메뉴 건너뛰기




Volumn 149, Issue 3, 2013, Pages 324-331

IL-2 therapy in type 1 diabetes: "Trials" and tribulations

Author keywords

Clinical trials; ; GVHD; ; HCV induced vasculitis; IL 2; ; Regulatory T cells; ; Type 1 diabetes;

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; RAPAMYCIN;

EID: 84887024554     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2013.02.005     Document Type: Review
Times cited : (50)

References (57)
  • 4
    • 79960912796 scopus 로고    scopus 로고
    • Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
    • Orban T., Bundy B., Becker D.J., DiMeglio L.A., Gitelman S.E., Goland R., et al. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet Jul 30 2011, 378(9789):412-419.
    • (2011) Lancet , vol.378 , Issue.9789 , pp. 412-419
    • Orban, T.1    Bundy, B.2    Becker, D.J.3    DiMeglio, L.A.4    Gitelman, S.E.5    Goland, R.6
  • 5
    • 41949097030 scopus 로고    scopus 로고
    • The biology of interleukin-2
    • Malek T.R. The biology of interleukin-2. Annu. Rev. Immunol. 2008, 26:453-479.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 6
    • 78649526238 scopus 로고    scopus 로고
    • Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases
    • Buckner J.H. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. Dec 2010, 10(12):849-859.
    • (2010) Nat. Rev. Immunol. , vol.10 , Issue.12 , pp. 849-859
    • Buckner, J.H.1
  • 8
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • Suzuki H., Kundig T.M., Furlonger C., Wakeham A., Timms E., Matsuyama T., et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science Jun 9 1995, 268(5216):1472-1476.
    • (1995) Science , vol.268 , Issue.5216 , pp. 1472-1476
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3    Wakeham, A.4    Timms, E.5    Matsuyama, T.6
  • 9
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford D.M., Chen J., Ferry J.A., Davidson L., Ma A., Alt F.W. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity Oct 1995, 3(4):521-530.
    • (1995) Immunity , vol.3 , Issue.4 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 11
    • 33646407305 scopus 로고    scopus 로고
    • A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?
    • Strieder T.G., Drexhage H.A., Lam-Tse W.K., Prummel M.F., Tijssen J.G., Wiersinga W.M. A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?. Autoimmunity Mar 2006, 39(2):93-98.
    • (2006) Autoimmunity , vol.39 , Issue.2 , pp. 93-98
    • Strieder, T.G.1    Drexhage, H.A.2    Lam-Tse, W.K.3    Prummel, M.F.4    Tijssen, J.G.5    Wiersinga, W.M.6
  • 14
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot J.D., Rasmussen J.P., Gavin M.A., Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. Nov 2005, 6(11):1142-1151.
    • (2005) Nat. Immunol. , vol.6 , Issue.11 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 17
    • 71049178714 scopus 로고    scopus 로고
    • Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation
    • Brusko T.M., Wasserfall C.H., Hulme M.A., Cabrera R., Schatz D., Atkinson M.A. Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation. PLoS One 2009, 4(11):e7980.
    • (2009) PLoS One , vol.4 , Issue.11
    • Brusko, T.M.1    Wasserfall, C.H.2    Hulme, M.A.3    Cabrera, R.4    Schatz, D.5    Atkinson, M.A.6
  • 18
    • 79955047654 scopus 로고    scopus 로고
    • Murine mesenchymal stem cells suppress T lymphocyte activation through IL-2 receptor alpha (CD25) cleavage by producing matrix metalloproteinases
    • Park M.J., Shin J.S., Kim Y.H., Hong S.H., Yang S.H., Shin J.Y., et al. Murine mesenchymal stem cells suppress T lymphocyte activation through IL-2 receptor alpha (CD25) cleavage by producing matrix metalloproteinases. Stem Cell Rev. Jun 2011, 7(2):381-393.
    • (2011) Stem Cell Rev. , vol.7 , Issue.2 , pp. 381-393
    • Park, M.J.1    Shin, J.S.2    Kim, Y.H.3    Hong, S.H.4    Yang, S.H.5    Shin, J.Y.6
  • 19
    • 0031975246 scopus 로고    scopus 로고
    • Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity
    • Schulz O., Sewell H.F., Shakib F. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. J. Exp. Med. Jan 19 1998, 187(2):271-275.
    • (1998) J. Exp. Med. , vol.187 , Issue.2 , pp. 271-275
    • Schulz, O.1    Sewell, H.F.2    Shakib, F.3
