    • 0036134884 scopus 로고    scopus 로고
    • Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinasepositive T/null-cell lymphoma
    • Zhang Q, Raghunath PN, Xue L, Majewski M, Carpentieri DF, Odum N, et al. Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinasepositive T/null-cell lymphoma. J Immunol 2002; 168: 466-474.
    • (2002) J Immunol , vol.168 , pp. 466-474
    • Zhang, Q.1    Raghunath, P.N.2    Xue, L.3    Majewski, M.4    Carpentieri, D.F.5    Odum, N.6
  • 89
    • 84861498667 scopus 로고    scopus 로고
    • Aberrant promoter methylation and loss of Suppressor of Cytokine Signalling-1 gene expression in the development of uterine cervical carcinogenesis
    • Sobti RC, Singh N, Hussain S, Suri V, Nijhawan R, Bharti AC, et al. Aberrant promoter methylation and loss of Suppressor of Cytokine Signalling-1 gene expression in the development of uterine cervical carcinogenesis. Cell Oncol 2011; 34: 533-543.
    • (2011) Cell Oncol , vol.34 , pp. 533-543
    • Sobti, R.C.1    Singh, N.2    Hussain, S.3    Suri, V.4    Nijhawan, R.5    Bharti, A.C.6
  • 91
    • 0042575343 scopus 로고    scopus 로고
    • Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms
    • Fukushima N, Sato N, Sahin F, Su GH, Hruban RH, Goggins M. Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer 2003; 89: 338-343.
    • (2003) Br J Cancer , vol.89 , pp. 338-343
    • Fukushima, N.1    Sato, N.2    Sahin, F.3    Su, G.H.4    Hruban, R.H.5    Goggins, M.6
  • 92
    • 18344415251 scopus 로고    scopus 로고
    • Hypermethylation associated inactivation of the SOCS-1 Gene, a JAK/STAT inhibitor, in human pancreatic cancers
    • Komazaki T, Nagai H, Emi M, Terada Y, Yabe A, Jin E, et al. Hypermethylation associated inactivation of the SOCS-1 Gene, a JAK/STAT inhibitor, in human pancreatic cancers. Jpn J Clin Oncol 2004; 34: 191-194.
    • (2004) Jpn J Clin Oncol , vol.34 , pp. 191-194
    • Komazaki, T.1    Nagai, H.2    Emi, M.3    Terada, Y.4    Yabe, A.5    Jin, E.6
  • 93
    • 49649125674 scopus 로고    scopus 로고
    • Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling
    • Liu S, Ren S, Howell P, Fodstad O, Riker AI. Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling. Pigment Cell Melanoma Res 2008; 21: 545-558.
    • (2008) Pigment Cell Melanoma Res , vol.21 , pp. 545-558
    • Liu, S.1    Ren, S.2    Howell, P.3    Fodstad, O.4    Riker, A.I.5
  • 95
    • 0036883618 scopus 로고    scopus 로고
    • Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas
    • Nagai H, Kim YS, Konishi N, Baba M, Kubota T, Yoshimura A, et al. Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas. Cancer Lett 2002; 186: 59-65.
    • (2002) Cancer Lett , vol.186 , pp. 59-65
    • Nagai, H.1    Kim, Y.S.2    Konishi, N.3    Baba, M.4    Kubota, T.5    Yoshimura, A.6
  • 96
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa H, Matsubara K, Qian G-S, Jackson P, Groopman JD, Manning JE, et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001; 28: 29-35.
    • (2001) Nat Genet , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.-S.3    Jackson, P.4    Groopman, J.D.5    Manning, J.E.6
  • 97
    • 0242610382 scopus 로고    scopus 로고
    • Methylationmediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis
    • Okochi O, Hibi K, Sakai M, Inoue S, Takeda S, Kaneko T, et al. Methylationmediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis. Clin Cancer Res 2003; 9: 5295-5298.
    • (2003) Clin Cancer Res , vol.9 , pp. 5295-5298
    • Okochi, O.1    Hibi, K.2    Sakai, M.3    Inoue, S.4    Takeda, S.5    Kaneko, T.6
  • 98
    • 3042592451 scopus 로고    scopus 로고
    • SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis
    • Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, et al. SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. J Exp Med 2004; 199: 1701-1707.
    • (2004) J Exp Med , vol.199 , pp. 1701-1707
    • Yoshida, T.1    Ogata, H.2    Kamio, M.3    Joo, A.4    Shiraishi, H.5    Tokunaga, Y.6
  • 99
    • 84886771529 scopus 로고    scopus 로고
    • Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis
    • Qiu X, Zheng J, Guo X, Gao X, Liu H, Tu Y, et al. Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis. Mol Cell Biochem 2013; 378: 99-106.
    • (2013) Mol Cell Biochem , vol.378 , pp. 99-106
    • Qiu, X.1    Zheng, J.2    Guo, X.3    Gao, X.4    Liu, H.5    Tu, Y.6
  • 100
    • 77149155643 scopus 로고    scopus 로고
    • Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
    • Li Y, de Haar C, Chen M, Deuring J, Gerrits MM, Smits R, et al. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut 2010; 59: 227-235.
    • (2010) Gut , vol.59 , pp. 227-235
    • Li, Y.1    De Haar, C.2    Chen, M.3    Deuring, J.4    Gerrits, M.M.5    Smits, R.6
  • 101
    • 84867322245 scopus 로고    scopus 로고
    • IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer
    • Li Y, Deuring J, Peppelenbosch MP, Kuipers EJ, de Haar C, van der Woude CJ. IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. Carcinogenesis 2012; 33: 1889-1896.
    • (2012) Carcinogenesis , vol.33 , pp. 1889-1896
    • Li, Y.1    Deuring, J.2    Peppelenbosch, M.P.3    Kuipers, E.J.4    De Haar, C.5    Van Der-Woude, C.J.6
  • 102
    • 0345492424 scopus 로고    scopus 로고
    • SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
    • He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, et al. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci 2003; 100: 14133-14138.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 14133-14138
    • He, B.1    You, L.2    Uematsu, K.3    Zang, K.4    Xu, Z.5    Lee, A.Y.6
  • 103
    • 79960846309 scopus 로고    scopus 로고
    • SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation
    • Lindemann C, Hackmann O, Delic S, Schmidt N, Reifenberger G, Riemenschneider M. SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation. Acta Neuropathologica 2011; 122: 241-251.
