메뉴 건너뛰기




Volumn 12, Issue 5, 2015, Pages 543-552

Tissue resident regulatory T cells: Novel therapeutic targets for human disease

Author keywords

Areg; Bone; Muscle Repair; Regulatory T cells; Skin memory Tregs; Tissue Tregs; Tumor; VAT Tregs

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3;

EID: 84941084485     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2015.23     Document Type: Review
Times cited : (53)

References (101)
  • 1
    • 84875427488 scopus 로고    scopus 로고
    • Regulatory T cells: Recommendations to simplify the nomenclature
    • Abbas, A.K., C. Benoist, J.A. Bluestone, et al. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol 2013; 14: 307-8.
    • (2013) Nat Immunol , vol.14 , pp. 307-308
    • Abbas, A.K.1    Benoist, C.2    Bluestone, J.A.3
  • 3
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 4
    • 0035413350 scopus 로고    scopus 로고
    • CD41CD25high regulatory cells in human peripheral blood
    • Baecher-Allan, C., J.A. Brown, G.J. Freeman, and D.A. Hafler. CD41CD25high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245-53.
    • (2001) J Immunol , vol.167 , pp. 1245-1253
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3    Hafler, D.A.4
  • 5
    • 0035525739 scopus 로고    scopus 로고
    • CD4(1)CD25(1) cells: A naturally occurring population of regulatory T cells
    • Ng, W.F., P.J. Duggan, F. Ponchel, et al. Human CD4(1)CD25(1) cells: a naturally occurring population of regulatory T cells. Blood 2001; 98: 2736-44.
    • (2001) Blood , vol.98 , pp. 2736-2744
    • Ng, W.F.1    Duggan, P.J.2    Ponchel, F.3
  • 6
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(1)CD25(1) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit, H., E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, and A.H. Enk. Identification and functional characterization of human CD4(1)CD25(1) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193: 1285-94.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 7
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4(1)CD25(1) T cells with regulatory properties from human blood
    • Dieckmann, D., H. Plottner, S. Berchtold, T. Berger, and G. Schuler. Ex vivo isolation and characterization of CD4(1)CD25(1) T cells with regulatory properties from human blood. J Exp Med 2001; 193: 1303-10.
    • (2001) J Exp Med , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 8
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., T. Nomura, and S. Sakaguchi. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 9
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD41CD252 T cells
    • Walker, M.R., D.J. Kasprowicz, V.H. Gersuk, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD41CD252 T cells. J Clin Invest 2003; 112: 1437-43.
    • (2003) J Clin Invest , vol.112 , pp. 1437-1443
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3
  • 11
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD41 T reg cells
    • Liu, W., A.L. Putnam, Z. Xu-Yu, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD41 T reg cells. J Exp Med 2006; 203: 1701-11.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 12
    • 79951831706 scopus 로고    scopus 로고
    • Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents
    • de Vries, I.J, C. Castelli, C. Huygens, et al. Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents. Clin Cancer Res 2011; 17: 841-8.
    • (2011) Clin Cancer Res , vol.17 , pp. 841-848
    • De Vries, I.J.1    Castelli, C.2    Huygens, C.3
  • 13
    • 80053141377 scopus 로고    scopus 로고
    • Highlights of years of immunology in Nature Reviews Immunology
    • Medzhitov R. E.M. Shevach G. Trinchieri et al. Highlights of years of immunology in Nature Reviews Immunology. Nat Rev Immunol 2011; 11: 693-702.
    • (2011) Nat Rev Immunol , vol.11 , pp. 693-702
    • Medzhitov, R.1    Shevach, E.M.2    Trinchieri, G.3
  • 15
    • 34548721641 scopus 로고    scopus 로고
    • Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis
    • Haas, J., B. Fritzsching, P. Trubswetter, et al. Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol 2007; 179: 1322-30.