  • 20
    • 56649095825 scopus 로고    scopus 로고
    • The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice
    • Dendrou C.A., Wicker L.S. The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. J. Clin. Immunol. Sep 9 2008, 6:685-696.
    • (2008) J. Clin. Immunol. , vol.6 , pp. 685-696
    • Dendrou, C.A.1    Wicker, L.S.2
  • 21
    • 56749178234 scopus 로고    scopus 로고
    • + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice
    • + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J. Immunol. Nov 1 2008, 181(9):6283-6292.
    • (2008) J. Immunol. , vol.181 , Issue.9 , pp. 6283-6292
    • Sgouroudis, E.1    Albanese, A.2    Piccirillo, C.A.3
  • 22
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang Q., Adams J.Y., Penaranda C., Melli K., Piaggio E., Sgouroudis E., et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity May 2008, 28(5):687-697.
    • (2008) Immunity , vol.28 , Issue.5 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3    Melli, K.4    Piaggio, E.5    Sgouroudis, E.6
  • 23
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • Yamanouchi J., Rainbow D., Serra P., Howlett S., Hunter K., Garner V.E., et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet. Mar 2007, 39(3):329-337.
    • (2007) Nat. Genet. , vol.39 , Issue.3 , pp. 329-337
    • Yamanouchi, J.1    Rainbow, D.2    Serra, P.3    Howlett, S.4    Hunter, K.5    Garner, V.E.6
  • 24
    • 77956257716 scopus 로고    scopus 로고
    • IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
    • Grinberg-Bleyer Y., Baeyens A., You S., Elhage R., Fourcade G., Gregoire S., et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J. Exp. Med. Aug 30 2010, 207(9):1871-1878.
    • (2010) J. Exp. Med. , vol.207 , Issue.9 , pp. 1871-1878
    • Grinberg-Bleyer, Y.1    Baeyens, A.2    You, S.3    Elhage, R.4    Fourcade, G.5    Gregoire, S.6
  • 26
    • 0036314243 scopus 로고    scopus 로고
    • Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
    • Rabinovitch A., Suarez-Pinzon W.L., Shapiro A.M., Rajotte R.V., Power R. Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes Mar 2002, 51(3):638-645.
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 638-645
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Shapiro, A.M.3    Rajotte, R.V.4    Power, R.5
  • 27
    • 33745211931 scopus 로고    scopus 로고
    • Defective regulatory and effector T cell functions in patients with FOXP3 mutations
    • Bacchetta R., Passerini L., Gambineri E., Dai M., Allan S.E., Perroni L., et al. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J. Clin. Invest. Jun 2006, 116(6):1713-1722.
    • (2006) J. Clin. Invest. , vol.116 , Issue.6 , pp. 1713-1722
    • Bacchetta, R.1    Passerini, L.2    Gambineri, E.3    Dai, M.4    Allan, S.E.5    Perroni, L.6
  • 28
    • 35348876040 scopus 로고    scopus 로고
    • IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity
    • Ochs H.D., Gambineri E., Torgerson T.R. IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol. Res. 2007, 38(1-3):112-121.
    • (2007) Immunol. Res. , vol.38 , Issue.1-3 , pp. 112-121
    • Ochs, H.D.1    Gambineri, E.2    Torgerson, T.R.3
  • 29
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin R.S., Ramsdell F., Peake J., Faravelli F., Casanova J.L., Buist N., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. Jan 2001, 27(1):18-20.
    • (2001) Nat. Genet. , vol.27 , Issue.1 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3    Faravelli, F.4    Casanova, J.L.5    Buist, N.6
  • 30
    • 80052649553 scopus 로고    scopus 로고
    • + T regulatory cells in human autoimmunity: more than a numbers game
    • + T regulatory cells in human autoimmunity: more than a numbers game. J. Immunol. Sep 1 2011, 187(5):2061-2066.
    • (2011) J. Immunol. , vol.187 , Issue.5 , pp. 2061-2066
    • Long, S.A.1    Buckner, J.H.2
  • 32
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S., Dayan C.M., Bishop A., Roep B.O., Peakman M., Tree T.I. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes Jan 2005, 54(1):92-99.
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5    Tree, T.I.6
  • 35
    • 33845691031 scopus 로고    scopus 로고
    • + T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop
    • + T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop. Ann. N. Y. Acad. Sci. Oct 2006, 1079:9-18.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1079 , pp. 9-18
    • Tree, T.I.1    Roep, B.O.2    Peakman, M.3
  • 39
    • 77958136352 scopus 로고    scopus 로고
    • Cutting edge: increased IL-17-secreting T cells in children with new-onset type 1 diabetes
    • Marwaha A.K., Crome S.Q., Panagiotopoulos C., Berg K.B., Qin H., Ouyang Q., et al. Cutting edge: increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J. Immunol. Oct 1 2010, 185(7):3814-3818.
    • (2010) J. Immunol. , vol.185 , Issue.7 , pp. 3814-3818
    • Marwaha, A.K.1    Crome, S.Q.2    Panagiotopoulos, C.3    Berg, K.B.4    Qin, H.5    Ouyang, Q.6
  • 40
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature Jun 7 2007, 447(7145):661-678.
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
  • 41
    • 42449094966 scopus 로고    scopus 로고
    • A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
    • Hakonarson H., Qu H.Q., Bradfield J.P., Marchand L., Kim C.E., Glessner J.T., et al. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes Apr 2008, 57(4):1143-1146.
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 1143-1146
    • Hakonarson, H.1    Qu, H.Q.2    Bradfield, J.P.3    Marchand, L.4    Kim, C.E.5    Glessner, J.T.6
  • 42
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd J.A., Walker N.M., Cooper J.D., Smyth D.J., Downes K., Plagnol V., et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. Jul 2007, 39(7):857-864.
    • (2007) Nat. Genet. , vol.39 , Issue.7 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3    Smyth, D.J.4    Downes, K.5    Plagnol, V.6
  • 43
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe C.E., Cooper J.D., Brusko T., Walker N.M., Smyth D.J., Bailey R., et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat. Genet. Aug 5 2007, 9:1074-1082.
    • (2007) Nat. Genet. , vol.9 , pp. 1074-1082
    • Lowe, C.E.1    Cooper, J.D.2    Brusko, T.3    Walker, N.M.4    Smyth, D.J.5    Bailey, R.6
  • 44
    • 79952280031 scopus 로고    scopus 로고
    • An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells
    • Long S.A., Cerosaletti K., Wan J.Y., Ho J.C., Tatum M., Wei S., et al. An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells. Genes Immun. Mar 2011, 12(2):116-125.
    • (2011) Genes Immun. , vol.12 , Issue.2 , pp. 116-125
    • Long, S.A.1    Cerosaletti, K.2    Wan, J.Y.3    Ho, J.C.4    Tatum, M.5    Wei, S.6
  • 45
    • 84944285022 scopus 로고
    • High-dose recombinant interleukin 2 in the treatment of patients with disseminated cancer. Responses, treatment-related morbidity, and histologic findings
    • Lotze M.T., Chang A.E., Seipp C.A., Simpson C., Vetto J.T., Rosenberg S.A. High-dose recombinant interleukin 2 in the treatment of patients with disseminated cancer. Responses, treatment-related morbidity, and histologic findings. JAMA Dec 12 1986, 256(22):3117-3124.
    • (1986) JAMA , vol.256 , Issue.22 , pp. 3117-3124
    • Lotze, M.T.1    Chang, A.E.2    Seipp, C.A.3    Simpson, C.4    Vetto, J.T.5    Rosenberg, S.A.6
  • 46
    • 0022349817 scopus 로고
    • Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer
    • Rosenberg S.A., Lotze M.T., Muul L.M., Leitman S., Chang A.E., Ettinghausen S.E., et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N. Engl. J. Med. Dec 5 1985, 313(23):1485-1492.
    • (1985) N. Engl. J. Med. , vol.313 , Issue.23 , pp. 1485-1492
    • Rosenberg, S.A.1    Lotze, M.T.2    Muul, L.M.3    Leitman, S.4    Chang, A.E.5    Ettinghausen, S.E.6
  • 48
    • 82555196118 scopus 로고    scopus 로고
    • Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
    • Saadoun D., Rosenzwajg M., Joly F., Six A., Carrat F., Thibault V., et al. Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N. Engl. J. Med. Dec 1 2011, 365(22):2067-2077.
    • (2011) N. Engl. J. Med. , vol.365 , Issue.22 , pp. 2067-2077
    • Saadoun, D.1    Rosenzwajg, M.2    Joly, F.3    Six, A.4    Carrat, F.5    Thibault, V.6
  • 49
    • 84865478468 scopus 로고    scopus 로고
    • Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function