    • (2011) Acta Neuropathologica , vol.122 , pp. 241-251
    • Lindemann, C.1    Hackmann, O.2    Delic, S.3    Schmidt, N.4    Reifenberger, G.5    Riemenschneider, M.6
  • 104
    • 57349117925 scopus 로고    scopus 로고
    • Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme
    • Martini M, Pallini R, Luongo G, Cenci T, Lucantoni C, Larocca LM. Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme. Int J Cancer 2008; 123: 2955-2960.
    • (2008) Int J Cancer , vol.123 , pp. 2955-2960
    • Martini, M.1    Pallini, R.2    Luongo, G.3    Cenci, T.4    Lucantoni, C.5    Larocca, L.M.6
  • 105
    • 78951493136 scopus 로고    scopus 로고
    • Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior
    • Pierconti F, Martini M, Pinto F, Cenci T, Capodimonti S, Calarco A, et al. Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. Prostate 2011; 71: 318-325.
    • (2011) Prostate , vol.71 , pp. 318-325
    • Pierconti, F.1    Martini, M.2    Pinto, F.3    Cenci, T.4    Capodimonti, S.5    Calarco, A.6
  • 107
    • 84908051990 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signalling in human neoplasms
    • Sasi W, Sharma AK, Mokbel K. The role of suppressors of cytokine signalling in human neoplasms. Mol Biol Int 2014; 2014: 630797.
    • (2014) Mol Biol Int , vol.2014 , pp. 630797
    • Sasi, W.1    Sharma, A.K.2    Mokbel, K.3
  • 108
    • 1542345461 scopus 로고    scopus 로고
    • Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
    • Fujitake S, Hibi K, Okochi O, Kodera Y, Ito K, Akiyama S, et al. Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients. J Gastroenterol 2004; 39: 120-124.
    • (2004) J Gastroenterol , vol.39 , pp. 120-124
    • Fujitake, S.1    Hibi, K.2    Okochi, O.3    Kodera, Y.4    Ito, K.5    Akiyama, S.6
  • 110
    • 8644249909 scopus 로고    scopus 로고
    • Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma
    • Oshimo Y, Kuraoka K, Nakayama H, Kitadai Y, Yoshida K, Chayama K, et al. Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma. Int J Cancer 2004; 112: 1003-1009.
    • (2004) Int J Cancer , vol.112 , pp. 1003-1009
    • Oshimo, Y.1    Kuraoka, K.2    Nakayama, H.3    Kitadai, Y.4    Yoshida, K.5    Chayama, K.6
  • 111
    • 34547199420 scopus 로고    scopus 로고
    • Methylation of Socs-3 and Socs-1 in the carcinogenesis of Barrett's adenocarcinoma
    • Tischoff I, Hengge UR, Vieth M, Ell C, Stolte M, Weber A, et al. Methylation of Socs-3 and Socs-1 in the carcinogenesis of Barrett's adenocarcinoma. Gut 2007; 56: 1047-1053.
    • (2007) Gut , vol.56 , pp. 1047-1053
    • Tischoff, I.1    Hengge, U.R.2    Vieth, M.3    Ell, C.4    Stolte, M.5    Weber, A.6
  • 112
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007; 117: 3988-4002.
    • (2007) J Clin Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3    Guarnieri, T.4    Giovannini, C.5    Taffurelli, M.6
  • 113
    • 55349104462 scopus 로고    scopus 로고
    • Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner
    • Studebaker AW, Storci G, Werbeck JL, Sansone P, Sasser AK, Tavolari S, et al. Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res 2008; 68: 9087-9095.
    • (2008) Cancer Res , vol.68 , pp. 9087-9095
    • Studebaker, A.W.1    Storci, G.2    Werbeck, J.L.3    Sansone, P.4    Sasser, A.K.5    Tavolari, S.6
  • 114
    • 68149170225 scopus 로고    scopus 로고
    • Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells
    • Walter M, Liang S, Ghosh S, Hornsby PJ, Li R. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 2009; 28: 2745-2755.
    • (2009) Oncogene , vol.28 , pp. 2745-2755
    • Walter, M.1    Liang, S.2    Ghosh, S.3    Hornsby, P.J.4    Li, R.5
  • 115
    • 51649096739 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells
    • Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, et al. Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells. Mol Cancer Res 2008; 6: 1099-1105.
    • (2008) Mol Cancer Res , vol.6 , pp. 1099-1105
    • Niu, G.1    Briggs, J.2    Deng, J.3    Ma, Y.4    Lee, H.5    Kortylewski, M.6
  • 116
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002; 21: 2000-2008.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3    Song, L.4    Haura, E.5    Turkson, J.6
  • 117
    • 24644457736 scopus 로고    scopus 로고
    • Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
    • Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 2005; 24: 5552-5560.
    • (2005) Oncogene , vol.24 , pp. 5552-5560
    • Xu, Q.1    Briggs, J.2    Park, S.3    Niu, G.4    Kortylewski, M.5    Zhang, S.6
  • 119
    • 67650495415 scopus 로고    scopus 로고
    • IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
    • Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 2009; 206: 1457-1464.
    • (2009) J Exp Med , vol.206 , pp. 1457-1464
    • Wang, L.1    Yi, T.2    Kortylewski, M.3    Pardoll, D.M.4    Zeng, D.5    Yu, H.6
  • 122
    • 84882668842 scopus 로고    scopus 로고
    • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora
    • Qiu J, Guo X, Chen ZM, He L, Sonnenberg GF, Artis D, et al. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 2013; 39: 386-399.
    • (2013) Immunity , vol.39 , pp. 386-399
    • Qiu, J.1    Guo, X.2    Chen, Z.M.3    He, L.4    Sonnenberg, G.F.5    Artis, D.6
  • 123
    • 84861989207 scopus 로고    scopus 로고
    • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    • Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 2012; 336: 1321-1325.