    • (2007) J Immunol , vol.179 , pp. 1322-1330
    • Haas, J.1    Fritzsching, B.2    Trubswetter, P.3
  • 16
    • 44849096534 scopus 로고    scopus 로고
    • Critical role of IL-and TGF-beta in generation, function and stabilization of Foxp31CD41 Treg
    • Horwitz, D.A., S.G. Zheng, J. Wang, and J.D. Gray. Critical role of IL-and TGF-beta in generation, function and stabilization of Foxp31CD41 Treg. Eur J Immunol 2008; 38: 912-5.
    • (2008) Eur J Immunol , vol.38 , pp. 912-915
    • Horwitz, D.A.1    Zheng, S.G.2    Wang, J.3    Gray, J.D.4
  • 17
    • 73849097617 scopus 로고    scopus 로고
    • The Th17/Treg functional imbalance during atherogenesis in ApoE(2/2) mice
    • Xie, J.J., J. Wang, T.T. Tang, et al. The Th17/Treg functional imbalance during atherogenesis in ApoE(2/2) mice. Cytokine 2010; 49: 185-93.
    • (2010) Cytokine , vol.49 , pp. 185-193
    • Xie ., J.J.1    Wang, J.2    Tang, T.T.3
  • 18
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang, X.O., R. Nurieva, G.J. Martinez, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008; 29: 44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3
  • 19
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells induce CD41CD252Foxp32 T cells or are selfinduced to become Th17 cells in the absence of exogenous TGFbeta
    • Xu, L., A. Kitani, I. Fuss, and W. Strober. Cutting edge: regulatory T cells induce CD41CD252Foxp32 T cells or are selfinduced to become Th17 cells in the absence of exogenous TGFbeta. J Immunol 2007; 178: 6725-9.
    • (2007) J Immunol , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 20
    • 78049373227 scopus 로고    scopus 로고
    • Cutting edge: All-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu
    • Zhou, X., N. Kong, J. Wang, et al. Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J Immunol 2010; 185: 2675-9.
    • (2010) J Immunol , vol.185 , pp. 2675-2679
    • Zhou, X.1    Kong, N.2    Wang, J.3
  • 21
    • 84906308941 scopus 로고    scopus 로고
    • Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions
    • Lu, L., Q. Lan, Z. Li, et al. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A 2010; 111: E3432-40.
    • (2010) Proc Natl Acad Sci U S A , vol.111 , pp. E3432-E3440
    • Lu, L.1    Lan, Q.2    Li, Z.3
  • 23
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio, S., K.M. Dwyer, W. Gao, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204: 1257-65.
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3
  • 24
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene, A., X. Peng, I.S. Hagemann, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 2011; 475: 226-30.
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3
  • 25
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta, D., M. Feuerer, A. Li, et al. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 2012; 486: 549-53.
    • (2012) Nature , vol.486 , pp. 549-553
    • Cipolletta, D.1    Feuerer, M.2    Li, A.3
  • 26
    • 84890050252 scopus 로고    scopus 로고
    • A special population of regulatory T cells potentiates muscle repair
    • Burzyn, D., W. Kuswanto, D. Kolodin, et al. A special population of regulatory T cells potentiates muscle repair. Cell 2013; 155: 1282-95.
    • (2013) Cell , vol.155 , pp. 1282-1295
    • Burzyn, D.1    Kuswanto, W.2    Kolodin, D.3
  • 27
    • 79954620910 scopus 로고    scopus 로고
    • Th17 cells express interleukin-10 receptor and are controlled by Foxp3(2) and Foxp31 regulatory CD41 T cells in an interleukin-10-dependent manner
    • Huber, S., N. Gagliani, E. Esplugues, et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3(2) and Foxp31 regulatory CD41 T cells in an interleukin-10-dependent manner. Immunity 2011; 34: 554-65.
    • (2011) Immunity , vol.34 , pp. 554-565
    • Huber, S.1    Gagliani, N.2    Esplugues, E.3
  • 28
    • 35449006679 scopus 로고    scopus 로고
    • Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
    • Cao, X., S.F. Cai, T.A. Fehniger, et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007; 27: 635-46.
