The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice

Journal of Clinical Immunology

Volumn 28, Issue 6, 2008, Pages 685-696

  Dendrou, Calliope A ^a   Wicker, Linda S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CD25; IL 2; IL 2RA; NOD mice; Type 1 diabetes

Indexed keywords

CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CELL FUNCTION; CLINICAL TRIAL; DIABETES CONTROL; DISEASE ACTIVITY; DISEASE COURSE; DISEASE PREDISPOSITION; DNA SPLICING; DRUG WITHDRAWAL; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC TRAIT; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE FUNCTION; MOLECULAR GENETICS; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ALTERNATIVE SPLICING; ANIMALS; AUTOIMMUNITY; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KILLER CELLS, NATURAL; MICE; MICE, INBRED NOD; NATURAL KILLER T-CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY;

EID: 56649095825     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-008-9237-9     Document Type: Review

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