    • (2012) Science , vol.336 , pp. 1321-1325
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Alenghat, T.3    Fung, T.C.4    Hutnick, N.A.5    Kunisawa, J.6
  • 124
    • 84866547629 scopus 로고    scopus 로고
    • Lymphotoxin regulates commensal responses to enable diet-induced obesity
    • Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, et al. Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol 2012; 13: 947-953.
    • (2012) Nat Immunol , vol.13 , pp. 947-953
    • Upadhyay, V.1    Poroyko, V.2    Kim, T.J.3    Devkota, S.4    Fu, S.5    Liu, D.6
  • 125
    • 84877839153 scopus 로고    scopus 로고
    • IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
    • Zenewicz LA, Yin X, Wang G, Elinav E, Hao L, Zhao L, et al. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. J Immunol 2013; 190: 5306-5312.
    • (2013) J Immunol , vol.190 , pp. 5306-5312
    • Zenewicz, L.A.1    Yin, X.2    Wang, G.3    Elinav, E.4    Hao, L.5    Zhao, L.6
  • 126
    • 84894055913 scopus 로고    scopus 로고
    • The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria
    • Behnsen J, Jellbauer S, Wong CP, Edwards RA, George MD, Ouyang W, et al. The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria. Immunity 2014; 40: 262-273.
    • (2014) Immunity , vol.40 , pp. 262-273
    • Behnsen, J.1    Jellbauer, S.2    Wong, C.P.3    Edwards, R.A.4    George, M.D.5    Ouyang, W.6
  • 127
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA, Haque SJ. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 2002; 21: 8404-8413.
    • (2002) Oncogene , vol.21 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 128
    • 0034085912 scopus 로고    scopus 로고
    • Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters
    • Stephanou A, Brar BK, Knight RA, Latchman DS. Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters. Cell Death Differ 2000; 7: 329-330.
    • (2000) Cell Death Differ , vol.7 , pp. 329-330
    • Stephanou, A.1    Brar, B.K.2    Knight, R.A.3    Latchman, D.S.4
  • 130
    • 77954156529 scopus 로고    scopus 로고
    • Stat3: Linking inflammation to epithelial cancer-more than a "gut" feeling?
    • Jarnicki A, Putoczki T, Ernst M. Stat3: linking inflammation to epithelial cancer-more than a "gut" feeling?. Cell Div 2010; 5: 14.
    • (2010) Cell Div , vol.5 , pp. 14
    • Jarnicki, A.1    Putoczki, T.2    Ernst, M.3
  • 131
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 2002; 62: 3351-3355.
    • (2002) Cancer Res , vol.62 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3    Nakashima, T.4    Kuratomi, Y.5    Azuma, K.6
  • 133
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, et al. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 2009; 28: 2940-2947.
    • (2009) Oncogene , vol.28 , pp. 2940-2947
    • Sullivan, N.J.1    Sasser, A.K.2    Axel, A.E.3    Vesuna, F.4    Raman, V.5    Ramirez, N.6
  • 134
    • 84055207487 scopus 로고    scopus 로고
    • IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAKSTAT3-SNAIL signaling pathway
    • Yadav A, Kumar B, Datta J, Teknos TN, Kumar P. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAKSTAT3-SNAIL signaling pathway. Mol Cancer Res 2011; 9: 1658-1667.
    • (2011) Mol Cancer Res , vol.9 , pp. 1658-1667
    • Yadav, A.1    Kumar, B.2    Datta, J.3    Teknos, T.N.4    Kumar, P.5
  • 135
    • 84900316922 scopus 로고    scopus 로고
    • A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma
    • Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, et al. A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell 2014; 25: 666-681.
    • (2014) Cancer Cell , vol.25 , pp. 666-681
    • Yuan, J.H.1    Yang, F.2    Wang, F.3    Ma, J.Z.4    Guo, Y.J.5    Tao, Q.F.6
  • 136
    • 40949103423 scopus 로고    scopus 로고
    • Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo
    • Dagvadorj A, Kirken RA, Leiby B, Karras J, Nevalainen MT. Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo. Clin Cancer Res 2008; 14: 1317-1324.
    • (2008) Clin Cancer Res , vol.14 , pp. 1317-1324
    • Dagvadorj, A.1    Kirken, R.A.2    Leiby, B.3    Karras, J.4    Nevalainen, M.T.5
  • 137
    • 45849116295 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 5 A/B in prostate and breast cancers
    • Tan SH, Nevalainen MT. Signal transducer and activator of transcription 5 A/B in prostate and breast cancers. Endocr Relat Cancer 2008; 15: 367-390.
    • (2008) Endocr Relat Cancer , vol.15 , pp. 367-390
    • Tan, S.H.1    Nevalainen, M.T.2
  • 138
    • 84894212213 scopus 로고    scopus 로고
    • Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice
    • Stuart E, Buchert M, Putoczki T, Thiem S, Farid R, Elzer J, et al. Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice. Mol Cancer Ther 2014; 13: 468-474.
    • (2014) Mol Cancer Ther , vol.13 , pp. 468-474
    • Stuart, E.1    Buchert, M.2    Putoczki, T.3    Thiem, S.4    Farid, R.5    Elzer, J.6
  • 140
    • 80051666957 scopus 로고    scopus 로고
    • Phospho-STAT5 expression is associated with poor prognosis of human colonic adenocarcinoma
    • Mao YL, Li ZW, Lou CJ, Pang D, Zhang YQ. Phospho-STAT5 expression is associated with poor prognosis of human colonic adenocarcinoma. Pathol Oncol Res 2011; 17: 333-339.
    • (2011) Pathol Oncol Res , vol.17 , pp. 333-339
    • Mao, Y.L.1    Li, Z.W.2    Lou, C.J.3    Pang, D.4    Zhang, Y.Q.5
  • 141
    • 3142707259 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade
    • Li H, Ahonen TJ, Alanen K, Xie J, LeBaron MJ, Pretlow TG, et al. Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade. Cancer Res 2004; 64: 4774-4782.
