메뉴 건너뛰기




Volumn 11, Issue 4, 2012, Pages 984-993

Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CEP 33779; INTERLEUKIN 1BETA; INTERLEUKIN 6; IRINOTECAN; JANUS KINASE 2 INHIBITOR; STAT3 PROTEIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

EID: 84862271596     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-11-0951     Document Type: Article
Times cited : (40)

References (47)
  • 1
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883-99.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
    • DOI 10.1002/cncr.22999
    • Hong DS, Angelo LS, Kurzrock R. Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 2007;110:1911-28. (Pubitemid 350036849)
    • (2007) Cancer , vol.110 , Issue.9 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3
  • 4
    • 1042302005 scopus 로고    scopus 로고
    • The stats of cancer - New molecular targets come of age
    • Yu H, Jove R. The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 2004;4:97-105. (Pubitemid 38198738)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 5
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 6
    • 77953479589 scopus 로고    scopus 로고
    • Inflammatory bowel disease and intestinal cancer: A paradigm of the Yin-Yang interplay between inflammation and cancer
    • Danese S, Mantovani A. Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene 2010;29:3313-23.
    • (2010) Oncogene , vol.29 , pp. 3313-3323
    • Danese, S.1    Mantovani, A.2
  • 8
    • 0026761751 scopus 로고
    • Colorectal cancer risk and mortality in patients with ulcerative colitis
    • Langholz E, Munkholm P, Davidsen M, Binder V. Colorectal cancer risk and mortality in patients with ulcerative colitis. Gastroenterology 1992;103:1444-51.
    • (1992) Gastroenterology , vol.103 , pp. 1444-1451
    • Langholz, E.1    Munkholm, P.2    Davidsen, M.3    Binder, V.4
  • 10
    • 78649368287 scopus 로고    scopus 로고
    • Inflammatory bowel disease as a risk factor for colorectal cancer
    • Lukas M. Inflammatory bowel disease as a risk factor for colorectal cancer. Dig Dis 2010;28:619-24.
    • (2010) Dig Dis , vol.28 , pp. 619-624
    • Lukas, M.1
  • 11
    • 59049099999 scopus 로고    scopus 로고
    • Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice
    • Erdman SE, Rao VP, Poutahidis T, Rogers AB, Taylor CL, Jackson EA, et al. Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. Proc Natl Acad Sci U S A 2009;106:1027-32.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1027-1032
    • Erdman, S.E.1    Rao, V.P.2    Poutahidis, T.3    Rogers, A.B.4    Taylor, C.L.5    Jackson, E.A.6
  • 12
    • 77649239393 scopus 로고    scopus 로고
    • Serum interleukin-6 levels in colorectal cancer patients - A summary of published results
    • Knupfer H, Preiss R. Serum interleukin-6 levels in colorectal cancer patients - a summary of published results. Int J Colorectal Dis 2010;25:135-40.
    • (2010) Int J Colorectal Dis , vol.25 , pp. 135-140
    • Knupfer, H.1    Preiss, R.2
  • 14
    • 79952715805 scopus 로고    scopus 로고
    • STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers
    • Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K, et al. STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clinical Cancer Res 2011;17:1452-62.
    • (2011) Clinical Cancer Res , vol.17 , pp. 1452-1462
    • Morikawa, T.1    Baba, Y.2    Yamauchi, M.3    Kuchiba, A.4    Nosho, K.5    Shima, K.6
  • 15
    • 34247281958 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction
    • DOI 10.1593/neo.06820
    • Tsareva SA, Moriggl R, Corvinus FM, Wiederanders B, Schutz A, Kovacic B, et al. Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 2007;9:279-91. (Pubitemid 46608295)
    • (2007) Neoplasia , vol.9 , Issue.4 , pp. 279-291
    • Tsareva, S.A.1    Moriggl, R.2    Corvinus, F.M.3    Wiederanders, B.4    Schutz, A.5    Kovacic, B.6    Friedrich, K.7
  • 17
    • 58649100056 scopus 로고    scopus 로고
    • Inflammation and cancer: IL-6 and STAT3 complete the link
    • Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 2009;15:79-80.