    • (2007) Immunity , vol.27 , pp. 635-646
    • Cao, X.1    Cai, S.F.2    Fehniger, T.A.3
  • 29
    • 36248976097 scopus 로고    scopus 로고
    • CD41CD251Foxp31 regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD41 T cells
    • Pandiyan, P., L. Zheng, S. Ishihara, J. Reed, and M.J. Lenardo. CD41CD251Foxp31 regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD41 T cells. Nat Immunol 2007; 8: 1353-62.
    • (2007) Nat Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 30
    • 84871719877 scopus 로고    scopus 로고
    • Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer
    • Pere, H., C. Tanchot, J. Bayry, et al. Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer. Oncoimmunology 2012; 1: 326-333.
    • (2012) Oncoimmunology , vol.1 , pp. 326-333
    • Pere, H.1    Tanchot, C.2    Bayry, J.3
  • 31
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp31 regulatory T cell function
    • Wing, K., Y. Onishi, P. Prieto-Martin, et al. CTLA-4 control over Foxp31 regulatory T cell function. Science 2008; 322: 271-5.
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 32
    • 77953639101 scopus 로고    scopus 로고
    • Regulatory T cells protect from local and systemic bone destruction in arthritis
    • Zaiss, M.M., B. Frey, A. Hess, et al. Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol 2010; 184: 7238-46.
    • (2010) J Immunol , vol.184 , pp. 7238-7246
    • Zaiss, M.M.1    Frey, B.2    Hess, A.3
  • 33
    • 82755182907 scopus 로고    scopus 로고
    • Tissular T(regs): A unique population of adipose-tissue-resident Foxp31CD41 T cells that impacts organismal metabolism
    • Cipolletta, D., D. Kolodin, C. Benoist, and D. Mathis. Tissular T(regs): a unique population of adipose-tissue-resident Foxp31CD41 T cells that impacts organismal metabolism. Semin Immunol 2011; 23: 431-7.
    • (2011) Semin Immunol , vol.23 , pp. 431-437
    • Cipolletta, D.1    Kolodin, D.2    Benoist, C.3    Mathis, D.4
  • 34
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer, M., L. Herrero, D. Cipolletta, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009; 15: 930-9.
    • (2009) Nat Med , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3
  • 35
    • 27944454429 scopus 로고    scopus 로고
    • Where CD41CD251 T reg cells impinge on autoimmune diabetes
    • Chen, Z., A.E. Herman, M. Matos, D. Mathis, and C. Benoist. Where CD41CD251 T reg cells impinge on autoimmune diabetes. J Exp Med 2005; 202: 1387-97.
    • (2005) J Exp Med , vol.202 , pp. 1387-1397
    • Chen, Z.1    Herman, A.E.2    Matos, M.3    Mathis, D.4    Benoist, C.5
  • 36
    • 33847021422 scopus 로고    scopus 로고
    • Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis
    • Nguyen, L.T., J. Jacobs, D. Mathis, and C. Benoist. Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum 2007; 56: 509-20.
    • (2007) Arthritis Rheum , vol.56 , pp. 509-520
    • Nguyen, L.T.1    Jacobs, J.2    Mathis, D.3    Benoist, C.4
  • 37
    • 34250336452 scopus 로고    scopus 로고
    • Altering the distribution of Foxp3(1) regulatory T cells results in tissue-specific inflammatory disease
    • Sather, B.D., P. Treuting, N. Perdue, et al. Altering the distribution of Foxp3(1) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 2007; 204: 1335-47.
    • (2007) J Exp Med , vol.204 , pp. 1335-1347
    • Sather, B.D.1    Treuting, P.2    Perdue, N.3
  • 38
    • 45949107443 scopus 로고    scopus 로고
    • Evidence for a selective migration of fetus-specific CD41CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy
    • Tilburgs, T., D.L. Roelen, B.J. van der Mast, et al. Evidence for a selective migration of fetus-specific CD41CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J Immunol 2008; 180: 5737-45.