    • (2004) Cancer Res , vol.64 , pp. 4774-4782
    • Li, H.1    Ahonen, T.J.2    Alanen, K.3    Xie, J.4    LeBaron, M.J.5    Pretlow, T.G.6
  • 142
    • 77952361681 scopus 로고    scopus 로고
    • Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation
    • Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, et al. Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation. Stem Cells 2010; 28: 928-938.
    • (2010) Stem Cells , vol.28 , pp. 928-938
    • Vafaizadeh, V.1    Klemmt, P.2    Brendel, C.3    Weber, K.4    Doebele, C.5    Britt, K.6
  • 143
    • 33750559636 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition
    • Lee TK, Man K, Poon RT, Lo CM, Yuen AP, Ng IO, et al. Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. Cancer Res 2006; 66: 9948-9956.
    • (2006) Cancer Res , vol.66 , pp. 9948-9956
    • Lee, T.K.1    Man, K.2    Poon, R.T.3    Lo, C.M.4    Yuen, A.P.5    Ng, I.O.6
  • 144
    • 84863756518 scopus 로고    scopus 로고
    • Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
    • Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 2012; 22: 91-105.
    • (2012) Cancer Cell , vol.22 , pp. 91-105
    • Wolf, M.J.1    Hoos, A.2    Bauer, J.3    Boettcher, S.4    Knust, M.5    Weber, A.6
  • 145
    • 66549120065 scopus 로고    scopus 로고
    • Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells
    • Xiong H, Su WY, Liang QC, Zhang ZG, Chen HM, Du W, et al. Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. Lab Invest 2009; 89: 717-725.
    • (2009) Lab Invest , vol.89 , pp. 717-725
    • Xiong, H.1    Su, W.Y.2    Liang, Q.C.3    Zhang, Z.G.4    Chen, H.M.5    Du, W.6
  • 146
    • 2942672845 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-5 activation and breast cancer prognosis
    • Nevalainen MT, Xie J, Torhorst J, Bubendorf L, Haas P, Kononen J, et al. Signal transducer and activator of transcription-5 activation and breast cancer prognosis. J Clin Oncol 2004; 22: 2053-2060.
    • (2004) J Clin Oncol , vol.22 , pp. 2053-2060
    • Nevalainen, M.T.1    Xie, J.2    Torhorst, J.3    Bubendorf, L.4    Haas, P.5    Kononen, J.6
  • 147
    • 77950684596 scopus 로고    scopus 로고
    • Disruption of the growth hormone-signal transducer and activator of transcription 5-insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis
    • Blaas L, Kornfeld JW, Schramek D, Musteanu M, Zollner G, Gumhold J, et al. Disruption of the growth hormone-signal transducer and activator of transcription 5-insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology 2010; 51: 1319-1326.
    • (2010) Hepatology , vol.51 , pp. 1319-1326
    • Blaas, L.1    Kornfeld, J.W.2    Schramek, D.3    Musteanu, M.4    Zollner, G.5    Gumhold, J.6
  • 148
    • 65549094595 scopus 로고    scopus 로고
    • Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation
    • Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L. Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. J Exp Med 2009; 206: 819-831.
    • (2009) J Exp Med , vol.206 , pp. 819-831
    • Hosui, A.1    Kimura, A.2    Yamaji, D.3    Zhu, B.M.4    Na, R.5    Hennighausen, L.6
  • 149
    • 79952666779 scopus 로고    scopus 로고
    • A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
    • Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, et al. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging 2010; 2: 823-842.
    • (2010) Aging , vol.2 , pp. 823-842
    • Demaria, M.1    Giorgi, C.2    Lebiedzinska, M.3    Esposito, G.4    D'Angeli, L.5    Bartoli, A.6
  • 150
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 153
    • 84896691813 scopus 로고    scopus 로고
    • The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation
    • Gough DJ, Koetz L, Levy DE. The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation. PLoS One 2013; 8: e83395.
    • (2013) PLoS One , vol.8 , pp. e83395
    • Gough, D.J.1    Koetz, L.2    Levy, D.E.3
  • 154
    • 78649451048 scopus 로고    scopus 로고
    • Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokinestimulated cells
    • Chueh FY, Leong KF, Yu CL. Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokinestimulated cells. Biochem Biophys Res Commun 2010; 402: 778-783.
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 778-783
    • Chueh, F.Y.1    Leong, K.F.2    Yu, C.L.3
  • 155
    • 84855781227 scopus 로고    scopus 로고
    • Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells
    • Bourguignon LY, Earle C, Wong G, Spevak CC, Krueger K. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene 2012; 31: 149-160.
    • (2012) Oncogene , vol.31 , pp. 149-160
    • Bourguignon, L.Y.1    Earle, C.2    Wong, G.3    Spevak, C.C.4    Krueger, K.5
  • 156
    • 62549106985 scopus 로고    scopus 로고
    • ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers
    • Brinkman JA, El-Ashry D. ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers. J Mammary Gland Biol Neoplasia 2009; 14: 67-78.
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , pp. 67-78
    • Brinkman, J.A.1    El-Ashry, D.2
  • 160
    • 79959560823 scopus 로고    scopus 로고
    • P19(ARF)/p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma
    • Schneller D, Machat G, Sousek A, Proell V, van Zijl F, Zulehner G, et al. p19(ARF)/p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma. Hepatology 2011; 54: 164-172.
    • (2011) Hepatology , vol.54 , pp. 164-172
    • Schneller, D.1    Machat, G.2    Sousek, A.3    Proell, V.4    Van Zijl, F.5    Zulehner, G.6
  • 161
    • 77249098774 scopus 로고    scopus 로고
    • Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice
    • e1-5
    • Musteanu M, Blaas L, Mair M, Schlederer M, Bilban M, Tauber S, et al. Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology 2010; 138: 1003-1011 e1-5.
    • (2010) Gastroenterology , vol.138 , pp. 1003-1011
    • Musteanu, M.1    Blaas, L.2    Mair, M.3    Schlederer, M.4    Bilban, M.5    Tauber, S.6
  • 162
    • 60649091298 scopus 로고    scopus 로고
    • Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation
    • Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 2009; 5: 200-211.