    • (2009) Cancer Cell , vol.15 , pp. 79-80
    • Bromberg, J.1    Wang, T.C.2
  • 18
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • DOI 10.1016/j.cell.2004.07.013, PII S0092867404006713
    • Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004;118:285-96. (Pubitemid 39061110)
    • (2004) Cell , vol.118 , Issue.3 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.-W.5    Egan, L.J.6    Kagnoff, M.F.7    Karin, M.8
  • 19
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009;15:103-13.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 20
    • 73849090217 scopus 로고    scopus 로고
    • IKK/NF-kappaB and STAT3 pathways: Central signalling hubs in inflammation-mediated tumour promotion and metastasis
    • Bollrath J, Greten FR. IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep 2009;10:1314-9.
    • (2009) EMBO Rep , vol.10 , pp. 1314-1319
    • Bollrath, J.1    Greten, F.R.2
  • 21
    • 23944476094 scopus 로고    scopus 로고
    • Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer
    • Atreya R, Neurath MF. Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin Rev Allergy Immunol 2005;28:187-96.
    • (2005) Clin Rev Allergy Immunol , vol.28 , pp. 187-196
    • Atreya, R.1    Neurath, M.F.2
  • 22
    • 34447629700 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon
    • DOI 10.1038/sj.onc.1210286, PII 1210286
    • Rigby RJ, Simmons JG, Greenhalgh CJ, Alexander WS, Lund PK. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 2007;26:4833-41. (Pubitemid 47093177)
    • (2007) Oncogene , vol.26 , Issue.33 , pp. 4833-4841
    • Rigby, R.J.1    Simmons, J.G.2    Greenhalgh, C.J.3    Alexander, W.S.4    Lund, P.K.5
  • 26
    • 79954620949 scopus 로고    scopus 로고
    • A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis
    • Stump KL, Lu LD, Dobrzanski P, Serdikoff C, Gingrich DE, Dugan BJ, et al. A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis. Arthritis Res Ther 2011;13:R68.
    • (2011) Arthritis Res Ther , vol.13
    • Stump, K.L.1    Lu, L.D.2    Dobrzanski, P.3    Serdikoff, C.4    Gingrich, D.E.5    Dugan, B.J.6
  • 27
    • 29744461120 scopus 로고    scopus 로고
    • Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice
    • DOI 10.1093/carcin/bgi205
    • Suzuki R, Kohno H, Sugie S, Nakagama H, Tanaka T. Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis 2006;27:162-9. (Pubitemid 43025257)
    • (2006) Carcinogenesis , vol.27 , Issue.1 , pp. 162-169
    • Suzuki, R.1    Kohno, H.2    Sugie, S.3    Nakagama, H.4    Tanaka, T.5
  • 28
    • 0344237231 scopus 로고    scopus 로고
    • A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    • DOI 10.1111/j.1349-7006.2003.tb01386.x
    • Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodiumsulfate. Cancer Sci 2003;94:965-73. (Pubitemid 37508979)
    • (2003) Cancer Science , vol.94 , Issue.11 , pp. 965-973
    • Tanaka, T.1    Kohno, H.2    Suzuki, R.3    Yamada, Y.4    Sugie, S.5    Mori, H.6
  • 29
    • 34548162712 scopus 로고    scopus 로고
    • An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    • DOI 10.1038/nprot.2007.279, PII NPROT.2007.279
    • Neufert C, Becker C, Neurath MF. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat Protoc 2007;2:1998-2004. (Pubitemid 47308138)
    • (2007) Nature Protocols , vol.2 , Issue.8 , pp. 1998-2004
    • Neufert, C.1    Becker, C.2    Neurath, M.F.3
  • 30
    • 78649505987 scopus 로고    scopus 로고
    • Novel method of monitoring trace cytokines and activated STAT molecules in the paws of arthritic mice using multiplex bead technology
    • Lu LD, Stump KL, Seavey MM. Novel method of monitoring trace cytokines and activated STAT molecules in the paws of arthritic mice using multiplex bead technology. BMC Immunol 2010;11:55.
