-
1
-
-
84930387020
-
T cells in the control of organ-specific autoimmunity
-
Bluestone JA, Bour-Jordan H, Cheng M, Anderson M. T cells in the control of organ-specific autoimmunity. J Clin Invest (2015) 125(6):2250-60. doi:10.1172/JCI78089
-
(2015)
J Clin Invest
, vol.125
, Issue.6
, pp. 2250-2260
-
-
Bluestone, J.A.1
Bour-Jordan, H.2
Cheng, M.3
Anderson, M.4
-
2
-
-
33645286546
-
Regulatory T cells, tumour immunity and immunotherapy
-
Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol (2006) 6(4):295-307. doi:10.1038/nri1806
-
(2006)
Nat Rev Immunol
, vol.6
, Issue.4
, pp. 295-307
-
-
Zou, W.1
-
3
-
-
84872339660
-
The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network
-
Voskens CJ, Goldinger SM, Loquai C, Robert C, Kaehler KC, Berking C, et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. PLoS One (2013) 8(1):e53745. doi:10.1371/journal.pone.0053745
-
(2013)
PLoS One
, vol.8
, Issue.1
-
-
Voskens, C.J.1
Goldinger, S.M.2
Loquai, C.3
Robert, C.4
Kaehler, K.C.5
Berking, C.6
-
4
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 363(8):711-23. doi:10.1056/NEJMoa1003466
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
5
-
-
0035186416
-
Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
-
Weiner HL. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev (2001) 182:207-14. doi:10.1034/j.1600-065X.2001.1820117.x
-
(2001)
Immunol Rev
, vol.182
, pp. 207-214
-
-
Weiner, H.L.1
-
6
-
-
84958548312
-
Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications
-
Roncarolo MG, Gregori S, Bacchetta R, Battaglia M. Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications. Curr Top Microbiol Immunol (2014) 380:39-68. doi:10.1007/978-3-662-43492-5_3
-
(2014)
Curr Top Microbiol Immunol
, vol.380
, pp. 39-68
-
-
Roncarolo, M.G.1
Gregori, S.2
Bacchetta, R.3
Battaglia, M.4
-
7
-
-
84941332054
-
New insights into the mechanisms of Treg function
-
Rothstein DM, Camirand G. New insights into the mechanisms of Treg function. Curr Opin Organ Transplant (2015) 20(4):376-84. doi:10.1097/MOT.0000000000000212
-
(2015)
Curr Opin Organ Transplant
, vol.20
, Issue.4
, pp. 376-384
-
-
Rothstein, D.M.1
Camirand, G.2
-
8
-
-
0035162560
-
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 27(1):68-73. doi:10.1038/83784
-
(2001)
Nat Genet
, vol.27
, Issue.1
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
Paeper, B.4
Clark, L.B.5
Yasayko, S.A.6
-
9
-
-
33745211931
-
Defective regulatory and effector T cell functions in patients with FOXP3 mutations
-
Bacchetta R, Passerini L, Gambineri E, Dai M, Allan SE, Perroni L, et al. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest (2006) 116(6):1713-22. doi:10.1172/JCI25112
-
(2006)
J Clin Invest
, vol.116
, Issue.6
, pp. 1713-1722
-
-
Bacchetta, R.1
Passerini, L.2
Gambineri, E.3
Dai, M.4
Allan, S.E.5
Perroni, L.6
-
10
-
-
35348876040
-
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity
-
Ochs HD, Gambineri E, Torgerson TR. IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res (2007) 38(1-3):112-21. doi:10.1007/s12026-007-0022-2
-
(2007)
Immunol Res
, vol.38
, Issue.1-3
, pp. 112-121
-
-
Ochs, H.D.1
Gambineri, E.2
Torgerson, T.R.3
-
11
-
-
0035163909
-
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
-
Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet (2001) 27(1):18-20. doi:10.1038/83707
-
(2001)
Nat Genet
, vol.27
, Issue.1
, pp. 18-20
-
-
Wildin, R.S.1
Ramsdell, F.2
Peake, J.3
Faravelli, F.4
Casanova, J.L.5
Buist, N.6
-
12
-
-
33847125247
-
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
-
Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 445(7129):766-70. doi:10.1038/nature05479
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 766-770
-
-
Wan, Y.Y.1
Flavell, R.A.2
-
13
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature (2007) 445(7129):771-5. doi:10.1038/nature05543
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 771-775
-
-
Gavin, M.A.1
Rasmussen, J.P.2
Fontenot, J.D.3
Vasta, V.4
Manganiello, V.C.5
Beavo, J.A.6
-
14
-
-
34247277666
-
Foxp3 in control of the regulatory T cell lineage
-
Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol (2007) 8(5):457-62. doi:10.1038/ni1455
-
(2007)
Nat Immunol
, vol.8
, Issue.5
, pp. 457-462
-
-
Zheng, Y.1
Rudensky, A.Y.2
-
15
-
-
84944742577
-
Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners
-
Lei H, Schmidt-Bleek K, Dienelt A, Reinke P, Volk HD. Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners. Front Pharmacol (2015) 6:184. doi:10.3389/fphar.2015.00184
-
(2015)
Front Pharmacol
, vol.6
, pp. 184
-
-
Lei, H.1
Schmidt-Bleek, K.2
Dienelt, A.3
Reinke, P.4
Volk, H.D.5
-
16
-
-
77954141914
-
FOXP3+ regulatory T cells in the human immune system
-
Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 10(7):490-500. doi:10.1038/nri2785
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.7
, pp. 490-500
-
-
Sakaguchi, S.1
Miyara, M.2
Costantino, C.M.3
Hafler, D.A.4
-
17
-
-
84941281157
-
Regulatory T cells: serious contenders in the promise for immunological tolerance in transplantation
-
Safinia N, Scotta C, Vaikunthanathan T, Lechler RI, Lombardi G. Regulatory T cells: serious contenders in the promise for immunological tolerance in transplantation. Front Immunol (2015) 6:438. doi:10.3389/fimmu.2015.00438
-
(2015)
Front Immunol
, vol.6
, pp. 438
-
-
Safinia, N.1
Scotta, C.2
Vaikunthanathan, T.3
Lechler, R.I.4
Lombardi, G.5
-
18
-
-
36248976097
-
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
-
Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol (2007) 8(12):1353-62. doi:10.1038/ni1536
-
(2007)
Nat Immunol
, vol.8
, Issue.12
, pp. 1353-1362
-
-
Pandiyan, P.1
Zheng, L.2
Ishihara, S.3
Reed, J.4
Lenardo, M.J.5
-
19
-
-
35449006679
-
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
-
Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity (2007) 27(4):635-46. doi:10.1016/j.immuni.2007.08.014
-
(2007)
Immunity
, vol.27
, Issue.4
, pp. 635-646
-
-
Cao, X.1
Cai, S.F.2
Fehniger, T.A.3
Song, J.4
Collins, L.I.5
Piwnica-Worms, D.R.6
-
20
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 322(5899):271-5. doi:10.1126/science.1160062
-
(2008)
Science
, vol.322
, Issue.5899
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
-
21
-
-
3142708571
-
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
-
Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A (2004) 101(28):10398-403. doi:10.1073/pnas.0403342101
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.28
, pp. 10398-10403
-
-
Paust, S.1
Lu, L.2
McCarty, N.3
Cantor, H.4
-
22
-
-
79955529454
-
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
-
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 332(6029):600-3. doi:10.1126/science.1202947
-
(2011)
Science
, vol.332
, Issue.6029
, pp. 600-603
-
-
Qureshi, O.S.1
Zheng, Y.2
Nakamura, K.3
Attridge, K.4
Manzotti, C.5
Schmidt, E.M.6
-
23
-
-
36549030784
-
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
-
Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 450(7169):566-9. doi:10.1038/nature06306
-
(2007)
Nature
, vol.450
, Issue.7169
, pp. 566-569
-
-
Collison, L.W.1
Workman, C.J.2
Kuo, T.T.3
Boyd, K.4
Wang, Y.5
Vignali, K.M.6
-
24
-
-
33746338535
-
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
-
Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev (2006) 212:28-50.