    • (2008) J Immunol , vol.180 , pp. 5737-5745
    • Tilburgs, T.1    Roelen, D.L.2    Van Der Mast, B.J.3
  • 39
    • 70349755645 scopus 로고    scopus 로고
    • How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets
    • Feuerer, M., Y. Shen, D.R. Littman, C. Benoist, and D. Mathis. How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity 2009; 31: 654-64.
    • (2009) Immunity , vol.31 , pp. 654-664
    • Feuerer, M.1    Shen, Y.2    Littman, D.R.3    Benoist, C.4    Mathis, D.5
  • 40
    • 84880894822 scopus 로고    scopus 로고
    • Tumor-infiltrating regulatory T cells: Phenotype, role, mechanism of expansion in situ and clinical significance
    • Tanchot, C., M. Terme, H. Pere, et al. Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance. Cancer Microenviron 2013; 6: 147-57.
    • (2013) Cancer Microenviron , vol.6 , pp. 147-157
    • Tanchot, C.1    Terme, M.2    Pere, H.3
  • 42
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng, C.N. and A.R. Saltiel. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011; 121: 2111-7.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 43
    • 84879506653 scopus 로고    scopus 로고
    • Fat-resident Tregs: An emerging guard protecting from obesity-associated metabolic disorders
    • Chen, X., Y. Wu, and L. Wang. Fat-resident Tregs: an emerging guard protecting from obesity-associated metabolic disorders. Obes Rev 2013; 14: 568-78.
    • (2013) Obes Rev , vol.14 , pp. 568-578
    • Chen, X.1    Wu, Y.2    Wang, L.3
  • 44
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesityassociated insulin resistance through immunotherapy
    • Winer, S., Y. Chan, G. Paltser, et al. Normalization of obesityassociated insulin resistance through immunotherapy. Nat Med 2009; 15: 921-9.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3
  • 45
    • 80755168875 scopus 로고    scopus 로고
    • Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy
    • Eller, K., A. Kirsch, A.M. Wolf, et al. Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy. Diabetes 2011; 60: 2954-62.
    • (2011) Diabetes , vol.60 , pp. 2954-2962
    • Eller, K.1    Kirsch, A.2    Wolf, A.M.3
  • 46
    • 0032540012 scopus 로고    scopus 로고
    • PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz, P., L. Nagy, J.G. Alvarez, V.A. Thomazy, and R.M. Evans. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998; 93: 241-52.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 47
    • 84919634599 scopus 로고    scopus 로고
    • Metabolic control of regulatory T cell development and function
    • Zeng, H. and H. Chi. Metabolic control of regulatory T cell development and function. Trends Immunol 2015; 36: 3-12.
    • (2015) Trends Immunol , vol.36 , pp. 3-12
    • Zeng, H.1    Chi, H.2
  • 48
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbederived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa, Y., Y. Obata, S. Fukuda, et al. Commensal microbederived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013; 504: 446-50.
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3
  • 49
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • Arpaia, N., C. Campbell, X. Fan, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013; 504: 451-5.
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3
  • 50
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith, P.M., M.R. Howitt, N. Panikov, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569-73.
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3
  • 51
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD41 T cell subsets
    • Michalek, R.D., V.A. Gerriets, S.R. Jacobs, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD41 T cell subsets. J Immunol 2011; 186: 3299-303.
    • (2011) J Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1    Gerriets, V.A.2    Jacobs, S.R.3
  • 52
    • 76049086229 scopus 로고    scopus 로고
    • PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization
    • Sugii, S., P. Olson, D.D. Sears, et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A 2009; 106: 22504-9.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 22504-22509
    • Sugii, S.1    Olson, P.2    Sears, D.D.3
  • 53
    • 84866706026 scopus 로고    scopus 로고
    • Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue
    • Pettersson, U.S, T.B. Walden, P.O. Carlsson, L. Jansson, and M. Phillipson. Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue. PLoS One 2012; 7: e46057.