    • (2010) BMC Immunol , vol.11 , pp. 55
    • Lu, L.D.1    Stump, K.L.2    Seavey, M.M.3
  • 31
    • 0027938828 scopus 로고
    • Dysplasia and early carcinoma in inflammatory bowel disease and colorectal adenomas
    • DOI 10.1016/0046-8177(94)90032-9
    • Pascal RR. Dysplasia and early carcinoma in inflammatory bowel disease and colorectal adenomas. Hum Pathol 1994;25:1160-71. (Pubitemid 24351499)
    • (1994) Human Pathology , vol.25 , Issue.11 , pp. 1160-1171
    • Pascal, R.R.1
  • 32
    • 0016374178 scopus 로고
    • Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats
    • Ward JM. Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab Invest 1974;30:505-13.
    • (1974) Lab Invest , vol.30 , pp. 505-513
    • Ward, J.M.1
  • 33
    • 65449180675 scopus 로고    scopus 로고
    • Colorectal carcinogenesis: Review of human and experimental animal studies
    • Tanaka T. Colorectal carcinogenesis: review of human and experimental animal studies. J Carcinog 2009;8:5.
    • (2009) J Carcinog , vol.8 , pp. 5
    • Tanaka, T.1
  • 34
    • 77957770455 scopus 로고    scopus 로고
    • Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase
    • Chumanevich AA, Poudyal D, Cui X, Davis T, Wood PA, Smith CD, et al. Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis 2010;31:1787-93.
    • (2010) Carcinogenesis , vol.31 , pp. 1787-1793
    • Chumanevich, A.A.1    Poudyal, D.2    Cui, X.3    Davis, T.4    Wood, P.A.5    Smith, C.D.6
  • 35
    • 57149109314 scopus 로고    scopus 로고
    • 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis
    • Clapper ML, Gary MA, Coudry RA, Litwin S, Chang WC, Devarajan K, et al. 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis. Inflamm Bowel Dis 2008;14:1341-7.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1341-1347
    • Clapper, M.L.1    Gary, M.A.2    Coudry, R.A.3    Litwin, S.4    Chang, W.C.5    Devarajan, K.6
  • 36
    • 25144490062 scopus 로고    scopus 로고
    • Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands
    • Kohno H, Suzuki R, Sugie S, Tanaka T. Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. BMC Cancer 2005;5:46.
    • (2005) BMC Cancer , vol.5 , pp. 46
    • Kohno, H.1    Suzuki, R.2    Sugie, S.3    Tanaka, T.4
  • 37
    • 77954008149 scopus 로고    scopus 로고
    • Targeting the proteasome: Partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis
    • Schmidt N, Gonzalez E, Visekruna A, Kuhl AA, Loddenkemper C, Mollenkopf H, et al. Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis. Gut 2010;59:896-906.
    • (2010) Gut , vol.59 , pp. 896-906
    • Schmidt, N.1    Gonzalez, E.2    Visekruna, A.3    Kuhl, A.A.4    Loddenkemper, C.5    Mollenkopf, H.6
  • 38
    • 66949138208 scopus 로고    scopus 로고
    • An antivascular endothelial growth factor receptor 2/fetal liver kinase-1 Listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and metastatic Her-2/neu +breast tumors in a mouse model
    • Seavey MM, Maciag PC, Al-Rawi N, Sewell D, Paterson Y. An antivascular endothelial growth factor receptor 2/fetal liver kinase-1 Listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and metastatic Her-2/neu +breast tumors in a mouse model. J Immunol 2009;182:5537-46.
