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Volumn 28, Issue 1, 2015, Pages 435-443

Differential regulation of Tregs and Th17/Th1 cells by a sirolimus-based regimen might be dependent on STAT-signaling in renal transplant recipients

Author keywords

Calcineurin inhibitors; Regulatory T cells; Renal transplantation; Sirolimus; Stat proteins; Th17 cells

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; RAPAMYCIN; STAT PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TACROLIMUS; CYTOKINE; IMMUNOSUPPRESSIVE AGENT;

EID: 84937422644     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.07.006     Document Type: Article
Times cited : (13)

References (22)
  • 1
    • 67649616484 scopus 로고    scopus 로고
    • Tacrolimus/sirolimus versus tacrolimus/mycophenolate in kidney transplantation: improved 3-year graft and patient survival in recent era
    • J. Gralla, and A.C. Wiseman Tacrolimus/sirolimus versus tacrolimus/mycophenolate in kidney transplantation: improved 3-year graft and patient survival in recent era Transplantation 87 2009 1712 1719
    • (2009) Transplantation , vol.87 , pp. 1712-1719
    • Gralla, J.1    Wiseman, A.C.2
  • 2
    • 34247582790 scopus 로고    scopus 로고
    • Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs
    • S.M. Flechner, D. Goldfarb, K. Solez, C.S. Modlin, B. Mastroianni, K. Savas, and et al. Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs Transplantation 83 2007 883 892
    • (2007) Transplantation , vol.83 , pp. 883-892
    • Flechner, S.M.1    Goldfarb, D.2    Solez, K.3    Modlin, C.S.4    Mastroianni, B.5    Savas, K.6
  • 3
    • 33847717932 scopus 로고    scopus 로고
    • Mycophenolate mofetil/sirolimus compared to other common immunosuppressive regimens in kidney transplantation
    • T.R. Srinivas, J.D. Schold, G. Guerra, A. Eagan, C.M. Bucci, and H.U. Meier-Kriesche Mycophenolate mofetil/sirolimus compared to other common immunosuppressive regimens in kidney transplantation Am. J. Transplant. 7 2007 586 594
    • (2007) Am. J. Transplant. , vol.7 , pp. 586-594
    • Srinivas, T.R.1    Schold, J.D.2    Guerra, G.3    Eagan, A.4    Bucci, C.M.5    Meier-Kriesche, H.U.6
  • 4
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • A. Laurence, C.M. Tato, T.S. Davidson, Y. Kanno, Z. Chen, Z. Yao, and et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation Immunity 26 2007 371 381
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6
  • 5
    • 81855206219 scopus 로고    scopus 로고
    • CNI induced Th17/Treg imbalance and susceptibility to renal dysfunction in renal transplantation
    • Y. Li, Y. Shi, Z. Huang, Y. Bai, Q. Niu, B. Cai, and et al. CNI induced Th17/Treg imbalance and susceptibility to renal dysfunction in renal transplantation Int. Immunopharmacol. 11 2011 2033 2038
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 2033-2038
    • Li, Y.1    Shi, Y.2    Huang, Z.3    Bai, Y.4    Niu, Q.5    Cai, B.6
  • 6
    • 84893094206 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease
    • H. Sugiyama, Y. Maeda, H. Nishimori, Y. Yamasuji, K.I. Matsuoka, N. Fujii, and et al. Mammalian target of rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease Biol. Blood Marrow Transplant. 20 2013 183 191
    • (2013) Biol. Blood Marrow Transplant. , vol.20 , pp. 183-191
    • Sugiyama, H.1    Maeda, Y.2    Nishimori, H.3    Yamasuji, Y.4    Matsuoka, K.I.5    Fujii, N.6
  • 7
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients
    • M. Battaglia, A. Stabilini, B. Migliavacca, J. Horejs-Hoeck, T. Kaupper, and M.G. Roncarolo Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients J. Immunol. 177 2006 8338 8347
    • (2006) J. Immunol. , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.G.6
  • 8
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4 + CD25 + FoxP3 + regulatory T cells
    • M. Battaglia, A. Stabilini, and M.G. Roncarolo Rapamycin selectively expands CD4 + CD25 + FoxP3 + regulatory T cells Blood 105 2005 4743 4748
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 9
    • 33845915103 scopus 로고    scopus 로고
    • Selective survival of naturally occurring human CD4 + CD25 + Foxp3 + regulatory T cells cultured with rapamycin
    • L. Strauss, T.L. Whiteside, A. Knights, C. Bergmann, A. Knuth, and A. Zippelius Selective survival of naturally occurring human CD4 + CD25 + Foxp3 + regulatory T cells cultured with rapamycin J. Immunol. 178 2007 320 329
    • (2007) J. Immunol. , vol.178 , pp. 320-329
    • Strauss, L.1    Whiteside, T.L.2    Knights, A.3    Bergmann, C.4    Knuth, A.5    Zippelius, A.6
  • 10
    • 84859852082 scopus 로고    scopus 로고
    • Rapamycin combined with allogenic immature dendritic cells selectively expands CD4 + CD25 + Foxp3 + regulatory T cells in rats
    • G.Y. Wang, Q. Zhang, Y. Yang, W.J. Chen, W. Liu, N. Jiang, and et al. Rapamycin combined with allogenic immature dendritic cells selectively expands CD4 + CD25 + Foxp3 + regulatory T cells in rats Hepatobiliary Pancreat. Dis. Int. 11 2012 203 208