-
(2006)
Immunol Rev
, vol.212
, pp. 28-50
-
-
Roncarolo, M.G.1
Gregori, S.2
Battaglia, M.3
Bacchetta, R.4
Fleischhauer, K.5
Levings, M.K.6
-
25
-
-
56649091213
-
Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function
-
Shevach EM, Davidson TS, Huter EN, Dipaolo RA, Andersson J. Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function. J Clin Immunol (2008) 28(6):640-6. doi:10.1007/s10875-008-9240-1
-
(2008)
J Clin Immunol
, vol.28
, Issue.6
, pp. 640-646
-
-
Shevach, E.M.1
Davidson, T.S.2
Huter, E.N.3
Dipaolo, R.A.4
Andersson, J.5
-
26
-
-
0029956024
-
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
-
Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med (1996) 183(6):2669-74. doi:10.1084/jem.183.6.2669
-
(1996)
J Exp Med
, vol.183
, Issue.6
, pp. 2669-2674
-
-
Powrie, F.1
Carlino, J.2
Leach, M.W.3
Mauze, S.4
Coffman, R.L.5
-
27
-
-
0035869432
-
IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
-
Hara M, Kingsley CI, Niimi M, Read S, Turvey SE, Bushell AR, et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol (2001) 166(6):3789-96. doi:10.4049/jimmunol.166.6.3789
-
(2001)
J Immunol
, vol.166
, Issue.6
, pp. 3789-3796
-
-
Hara, M.1
Kingsley, C.I.2
Niimi, M.3
Read, S.4
Turvey, S.E.5
Bushell, A.R.6
-
28
-
-
80955178941
-
Regulatory T cells: stability revisited
-
Bailey-Bucktrout SL, Bluestone JA. Regulatory T cells: stability revisited. Trends Immunol (2011) 32(7):301-6. doi:10.1016/j.it.2011.04.002
-
(2011)
Trends Immunol
, vol.32
, Issue.7
, pp. 301-306
-
-
Bailey-Bucktrout, S.L.1
Bluestone, J.A.2
-
29
-
-
58149188480
-
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
-
Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, Buckner JH. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol (2008) 181(10):7350-5. doi:10.4049/jimmunol.181.10.7350
-
(2008)
J Immunol
, vol.181
, Issue.10
, pp. 7350-7355
-
-
Schneider, A.1
Rieck, M.2
Sanda, S.3
Pihoker, C.4
Greenbaum, C.5
Buckner, J.H.6
-
30
-
-
84875427488
-
Regulatory T cells: recommendations to simplify the nomenclature
-
Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, et al. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 14(4):307-8. doi:10.1038/ni.2554
-
(2013)
Nat Immunol
, vol.14
, Issue.4
, pp. 307-308
-
-
Abbas, A.K.1
Benoist, C.2
Bluestone, J.A.3
Campbell, D.J.4
Ghosh, S.5
Hori, S.6
-
31
-
-
84883679673
-
Peripherally induced tregs-role in immune homeostasis and autoimmunity
-
Yadav M, Stephan S, Bluestone JA. Peripherally induced tregs-role in immune homeostasis and autoimmunity. Front Immunol (2013) 4:232. doi:10.3389/fimmu.2013.00232
-
(2013)
Front Immunol
, vol.4
, pp. 232
-
-
Yadav, M.1
Stephan, S.2
Bluestone, J.A.3
-
32
-
-
79954559096
-
T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells
-
Cheng G, Yu A, Malek TR. T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol Rev (2011) 241(1):63-76. doi:10.1111/j.1600-065X.2011.01004.x
-
(2011)
Immunol Rev
, vol.241
, Issue.1
, pp. 63-76
-
-
Cheng, G.1
Yu, A.2
Malek, T.R.3
-
33
-
-
77956475716
-
Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells
-
Simonetta F, Chiali A, Cordier C, Urrutia A, Girault I, Bloquet S, et al. Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells. Eur J Immunol (2010) 40(9):2528-38. doi:10.1002/eji.201040531
-
(2010)
Eur J Immunol
, vol.40
, Issue.9
, pp. 2528-2538
-
-
Simonetta, F.1
Chiali, A.2
Cordier, C.3
Urrutia, A.4
Girault, I.5
Bloquet, S.6
-
34
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 203(7):1701-11. doi:10.1084/jem.20060772
-
(2006)
J Exp Med
, vol.203
, Issue.7
, pp. 1701-1711
-
-
Liu, W.1
Putnam, A.L.2
Xu-Yu, Z.3
Szot, G.L.4
Lee, M.R.5
Zhu, S.6
-
35
-
-
77956254094
-
Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells
-
Mandapathil M, Szczepanski MJ, Szajnik M, Ren J, Jackson EK, Johnson JT, et al. Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. J Biol Chem (2010) 285(36):27571-80. doi:10.1074/jbc. M110.127100
-
(2010)
J Biol Chem
, vol.285
, Issue.36
, pp. 27571-27580
-
-
Mandapathil, M.1
Szczepanski, M.J.2
Szajnik, M.3
Ren, J.4
Jackson, E.K.5
Johnson, J.T.6
-
36
-
-
84905657094
-
Extracellular adenosine-mediated modulation of regulatory T cells
-
Ohta A, Sitkovsky M. Extracellular adenosine-mediated modulation of regulatory T cells. Front Immunol (2014) 5:304. doi:10.3389/fimmu.2014.00304
-
(2014)
Front Immunol
, vol.5
, pp. 304
-
-
Ohta, A.1
Sitkovsky, M.2
-
37
-
-
33750832563
-
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
-
Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol (2006) 177(10):6780-6. doi:10.4049/jimmunol.177.10.6780
-
(2006)
J Immunol
, vol.177
, Issue.10
, pp. 6780-6786
-
-
Kobie, J.J.1
Shah, P.R.2
Yang, L.3
Rebhahn, J.A.4
Fowell, D.J.5
Mosmann, T.R.6
-
38
-
-
84884206864
-
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis
-
Delgoffe GM, Woo SR, Turnis ME, Gravano DM, Guy C, Overacre AE, et al. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature (2013) 501(7466):252-6. doi:10.1038/nature12428
-
(2013)
Nature
, vol.501
, Issue.7466
, pp. 252-256
-
-
Delgoffe, G.M.1
Woo, S.R.2
Turnis, M.E.3
Gravano, D.M.4
Guy, C.5
Overacre, A.E.6
-
39
-
-
84867901322
-
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
-
Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med (2012) 209(10):S1-19. doi:10.1084/jem.20120822
-
(2012)
J Exp Med
, vol.209
, Issue.10
, pp. S1-S19
-
-
Yadav, M.1
Louvet, C.2
Davini, D.3
Gardner, J.M.4
Martinez-Llordella, M.5
Bailey-Bucktrout, S.6
-
40
-
-
77951638740
-
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
-
Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 184(7):3433-41. doi:10.4049/jimmunol.0904028
-
(2010)
J Immunol
, vol.184
, Issue.7
, pp. 3433-3441
-
-
Thornton, A.M.1
Korty, P.E.2
Tran, D.Q.3
Wohlfert, E.A.4
Murray, P.E.5
Belkaid, Y.6
-
41
-
-
84856567623
-
Expression of Helios in peripherally induced Foxp3+ regulatory T cells
-
Gottschalk RA, Corse E, Allison JP. Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol (2012) 188(3):976-80. doi:10.4049/jimmunol.1102964
-
(2012)
J Immunol
, vol.188
, Issue.3
, pp. 976-980
-
-
Gottschalk, R.A.1
Corse, E.2
Allison, J.P.3
-
42
-
-
84898681799
-
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
-
Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity (2014) 40(4):569-81. doi:10.1016/j.immuni.2014.02.012
-
(2014)
Immunity
, vol.40
, Issue.4
, pp. 569-581
-
-
Joller, N.1
Lozano, E.2
Burkett, P.R.3
Patel, B.4
Xiao, S.5
Zhu, C.6
-
43
-
-
84932082421
-
Divergent phenotypes of human regulatory T cells expressing the receptors TIGIT and CD226
-
Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, et al. Divergent phenotypes of human regulatory T cells expressing the receptors TIGIT and CD226. J Immunol (2015) 195(1):145-55. doi:10.4049/jimmunol.1402381
-
(2015)
J Immunol
, vol.195
, Issue.1
, pp. 145-155
-
-
Fuhrman, C.A.1
Yeh, W.I.2
Seay, H.R.3
Saikumar Lakshmi, P.4
Chopra, G.5
Zhang, L.6
-
44
-
-
84927619774
-
Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells
-
Bin Dhuban K, d'Hennezel E, Nashi E, Bar-Or A, Rieder S, Shevach EM, et al. Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells. J Immunol (2015) 194(8):3687-96. doi:10.4049/jimmunol.1401803
-
(2015)
J Immunol
, vol.194
, Issue.8
, pp. 3687-3696
-
-
Bin Dhuban, K.1
d'Hennezel, E.2
Nashi, E.3
Bar-Or, A.4
Rieder, S.5
Shevach, E.M.6
-
45
-
-
84892502529
-
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
-
Smigiel KS, Richards E, Srivastava S, Thomas KR, Dudda JC, Klonowski KD, et al. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med (2014) 211(1):121-36. doi:10.1084/jem.20131142
-
(2014)
J Exp Med
, vol.211
, Issue.1
, pp. 121-136
-
-
Smigiel, K.S.1
Richards, E.2
Srivastava, S.3
Thomas, K.R.4
Dudda, J.C.5
Klonowski, K.D.6
-
46
-
-
60149085254
-
A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells
-
Yu A, Zhu L, Altman NH, Malek TR. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity (2009) 30(2):204-17. doi:10.1016/j.immuni.2008.11.014
-
(2009)
Immunity
, vol.30
, Issue.2
, pp. 204-217
-
-
Yu, A.1
Zhu, L.2
Altman, N.H.3
Malek, T.R.4
-
47
-
-
78650668123
-
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells
-
Barron L, Dooms H, Hoyer KK, Kuswanto W, Hofmann J, O'Gorman WE, et al. Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells. J Immunol (2010) 185(11):6426-30. doi:10.4049/jimmunol.0903940
-
(2010)
J Immunol
, vol.185
, Issue.11
, pp. 6426-6430
-
-
Barron, L.1
Dooms, H.2
Hoyer, K.K.3
Kuswanto, W.4
Hofmann, J.5
O'Gorman, W.E.6
-
48
-
-
0028783963
-
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
-
Sadlack B, Löhler J, Schorle H, Klebb G, Haber H, Sickel E, et al. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol (1995) 25(11):3053-9. doi:10.1002/eji.1830251111
-
(1995)
Eur J Immunol
, vol.25
, Issue.11
, pp. 3053-3059
-
-
Sadlack, B.1
Löhler, J.2
Schorle, H.3
Klebb, G.4
Haber, H.5
Sickel, E.6
-
49
-
-
0029028363
-
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
-
Suzuki H, Kündig TM, Furlonger C, Wakeham A, Timms E, Matsuyama T, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science (1995) 268(5216):1472-6. doi:10.1126/science.7770771
-
(1995)
Science
, vol.268
, Issue.5216
, pp. 1472-1476
-
-
Suzuki, H.1
Kündig, T.M.2
Furlonger, C.3
Wakeham, A.4
Timms, E.5
Matsuyama, T.6
-
50
-
-
33846805925
-
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes
-
Caudy AA, Reddy ST, Chatila T, Atkinson JP, Verbsky JW. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol (2007) 119(2):482-7. doi:10.1016/j.jaci.2006.10.007
-
(2007)
J Allergy Clin Immunol
, vol.119
, Issue.2
, pp. 482-487
-
-
Caudy, A.A.1
Reddy, S.T.2
Chatila, T.3
Atkinson, J.P.4
Verbsky, J.W.5
-
51
-
-
33847246293
-
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
-
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 39(3):329-37. doi:10.1038/ng1958
-
(2007)
Nat Genet
, vol.39
, Issue.3
, pp. 329-337
-
-
Yamanouchi, J.1
Rainbow, D.2
Serra, P.3
Howlett, S.4
Hunter, K.5
Garner, V.E.6
-
52
-
-
77449143100
-
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
-
Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, Zhang S, et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2010) 59(2):407-15. doi:10.2337/db09-0694
-
(2010)
Diabetes
, vol.59
, Issue.2
, pp. 407-415
-
-
Long, S.A.1
Cerosaletti, K.2
Bollyky, P.L.3
Tatum, M.4
Shilling, H.5
Zhang, S.6
-
53
-
-
0036170938
-
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
-
Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 3(2):135-42. doi:10.1038/ni759
-
(2002)
Nat Immunol
, vol.3
, Issue.2
, pp. 135-142
-
-
Shimizu, J.1
Yamazaki, S.2
Takahashi, T.3
Ishida, Y.4
Sakaguchi, S.5
-
54
-
-
33746575650
-
The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?
