Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers

Japanese Journal of Clinical Oncology

Volumn 34, Issue 4, 2004, Pages 191-194

  Komazaki, Toshiaki ^a   Nagai, Hisaki ^a   Emi, Mitsuru ^a   Terada, Yoshie ^a   Yabe, Aya ^a   Jin, Enjing ^a   Kawanami, Ooiti ^a   Konishi, Noboru ^b   Moriyama, Yukichi ^a   Naka, Tetsuji ^c   Kishimoto, Tadamitsu ^c  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Gene expression; Hepatocellular carcinoma (HCC); Hypermethylation; Immunohistochemistry; Pancreatic cancer; SSI 1 SOCS 1 JAB

Indexed keywords

JANUS KINASE; MESSENGER RNA; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; CARRIER PROTEIN; REPRESSOR PROTEIN; SIGNAL PEPTIDE; SOCS1 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING;

ADULT; AGED; ALLELE; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE INACTIVATION; GENE SILENCING; GENETIC CODE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PANCREAS CANCER; PROMOTER REGION; PROTEIN METHYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; DNA METHYLATION; GENETICS; METABOLISM; MIDDLE AGED; PANCREAS TUMOR; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; CARRIER PROTEINS; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 18344415251     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hyh035     Document Type: Article

References (15)

1. Hruban RH, Lacobuzio-Donahue C, Wilentz RE. Molecular pathology of pancreatic cancer. Cancer J 2001;7:251-8.
2. Hahn SA, Seymour AB, Hoque AT, Schutte M, da Costa LT, Redston MS, et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res 1995;55:4670-5.
3. Kimura M, Abe T, Sunamura M, Matsuno S, Horii A. Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma; identification of a 1-cM region of common allelic loss. Genes Chromosome Cancer 1996;17:88-93.
4. Bardi G, Johansson B, Pandis N, Mandahl N, Bak-Jensen E, Andren-Sandberg A, et al. Karyotypic abnormalities in tumours of the pancreas. Br J Cancer 1993;67:1106-12.
5. Johansson B, Bardi G, Pandis N, Gorunova L, Backman PL, Mandahl N, et al. Karyotypic pattern of pancreatic adenocarcinomas correlates with survival and tumour grade. Int J Cancer 1994;58:8-13.
6. Kimura M, Furukawa T, Abe T, Yatsuoka T, Youssef EM, Yokoyama T, et al. Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer. Cancer Res 1998;58:2456-60.
7. Abe T, Makino M, Furukawa T, Ouyang H, Kimura M, Yatsuoka T, et al. Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer. Genes Chromosome Cancer 1999;25:60-4.
8. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997;387:924-7.
9. Jones PA, Laird PW. Cancer epigenetics comes of age. Nature Genet 1999;21:163-7.
10. Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 require both tyrosine and serine phosphorylation. Cell 1995;82:241-50.
11. Krebs DL, Hilton DJ. SOCS: Physiological suppressors of cytokine signalling. J Cell Science 2000;113:2813-9.
12. Garcia R, Jove R. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. J Biomed Sci 1998;5:79-85.
13. Yoshikawa H, Matsubara K. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nature Genet 2001;28(1): 29-35.
14. Galm O, Yoshikawa H. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 2003;101(7):2784-8.
15. Turkson J, Bowman T, Adnane J, Zhang Y, Djeu JY, Sekharam M, et al. Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol Cell Biol 1999;19:7519-28.