    • (2009) Cell Host Microbe , vol.5 , pp. 200-211
    • Buchon, N.1    Broderick, N.A.2    Poidevin, M.3    Pradervand, S.4    Lemaitre, B.5
  • 163
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 2009; 137: 1343-1355.
    • (2009) Cell , vol.137 , pp. 1343-1355
    • Jiang, H.1    Patel, P.H.2    Kohlmaier, A.3    Grenley, M.O.4    McEwen, D.G.5    Edgar, B.A.6
  • 164
    • 73549097743 scopus 로고    scopus 로고
    • JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage
    • Beebe K, Lee WC, Micchelli CA. JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev Biol 2010; 338: 28-37.
    • (2010) Dev Biol , vol.338 , pp. 28-37
    • Beebe, K.1    Lee, W.C.2    Micchelli, C.A.3
  • 165
    • 79955133184 scopus 로고    scopus 로고
    • EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
    • Biteau B, Jasper H. EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 2011; 138: 1045-1055.
    • (2011) Development , vol.138 , pp. 1045-1055
    • Biteau, B.1    Jasper, H.2
  • 166
    • 84870044742 scopus 로고    scopus 로고
    • Non-autonomous crosstalk between the Jak/Stat and EGFR pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut
    • Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ. Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development 2012; 139: 4524-4535.
    • (2012) Development , vol.139 , pp. 4524-4535
    • Cordero, J.B.1    Stefanatos, R.K.2    Myant, K.3    Vidal, M.4    Sansom, O.J.5
  • 167
    • 78650202455 scopus 로고    scopus 로고
    • The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    • Karpowicz P, Perez J, Perrimon N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 2010; 137: 4135-4145.
    • (2010) Development , vol.137 , pp. 4135-4145
    • Karpowicz, P.1    Perez, J.2    Perrimon, N.3
  • 168
    • 0028123790 scopus 로고
    • A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy
    • Du XX, Doerschuk CM, Orazi A, Williams DA. A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy. Blood 1994; 83: 33-37.
    • (1994) Blood , vol.83 , pp. 33-37
    • Du, X.X.1    Doerschuk, C.M.2    Orazi, A.3    Williams, D.A.4
  • 169
    • 0028206875 scopus 로고
    • Interleukin-11: A multifunctional growth factor derived from the hematopoietic microenvironment
    • Du XX, Williams DA. Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment. Blood 1994; 83: 2023-2030.
    • (1994) Blood , vol.83 , pp. 2023-2030
    • Du, X.X.1    Williams, D.A.2
  • 170
    • 0029101159 scopus 로고
    • Interleukin-11 protects the clonogenic stem cells in murine small-intestinal crypts from impairment of their reproductive capacity by radiation
    • Potten CS. Interleukin-11 protects the clonogenic stem cells in murine small-intestinal crypts from impairment of their reproductive capacity by radiation. Int J Cancer 1995; 62: 356-361.
    • (1995) Int J Cancer , vol.62 , pp. 356-361
    • Potten, C.S.1
  • 171
    • 0029839502 scopus 로고    scopus 로고
    • Protection of the small intestinal clonogenic stem cells from radiation-induced damage by pretreatment with interleukin 11 also increases murine survival time
    • Potten CS. Protection of the small intestinal clonogenic stem cells from radiation-induced damage by pretreatment with interleukin 11 also increases murine survival time. Stem Cells 1996; 14: 452-459.
    • (1996) Stem Cells , vol.14 , pp. 452-459
    • Potten, C.S.1
  • 172
    • 0030006884 scopus 로고    scopus 로고
    • Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation
    • Orazi A, Du X, Yang Z, Kashai M, Williams DA. Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation. Lab Invest 1996; 75: 33-42.
    • (1996) Lab Invest , vol.75 , pp. 33-42
    • Orazi, A.1    Du, X.2    Yang, Z.3    Kashai, M.4    Williams, D.A.5
  • 173
    • 20144388992 scopus 로고    scopus 로고
    • Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors
    • Ferrand A, Bertrand C, Portolan G, Cui G, Carlson J, Pradayrol L, et al. Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors. Cancer Res 2005; 65: 2770-2777.
    • (2005) Cancer Res , vol.65 , pp. 2770-2777
    • Ferrand, A.1    Bertrand, C.2    Portolan, G.3    Cui, G.4    Carlson, J.5    Pradayrol, L.6
  • 174
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Cancer Genome Atlas Research N, Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014; 513: 202-209.
    • (2014) Nature , vol.513 , pp. 202-209
  • 176
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004; 21: 491-501.
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3    Lehr, H.A.4    Wirtz, S.5    Nikolaev, A.6
  • 177
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009; 15: 103-113.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 178
    • 84862271596 scopus 로고    scopus 로고
    • Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer
    • Seavey MM, Lu LD, Stump KL, Wallace NH, Hockeimer W, O'Kane TM, et al. Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer. Mol Cancer Ther 2012; 11: 984-993.
    • (2012) Mol Cancer Ther , vol.11 , pp. 984-993
    • Seavey, M.M.1    Lu, L.D.2    Stump, K.L.3    Wallace, N.H.4    Hockeimer, W.5    O'Kane, T.M.6
  • 179
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cellcycle progression during colitis-associated tumorigenesis
    • Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cellcycle progression during colitis-associated tumorigenesis. Cancer Cell 2009; 15: 91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    Von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5    Bateman, T.6
  • 180
    • 43049096401 scopus 로고    scopus 로고
    • STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
    • Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest 2008; 118: 1727-1738.
    • (2008) J Clin Invest , vol.118 , pp. 1727-1738
    • Ernst, M.1    Najdovska, M.2    Grail, D.3    Lundgren-May, T.4    Buchert, M.5    Tye, H.6
  • 181
    • 84900532291 scopus 로고    scopus 로고
    • Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo
    • Judd LM, Menheniott TR, Ling H, Jackson CB, Howlett M, Kalantzis A, et al. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PLoS One 2014; 9: e95993.