-
Shevach EM, Stephens GL. The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat Rev Immunol (2006) 6(8):613-8. doi:10.1038/nri1867
-
(2006)
Nat Rev Immunol
, vol.6
, Issue.8
, pp. 613-618
-
-
Shevach, E.M.1
Stephens, G.L.2
-
55
-
-
14744285671
-
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR
-
Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood (2005) 105(7):2845-51. doi:10.1182/blood-2004-07-2959
-
(2005)
Blood
, vol.105
, Issue.7
, pp. 2845-2851
-
-
Valzasina, B.1
Guiducci, C.2
Dislich, H.3
Killeen, N.4
Weinberg, A.D.5
Colombo, M.P.6
-
56
-
-
33748362628
-
OX40 ligand shuts down IL-10-producing regulatory T cells
-
Ito T, Wang YH, Duramad O, Hanabuchi S, Perng OA, Gilliet M, et al. OX40 ligand shuts down IL-10-producing regulatory T cells. Proc Natl Acad Sci U S A (2006) 103(35):13138-43. doi:10.1073/pnas.0603107103
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.35
, pp. 13138-13143
-
-
Ito, T.1
Wang, Y.H.2
Duramad, O.3
Hanabuchi, S.4
Perng, O.A.5
Gilliet, M.6
-
57
-
-
33845491455
-
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
-
Hoffmann P, Eder R, Boeld TJ, Doser K, Piseshka B, Andreesen R, et al. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood (2006) 108(13):4260-7. doi:10.1182/blood-2006-06-027409
-
(2006)
Blood
, vol.108
, Issue.13
, pp. 4260-4267
-
-
Hoffmann, P.1
Eder, R.2
Boeld, T.J.3
Doser, K.4
Piseshka, B.5
Andreesen, R.6
-
58
-
-
66949171924
-
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
-
Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity (2009) 30(6):899-911. doi:10.1016/j.immuni.2009.03.019
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 899-911
-
-
Miyara, M.1
Yoshioka, Y.2
Kitoh, A.3
Shima, T.4
Wing, K.5
Niwa, A.6
-
59
-
-
77951234655
-
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells
-
Mandapathil M, Hilldorfer B, Szczepanski MJ, Czystowska M, Szajnik M, Ren J, et al. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem (2010) 285(10):7176-86. doi:10.1074/jbc. M109.047423
-
(2010)
J Biol Chem
, vol.285
, Issue.10
, pp. 7176-7186
-
-
Mandapathil, M.1
Hilldorfer, B.2
Szczepanski, M.J.3
Czystowska, M.4
Szajnik, M.5
Ren, J.6
-
60
-
-
37549018472
-
Characterization of mouse CD4 T cell subsets defined by expression of KLRG1
-
Beyersdorf N, Ding X, Tietze JK, Hanke T. Characterization of mouse CD4 T cell subsets defined by expression of KLRG1. Eur J Immunol (2007) 37(12):3445-54. doi:10.1002/eji.200737126
-
(2007)
Eur J Immunol
, vol.37
, Issue.12
, pp. 3445-3454
-
-
Beyersdorf, N.1
Ding, X.2
Tietze, J.K.3
Hanke, T.4
-
61
-
-
67649170980
-
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
-
Feuerer M, Hill JA, Mathis D, Benoist C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 10(7):689-95. doi:10.1038/ni.1760
-
(2009)
Nat Immunol
, vol.10
, Issue.7
, pp. 689-695
-
-
Feuerer, M.1
Hill, J.A.2
Mathis, D.3
Benoist, C.4
-
62
-
-
34249806715
-
Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses
-
Stephens GL, Andersson J, Shevach EM. Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol (2007) 178(11):6901-11. doi:10.4049/jimmunol.178.11.6901
-
(2007)
J Immunol
, vol.178
, Issue.11
, pp. 6901-6911
-
-
Stephens, G.L.1
Andersson, J.2
Shevach, E.M.3
-
63
-
-
84856585744
-
ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice
-
Kornete M, Sgouroudis E, Piccirillo CA. ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice. J Immunol (2012) 188(3):1064-74. doi:10.4049/jimmunol.1101303
-
(2012)
J Immunol
, vol.188
, Issue.3
, pp. 1064-1074
-
-
Kornete, M.1
Sgouroudis, E.2
Piccirillo, C.A.3
-
64
-
-
0038433326
-
Transcriptional regulation of th2 differentiation by inducible costimulator
-
Nurieva RI, Duong J, Kishikawa H, Dianzani U, Rojo JM, Ho IC, et al. Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 18(6):801-11. doi:10.1016/S1074-7613(03)00144-4
-
(2003)
Immunity
, vol.18
, Issue.6
, pp. 801-811
-
-
Nurieva, R.I.1
Duong, J.2
Kishikawa, H.3
Dianzani, U.4
Rojo, J.M.5
Ho, I.C.6
-
65
-
-
11144357191
-
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells
-
Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, et al. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 172(9):5287-96. doi:10.4049/jimmunol.172.9.5287
-
(2004)
J Immunol
, vol.172
, Issue.9
, pp. 5287-5296
-
-
Bensinger, S.J.1
Walsh, P.T.2
Zhang, J.3
Carroll, M.4
Parsons, R.5
Rathmell, J.C.6
-
66
-
-
33746189406
-
FOXP3 and NFAT: partners in tolerance
-
Rudensky AY, Gavin M, Zheng Y. FOXP3 and NFAT: partners in tolerance. Cell (2006) 126(2):253-6. doi:10.1016/j.cell.2006.07.005
-
(2006)
Cell
, vol.126
, Issue.2
, pp. 253-256
-
-
Rudensky, A.Y.1
Gavin, M.2
Zheng, Y.3
-
67
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol (2008) 9(2):194-202. doi:10.1038/ni1549
-
(2008)
Nat Immunol
, vol.9
, Issue.2
, pp. 194-202
-
-
Tone, Y.1
Furuuchi, K.2
Kojima, Y.3
Tykocinski, M.L.4
Greene, M.I.5
Tone, M.6
-
68
-
-
34447568209
-
Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT
-
Hu H, Djuretic I, Sundrud MS, Rao A. Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT. Trends Immunol (2007) 28(8):329-32. doi:10.1016/j.it.2007.06.006
-
(2007)
Trends Immunol
, vol.28
, Issue.8
, pp. 329-332
-
-
Hu, H.1
Djuretic, I.2
Sundrud, M.S.3
Rao, A.4
-
69
-
-
77957025756
-
Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
-
Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W. Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity (2010) 33(3):313-25. doi:10.1016/j.immuni.2010.09.001
-
(2010)
Immunity
, vol.33
, Issue.3
, pp. 313-325
-
-
Xu, L.1
Kitani, A.2
Stuelten, C.3
McGrady, G.4
Fuss, I.5
Strober, W.6
-
70
-
-
84923607143
-
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
-
Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, et al. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nat Immunol (2015) 16(3):276-85. doi:10.1038/ni0515-544d
-
(2015)
Nat Immunol
, vol.16
, Issue.3
, pp. 276-285
-
-
Vasanthakumar, A.1
Moro, K.2
Xin, A.3
Liao, Y.4
Gloury, R.5
Kawamoto, S.6
-
71
-
-
79952938313
-
Maturation of effector regulatory T cells
-
Ohkura N, Sakaguchi S. Maturation of effector regulatory T cells. Nat Immunol (2011) 12(4):283-4. doi:10.1038/ni0411-283
-
(2011)
Nat Immunol
, vol.12
, Issue.4
, pp. 283-284
-
-
Ohkura, N.1
Sakaguchi, S.2
-
72
-
-
79952955744
-
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
-
Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M, et al. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol (2011) 12(4):304-11. doi:10.1038/ni.2006
-
(2011)
Nat Immunol
, vol.12
, Issue.4
, pp. 304-311
-
-
Cretney, E.1
Xin, A.2
Shi, W.3
Minnich, M.4
Masson, F.5
Miasari, M.6
-
73
-
-
84862986986
-
PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells
-
Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, et al. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 486(7404):549-53. doi:10.1038/nature11132
-
(2012)
Nature
, vol.486
, Issue.7404
, pp. 549-553
-
-
Cipolletta, D.1
Feuerer, M.2
Li, A.3
Kamei, N.4
Lee, J.5
Shoelson, S.E.6
-
74
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 15(8):930-9. doi:10.1038/nm.2002
-
(2009)
Nat Med
, vol.15
, Issue.8
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
Nayer, A.6
-
75
-
-
84872551703
-
Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells
-
Wakamatsu E, Mathis D, Benoist C. Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proc Natl Acad Sci U S A (2013) 110(3):1023-8. doi:10.1073/pnas.1220688110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.3
, pp. 1023-1028
-
-
Wakamatsu, E.1
Mathis, D.2
Benoist, C.3
-
76
-
-
84915745730
-
Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy
-
Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, et al. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood (2014) 124(24):3572-6. doi:10.1182/blood-2014-07-587493
-
(2014)
Blood
, vol.124
, Issue.24
, pp. 3572-3576
-
-
Van Gool, F.1
Molofsky, A.B.2
Morar, M.M.3
Rosenzwajg, M.4
Liang, H.E.5
Klatzmann, D.6
-
77
-
-
34447286911
-
CD4+CD25highFOXP3+ regulatory T cells in peripheral blood are primarily of effector memory phenotype
-
author reply 2630-2
-
Beyer M, Schultze JL. CD4+CD25highFOXP3+ regulatory T cells in peripheral blood are primarily of effector memory phenotype. J Clin Oncol (2007) 25(18):2628-30. doi:10.1200/JCO.2006.08.0192 author reply 2630-2
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
, pp. 2628-2630
-
-
Beyer, M.1
Schultze, J.L.2
-
78
-
-
84941784875
-