    • (2012) Hepatobiliary Pancreat. Dis. Int. , vol.11 , pp. 203-208
    • Wang, G.Y.1    Zhang, Q.2    Yang, Y.3    Chen, W.J.4    Liu, W.5    Jiang, N.6
  • 11
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • G.M. Delgoffe, T.P. Kole, Y. Zheng, P.E. Zarek, K.L. Matthews, B. Xiao, and et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment Immunity 30 2009 832 844
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3    Zarek, P.E.4    Matthews, K.L.5    Xiao, B.6
  • 12
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • G.M. Delgoffe, K.N. Pollizzi, A.T. Waickman, E. Heikamp, D.J. Meyers, M.R. Horton, and et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 Nat. Immunol. 12 2011 295 303
    • (2011) Nat. Immunol. , vol.12 , pp. 295-303
    • Delgoffe, G.M.1    Pollizzi, K.N.2    Waickman, A.T.3    Heikamp, E.4    Meyers, D.J.5    Horton, M.R.6
  • 13
    • 77249158089 scopus 로고    scopus 로고
    • Implication of Th17 and Th1 cells in patients with chronic active hepatitis B
    • J. Ge, K. Wang, Q.H. Meng, Z.X. Qi, F.L. Meng, and Y.C. Fan Implication of Th17 and Th1 cells in patients with chronic active hepatitis B J. Clin. Immunol. 30 2010 60 67
    • (2010) J. Clin. Immunol. , vol.30 , pp. 60-67
    • Ge, J.1    Wang, K.2    Meng, Q.H.3    Qi, Z.X.4    Meng, F.L.5    Fan, Y.C.6
  • 14
    • 77950182472 scopus 로고    scopus 로고
    • Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients
    • W. Wu, J. Li, F. Chen, H. Zhu, G. Peng, and Z. Chen Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients J. Gastroenterol. Hepatol. 25 2010 750 757
    • (2010) J. Gastroenterol. Hepatol. , vol.25 , pp. 750-757
    • Wu, W.1    Li, J.2    Chen, F.3    Zhu, H.4    Peng, G.5    Chen, Z.6
  • 15
    • 0032105481 scopus 로고    scopus 로고
    • Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
    • S.N. Sehgal Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression Clin. Biochem. 31 1998 335 340
    • (1998) Clin. Biochem. , vol.31 , pp. 335-340
    • Sehgal, S.N.1
  • 16
    • 46949088630 scopus 로고    scopus 로고
    • De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
    • J. Kang, S.J. Huddleston, J.M. Fraser, and A. Khoruts De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR J. Leukoc. Biol. 83 2008 1230 1239
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 1230-1239
    • Kang, J.1    Huddleston, S.J.2    Fraser, J.M.3    Khoruts, A.4
  • 17
    • 35748956420 scopus 로고    scopus 로고
    • Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3 + T regulatory cells
    • H. Kopf, G.M. de la Rosa, O.M. Howard, and X. Chen Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3 + T regulatory cells Int. Immunopharmacol. 7 2007 1819 1824
    • (2007) Int. Immunopharmacol. , vol.7 , pp. 1819-1824
    • Kopf, H.1    De La Rosa, G.M.2    Howard, O.M.3    Chen, X.4
  • 18
    • 33745861719 scopus 로고    scopus 로고
    • Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4 + T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4 + T cells
    • D. Valmori, V. Tosello, N.E. Souleimanian, E. Godefroy, L. Scotto, Y. Wang, and et al. Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4 + T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4 + T cells J. Immunol. 177 2006 944 949
    • (2006) J. Immunol. , vol.177 , pp. 944-949
    • Valmori, D.1    Tosello, V.2    Souleimanian, N.E.3    Godefroy, E.4    Scotto, L.5    Wang, Y.6
  • 19
    • 84860187314 scopus 로고    scopus 로고
    • Inflammation-driven reprogramming of CD4 + Foxp3 + regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo
    • D. Unutmaz, E. Yurchenko, M.T. Shio, T.C. Huang, Martins M. Da Silva, M. Szyf, and et al. Inflammation-driven reprogramming of CD4 + Foxp3 + regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo PLoS One 7 2012 e35572
    • (2012) PLoS One , vol.7
    • Unutmaz, D.1    Yurchenko, E.2    Shio, M.T.3    Huang, T.C.4    Da Silva, M.M.5    Szyf, M.6
  • 20
    • 84879805222 scopus 로고    scopus 로고
    • Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis
    • H. Yin, X. Li, B. Zhang, T. Liu, B. Yuan, Q. Ni, and et al. Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis Immunology 139 2013 494 502
    • (2013) Immunology , vol.139 , pp. 494-502
    • Yin, H.1    Li, X.2    Zhang, B.3    Liu, T.4    Yuan, B.5    Ni, Q.6
  • 21
    • 54249117326 scopus 로고    scopus 로고
    • The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells
    • T.Y. Wuest, J. Willette-Brown, S.K. Durum, and A.A. Hurwitz The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells J. Leukoc. Biol. 84 2008 973 980
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 973-980
    • Wuest, T.Y.1    Willette-Brown, J.2    Durum, S.K.3    Hurwitz, A.A.4


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