    • (2012) PLoS One , vol.7 , pp. e46057
    • Pettersson, U.S.1    Walden, T.B.2    Carlsson, P.O.3    Jansson, L.4    Phillipson, M.5
  • 54
    • 77953110535 scopus 로고    scopus 로고
    • Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
    • Ilan, Y., R. Maron, A.M. Tukpah, et al. Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci U S A 2010; 107: 9765-70.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9765-9770
    • Ilan, Y.1    Maron, R.2    Tukpah, A.M.3
  • 55
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn, O. and J.M. Olefsky. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012; 18: 363-74.
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 56
    • 34547778498 scopus 로고    scopus 로고
    • Do regulatory T cells contribute to Th1 skewness in obesity?
    • Svec, P., B. Vasarhelyi, B. Paszthy, et al. Do regulatory T cells contribute to Th1 skewness in obesity? Exp Clin Endocrinol Diabetes 2007; 115: 439-43.
    • (2007) Exp Clin Endocrinol Diabetes , vol.115 , pp. 439-443
    • Svec, P.1    Vasarhelyi, B.2    Paszthy, B.3
  • 57
    • 80052023563 scopus 로고    scopus 로고
    • Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation
    • Beyer, M., Y. Thabet, R.U. Muller, et al. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 2011; 12: 898-907.
    • (2011) Nat Immunol , vol.12 , pp. 898-907
    • Beyer, M.1    Thabet, Y.2    Muller, R.U.3
  • 58
    • 84907070734 scopus 로고    scopus 로고
    • Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis
    • Bending, D., A.M. Pesenacker, S. Ursu, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis. J Immunol 2014; 193: 2699-708.
    • (2014) J Immunol , vol.193 , pp. 2699-2708
    • Bending, D.1    Pesenacker, A.M.2    Ursu, S.3
  • 59
    • 84908257266 scopus 로고    scopus 로고
    • Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy
    • Villalta, S.A., W. Rosenthal, L. Martinez, et al. Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med 2014; 6: 258ra142.
    • (2014) Sci Transl Med , vol.6 , pp. 258ra142
    • Villalta, S.A.1    Rosenthal, W.2    Martinez, L.3
  • 60
    • 77951700255 scopus 로고    scopus 로고
    • Regulatory interactions between muscle and the immune system during muscle regeneration
    • Tidball, J.G. and S.A. Villalta. Regulatory interactions between muscle and the immune system during muscle regeneration. Am J Physiol Regul Integr Comp Physiol 2010; 298: R1173-87.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298 , pp. R1173-R1187
    • Tidball, J.G.1    Villalta, S.A.2
  • 62
    • 84903216099 scopus 로고    scopus 로고
    • Foxp31 CD41 T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation
    • Weirather, J., U.D. Hofmann, N. Beyersdorf, et al. Foxp31 CD41 T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation. Circ Res 2014; 115: 55-67.
    • (2014) Circ Res , vol.115 , pp. 55-67
    • Weirather, J.1    Hofmann, U.D.2    Beyersdorf, N.3
  • 64
    • 77954934938 scopus 로고    scopus 로고
    • Amphiregulin promotes intestinal epithelial regeneration: Roles of intestinal subepithelial myofibroblasts
    • Shao, J. and H. Sheng. Amphiregulin promotes intestinal epithelial regeneration: roles of intestinal subepithelial myofibroblasts. Endocrinology 2010; 151: 3728-37.
    • (2010) Endocrinology , vol.151 , pp. 3728-3737
    • Shao, J.1    Sheng, H.2
  • 65
    • 85027948313 scopus 로고    scopus 로고
    • Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    • Monticelli, L.A., G.F. Sonnenberg, M.C. Abt, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol 2011; 12: 1045-54.
    • (2011) Nat Immunol , vol.12 , pp. 1045-1054
    • Monticelli, L.A.1    Sonnenberg, G.F.2    Abt, M.C.3
  • 66
    • 33846059442 scopus 로고    scopus 로고
    • Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence
    • Golding, J.P., E. Calderbank, T.A. Partridge, and J.R. Beauchamp. Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence. Exp Cell Res 2007; 313: 341-56.
    • (2007) Exp Cell Res , vol.313 , pp. 341-356
    • Golding, J.P.1    Calderbank, E.2    Partridge, T.A.3    Beauchamp, J.R.4
  • 67
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou, W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005; 5: 263-74.