Control of regulatory T cell migration, function, and homeostasis
-
Campbell DJ. Control of regulatory T cell migration, function, and homeostasis. J Immunol (2015) 195(6):2507-13. doi:10.4049/jimmunol.1500801
-
(2015)
J Immunol
, vol.195
, Issue.6
, pp. 2507-2513
-
-
Campbell, D.J.1
-
79
-
-
84941084485
-
Tissue resident regulatory T cells: novel therapeutic targets for human disease
-
Zhou X, Tang J, Cao H, Fan H, Li B. Tissue resident regulatory T cells: novel therapeutic targets for human disease. Cell Mol Immunol (2015) 12(5):543-52. doi:10.1038/cmi.2015.23
-
(2015)
Cell Mol Immunol
, vol.12
, Issue.5
, pp. 543-552
-
-
Zhou, X.1
Tang, J.2
Cao, H.3
Fan, H.4
Li, B.5
-
80
-
-
84886694563
-
Regulatory T cells in nonlymphoid tissues
-
Burzyn D, Benoist C, Mathis D. Regulatory T cells in nonlymphoid tissues. Nat Immunol (2013) 14(10):1007-13. doi:10.1038/ni.2683
-
(2013)
Nat Immunol
, vol.14
, Issue.10
, pp. 1007-1013
-
-
Burzyn, D.1
Benoist, C.2
Mathis, D.3
-
81
-
-
84888872209
-
Controlling the frontier: regulatory T-cells and intestinal homeostasis
-
Bollrath J, Powrie FM. Controlling the frontier: regulatory T-cells and intestinal homeostasis. Semin Immunol (2013) 25(5):352-7. doi:10.1016/j.smim.2013.09.002
-
(2013)
Semin Immunol
, vol.25
, Issue.5
, pp. 352-357
-
-
Bollrath, J.1
Powrie, F.M.2
-
82
-
-
84890050252
-
A special population of regulatory T cells potentiates muscle repair
-
Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, et al. A special population of regulatory T cells potentiates muscle repair. Cell (2013) 155(6):1282-95. doi:10.1016/j.cell.2013.10.054
-
(2013)
Cell
, vol.155
, Issue.6
, pp. 1282-1295
-
-
Burzyn, D.1
Kuswanto, W.2
Kolodin, D.3
Shadrach, J.L.4
Cerletti, M.5
Jang, Y.6
-
83
-
-
84940380928
-
A distinct function of regulatory T cells in tissue protection
-
Arpaia N, Green JA, Moltedo B, Arvey A, Hemmers S, Yuan S, et al. A distinct function of regulatory T cells in tissue protection. Cell (2015) 162(5):1078-89. doi:10.1016/j.cell.2015.08.021
-
(2015)
Cell
, vol.162
, Issue.5
, pp. 1078-1089
-
-
Arpaia, N.1
Green, J.A.2
Moltedo, B.3
Arvey, A.4
Hemmers, S.5
Yuan, S.6
-
84
-
-
84892448554
-
Regulatory T cells in cancer immunotherapy
-
Nishikawa H, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Curr Opin Immunol (2014) 27:1-7. doi:10.1016/j.coi.2013.12.005
-
(2014)
Curr Opin Immunol
, vol.27
, pp. 1-7
-
-
Nishikawa, H.1
Sakaguchi, S.2
-
85
-
-
4644224624
-
Fatal attraction: tumors beckon regulatory T cells
-
Shevach EM. Fatal attraction: tumors beckon regulatory T cells. Nat Med (2004) 10(9):900-1. doi:10.1038/nm0904-900
-
(2004)
Nat Med
, vol.10
, Issue.9
, pp. 900-901
-
-
Shevach, E.M.1
-
86
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 10(9):942-9. doi:10.1038/nm1093
-
(2004)
Nat Med
, vol.10
, Issue.9
, pp. 942-949
-
-
Curiel, T.J.1
Coukos, G.2
Zou, L.3
Alvarez, X.4
Cheng, P.5
Mottram, P.6
-
87
-
-
79960393113
-
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T-reg cells
-
Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T-reg cells. Nature (2011) 475(7355):226-U141. doi:10.1038/nature10169
-
(2011)
Nature
, vol.475
, Issue.7355
-
-
Facciabene, A.1
Peng, X.2
Hagemann, I.S.3
Balint, K.4
Barchetti, A.5
Wang, L.P.6
-
88
-
-
79955028001
-
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
-
McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol (2011) 186(7):3918-26. doi:10.4049/jimmunol.1003099
-
(2011)
J Immunol
, vol.186
, Issue.7
, pp. 3918-3926
-
-
McClymont, S.A.1
Putnam, A.L.2
Lee, M.R.3
Esensten, J.H.4
Liu, W.5
Hulme, M.A.6
-
89
-
-
31544482746
-
Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
-
Coenen JJ, Koenen HJ, van Rijssen E, Hilbrands LB, Joosten I. Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells. Blood (2006) 107(3):1018-23. doi:10.1182/blood-2005-07-3032
-
(2006)
Blood
, vol.107
, Issue.3
, pp. 1018-1023
-
-
Coenen, J.J.1
Koenen, H.J.2
van Rijssen, E.3
Hilbrands, L.B.4
Joosten, I.5
-
90
-
-
37349080895
-
Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury
-
Ruggenenti P, Perico N, Gotti E, Cravedi P, D'Agati V, Gagliardini E, et al. Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury. Transplantation (2007) 84(8):956-64. doi:10.1097/01.tp.0000284808.28353.2c
-
(2007)
Transplantation
, vol.84
, Issue.8
, pp. 956-964
-
-
Ruggenenti, P.1
Perico, N.2
Gotti, E.3
Cravedi, P.4
D'Agati, V.5
Gagliardini, E.6
-
91
-
-
33747889822
-
Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients
-
Segundo DS, Ruiz JC, Izquierdo M, Fernández-Fresnedo G, Gómez-Alamillo C, Merino R, et al. Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients. Transplantation (2006) 82(4):550-7. doi:10.1097/01.tp.0000229473.95202.50
-
(2006)
Transplantation
, vol.82
, Issue.4
, pp. 550-557
-
-
Segundo, D.S.1
Ruiz, J.C.2
Izquierdo, M.3
Fernández-Fresnedo, G.4
Gómez-Alamillo, C.5
Merino, R.6
-
92
-
-
34250156673
-
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
-
Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant (2007) 7(7):1722-32. doi:10.1111/j.1600-6143.2007.01842.x
-
(2007)
Am J Transplant
, vol.7
, Issue.7
, pp. 1722-1732
-
-
Gao, W.1
Lu, Y.2
El Essawy, B.3
Oukka, M.4
Kuchroo, V.K.5
Strom, T.B.6
-
93
-
-
33745633856
-
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
-
Zeiser R, Nguyen VH, Beilhack A, Buess M, Schulz S, Baker J, et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood (2006) 108(1):390-9. doi:10.1182/blood-2006-01-0329
-
(2006)
Blood
, vol.108
, Issue.1
, pp. 390-399
-
-
Zeiser, R.1
Nguyen, V.H.2
Beilhack, A.3
Buess, M.4
Schulz, S.5
Baker, J.6
-
94
-
-
77957054466
-
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism
-
Powell JD, Delgoffe GM. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity (2010) 33(3):301-11. doi:10.1016/j.immuni.2010.09.002
-
(2010)
Immunity
, vol.33
, Issue.3
, pp. 301-311
-
-
Powell, J.D.1
Delgoffe, G.M.2
-
95
-
-
79952448587
-
FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents
-
Ohkura N, Hamaguchi M, Sakaguchi S. FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents. Trends Pharmacol Sci (2011) 32(3):158-66. doi:10.1016/j.tips.2010.12.004
-
(2011)
Trends Pharmacol Sci
, vol.32
, Issue.3
, pp. 158-166
-
-
Ohkura, N.1
Hamaguchi, M.2
Sakaguchi, S.3
-
96
-
-
20444373376
-
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
-
Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood (2005) 105(12):4743-8. doi:10.1182/blood-2004-10-3932
-
(2005)
Blood
, vol.105
, Issue.12
, pp. 4743-4748
-
-
Battaglia, M.1
Stabilini, A.2
Roncarolo, M.G.3
-
97
-
-
33845379986
-
Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
-
Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol (2006) 177(12):8338-47. doi:10.4049/jimmunol.177.12.8338
-
(2006)
J Immunol
, vol.177
, Issue.12
, pp. 8338-8347
-
-
Battaglia, M.1
Stabilini, A.2
Migliavacca, B.3
Horejs-Hoeck, J.4
Kaupper, T.5
Roncarolo, M.G.6
-
98
-
-
33745861719
-
Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4(+) T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4(+) T cells
-
Valmori D, Tosello V, Souleimanian NE, Godefroy E, Scotto L, Wang Y, et al. Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4(+) T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4(+) T cells. J Immunol (2006) 177(2):944-9. doi:10.4049/jimmunol.177.2.944
-
(2006)
J Immunol
, vol.177
, Issue.2
, pp. 944-949
-
-
Valmori, D.1
Tosello, V.2
Souleimanian, N.E.3
Godefroy, E.4
Scotto, L.5
Wang, Y.6
-
99
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 30(6):832-44. doi:10.1016/j.immuni.2009.04.014
-
(2009)
Immunity
, vol.30
, Issue.6
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
-
100
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 12(4):295-303. doi:10.1038/ni.2005
-
(2011)
Nat Immunol
, vol.12
, Issue.4
, pp. 295-303
-
-
Delgoffe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
-
101
-
-
35748956420
-
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
-
Kopf H, de la Rosa GM, Howard OM, Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int Immunopharmacol (2007) 7(13):1819-24. doi:10.1016/j.intimp.2007.08.027
-
(2007)
Int Immunopharmacol
, vol.7
, Issue.13
, pp. 1819-1824
-
-
Kopf, H.1
de la Rosa, G.M.2
Howard, O.M.3
Chen, X.4
-
102
-
-
84938597826
-
Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells
-
Yuan LF, Li GD, Ren XJ, Nian H, Li XR, Zhang XM. Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells. Int J Ophthalmol (2015) 8(4):659-64. doi:10.3980/j.issn.2222-3959.2015.04.03