    • (2014) PLoS One , vol.9 , pp. e95993
    • Judd, L.M.1    Menheniott, T.R.2    Ling, H.3    Jackson, C.B.4    Howlett, M.5    Kalantzis, A.6
  • 182
    • 84907879855 scopus 로고    scopus 로고
    • Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration
    • Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, et al. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration. Sci Signal 2014; 7: ra92.
    • (2014) Sci Signal , vol.7 , pp. ra92
    • Phesse, T.J.1    Buchert, M.2    Stuart, E.3    Flanagan, D.J.4    Faux, M.5    Afshar-Sterle, S.6
  • 183
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6
  • 184
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 2009; 457: 200-204.
    • (2009) Nature , vol.457 , pp. 200-204
    • Rebouissou, S.1    Amessou, M.2    Couchy, G.3    Poussin, K.4    Imbeaud, S.5    Pilati, C.6
  • 185
    • 79960346759 scopus 로고    scopus 로고
    • Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
    • Pilati C, Amessou M, Bihl MP, Balabaud C, Nhieu JT, Paradis V, et al. Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. J Exp Med 2011; 208: 1359-1366.
    • (2011) J Exp Med , vol.208 , pp. 1359-1366
    • Pilati, C.1    Amessou, M.2    Bihl, M.P.3    Balabaud, C.4    Nhieu, J.T.5    Paradis, V.6
  • 186
    • 84894583202 scopus 로고    scopus 로고
    • Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma
    • Poussin K, Pilati C, Couchy G, Calderaro J, Bioulac-Sage P, Bacq Y, et al. Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma. Oncoimmunology 2013; 2: e27090.
    • (2013) Oncoimmunology , vol.2 , pp. e27090
    • Poussin, K.1    Pilati, C.2    Couchy, G.3    Calderaro, J.4    Bioulac-Sage, P.5    Bacq, Y.6
  • 187
    • 34848906227 scopus 로고    scopus 로고
    • Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells
    • Fuke H, Shiraki K, Sugimoto K, Tanaka J, Beppu T, Yoneda K, et al. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochem Biophys Res Commun 2007; 363: 738-744.
    • (2007) Biochem Biophys Res Commun , vol.363 , pp. 738-744
    • Fuke, H.1    Shiraki, K.2    Sugimoto, K.3    Tanaka, J.4    Beppu, T.5    Yoneda, K.6
  • 188
    • 84916878743 scopus 로고    scopus 로고
    • Development of a novel azaspirane that targets the JAK-STAT pathway in hepatocellular carcinoma in vitro and in vivo
    • Mohan CD, Bharathkumar H, Bulusu KC, Pandey V, Rangappa S, Fuchs JE, et al. Development of a novel azaspirane that targets the JAK-STAT pathway in hepatocellular carcinoma in vitro and in vivo. J Biol Chem 2014; 289: 34296-34307.
    • (2014) J Biol Chem , vol.289 , pp. 34296-34307
    • Mohan, C.D.1    Bharathkumar, H.2    Bulusu, K.C.3    Pandey, V.4    Rangappa, S.5    Fuchs, J.E.6
  • 189
    • 84894728163 scopus 로고    scopus 로고
    • Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma
    • Zhang L, Yang Z, Ma A, Qu Y, Xia S, Xu D, et al. Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma. Hepatology 2014; 59: 178-189.
    • (2014) Hepatology , vol.59 , pp. 178-189
    • Zhang, L.1    Yang, Z.2    Ma, A.3    Qu, Y.4    Xia, S.5    Xu, D.6
  • 190
    • 37349098725 scopus 로고    scopus 로고
    • Autocrine IL-6 signaling: A key event in tumorigenesis?
    • Grivennikov S, Karin M. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell 2008; 13: 7-9.
    • (2008) Cancer Cell , vol.13 , pp. 7-9
    • Grivennikov, S.1    Karin, M.2
  • 191
    • 78649789584 scopus 로고    scopus 로고
    • IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
    • Lederle W, Depner S, Schnur S, Obermueller E, Catone N, Just A, et al. IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines. Int J Cancer 2011; 128: 2803-2814.
    • (2011) Int J Cancer , vol.128 , pp. 2803-2814
    • Lederle, W.1    Depner, S.2    Schnur, S.3    Obermueller, E.4    Catone, N.5    Just, A.6
  • 192
    • 84883718528 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
    • Kan Z, Zheng H, Liu X, Li S, Barber TD, Gong Z, et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res 2013; 23: 1422-1433.
    • (2013) Genome Res , vol.23 , pp. 1422-1433
    • Kan, Z.1    Zheng, H.2    Liu, X.3    Li, S.4    Barber, T.D.5    Gong, Z.6
  • 193
    • 84874099238 scopus 로고    scopus 로고
    • SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells
    • Leibowitz MS, Srivastava RM, Andrade Filho PA, Egloff AM, Wang L, Seethala RR, et al. SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells. Clin Cancer Res 2013; 19: 798-808.
    • (2013) Clin Cancer Res , vol.19 , pp. 798-808
    • Leibowitz, M.S.1    Srivastava, R.M.2    Andrade Filho, P.A.3    Egloff, A.M.4    Wang, L.5    Seethala, R.R.6
  • 194
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
    • Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 1998; 102: 1385-1392.
    • (1998) J Clin Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3    Zhou, M.Y.4    Zeng, Q.5    Pitt, A.S.6
  • 195
    • 12944272024 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    • Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci USA 2000; 97: 4227-4232.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4227-4232
    • Grandis, J.R.1    Drenning, S.D.2    Zeng, Q.3    Watkins, S.C.4    Melhem, M.F.5    Endo, S.6
  • 196
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007; 7: 41-51.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 198
    • 30144436273 scopus 로고    scopus 로고
    • The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
    • Lucet IS, Fantino E, Styles M, Bamert R, Patel O, Broughton SE, et al. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood 2006; 107: 176-183.
    • (2006) Blood , vol.107 , pp. 176-183
    • Lucet, I.S.1    Fantino, E.2    Styles, M.3    Bamert, R.4    Patel, O.5    Broughton, S.E.6
  • 200
    • 84878951826 scopus 로고    scopus 로고
    • Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • Pardanani A, Laborde RR, Lasho TL, Finke C, Begna K, Al-Kali A, et al. Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis. Leukemia 2013; 27: 1322-1327.