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 68
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel, T.J., G. Coukos, L. Zou, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10: 942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 69
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a mechanism of CD81 T cell tolerance in cancer
    • Nagaraj, S., K. Gupta, V. Pisarev, et al. Altered recognition of antigen is a mechanism of CD81 T cell tolerance in cancer. Nat Med 2007; 13: 828-35.
    • (2007) Nat Med , vol.13 , pp. 828-835
    • Nagaraj, S.1    Gupta, K.2    Pisarev, V.3
  • 71
    • 84860507700 scopus 로고    scopus 로고
    • T-regulatory cells: Key players in tumor immune escape and angiogenesis
    • Facciabene, A., G.T. Motz, and G. Coukos. T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res 2012; 72: 2162-71.
    • (2012) Cancer Res , vol.72 , pp. 2162-2171
    • Facciabene, A.1    Motz, G.T.2    Coukos, G.3
  • 72
    • 0037448353 scopus 로고    scopus 로고
    • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    • Zhang, L . , J.R. Conejo-Garcia, D. Katsaros, et al . Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 2003; 348: 203-13.
    • (2003) N Engl J Med , vol.348 , pp. 203-213
    • Zhang, L.1    Conejo-Garcia, J.R.2    Katsaros, D.3
  • 73
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. and R.A. Weinberg. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 74
    • 0037699015 scopus 로고    scopus 로고
    • Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression
    • Dirkx, A.E., M.G. Oude Egbrink, M.J. Kuijpers, et al. Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression. Cancer Res 2003; 63: 2322-9.
    • (2003) Cancer Res , vol.63 , pp. 2322-2329
    • Dirkx, A.E.1    Oude Egbrink, M.G.2    Kuijpers, M.J.3
  • 75
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 76
    • 43749112760 scopus 로고    scopus 로고
    • Vascular normalization in Rgs5-deficient tumours promotes immune destruction
    • Hamzah, J., M. Jugold, F. Kiessling, et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 2008; 453: 410-4.
    • (2008) Nature , vol.453 , pp. 410-414
    • Hamzah, J.1    Jugold, M.2    Kiessling, F.3
  • 77
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao, S., Q. Wu, S. Sathornsumetee, et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006; 66: 7843-8.
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 78
    • 34447117552 scopus 로고    scopus 로고
    • A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism
    • Manning, E.A., J.G. Ullman, J.M. Leatherman, et al. A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism. Clin Cancer Res 2007; 13: 3951-9.
    • (2007) Clin Cancer Res , vol.13 , pp. 3951-3959
    • Manning, E.A.1    Ullman, J.G.2    Leatherman, J.M.3
  • 79
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali, R.K., Z. Yu, M.R. Theoret, D. Chinnasamy, N.P. Restifo, and S.A. Rosenberg. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res 2010; 70: 6171-80.
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 80
    • 84867902940 scopus 로고    scopus 로고
    • Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
    • Huang, Y., J. Yuan, E. Righi, et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A 2012; 109: 17561-6.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17561-17566
    • Huang, Y.1    Yuan, J.2    Righi, E.3
  • 81
    • 0028787355 scopus 로고
    • Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis
    • Pearlman, J.D., M.G. Hibberd, M.L. Chuang, et al. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nat Med 1995; 1: 1085-9.
    • (1995) Nat Med , vol.1 , pp. 1085-1089
    • Pearlman, J.D.1    Hibberd, M.G.2    Chuang, M.L.3
  • 82
    • 64949148656 scopus 로고    scopus 로고
    • The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions
    • Wada, J., H. Suzuki, R. Fuchino, et al. The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions. Anticancer Res 2009; 29: 881-8.