-
(2015)
Int J Ophthalmol
, vol.8
, Issue.4
, pp. 659-664
-
-
Yuan, L.F.1
Li, G.D.2
Ren, X.J.3
Nian, H.4
Li, X.R.5
Zhang, X.M.6
-
103
-
-
33746368487
-
Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells
-
Battaglia M, Stabilini A, Draghici E, Migliavacca B, Gregori S, Bonifacio E, et al. Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells. Diabetes (2006) 55(6):1571-80. doi:10.2337/db05-1576
-
(2006)
Diabetes
, vol.55
, Issue.6
, pp. 1571-1580
-
-
Battaglia, M.1
Stabilini, A.2
Draghici, E.3
Migliavacca, B.4
Gregori, S.5
Bonifacio, E.6
-
104
-
-
51849122220
-
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
-
Monti P, Scirpoli M, MaffiP, Piemonti L, Secchi A, Bonifacio E, et al. Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. Diabetes (2008) 57(9):2341-7. doi:10.2337/db08-0138
-
(2008)
Diabetes
, vol.57
, Issue.9
, pp. 2341-2347
-
-
Monti, P.1
Scirpoli, M.2
Maffi, P.3
Piemonti, L.4
Secchi, A.5
Bonifacio, E.6
-
105
-
-
84945474291
-
Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients
-
Gong N, Chen Z, Wang J, Fang A, Li Y, Xiang Y, et al. Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients. Cell Immunol (2015) 297(2):87-93. doi:10.1016/j.cellimm.2015.07.002
-
(2015)
Cell Immunol
, vol.297
, Issue.2
, pp. 87-93
-
-
Gong, N.1
Chen, Z.2
Wang, J.3
Fang, A.4
Li, Y.5
Xiang, Y.6
-
106
-
-
84937422644
-
Differential regulation of Tregs and Th17/Th1 cells by a sirolimus-based regimen might be dependent on STAT-signaling in renal transplant recipients
-
Li Y, Shi Y, Liao Y, Yan L, Zhang Q, Wang L. Differential regulation of Tregs and Th17/Th1 cells by a sirolimus-based regimen might be dependent on STAT-signaling in renal transplant recipients. Int Immunopharmacol (2015) 28(1):435-43. doi:10.1016/j.intimp.2015.07.006
-
(2015)
Int Immunopharmacol
, vol.28
, Issue.1
, pp. 435-443
-
-
Li, Y.1
Shi, Y.2
Liao, Y.3
Yan, L.4
Zhang, Q.5
Wang, L.6
-
107
-
-
84944155213
-
Oscillatory mTOR inhibition and T increase in kidney transplantation
-
Sabbatini M, Ruggiero G, Palatucci AT, Rubino V, Federico S, Giovazzino A, et al. Oscillatory mTOR inhibition and T increase in kidney transplantation. Clin Exp Immunol (2015) 182(2):230-40. doi:10.1111/cei.12669
-
(2015)
Clin Exp Immunol
, vol.182
, Issue.2
, pp. 230-240
-
-
Sabbatini, M.1
Ruggiero, G.2
Palatucci, A.T.3
Rubino, V.4
Federico, S.5
Giovazzino, A.6
-
108
-
-
84887024554
-
IL-2 therapy in type 1 diabetes: "Trials" and tribulations
-
Long SA, Buckner JH, Greenbaum CJ. IL-2 therapy in type 1 diabetes: "Trials" and tribulations. Clin Immunol (2013) 149(3):324-31. doi:10.1016/j.clim.2013.02.005
-
(2013)
Clin Immunol
, vol.149
, Issue.3
, pp. 324-331
-
-
Long, S.A.1
Buckner, J.H.2
Greenbaum, C.J.3
-
109
-
-
41949097030
-
The biology of interleukin-2
-
Malek TR. The biology of interleukin-2. Annu Rev Immunol (2008) 26:453-79. doi:10.1146/annurev.immunol.26.021607.090357
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
110
-
-
65549091509
-
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
-
Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, et al. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med (2009) 206(4):751-60. doi:10.1084/jem.20082824
-
(2009)
J Exp Med
, vol.206
, Issue.4
, pp. 751-760
-
-
Webster, K.E.1
Walters, S.2
Kohler, R.E.3
Mrkvan, T.4
Boyman, O.5
Surh, C.D.6
-
111
-
-
84928591321
-
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
-
Klatzmann D, Abbas AK. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol (2015) 15(5):283-94. doi:10.1038/nri3823
-
(2015)
Nat Rev Immunol
, vol.15
, Issue.5
, pp. 283-294
-
-
Klatzmann, D.1
Abbas, A.K.2
-
112
-
-
33748335576
-
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs
-
Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, et al. PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 116(9):2521-31. doi:10.1172/JCI28057
-
(2006)
J Clin Invest
, vol.116
, Issue.9
, pp. 2521-2531
-
-
Walsh, P.T.1
Buckler, J.L.2
Zhang, J.3
Gelman, A.E.4
Dalton, N.M.5
Taylor, D.K.6
-
113
-
-
34548367511
-
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
-
Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 39(9):1074-82. doi:10.1038/ng2102
-
(2007)
Nat Genet
, vol.39
, Issue.9
, pp. 1074-1082
-
-
Lowe, C.E.1
Cooper, J.D.2
Brusko, T.3
Walker, N.M.4
Smyth, D.J.5
Bailey, R.6
-
114
-
-
56649095825
-
The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice
-
Dendrou CA, Wicker LS. The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. J Clin Immunol (2008) 28(6):685-96. doi:10.1007/s10875-008-9237-9
-
(2008)
J Clin Immunol
, vol.28
, Issue.6
, pp. 685-696
-
-
Dendrou, C.A.1
Wicker, L.S.2
-
115
-
-
43049174722
-
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
-
Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 28(5):687-97. doi:10.1016/j.immuni.2008.03.016
-
(2008)
Immunity
, vol.28
, Issue.5
, pp. 687-697
-
-
Tang, Q.1
Adams, J.Y.2
Penaranda, C.3
Melli, K.4
Piaggio, E.5
Sgouroudis, E.6
-
116
-
-
84860317093
-
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
-
Garg G, Tyler JR, Yang JH, Cutler AJ, Downes K, Pekalski M, et al. Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol (2012) 188(9):4644-53. doi:10.4049/jimmunol.1100272
-
(2012)
J Immunol
, vol.188
, Issue.9
, pp. 4644-4653
-
-
Garg, G.1
Tyler, J.R.2
Yang, J.H.3
Cutler, A.J.4
Downes, K.5
Pekalski, M.6
-
117
-
-
77956257716
-
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
-
Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med (2010) 207(9):1871-8. doi:10.1084/jem.20100209
-
(2010)
J Exp Med
, vol.207
, Issue.9
, pp. 1871-1878
-
-
Grinberg-Bleyer, Y.1
Baeyens, A.2
You, S.3
Elhage, R.4
Fourcade, G.5
Gregoire, S.6
-
118
-
-
84887512828
-
Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response
-
Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, et al. Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity (2013) 39(5):949-62. doi:10.1016/j.immuni.2013.10.016
-
(2013)
Immunity
, vol.39
, Issue.5
, pp. 949-962
-
-
Bailey-Bucktrout, S.L.1
Martinez-Llordella, M.2
Zhou, X.3
Anthony, B.4
Rosenthal, W.5
Luche, H.6
-
119
-
-
84944285022
-
High-dose recombinant interleukin 2 in the treatment of patients with disseminated cancer. Responses, treatment-related morbidity, and histologic findings
-
Lotze MT, Chang AE, Seipp CA, Simpson C, Vetto JT, Rosenberg SA. High-dose recombinant interleukin 2 in the treatment of patients with disseminated cancer. Responses, treatment-related morbidity, and histologic findings. JAMA (1986) 256(22):3117-24. doi:10.1001/jama.256.22.3117
-
(1986)
JAMA
, vol.256
, Issue.22
, pp. 3117-3124
-
-
Lotze, M.T.1
Chang, A.E.2
Seipp, C.A.3
Simpson, C.4
Vetto, J.T.5
Rosenberg, S.A.6
-
120
-
-
0022349817
-
Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer
-
Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE, et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med (1985) 313(23):1485-92. doi:10.1056/NEJM198512053132327
-
(1985)
N Engl J Med
, vol.313
, Issue.23
, pp. 1485-1492
-
-
Rosenberg, S.A.1
Lotze, M.T.2
Muul, L.M.3
Leitman, S.4
Chang, A.E.5
Ettinghausen, S.E.6
-
121
-
-
84891488474
-
The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation
-
Bayer AL, Pugliese A, Malek TR. The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation. Immunol Res (2013) 57(1-3):197-209. doi:10.1007/s12026-013-8452-5
-
(2013)
Immunol Res
, vol.57
, Issue.1-3
, pp. 197-209
-
-
Bayer, A.L.1
Pugliese, A.2
Malek, T.R.3
-
122
-
-
82555192217
-
The yin and yang of interleukin-2-mediated immunotherapy
-
Bluestone JA. The yin and yang of interleukin-2-mediated immunotherapy. N Engl J Med (2011) 365(22):2129-31. doi:10.1056/NEJMe1110900
-
(2011)
N Engl J Med
, vol.365
, Issue.22
, pp. 2129-2131
-
-
Bluestone, J.A.1
-
123
-
-
82555168440
-
Interleukin-2 and regulatory T cells in graft-versus-host disease
-
Koreth J, Matsuoka K, Kim HT, McDonough SM, Bindra B, Alyea EP III, et al. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med (2011) 365(22):2055-66. doi:10.1056/NEJMoa1108188
-
(2011)
N Engl J Med
, vol.365
, Issue.22
, pp. 2055-2066
-
-
Koreth, J.1
Matsuoka, K.2
Kim, H.T.3
McDonough, S.M.4
Bindra, B.5
Alyea, E.P.6
-
124
-
-
82555196118
-
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
-
Saadoun D, Rosenzwajg M, Joly F, Six A, Carrat F, Thibault V, et al. Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N Engl J Med (2011) 365(22):2067-77. doi:10.1056/NEJMoa1105143