    • (2013) Leukemia , vol.27 , pp. 1322-1327
    • Pardanani, A.1    Laborde, R.R.2    Lasho, T.L.3    Finke, C.4    Begna, K.5    Al-Kali, A.6
  • 203
    • 84901691483 scopus 로고    scopus 로고
    • A1.72 Baricitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: Safety and efficacy in an open-label, long-term extension study1
    • Taylor P, Genovese M, Keystone E, Schlichting D, Beattie S, Macias W. A1.72 Baricitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: safety and efficacy in an open-label, long-term extension study1. Ann Rheum Dis 2014; 73: A31.
    • (2014) Ann Rheum Dis , vol.73 , pp. A31
    • Taylor, P.1    Genovese, M.2    Keystone, E.3    Schlichting, D.4    Beattie, S.5    Macias, W.6
  • 204
    • 84904286774 scopus 로고    scopus 로고
    • Selective JAK inhibitors in development for rheumatoid arthritis
    • Norman P. Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs 2014; 23: 1067-1077.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 1067-1077
    • Norman, P.1
  • 205
    • 79953043687 scopus 로고    scopus 로고
    • Jak1 has a dominant role over Jak3 in signal transduction through gammac-containing cytokine receptors
    • Haan C, Rolvering C, Raulf F, Kapp M, Druckes P, Thoma G, et al. Jak1 has a dominant role over Jak3 in signal transduction through gammac-containing cytokine receptors. Chem Biol 2011; 18: 314-323.
    • (2011) Chem Biol , vol.18 , pp. 314-323
    • Haan, C.1    Rolvering, C.2    Raulf, F.3    Kapp, M.4    Druckes, P.5    Thoma, G.6
  • 206
    • 84907210908 scopus 로고    scopus 로고
    • Selective inhibitors of the Janus kinase Jak3-Are they effective?
    • Thoma G, Druckes P, Zerwes HG. Selective inhibitors of the Janus kinase Jak3-Are they effective? Bioorg Med Chem Lett 2014; 24: 4617-4621.
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 4617-4621
    • Thoma, G.1    Druckes, P.2    Zerwes, H.G.3
  • 208
    • 82555173115 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells
    • Fiskus W, Verstovsek S, Manshouri T, Rao R, Balusu R, Venkannagari S, et al. Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells. Clin Cancer Res 2011; 17: 7347-7358.
    • (2011) Clin Cancer Res , vol.17 , pp. 7347-7358
    • Fiskus, W.1    Verstovsek, S.2    Manshouri, T.3    Rao, R.4    Balusu, R.5    Venkannagari, S.6
  • 209
    • 83555174315 scopus 로고    scopus 로고
    • The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells
    • Monaghan KA, Khong T, Burns CJ, Spencer A. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia 2011; 25: 1891-1899.
    • (2011) Leukemia , vol.25 , pp. 1891-1899
    • Monaghan, K.A.1    Khong, T.2    Burns, C.J.3    Spencer, A.4
  • 210
  • 211
    • 84864033013 scopus 로고    scopus 로고
    • The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML
    • Novotny-Diermayr V, Hart S, Goh KC, Cheong A, Ong LC, Hentze H, et al. The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML. Blood Cancer J 2012; 2: e69.
    • (2012) Blood Cancer J , vol.2 , pp. e69
    • Novotny-Diermayr, V.1    Hart, S.2    Goh, K.C.3    Cheong, A.4    Ong, L.C.5    Hentze, H.6
  • 212
    • 73949136283 scopus 로고    scopus 로고
    • Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells
    • Wang Y, Fiskus W, Chong DG, Buckley KM, Natarajan K, Rao R, et al. Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells. Blood 2009; 114: 5024-5033.
    • (2009) Blood , vol.114 , pp. 5024-5033
    • Wang, Y.1    Fiskus, W.2    Chong, D.G.3    Buckley, K.M.4    Natarajan, K.5    Rao, R.6
  • 213
    • 84888123497 scopus 로고    scopus 로고
    • JAK1/2 and Pandeacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease
    • Evrot E, Ebel N, Romanet V, Roelli C, Andraos R, Qian Z, et al. JAK1/2 and Pandeacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease. Clin Cancer Res 2013; 19: 6230-6241.
    • (2013) Clin Cancer Res , vol.19 , pp. 6230-6241
    • Evrot, E.1    Ebel, N.2    Romanet, V.3    Roelli, C.4    Andraos, R.5    Qian, Z.6
  • 214
    • 84877670562 scopus 로고    scopus 로고
    • Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells
    • Fiskus W, Verstovsek S, Manshouri T, Smith JE, Peth K, Abhyankar S, et al. Dual PI3K/AKT/mTOR inhibitor BEZ235 synergistically enhances the activity of JAK2 inhibitor against cultured and primary human myeloproliferative neoplasm cells. Mol Cancer Ther 2013; 12: 577-588.
    • (2013) Mol Cancer Ther , vol.12 , pp. 577-588
    • Fiskus, W.1    Verstovsek, S.2    Manshouri, T.3    Smith, J.E.4    Peth, K.5    Abhyankar, S.6
  • 215
    • 77649208164 scopus 로고    scopus 로고
    • Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor
    • Pecquet C, Staerk J, Chaligne R, Goss V, Lee KA, Zhang X, et al. Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor. Blood 2010; 115: 1037-1048.
    • (2010) Blood , vol.115 , pp. 1037-1048
    • Pecquet, C.1    Staerk, J.2    Chaligne, R.3    Goss, V.4    Lee, K.A.5    Zhang, X.6
  • 216
    • 84891160533 scopus 로고    scopus 로고
    • Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors
    • Choong ML, Pecquet C, Pendharkar V, Diaconu CC, Yong JW, Tai SJ, et al. Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors. J Cell Mol Med 2013; 17: 1397-1409.