    • (2009) Anticancer Res , vol.29 , pp. 881-888
    • Wada, J.1    Suzuki, H.2    Fuchino, R.3
  • 83
    • 34547210257 scopus 로고    scopus 로고
    • Intratumoral FOXP3 expression in infiltrating breast carcinoma: Its association with clinicopathologic parameters and angiogenesis
    • Gupta, S., K. Joshi, J.D. Wig, and S.K. Arora. Intratumoral FOXP3 expression in infiltrating breast carcinoma: Its association with clinicopathologic parameters and angiogenesis. Acta Oncol 2007; 46: 792-7.
    • (2007) Acta Oncol , vol.46 , pp. 792-797
    • Gupta, S.1    Joshi, K.2    Wig, J.D.3    Arora, S.K.4
  • 84
    • 47249112494 scopus 로고    scopus 로고
    • The presence of tumor-infiltrating FOXP31 lymphocytes correlates with intratumoral angiogenesis in endometrial cancer
    • Giatromanolaki, A., G.J. Bates, M.I. Koukourakis, et al. The presence of tumor-infiltrating FOXP31 lymphocytes correlates with intratumoral angiogenesis in endometrial cancer. Gynecol Oncol 2008; 110: 216-21.
    • (2008) Gynecol Oncol , vol.110 , pp. 216-221
    • Giatromanolaki, A.1    Bates, G.J.2    Koukourakis, M.I.3
  • 85
    • 0344153890 scopus 로고    scopus 로고
    • CD41/CD251regulatory cells inhibit activation of tumor-primed CD41 T cells with IFNgamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination
    • Casares, N., L. Arribillaga, P. Sarobe, et al. CD41/CD251regulatory cells inhibit activation of tumor-primed CD41 T cells with IFNgamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination. J Immunol 2003; 171: 5931-9.
    • (2003) J Immunol , vol.171 , pp. 5931-5939
    • Casares, N.1    Arribillaga, L.2    Sarobe, P.3
  • 86
    • 84871684240 scopus 로고    scopus 로고
    • Presence of tumour-infiltrating FOXP31 lymphocytes correlates with immature tumour angiogenesis in renal cell carcinomas
    • Zhan, H.L., X. Gao, X.F. Zhou, X.Y. Pu, and D.J. Wang. Presence of tumour-infiltrating FOXP31 lymphocytes correlates with immature tumour angiogenesis in renal cell carcinomas. Asian Pac J Cancer Prev 2012; 13: 867-72.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 867-872
    • Zhan, H.L.1    Gao, X.2    Zhou, X.F.3    Pu, X.Y.4    Wang, D.J.5
  • 87
    • 84877990557 scopus 로고    scopus 로고
    • Control of regulatory T cells and T helper cells in human diseases: From bench to bedside
    • Zhou, X., B. Li, H. Fan, and Z. Liu. Control of regulatory T cells and T helper cells in human diseases: from bench to bedside. J Mol Cell Biol 2013; 5: 210-1.
    • (2013) J Mol Cell Biol , vol.5 , pp. 210-211
    • Zhou, X.1    Li, B.2    Fan, H.3    Liu, Z.4
  • 88
    • 41149179666 scopus 로고    scopus 로고
    • Ruthenium porphyrin compounds for photodynamic therapy of cancer
    • Schmitt, F., P. Govindaswamy, G. Suss-Fink, et al. Ruthenium porphyrin compounds for photodynamic therapy of cancer. J Med Chem 2008; 51: 1811-6.
    • (2008) J Med Chem , vol.51 , pp. 1811-1816
    • Schmitt, F.1    Govindaswamy, P.2    Suss-Fink, G.3
  • 89
    • 73149103231 scopus 로고    scopus 로고
    • Therapeutic activity of sunitinib for Her2/neu induced mammary cancer in FVB mice
    • Abe, F., I. Younos, S. Westphal, et al. Therapeutic activity of sunitinib for Her2/neu induced mammary cancer in FVB mice. Int Immunopharmacol 2010; 10: 140-5.
    • (2010) Int Immunopharmacol , vol.10 , pp. 140-145
    • Abe, F.1    Younos, I.2    Westphal, S.3
  • 90
    • 78149281950 scopus 로고    scopus 로고
    • A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients
    • Adotevi, O., H. Pere, P. Ravel, et al. A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients. J Immunother 2010; 33: 991-8.