-
(2011)
N Engl J Med
, vol.365
, Issue.22
, pp. 2067-2077
-
-
Saadoun, D.1
Rosenzwajg, M.2
Joly, F.3
Six, A.4
Carrat, F.5
Thibault, V.6
-
125
-
-
84865478468
-
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function
-
Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function. Diabetes (2012) 61(9):2340-8. doi:10.2337/db12-0049
-
(2012)
Diabetes
, vol.61
, Issue.9
, pp. 2340-2348
-
-
Long, S.A.1
Rieck, M.2
Sanda, S.3
Bollyky, J.B.4
Samuels, P.L.5
Goland, R.6
-
126
-
-
84887625676
-
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
-
Hartemann A, Bensimon G, Payan CA, Jacqueminet S, Bourron O, Nicolas N, et al. Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol (2013) 1(4):295-305. doi:10.1016/S2213-8587(13)70113-X
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, Issue.4
, pp. 295-305
-
-
Hartemann, A.1
Bensimon, G.2
Payan, C.A.3
Jacqueminet, S.4
Bourron, O.5
Nicolas, N.6
-
127
-
-
84876012054
-
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
-
Matsuoka K, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y, et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med (2013) 5(179):179ra43. doi:10.1126/scitranslmed.3005265
-
(2013)
Sci Transl Med
, vol.5
, Issue.179
-
-
Matsuoka, K.1
Koreth, J.2
Kim, H.T.3
Bascug, G.4
McDonough, S.5
Kawano, Y.6
-
128
-
-
0036314243
-
Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
-
Rabinovitch A, Suarez-Pinzon WL, Shapiro AM, Rajotte RV, Power R. Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes (2002) 51(3):638-45. doi:10.2337/diabetes.51.3.638
-
(2002)
Diabetes
, vol.51
, Issue.3
, pp. 638-645
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
Shapiro, A.M.3
Rajotte, R.V.4
Power, R.5
-
129
-
-
84928586624
-
Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes
-
Yu A, Snowhite I, Vendrame F, Rosenzwajg M, Klatzmann D, Pugliese A, et al. Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes (2015) 64(6):2172-83. doi:10.2337/db14-1322
-
(2015)
Diabetes
, vol.64
, Issue.6
, pp. 2172-2183
-
-
Yu, A.1
Snowhite, I.2
Vendrame, F.3
Rosenzwajg, M.4
Klatzmann, D.5
Pugliese, A.6
-
130
-
-
84928589620
-
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
-
Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, et al. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun (2015) 58:48-58. doi:10.1016/j.jaut.2015.01.001
-
(2015)
J Autoimmun
, vol.58
, pp. 48-58
-
-
Rosenzwajg, M.1
Churlaud, G.2
Mallone, R.3
Six, A.4
Dérian, N.5
Chaara, W.6
-
131
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
-
Chatenoud L, Primo J, Bach JF. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol (1997) 158(6):2947-54.
-
(1997)
J Immunol
, vol.158
, Issue.6
, pp. 2947-2954
-
-
Chatenoud, L.1
Primo, J.2
Bach, J.F.3
-
132
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud L, Thervet E, Primo J, Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci U S A (1994) 91(1):123-7. doi:10.1073/pnas.91.1.123
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.1
, pp. 123-127
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
133
-
-
84879540926
-
CD3 monoclonal antibodies: a first step towards operational immune tolerance in the clinic
-
Chatenoud L, Waldmann H. CD3 monoclonal antibodies: a first step towards operational immune tolerance in the clinic. Rev Diabet Stud (2012) 9(4):372-81. doi:10.1900/RDS.2012.9.372
-
(2012)
Rev Diabet Stud
, vol.9
, Issue.4
, pp. 372-381
-
-
Chatenoud, L.1
Waldmann, H.2
-
134
-
-
77649169766
-
Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies?
-
Chatenoud L. Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies? Nat Rev Endocrinol (2010) 6(3):149-57. doi:10.1038/nrendo.2009.275
-
(2010)
Nat Rev Endocrinol
, vol.6
, Issue.3
, pp. 149-157
-
-
Chatenoud, L.1
-
135
-
-
79551715405
-
Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance
-
Kuhn C, You S, Valette F, Hale G, van Endert P, Bach JF, et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med (2011) 3(68):68ra10. doi:10.1126/scitranslmed.3001830
-
(2011)
Sci Transl Med
, vol.3
, Issue.68
-
-
Kuhn, C.1
You, S.2
Valette, F.3
Hale, G.4
van Endert, P.5
Bach, J.F.6
-
136
-
-
80051931752
-
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells
-
Penaranda C, Tang Q, Bluestone JA. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol (2011) 187(4):2015-22. doi:10.4049/jimmunol.1100713
-
(2011)
J Immunol
, vol.187
, Issue.4
, pp. 2015-2022
-
-
Penaranda, C.1
Tang, Q.2
Bluestone, J.A.3
-
137
-
-
0141796312
-
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
-
Belghith M, Bluestone JA, Barriot S, Mégret J, Bach JF, Chatenoud L. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med (2003) 9(9):1202-8. doi:10.1038/nm924
-
(2003)
Nat Med
, vol.9
, Issue.9
, pp. 1202-1208
-
-
Belghith, M.1
Bluestone, J.A.2
Barriot, S.3
Mégret, J.4
Bach, J.F.5
Chatenoud, L.6
-
138
-
-
79960919901
-
Control of TH17 cells occurs in the small intestine
-
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, et al. Control of TH17 cells occurs in the small intestine. Nature (2011) 475(7357):514-8. doi:10.1038/nature10228
-
(2011)
Nature
, vol.475
, Issue.7357
, pp. 514-518
-
-
Esplugues, E.1
Huber, S.2
Gagliani, N.3
Hauser, A.E.4
Town, T.5
Wan, Y.Y.6
-
139
-
-
84856274206
-
Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients
-
Waldron-Lynch F, Henegariu O, Deng S, Preston-Hurlburt P, Tooley J, Flavell R, et al. Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Sci Transl Med (2012) 4(118):118ra12. doi:10.1126/scitranslmed.3003401
-
(2012)
Sci Transl Med
, vol.4
, Issue.118
-
-
Waldron-Lynch, F.1
Henegariu, O.2
Deng, S.3
Preston-Hurlburt, P.4
Tooley, J.5
Flavell, R.6
-
140
-
-
84868194883
-
Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing
-
You S, Zuber J, Kuhn C, Baas M, Valette F, Sauvaget V, et al. Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing. Am J Transplant (2012) 12(11):2909-19. doi:10.1111/j.1600-6143.2012.04213.x
-
(2012)
Am J Transplant
, vol.12
, Issue.11
, pp. 2909-2919
-
-
You, S.1
Zuber, J.2
Kuhn, C.3
Baas, M.4
Valette, F.5
Sauvaget, V.6
-
141
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, et al. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes (2005) 54(6):1763-9. doi:10.2337/diabetes.54.6.1763
-
(2005)
Diabetes
, vol.54
, Issue.6
, pp. 1763-1769
-
-
Herold, K.C.1
Gitelman, S.E.2
Masharani, U.3
Hagopian, W.4
Bisikirska, B.5
Donaldson, D.6
-
142
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med (2002) 346(22):1692-8. doi:10.1056/NEJMoa012864
-
(2002)
N Engl J Med
, vol.346
, Issue.22
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
-
143
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med (2005) 352(25):2598-608. doi:10.1056/NEJMoa043980
-
(2005)
N Engl J Med
, vol.352
, Issue.25
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
Mathieu, C.4
Kaufman, L.5
Hale, G.6
-
144
-
-
77949266510
-
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
-
Keymeulen B, Walter M, Mathieu C, Kaufman L, Gorus F, Hilbrands R, et al. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia (2010) 53(4):614-23. doi:10.1007/s00125-009-1644-9
-
(2010)
Diabetologia
, vol.53
, Issue.4
, pp. 614-623
-
-
Keymeulen, B.1
Walter, M.2
Mathieu, C.3
Kaufman, L.4
Gorus, F.5
Hilbrands, R.6
-
145
-
-
80051471700
-
Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial
-
Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ Jr, et al. Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial. Lancet (2011) 378(9790):487-97. doi:10.1016/S0140-6736(11)60931-8
-
(2011)
Lancet
, vol.378
, Issue.9790
, pp. 487-497
-
-
Sherry, N.1
Hagopian, W.2
Ludvigsson, J.3
Jain, S.M.4
Wahlen, J.5
Ferry, R.J.6
-
146
-
-
84887025288
-
Anti-CD3 clinical trials in type 1 diabetes mellitus
-
Daifotis AG, Koenig S, Chatenoud L, Herold KC. Anti-CD3 clinical trials in type 1 diabetes mellitus. Clin Immunol (2013) 149(3):268-78. doi:10.1016/j.clim.2013.05.001
-
(2013)
Clin Immunol
, vol.149
, Issue.3
, pp. 268-278
-
-
Daifotis, A.G.1
Koenig, S.2
Chatenoud, L.3
Herold, K.C.4
-
147
-
-
77957147196
-
Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF
-
Ablamunits V, Bisikirska B, Herold KC. Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF. Eur J Immunol (2010) 40(10):2891-901. doi:10.1002/eji.201040485
-
(2010)
Eur J Immunol
, vol.40
, Issue.10
, pp. 2891-2901
-
-
Ablamunits, V.1
Bisikirska, B.2
Herold, K.C.3
-
148
-
-
77949513969
-
