Lymphotoxin regulates commensal responses to enable diet-induced obesity

Nature Immunology

Volumn 13, Issue 10, 2012, Pages 947-953

  Upadhyay, Vaibhav ^a   Poroyko, Valeriy ^a   Kim, Tae Jin ^a   Devkota, Suzanne ^a   Fu, Sherry ^a   Liu, Donald ^a   Tumanov, Alexei V ^a   Koroleva, Ekaterina P ^a   Deng, Liufu ^a   Nagler, Cathryn ^a   Chang, Eugene B ^a   Tang, Hong ^b   Fu, Yang Xin ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 22; INTERLEUKIN 23; LYMPHOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; GERMFREE ANIMAL; MICROBIAL COMMUNITY; MICROFLORA; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; BACTERIA; CECUM; DIET; ENERGY METABOLISM; GERM-FREE LIFE; IMMUNITY, MUCOSAL; INTERLEUKIN-23; INTERLEUKINS; LYMPHOTOXIN BETA RECEPTOR; LYMPHOTOXIN-ALPHA; METAGENOME; MICE; MICE, KNOCKOUT; OBESITY; WEIGHT GAIN;

EID: 84866547629     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2403     Document Type: Article

References (41)

1. Wang, Y., Beydoun, M.A., Liang, L., Caballero, B. & Kumanyika, S.K. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 16, 2323-2330 (2008).
2. Centers for Disease Control and Prevention. Adult Obesity Facts. http://www.cdc. gov/obesity/data/trends.html#State (2010).
3. Flegal, K.M., Carroll, M.D., Ogden, C.L. & Curtin, L.R. Prevalence and trends in obesity among US adults, 1999-2008. J. Am. Med. Assoc. 303, 235-241 (2010).
4. Stunkard, A.J., Foch, T.T. & Hrubec, Z. A twin study of human obesity. J. Am. Med. Assoc. 256, 51-54 (1986). (Pubitemid 16093199)
5. Stunkard, A.J. et al. An adoption study of human obesity. N. Engl. J. Med. 314, 193-198 (1986). (Pubitemid 16183148)
6. Turnbaugh, P.J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006). (Pubitemid 46018515)
7. Turnbaugh, P.J. et al. A core gut microbiome in obese and lean twins. Nature 457, 480-484 (2009).
8. Turnbaugh, P.J., Bäckhed, F., Fulton, L. & Gordon, J.I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3, 213-223 (2008). (Pubitemid 351494716)
9. Bäckhed, F., Manchester, J.K., Semenkovich, C.F. & Gordon, J.I. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl. Acad. Sci. USA 104, 979-984 (2007). (Pubitemid 46154722)
10. Muegge, B.D. et al. Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science 332, 970-974 (2011).
11. Faith, J.J., McNulty, N.P., Rey, F.E. & Gordon, J.I. Predicting a human gut microbiota's response to diet in gnotobiotic mice. Science 333, 101-104 (2011).
12. Eberl, G. A new vision of immunity: homeostasis of the superorganism. Mucosal Immunol. 3, 450-460 (2010).
13. Henao-Mejia, J. et al. Infammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179-185 (2012).
14. Vijay-Kumar, M. et al. Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science 328, 228-231 (2010).
15. Norman, R.A., Bogardus, C. & Ravussin, E. Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J. Clin. Invest. 96, 158-162 (1995).
16. Mahajan, A. et al. Obesity-dependent association of the TNF/LTA locus with type 2 diabetes in North Indians. J. Mol. Med. 88, 515-522 (2010).
17. Hotamisligil, G.S. Infammation and metabolic disorders. Nature 444, 860-867 (2006).
18. Wellen, K.E. & Hotamisligil, G.S. Infammation, stress, and diabetes. J. Clin. Invest. 115, 1111-1119 (2005).
19. Pamir, N., McMillen, T.S., Edgel, K.A., Kim, F. & LeBoeuf, R.C. Defciency of lymphotoxin-alpha does not exacerbate high-fat diet-induced obesity but does enhance infammation in mice. Am. J. Physiol. Endocrinol. Metab. 301, E961-E971 (2012).
20. Fu, Y.-X. & Chaplin, D.D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399-433 (1999). (Pubitemid 29241130)
21. Ota, N. et al. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat. Immunol. 12, 941-948 (2011).
22. Tumanov, A.V. et al. Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe 10, 44-53 (2011).
23. Uysal, K.T., Wiesbrock, S.M., Marino, M.W. & Hotamisligil, G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389, 610-614 (1997). (Pubitemid 27446179)
24. Turnbaugh, P.J. et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci. Transl. Med. 1, 6ra14 (2009).
25. Savage, D.C. Microbial ecology of the gastrointestinal tract. Annu. Rev. Microbiol. 31, 107-133 (1977).
26. Wu, H.-J. et al. Gut-residing segmented flamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815-827 (2010).
27. Klaasen, H.L. et al. Apathogenic, intestinal, segmented, flamentous bacteria stimulate the mucosal immune system of mice. Infect. Immun. 61, 303-306 (1993). (Pubitemid 23015431)
28. Ivanov, I.I. et al. Induction of intestinal Th17 cells by segmented flamentous bacteria. Cell 139, 485-498 (2009).
29. Sczesnak, A. et al. The genome of Th17 cell-inducing segmented flamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe 10, 260-272 (2011).
30. Prakash, T. et al. Complete genome sequences of rat and mouse segmented flamentous bacteria, a potent inducer of Th17 cell differentiation. Cell Host Microbe 10, 273-284 (2011).
31. Lathrop, S.K. et al. Peripheral education of the immune system by colonic commensal microbiota. Nature 478, 250-254 (2011).
32. Cella, M. et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457, 722-725 (2009).
33. Ley, R.E. et al. Evolution of mammals and their gut microbes. Science 320, 1647-1651 (2008). (Pubitemid 351931256)
34. Vaishnava, S. et al. The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255-258 (2011).
35. Rawls, J.F., Mahowald, M.A., Ley, R.E. & Gordon, J.I. Reciprocal gut microbiota transplants from zebrafsh and mice to germ-free recipients reveal host habitat selection. Cell 127, 423-433 (2006). (Pubitemid 44572375)
36. Ding, S. et al. High-fat diet: bacteria interactions promote intestinal infammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS ONE 5, e12191 (2010).
37. Poroyko, V. et al. Gut microbial gene expression in mother-fed and formula-fed piglets. PLoS ONE 5, e12459 (2010).
38. Schloss, P.D. et al. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl. Environ. Microbiol. 75, 7537-7541 (2009).
39. White, J.R., Nagarajan, N. & Pop, M. Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput. Biol. 5, e1000352 (2009).
40. Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282-289 (2008). (Pubitemid 351347912)
41. Zhao, S. & Fernald, R.D. Comprehensive algorithm for quantitative real-time polymerase chain reaction. J. Comput. Biol. 12, 1047-1064 (2005). (Pubitemid 41580022)