    • (2010) J Immunother , vol.33 , pp. 991-998
    • Adotevi, O.1    Pere, H.2    Ravel, P.3
  • 91
    • 77955373402 scopus 로고    scopus 로고
    • Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation
    • Zaiss, M.M., K. Sarter, A. Hess, et al. Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation. Arthritis Rheum 2010; 62: 2328-38.
    • (2010) Arthritis Rheum , vol.62 , pp. 2328-2338
    • Zaiss, M.M.1    Sarter, K.2    Hess, A.3
  • 92
    • 40949097683 scopus 로고    scopus 로고
    • Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression
    • Mahnke, K., T. Bedke, and A.H. Enk. Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression. Cell Immunol 2007; 250: 1-13.
    • (2007) Cell Immunol , vol.250 , pp. 1-13
    • Mahnke, K.1    Bedke, T.2    Enk, A.H.3
  • 93
    • 37649012017 scopus 로고    scopus 로고
    • Use of CFSE to monitor ex vivo regulatory T-cell suppression of CD41and CD81T-cell proliferation within unseparated mononuclear cells from malignant and nonmalignant human lymph node biopsies
    • Hilchey, S.P. and S.H. Bernstein. Use of CFSE to monitor ex vivo regulatory T-cell suppression of CD41and CD81T-cell proliferation within unseparated mononuclear cells from malignant and nonmalignant human lymph node biopsies. Immunol Invest 2007; 36: 629-48.
    • (2007) Immunol Invest , vol.36 , pp. 629-648
    • Hilchey, S.P.1    Bernstein, S.H.2
  • 94
    • 84864878463 scopus 로고    scopus 로고
    • Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells
    • Kong, N., Q. Lan, M. Chen, et al. Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells. Ann Rheum Dis 2012; 71: 1567-72.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1567-1572
    • Kong, N.1    Lan, Q.2    Chen, M.3
  • 95
    • 84899630165 scopus 로고    scopus 로고
    • Mechanisms regulating skin immunity and inflammation
    • Pasparakis, M., I. Haase, and F.O. Nestle. Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol 2014; 14: 289-301.
    • (2014) Nat Rev Immunol , vol.14 , pp. 289-301
    • Pasparakis, M.1    Haase, I.2    Nestle, F.O.3
  • 96
    • 65249134069 scopus 로고    scopus 로고
    • Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    • Gebhardt, T., L.M. Wakim, L. Eidsmo, P.C. Reading, W.R. Heath, and F.R. Carbone. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol 2009; 10: 524-30.
    • (2009) Nat Immunol , vol.10 , pp. 524-530
    • Gebhardt, T.1    Wakim, L.M.2    Eidsmo, L.3    Reading, P.C.4    Heath, W.R.5    Carbone, F.R.6
  • 98
    • 84892760241 scopus 로고    scopus 로고
    • Regulatory T cells shape the resident memory T cell response to virus infection in the tissues
    • Graham, J.B., A. Da Costa, and J.M. Lund. Regulatory T cells shape the resident memory T cell response to virus infection in the tissues. J Immunol 2013; 192: 683-90.
    • (2013) J Immunol , vol.192 , pp. 683-690
    • Graham, J.B.1    Da Costa, A.2    Lund, J.M.3
  • 100
    • 84879616239 scopus 로고    scopus 로고
    • Immune cells control skin lymphatic electrolyte homeostasis and blood pressure
    • Wiig, H., A. Schroder, W. Neuhofer, et al. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest 2013; 123: 2803-15.
    • (2013) J Clin Invest , vol.123 , pp. 2803-2815
    • Wiig, H.1    Schroder, A.2    Neuhofer, W.3
  • 101
    • 77954223152 scopus 로고    scopus 로고
    • Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
    • Petukhova, L., M. Duvic, M. Hordinsky, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 2010; 466: 113-7.
    • (2010) Nature , vol.466 , pp. 113-117
    • Petukhova, L.1    Duvic, M.2    Hordinsky, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.