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
-
Keymeulen B, Candon S, Fafi-Kremer S, Ziegler A, Leruez-Ville M, Mathieu C, et al. Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood (2010) 115(6):1145-55. doi:10.1182/blood-2009-02-204875
-
(2010)
Blood
, vol.115
, Issue.6
, pp. 1145-1155
-
-
Keymeulen, B.1
Candon, S.2
Fafi-Kremer, S.3
Ziegler, A.4
Leruez-Ville, M.5
Mathieu, C.6
-
149
-
-
84953839594
-
Changes in T-cell subsets identify responders to FcR non-binding anti-CD3 mAb (teplizumab) in patients with Type 1 diabetes
-
Tooley JE, Vudattu N, Choi J, Cotsapas C, Devine L, Raddassi K, et al. Changes in T-cell subsets identify responders to FcR non-binding anti-CD3 mAb (teplizumab) in patients with Type 1 diabetes. Eur J Immunol (2015). doi:10.1002/eji.201545708
-
(2015)
Eur J Immunol
-
-
Tooley, J.E.1
Vudattu, N.2
Choi, J.3
Cotsapas, C.4
Devine, L.5
Raddassi, K.6
-
150
-
-
33744990181
-
Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25-LAP+ T cells
-
Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, et al. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25-LAP+ T cells. Nat Med (2006) 12(6):627-35. doi:10.1038/nm1408
-
(2006)
Nat Med
, vol.12
, Issue.6
, pp. 627-635
-
-
Ochi, H.1
Abraham, M.2
Ishikawa, H.3
Frenkel, D.4
Yang, K.5
Basso, A.S.6
-
151
-
-
78649861228
-
Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant
-
Wu HY, Maron R, Tukpah AM, Weiner HL. Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant. J Immunol (2010) 185(6):3401-7. doi:10.4049/jimmunol.1000836
-
(2010)
J Immunol
, vol.185
, Issue.6
, pp. 3401-3407
-
-
Wu, H.Y.1
Maron, R.2
Tukpah, A.M.3
Weiner, H.L.4
-
152
-
-
58749093614
-
Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25-LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
-
Wu HY, Quintana FJ, Weiner HL. Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25-LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J Immunol (2008) 181(9):6038-50. doi:10.4049/jimmunol.181.9.6038
-
(2008)
J Immunol
, vol.181
, Issue.9
, pp. 6038-6050
-
-
Wu, H.Y.1
Quintana, F.J.2
Weiner, H.L.3
-
153
-
-
34547563816
-
Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody
-
Ishikawa H, Ochi H, Chen ML, Frenkel D, Maron R, Weiner HL. Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes (2007) 56(8):2103-9. doi:10.2337/db06-1632
-
(2007)
Diabetes
, vol.56
, Issue.8
, pp. 2103-2109
-
-
Ishikawa, H.1
Ochi, H.2
Chen, M.L.3
Frenkel, D.4
Maron, R.5
Weiner, H.L.6
-
154
-
-
65649117701
-
Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells
-
Wu HY, Center EM, Tsokos GC, Weiner HL. Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus (2009) 18(7):586-96. doi:10.1177/0961203308100511
-
(2009)
Lupus
, vol.18
, Issue.7
, pp. 586-596
-
-
Wu, H.Y.1
Center, E.M.2
Tsokos, G.C.3
Weiner, H.L.4
-
155
-
-
84883360314
-
Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes
-
Hu C, Ding H, Zhang X, Wong FS, Wen L. Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes. Diabetes (2013) 62(8):2849-58. doi:10.2337/db12-1175
-
(2013)
Diabetes
, vol.62
, Issue.8
, pp. 2849-2858
-
-
Hu, C.1
Ding, H.2
Zhang, X.3
Wong, F.S.4
Wen, L.5
-
156
-
-
84929839467
-
Oral administration of OKT3 MAb to patients with NASH, promotes regulatory T-cell induction, and alleviates insulin resistance: results of a phase IIa blinded placebo-controlled trial
-
Lalazar G, Mizrahi M, Turgeman I, Adar T, Ben Ya'acov A, Shabat Y, et al. Oral administration of OKT3 MAb to patients with NASH, promotes regulatory T-cell induction, and alleviates insulin resistance: results of a phase IIa blinded placebo-controlled trial. J Clin Immunol (2015) 35(4):399-407. doi:10.1007/s10875-015-0160-6
-
(2015)
J Clin Immunol
, vol.35
, Issue.4
, pp. 399-407
-
-
Lalazar, G.1
Mizrahi, M.2
Turgeman, I.3
Adar, T.4
Ben Ya'acov, A.5
Shabat, Y.6
-
157
-
-
77249178418
-
Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells
-
Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, et al. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol (2010) 30(1):167-77. doi:10.1007/s10875-009-9323-7
-
(2010)
J Clin Immunol
, vol.30
, Issue.1
, pp. 167-177
-
-
Ilan, Y.1
Zigmond, E.2
Lalazar, G.3
Dembinsky, A.4
Ben Ya'acov, A.5
Hemed, N.6
-
158
-
-
84934765248
-
Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: results of a phase-2a placebo-controlled trial
-
Halota W, Ferenci P, Kozielewicz D, Dybowska D, Lisovoder N, Samira S, et al. Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: results of a phase-2a placebo-controlled trial. J Viral Hepat (2015) 22(8):651-7. doi:10.1111/jvh.12369
-
(2015)
J Viral Hepat
, vol.22
, Issue.8
, pp. 651-657
-
-
Halota, W.1
Ferenci, P.2
Kozielewicz, D.3
Dybowska, D.4
Lisovoder, N.5
Samira, S.6
-
159
-
-
0018565284
-
Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes
-
Like AA, Rossini AA, Guberski DL, Appel MC, Williams RM. Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science (1979) 206(4425):1421-3. doi:10.1126/science.388619
-
(1979)
Science
, vol.206
, Issue.4425
, pp. 1421-1423
-
-
Like, A.A.1
Rossini, A.A.2
Guberski, D.L.3
Appel, M.C.4
Williams, R.M.5
-
160
-
-
34548570080
-
Anti-thymocyte globulin (ATG) prevents autoimmune encephalomyelitis by expanding myelin antigen-specific Foxp3+ regulatory T cells
-
Chung DT, Korn T, Richard J, Ruzek M, Kohm AP, Miller S, et al. Anti-thymocyte globulin (ATG) prevents autoimmune encephalomyelitis by expanding myelin antigen-specific Foxp3+ regulatory T cells. Int Immunol (2007) 19(8):1003-10. doi:10.1093/intimm/dxm078
-
(2007)
Int Immunol
, vol.19
, Issue.8
, pp. 1003-1010
-
-
Chung, D.T.1
Korn, T.2
Richard, J.3
Ruzek, M.4
Kohm, A.P.5
Miller, S.6
-
161
-
-
33744505629
-
Short administration of polyclonal anti-T cell antibody (ALS) in NOD mice with extensive insulitis prevents subsequent development of autoimmune diabetes
-
Ogawa N, Minamimura K, Kodaka T, Maki T. Short administration of polyclonal anti-T cell antibody (ALS) in NOD mice with extensive insulitis prevents subsequent development of autoimmune diabetes. J Autoimmun (2006) 26(4):225-31. doi:10.1016/j.jaut.2006.03.001
-
(2006)
J Autoimmun
, vol.26
, Issue.4
, pp. 225-231
-
-
Ogawa, N.1
Minamimura, K.2
Kodaka, T.3
Maki, T.4
-
162
-
-
40749153195
-
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation
-
Simon G, Parker M, Ramiya V, Wasserfall C, Huang Y, Bresson D, et al. Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation. Diabetes (2008) 57(2):405-14. doi:10.2337/db06-1384
-
(2008)
Diabetes
, vol.57
, Issue.2
, pp. 405-414
-
-
Simon, G.1
Parker, M.2
Ramiya, V.3
Wasserfall, C.4
Huang, Y.5
Bresson, D.6
-
163
-
-
4644257021
-
Management of patients receiving antithymocyte globulin for aplastic anemia and myelodysplastic syndrome
-
Bevans MF, Shalabi RA. Management of patients receiving antithymocyte globulin for aplastic anemia and myelodysplastic syndrome. Clin J Oncol Nurs (2004) 8(4):377-82. doi:10.1188/04.CJON.377-382
-
(2004)
Clin J Oncol Nurs
, vol.8
, Issue.4
, pp. 377-382
-
-
Bevans, M.F.1
Shalabi, R.A.2
-
164
-
-
27544468772
-
Antithymocyte globulin for prevention of graft-versus-host disease
-
Bacigalupo A. Antithymocyte globulin for prevention of graft-versus-host disease. Curr Opin Hematol (2005) 12(6):457-62. doi:10.1097/01.moh.0000183726.42063.ec
-
(2005)
Curr Opin Hematol
, vol.12
, Issue.6
, pp. 457-462
-
-
Bacigalupo, A.1
-
165
-
-
33646057433
-
CD4+ regulatory T cells are spared from deletion by antilymphocyte serum, a polyclonal anti-T cell antibody
-
Minamimura K, Gao W, Maki T. CD4+ regulatory T cells are spared from deletion by antilymphocyte serum, a polyclonal anti-T cell antibody. J Immunol (2006) 176(7):4125-32. doi:10.4049/jimmunol.176.7.4125
-
(2006)
J Immunol
, vol.176
, Issue.7
, pp. 4125-4132
-
-
Minamimura, K.1
Gao, W.2
Maki, T.3
-
166
-
-
33749259809
-
A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells
-
Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N. A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol (2006) 17(10):2844-53. doi:10.1681/ASN.2006050422
-
(2006)
J Am Soc Nephrol
, vol.17
, Issue.10
, pp. 2844-2853
-
-
Lopez, M.1
Clarkson, M.R.2
Albin, M.3
Sayegh, M.H.4
Najafian, N.5
-
167
-
-
43549114342
-
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro
-
Feng X, Kajigaya S, Solomou EE, Keyvanfar K, Xu X, Raghavachari N, et al. Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro. Blood (2008) 111(7):3675-83. doi:10.1182/blood-2008-01-130146
-
(2008)
Blood