    • Long S.A., Rieck M., Sanda S., Bollyky J.B., Samuels P.L., Goland R., et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs beta-cell function. Diabetes Sep 2012, 61(9):2340-2348.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2340-2348
    • Long, S.A.1    Rieck, M.2    Sanda, S.3    Bollyky, J.B.4    Samuels, P.L.5    Goland, R.6
  • 50
    • 51849115547 scopus 로고    scopus 로고
    • Correlation of clinical and virologic responses to antiviral treatment and regulatory T cell evolution in patients with hepatitis C virus-induced mixed cryoglobulinemia vasculitis
    • Landau D.A., Rosenzwajg M., Saadoun D., Trebeden-Negre H., Klatzmann D., Cacoub P. Correlation of clinical and virologic responses to antiviral treatment and regulatory T cell evolution in patients with hepatitis C virus-induced mixed cryoglobulinemia vasculitis. Arthritis Rheum. Sep 2008, 58(9):2897-2907.
    • (2008) Arthritis Rheum. , vol.58 , Issue.9 , pp. 2897-2907
    • Landau, D.A.1    Rosenzwajg, M.2    Saadoun, D.3    Trebeden-Negre, H.4    Klatzmann, D.5    Cacoub, P.6
  • 51
    • 0042914703 scopus 로고    scopus 로고
    • Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
    • Yang J.C., Sherry R.M., Steinberg S.M., Topalian S.L., Schwartzentruber D.J., Hwu P., et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J. Clin. Oncol. Aug 15 2003, 21(16):3127-3132.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.16 , pp. 3127-3132
    • Yang, J.C.1    Sherry, R.M.2    Steinberg, S.M.3    Topalian, S.L.4    Schwartzentruber, D.J.5    Hwu, P.6
  • 52
    • 8244253669 scopus 로고    scopus 로고
    • Prospective randomized trial of lisofylline for the prevention of toxicities of high-dose interleukin 2 therapy in advanced renal cancer and malignant melanoma
    • Margolin K., Atkins M., Sparano J., Sosman J., Weiss G., Lotze M., et al. Prospective randomized trial of lisofylline for the prevention of toxicities of high-dose interleukin 2 therapy in advanced renal cancer and malignant melanoma. Clin. Cancer Res. Apr 1997, 3(4):565-572.
    • (1997) Clin. Cancer Res. , vol.3 , Issue.4 , pp. 565-572
    • Margolin, K.1    Atkins, M.2    Sparano, J.3    Sosman, J.4    Weiss, G.5    Lotze, M.6
  • 53
    • 15644364246 scopus 로고    scopus 로고
    • A two-part phase I trial of high-dose interleukin 2 in combination with soluble (Chinese hamster ovary) interleukin 1 receptor
    • McDermott D.F., Trehu E.G., Mier J.W., Sorce D., Rand W., Ronayne L., et al. A two-part phase I trial of high-dose interleukin 2 in combination with soluble (Chinese hamster ovary) interleukin 1 receptor. Clin. Cancer Res. May 1998, 4(5):1203-1213.
    • (1998) Clin. Cancer Res. , vol.4 , Issue.5 , pp. 1203-1213
    • McDermott, D.F.1    Trehu, E.G.2    Mier, J.W.3    Sorce, D.4    Rand, W.5    Ronayne, L.6
  • 54
    • 9544240332 scopus 로고    scopus 로고
    • Phase I trial of interleukin 2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera
    • Trehu E.G., Mier J.W., Dubois J.S., Sorce D., Klempner M.S., Epstein M., et al. Phase I trial of interleukin 2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera. Clin. Cancer Res. Aug 1996, 2(8):1341-1351.
    • (1996) Clin. Cancer Res. , vol.2 , Issue.8 , pp. 1341-1351
    • Trehu, E.G.1    Mier, J.W.2    Dubois, J.S.3    Sorce, D.4    Klempner, M.S.5    Epstein, M.6
  • 55
    • 0035425425 scopus 로고    scopus 로고
    • Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma
    • Phan G.Q., Attia P., Steinberg S.M., White D.E., Rosenberg S.A. Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma. J. Clin. Oncol. Aug 1 2001, 19(15):3477-3482.
    • (2001) J. Clin. Oncol. , vol.19 , Issue.15 , pp. 3477-3482
    • Phan, G.Q.1    Attia, P.2    Steinberg, S.M.3    White, D.E.4    Rosenberg, S.A.5
  • 56
    • 0023888654 scopus 로고
    • Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells
    • Atkins M.B., Mier J.W., Parkinson D.R., Gould J.A., Berkman E.M., Kaplan M.M. Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells. N. Engl. J. Med. Jun 16 1988, 318(24):1557-1563.
    • (1988) N. Engl. J. Med. , vol.318 , Issue.24 , pp. 1557-1563
    • Atkins, M.B.1    Mier, J.W.2    Parkinson, D.R.3    Gould, J.A.4    Berkman, E.M.5    Kaplan, M.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.