    • (2009) J Immunol , vol.182 , pp. 5537-5546
    • Seavey, M.M.1    Maciag, P.C.2    Al-Rawi, N.3    Sewell, D.4    Paterson, Y.5
  • 39
    • 84855965736 scopus 로고    scopus 로고
    • Effect of prolonged formalin fixation on immunohistochemical staining for the proliferation marker Ki67
    • Hitchman E, Hodgkinson C, Roberts D, Ashton G, Yunus Z, Byers R, et al. Effect of prolonged formalin fixation on immunohistochemical staining for the proliferation marker Ki67. Histopathology 2011;59:1261-3.
    • (2011) Histopathology , vol.59 , pp. 1261-1263
    • Hitchman, E.1    Hodgkinson, C.2    Roberts, D.3    Ashton, G.4    Yunus, Z.5    Byers, R.6
  • 40
    • 77956205298 scopus 로고    scopus 로고
    • CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice
    • Haile LA, Gamrekelashvili J, Manns MP, Korangy F, Greten TF. CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice. J Immunol 2010;185:203-10.
    • (2010) J Immunol , vol.185 , pp. 203-210
    • Haile, L.A.1    Gamrekelashvili, J.2    Manns, M.P.3    Korangy, F.4    Greten, T.F.5
  • 41
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • DOI 10.1038/nri1995, PII NRI1995
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51. (Pubitemid 46020826)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.1 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 42
    • 70949094349 scopus 로고    scopus 로고
    • The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
    • Hedvat M, Huszar D, Herrmann A, Gozgit JM, Schroeder A, Sheehy A, et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 2009;16:487-97.
    • (2009) Cancer Cell , vol.16 , pp. 487-497
    • Hedvat, M.1    Huszar, D.2    Herrmann, A.3    Gozgit, J.M.4    Schroeder, A.5    Sheehy, A.6
  • 43
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-kappaB action regulated by reversible acetylation
    • DOI 10.1126/science.1062374
    • Chen L, Fischle W, Verdin E, Greene WC. Duration of nuclear NFkappaB action regulated by reversible acetylation. Science 2001;293: 1653-7. (Pubitemid 32807844)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1653-1657
    • Chen, L.-F.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 44
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
    • Lee H, Herrmann A, Deng JH, Kujawski M, Niu G, Li Z, et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 2009;15:283-93.
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1    Herrmann, A.2    Deng, J.H.3    Kujawski, M.4    Niu, G.5    Li, Z.6
  • 45
    • 33748537056 scopus 로고    scopus 로고
    • Intracellular Signals and Events Activated by Cytokines of the Tumor Necrosis Factor Superfamily: From Simple Paradigms to Complex Mechanisms
    • DOI 10.1016/S0074-7696(06)52002-9, PII S0074769606520029, A Survey of Cell Biology
    • Grivennikov SI, Kuprash DV, Liu ZG, Nedospasov SA. Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: from simple paradigms to complex mechanisms. Int Rev Cytol 2006;252:129-61. (Pubitemid 44375088)
    • (2006) International Review of Cytology , vol.252 , pp. 129-161
    • Grivennikov, S.I.1    Kuprash, D.V.2    Liu, Z.3    Nedospasov, S.A.4
  • 46
    • 37349098725 scopus 로고    scopus 로고
    • Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?
    • DOI 10.1016/j.ccr.2007.12.020, PII S1535610807003790
    • Grivennikov S, Karin M. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell 2008;13:7-9. (Pubitemid 350309747)
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 7-9
    • Grivennikov, S.1    Karin, M.2
  • 47
    • 79953749145 scopus 로고    scopus 로고
    • The unholy trinity: Inflammation, cytokines, and STAT3 shape the cancer microenvironment
    • Li N, Grivennikov SI, Karin M. The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell 2011;19:429-31.
    • (2011) Cancer Cell , vol.19 , pp. 429-431
    • Li, N.1    Grivennikov, S.I.2    Karin, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.