Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Judd, Louise M ^a   Menheniott, Treve R ^a   Ling, Hui ^c   Jackson, Cameron B ^a   Howlett, Meegan ^a   Kalantzis, Anastasia ^a   Priebe, Waldemar ^b   Giraud, Andrew S ^a  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 11; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; JANUS KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WP 1006; 3 (6 BROMO 2 PYRIDINYL) 2 CYANO N (1 PHENYLETHYL)ACRYLAMIDE; JAK2 PROTEIN, HUMAN; PYRIDINE DERIVATIVE; TYRPHOSTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; NEUTROPHIL COUNT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STOMACH CANCER; ANIMAL; DRUG EFFECTS; METABOLISM; MOUSE; PHOSPHORYLATION; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INTERLEUKIN-11; INTERLEUKIN-6; JANUS KINASE 2; MICE; PHOSPHORYLATION; PYRIDINES; STAT3 TRANSCRIPTION FACTOR; STOMACH NEOPLASMS; TYRPHOSTINS;

EID: 84900532291     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095993     Document Type: Article

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