    • (2013) J Cell Mol Med , vol.17 , pp. 1397-1409
    • Choong, M.L.1    Pecquet, C.2    Pendharkar, V.3    Diaconu, C.C.4    Yong, J.W.5    Tai, S.J.6
  • 217
    • 33846927933 scopus 로고    scopus 로고
    • Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
    • Harir N, Pecquet C, Kerenyi M, Sonneck K, Kovacic B, Nyga R, et al. Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood 2007; 109: 1678-1686.
    • (2007) Blood , vol.109 , pp. 1678-1686
    • Harir, N.1    Pecquet, C.2    Kerenyi, M.3    Sonneck, K.4    Kovacic, B.5    Nyga, R.6
  • 218
    • 77951041842 scopus 로고    scopus 로고
    • Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells
    • Will B, Siddiqi T, Jorda MA, Shimamura T, Luptakova K, Staber PB, et al. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood 2010; 115: 2901-2909.
    • (2010) Blood , vol.115 , pp. 2901-2909
    • Will, B.1    Siddiqi, T.2    Jorda, M.A.3    Shimamura, T.4    Luptakova, K.5    Staber, P.B.6
  • 219
    • 84896729356 scopus 로고    scopus 로고
    • Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway
    • Joung YH, Na YM, Yoo YB, Darvin P, Sp N, Kang DY, et al. Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway. Int J Oncol 2014; 44: 883-895.
    • (2014) Int J Oncol , vol.44 , pp. 883-895
    • Joung, Y.H.1    Na, Y.M.2    Yoo, Y.B.3    Darvin, P.4    Sp, N.5    Kang, D.Y.6
  • 220
    • 84882768125 scopus 로고    scopus 로고
    • P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387
    • Durmus S, Xu N, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH. P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387. Pharmacol Res 2013; 76: 9-16.
    • (2013) Pharmacol Res , vol.76 , pp. 9-16
    • Durmus, S.1    Xu, N.2    Sparidans, R.W.3    Wagenaar, E.4    Beijnen, J.H.5    Schinkel, A.H.6
  • 221
    • 84865735256 scopus 로고    scopus 로고
    • Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
    • Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, et al. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature 2012; 489: 155-159.
    • (2012) Nature , vol.489 , pp. 155-159
    • Koppikar, P.1    Bhagwat, N.2    Kilpivaara, O.3    Manshouri, T.4    Adli, M.5    Hricik, T.6
  • 222
    • 77951884693 scopus 로고    scopus 로고
    • LLL-3 a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate
    • Mencalha AL, Du Rocher B, Salles D, Binato R, Abdelhay E. LLL-3 a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate. Cancer Chemother Pharmacol 2010; 65: 1039-1046.
    • (2010) Cancer Chemother Pharmacol , vol.65 , pp. 1039-1046
    • Mencalha, A.L.1    Du Rocher, B.2    Salles, D.3    Binato, R.4    Abdelhay, E.5
  • 223
    • 84921376961 scopus 로고    scopus 로고
    • CD147 promotes Srcdependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells
    • Wang SJ, Cui HY, Liu YM, Zhao P, Zhang Y, Fu ZG, et al. CD147 promotes Srcdependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells. Oncotarget 2015; 6: 243-257.
    • (2015) Oncotarget , vol.6 , pp. 243-257
    • Wang, S.J.1    Cui, H.Y.2    Liu, Y.M.3    Zhao, P.4    Zhang, Y.5    Fu, Z.G.6
  • 224
    • 3242700398 scopus 로고    scopus 로고
    • Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways
    • Read RD, Bach EA, Cagan RL. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol 2004; 24: 6676-6689.
    • (2004) Mol Cell Biol , vol.24 , pp. 6676-6689
    • Read, R.D.1    Bach, E.A.2    Cagan, R.L.3
  • 225
    • 84865062499 scopus 로고    scopus 로고
    • Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor
    • Marit MR, Chohan M, Matthew N, Huang K, Kuntz DA, Rose DR, et al. Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor. PLoS One 2012; 7: e43437.
    • (2012) PLoS One , vol.7 , pp. e43437
    • Marit, M.R.1    Chohan, M.2    Matthew, N.3    Huang, K.4    Kuntz, D.A.5    Rose, D.R.6
  • 226
    • 0035068349 scopus 로고    scopus 로고
    • Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by twodimensional electrophoresis
    • Nagai H, Kim YS, Lee KT, Chu MY, Konishi N, Fujimoto J, et al. Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by twodimensional electrophoresis. J Hepatol 2001; 34: 416-421.
    • (2001) J Hepatol , vol.34 , pp. 416-421
    • Nagai, H.1    Kim, Y.S.2    Lee, K.T.3    Chu, M.Y.4    Konishi, N.5    Fujimoto, J.6
  • 227
    • 0037227602 scopus 로고    scopus 로고
    • Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas
    • Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, Jin E, et al. Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. J Hum Genet 2003; 48: 65-69.
    • (2003) J Hum Genet , vol.48 , pp. 65-69
    • Nagai, H.1    Naka, T.2    Terada, Y.3    Komazaki, T.4    Yabe, A.5    Jin, E.6
  • 228
    • 84903441759 scopus 로고    scopus 로고
    • ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer
    • Van Schaeybroeck S, Kalimutho M, Dunne PD, Carson R, Allen W, Jithesh PV, et al. ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer. Cell Rep 2014; 7: 1940-1955.
    • (2014) Cell Rep , vol.7 , pp. 1940-1955
    • Van Schaeybroeck, S.1    Kalimutho, M.2    Dunne, P.D.3    Carson, R.4    Allen, W.5    Jithesh, P.V.6
  • 229
    • 84905726946 scopus 로고    scopus 로고
    • Drug resistance via feedback activation of stat3 in oncogene-addicted cancer cells
    • Lee HJ, Zhuang G, Cao Y, Du P, Kim HJ, Settleman J. Drug resistance via feedback activation of stat3 in oncogene-addicted cancer cells. Cancer Cell 2014; 26: 207-221.
    • (2014) Cancer Cell , vol.26 , pp. 207-221
    • Lee, H.J.1    Zhuang, G.2    Cao, Y.3    Du, P.4    Kim, H.J.5    Settleman, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.