, vol.111
, Issue.7
, pp. 3675-3683
-
-
Feng, X.1
Kajigaya, S.2
Solomou, E.E.3
Keyvanfar, K.4
Xu, X.5
Raghavachari, N.6
-
168
-
-
84916228570
-
Induction of suppressive allogeneic regulatory T cells via rabbit antithymocyte polyclonal globulin during homeostatic proliferation in rat kidney transplantation
-
Valdez-Ortiz R, Bestard O, Llaudó I, Franquesa M, Cerezo G, Torras J, et al. Induction of suppressive allogeneic regulatory T cells via rabbit antithymocyte polyclonal globulin during homeostatic proliferation in rat kidney transplantation. Transpl Int (2015) 28(1):108-19. doi:10.1111/tri.12448
-
(2015)
Transpl Int
, vol.28
, Issue.1
, pp. 108-119
-
-
Valdez-Ortiz, R.1
Bestard, O.2
Llaudó, I.3
Franquesa, M.4
Cerezo, G.5
Torras, J.6
-
169
-
-
77956168784
-
Immune reconstitution following rabbit antithymocyte globulin
-
Gurkan S, Luan Y, Dhillon N, Allam SR, Montague T, Bromberg JS, et al. Immune reconstitution following rabbit antithymocyte globulin. Am J Transplant (2010) 10(9):2132-41. doi:10.1111/j.1600-6143.2010.03210.x
-
(2010)
Am J Transplant
, vol.10
, Issue.9
, pp. 2132-2141
-
-
Gurkan, S.1
Luan, Y.2
Dhillon, N.3
Allam, S.R.4
Montague, T.5
Bromberg, J.S.6
-
170
-
-
84925297594
-
ATG-induced accelerated immune senescence: clinical implications in renal transplant recipients
-
Crepin T, Carron C, Roubiou C, Gaugler B, Gaiffe E, Simula-Faivre D, et al. ATG-induced accelerated immune senescence: clinical implications in renal transplant recipients. Am J Transplant (2015) 15(4):1028-38. doi:10.1111/ajt.13092
-
(2015)
Am J Transplant
, vol.15
, Issue.4
, pp. 1028-1038
-
-
Crepin, T.1
Carron, C.2
Roubiou, C.3
Gaugler, B.4
Gaiffe, E.5
Simula-Faivre, D.6
-
171
-
-
79961206913
-
Induction of self-antigen-specific Foxp3+ regulatory T cells in the periphery by lymphodepletion treatment with anti-mouse thymocyte globulin in mice
-
Lu Y, Suzuki J, Guillioli M, Umland O, Chen Z. Induction of self-antigen-specific Foxp3+ regulatory T cells in the periphery by lymphodepletion treatment with anti-mouse thymocyte globulin in mice. Immunology (2011) 134(1):50-9. doi:10.1111/j.1365-2567.2011.03466.x
-
(2011)
Immunology
, vol.134
, Issue.1
, pp. 50-59
-
-
Lu, Y.1
Suzuki, J.2
Guillioli, M.3
Umland, O.4
Chen, Z.5
-
172
-
-
0038385972
-
An international, randomized, double-blind, placebo-controlled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis
-
Lebwohl M, Christophers E, Langley R, Ortonne JP, Roberts J, Griffiths CE, et al. An international, randomized, double-blind, placebo-controlled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis. Arch Dermatol (2003) 139(6):719-27. doi:10.1001/archderm.139.6.719
-
(2003)
Arch Dermatol
, vol.139
, Issue.6
, pp. 719-727
-
-
Lebwohl, M.1
Christophers, E.2
Langley, R.3
Ortonne, J.P.4
Roberts, J.5
Griffiths, C.E.6
-
173
-
-
0038824717
-
Alefacept therapy produces remission for patients with chronic plaque psoriasis
-
Krueger GG, Ellis CN. Alefacept therapy produces remission for patients with chronic plaque psoriasis. Br J Dermatol (2003) 148(4):784-8. doi:10.1046/j.1365-2133.2003.05239.x
-
(2003)
Br J Dermatol
, vol.148
, Issue.4
, pp. 784-788
-
-
Krueger, G.G.1
Ellis, C.N.2
-
174
-
-
0142182716
-
CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study
-
Gottlieb AB, Casale TB, Frankel E, Goffe B, Lowe N, Ochs HD, et al. CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study. J Am Acad Dermatol (2003) 49(5):816-25. doi:10.1016/S0190-9622(03)01836-X
-
(2003)
J Am Acad Dermatol
, vol.49
, Issue.5
, pp. 816-825
-
-
Gottlieb, A.B.1
Casale, T.B.2
Frankel, E.3
Goffe, B.4
Lowe, N.5
Ochs, H.D.6
-
175
-
-
34447329553
-
Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
-
Chamian F, Lin SL, Lee E, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, et al. Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis. J Transl Med (2007) 5:27. doi:10.1186/1479-5876-5-27
-
(2007)
J Transl Med
, vol.5
, pp. 27
-
-
Chamian, F.1
Lin, S.L.2
Lee, E.3
Kikuchi, T.4
Gilleaudeau, P.5
Sullivan-Whalen, M.6
-
176
-
-
0035954670
-
Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes
-
Ellis CN, Krueger GG, Alefacept Clinical Study Group. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med (2001) 345(4):248-55. doi:10.1056/NEJM200107263450403
-
(2001)
N Engl J Med
, vol.345
, Issue.4
, pp. 248-255
-
-
Ellis, C.N.1
Krueger, G.G.2
-
177
-
-
84939218518
-
Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients
-
Rigby MR, Harris KM, Pinckney A, DiMeglio LA, Rendell MS, Felner EI, et al. Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest (2015) 125(8):3285-96. doi:10.1172/JCI81722
-
(2015)
J Clin Invest
, vol.125
, Issue.8
, pp. 3285-3296
-
-
Rigby, M.R.1
Harris, K.M.2
Pinckney, A.3
DiMeglio, L.A.4
Rendell, M.S.5
Felner, E.I.6
-
178
-
-
62749201002
-
Expansion of human regulatory T-cells from patients with type 1 diabetes
-
Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, et al. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes (2009) 58(3):652-62. doi:10.2337/db08-1168
-
(2009)
Diabetes
, vol.58
, Issue.3
, pp. 652-662
-
-
Putnam, A.L.1
Brusko, T.M.2
Lee, M.R.3
Liu, W.4
Szot, G.L.5
Ghosh, T.6
-
179
-
-
84863840517
-
Regulatory T-cell therapy for transplantation: how many cells do we need?
-
Tang Q, Lee K. Regulatory T-cell therapy for transplantation: how many cells do we need? Curr Opin Organ Transplant (2012) 17(4):349-54. doi:10.1097/MOT.0b013e328355a992
-
(2012)
Curr Opin Organ Transplant
, vol.17
, Issue.4
, pp. 349-354
-
-
Tang, Q.1
Lee, K.2
-
180
-
-
84887194102
-
Regulatory T-cell therapy in transplantation: moving to the clinic
-
Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med (2013) 3(11):a015552. doi:10.1101/cshperspect.a015552
-
(2013)
Cold Spring Harb Perspect Med
, vol.3
, Issue.11
-
-
Tang, Q.1
Bluestone, J.A.2
-
181
-
-
84856908569
-
CD4(+)Foxp3(+) regulatory T cell therapy in transplantation
-
Tang Q, Bluestone JA, Kang SM. CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J Mol Cell Biol (2012) 4(1):11-21. doi:10.1093/jmcb/mjr047
-
(2012)
J Mol Cell Biol
, vol.4
, Issue.1
, pp. 11-21
-
-
Tang, Q.1
Bluestone, J.A.2
Kang, S.M.3
-
182
-
-
84899144218
-
Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets-results of one year follow-up
-
Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, Grabowska M, Derkowska I, Juscinska J, et al. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets-results of one year follow-up. Clin Immunol (2014) 153(1):23-30. doi:10.1016/j.clim.2014.03.016
-
(2014)
Clin Immunol
, vol.153
, Issue.1
, pp. 23-30
-
-
Marek-Trzonkowska, N.1
Mysliwiec, M.2
Dobyszuk, A.3
Grabowska, M.4
Derkowska, I.5
Juscinska, J.6
-
183
-
-
84954443667
-
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
-
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, et al. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Trans Med (2015) 7:315ra. doi:10.1126/scitranslmed.aad4134
-
(2015)
Sci Trans Med
, vol.7
-
-
Bluestone, J.A.1
Buckner, J.H.2
Fitch, M.3
Gitelman, S.E.4
Gupta, S.5
Hellerstein, M.K.6
-
184
-
-
39149134919
-
Measurement of cell proliferation by heavy water labeling
-
Busch R, Neese RA, Awada M, Hayes GM, Hellerstein MK. Measurement of cell proliferation by heavy water labeling. Nat Protoc (2007) 2(12):3045-57. doi:10.1038/nprot.2007.420
-
(2007)
Nat Protoc
, vol.2
, Issue.12
, pp. 3045-3057
-
-
Busch, R.1
Neese, R.A.2
Awada, M.3
Hayes, G.M.4
Hellerstein, M.K.5
-
185
-
-
78751696183
-
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
-
Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood (2011) 117(3):1061-70. doi:10.1182/blood-2010-07-293795
-
(2011)
Blood
, vol.117
, Issue.3
, pp. 1061-1070
-
-
Brunstein, C.G.1
Miller, J.S.2
Cao, Q.3
McKenna, D.H.4
Hippen, K.L.5
Curtsinger, J.6
-
186
-
-
84982091033
-
Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo
-
Parmar S, Liu X, Najjar A, Shah N, Yang H, Yvon E, et al. Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo. Blood (2015) 125(9):1502-6. doi:10.1182/blood-2014-10-603449
-
(2015)
Blood
, vol.125
, Issue.9
, pp. 1502-1506
-
-
Parmar, S.1
Liu, X.2
Najjar, A.3
Shah, N.4
Yang, H.5
Yvon, E.6
-
187
-
-
84900314611
-
CRISPR-Cas systems for editing, regulating and targeting genomes
-
Sander JD, Joung JK. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol (2014) 32(4):347-55. doi:10.1038/nbt.2842
-
(2014)
Nat Biotechnol
, vol.32
, Issue.4
, pp. 347-355
-
-
Sander, J.D.1
Joung, J.K.2
|