A Distinct Function of Regulatory T Cells in Tissue Protection

Cell

Volumn 162, Issue 5, 2015, Pages 1078-1089

  Arpaia, Nicholas ^a   Green, Jesse A ^a   Moltedo, Bruno ^a   Arvey, Aaron ^a   Hemmers, Saskia ^a   Yuan, Shaopeng ^a,b   Treuting, Piper M ^c   Rudensky, Alexander Y ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; INTERLEUKIN 18; INTERLEUKIN 33; SUPPRESSOR FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; INFLUENZA; INFLUENZA VIRUS; LUNG INJURY; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SUPPRESSOR CELL; TISSUE REPAIR; VIRUS LOAD; ANIMAL; AUTOIMMUNITY; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; LUNG; LYMPHOCYTE ACTIVATION; PATHOLOGY;

ORTHOMYXOVIRIDAE;

AMPHIREGULIN; ANIMALS; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; HUMANS; INFLUENZA, HUMAN; LUNG; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; SUPPRESSOR FACTORS, IMMUNOLOGIC; T-LYMPHOCYTES, REGULATORY;

EID: 84940380928     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.08.021     Document Type: Article

References (35)

1. N. Arpaia, C. Campbell, X. Fan, S. Dikiy, J. van der Veeken, P. deRoos, H. Liu, J.R. Cross, K. Pfeffer, P.J. Coffer, and A.Y. Rudensky Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Nature 504 2013 451 455
2. A. Arvey, J. van der Veeken, R.M. Samstein, Y. Feng, J.A. Stamatoyannopoulos, and A.Y. Rudensky Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells Nat. Immunol. 15 2014 580 587
3. C. Asseman, S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation J. Exp. Med. 190 1999 995 1004
4. F. Bedoya, G.S. Cheng, A. Leibow, N. Zakhary, K. Weissler, V. Garcia, M. Aitken, E. Kropf, D.S. Garlick, E.J. Wherry, and et al. Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice J. Immunol. 190 2013 6115 6125
5. C. Berasain, and M.A. Avila Amphiregulin Semin. Cell Dev. Biol. 28 2014 31 41
6. E.L. Brincks, A.D. Roberts, T. Cookenham, S. Sell, J.E. Kohlmeier, M.A. Blackman, and D.L. Woodland Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection J. Immunol. 190 2013 3438 3446
7. D. Burzyn, C. Benoist, and D. Mathis Regulatory T cells in nonlymphoid tissues Nat. Immunol. 14 2013 1007 1013
8. D. Burzyn, W. Kuswanto, D. Kolodin, J.L. Shadrach, M. Cerletti, Y. Jang, E. Sefik, T.G. Tan, A.J. Wagers, C. Benoist, and D. Mathis A special population of regulatory T cells potentiates muscle repair Cell 155 2013 1282 1295
9. D. Cipolletta, M. Feuerer, A. Li, N. Kamei, J. Lee, S.E. Shoelson, C. Benoist, and D. Mathis PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells Nature 486 2012 549 553
10. F.R. D'Alessio, K. Tsushima, N.R. Aggarwal, E.E. West, M.H. Willett, M.F. Britos, M.R. Pipeling, R.G. Brower, R.M. Tuder, J.F. McDyer, and L.S. King CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury J. Clin. Invest. 119 2009 2898 2913
11. K. Deacon, and A.J. Knox Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8 and VEGF expression in airway epithelial cells Am. J. Physiol. Lung Cell. Mol. Physiol. 2015 10.1152/ajplung.00390.2014 Published online June 5, 2015
12. S.L. Epstein, C.Y. Lo, J.A. Misplon, and J.R. Bennink Mechanism of protective immunity against influenza virus infection in mice without antibodies J. Immunol. 160 1998 322 327
13. M. Feuerer, L. Herrero, D. Cipolletta, A. Naaz, J. Wong, A. Nayer, J. Lee, A.B. Goldfine, C. Benoist, S. Shoelson, and D. Mathis Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters Nat. Med. 15 2009 930 939
14. J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat. Immunol. 4 2003 330 336
15. O.J. Harrison, N. Srinivasan, J. Pott, C. Schiering, T. Krausgruber, N.E. Ilott, and K.J. Maloy Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3 Treg cell function in the intestine Mucosal Immunol. 2015 10.1038/mi.2015.13 Published online March 4, 2015
16. A.M. Jamieson, L. Pasman, S. Yu, P. Gamradt, R.J. Homer, T. Decker, and R. Medzhitov Role of tissue protection in lethal respiratory viral-bacterial coinfection Science 340 2013 1230 1234
17. S.Z. Josefowicz, L.F. Lu, and A.Y. Rudensky Regulatory T cells: mechanisms of differentiation and function Annu. Rev. Immunol. 30 2012 531 564
18. R. Khattri, T. Cox, S.A. Yasayko, and F. Ramsdell An essential role for Scurfin in CD4+CD25+ T regulatory cells Nat. Immunol. 4 2003 337 342
19. J.M. Kim, J.P. Rasmussen, and A.Y. Rudensky Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice Nat. Immunol. 8 2007 191 197
20. A.G. Levine, A. Arvey, W. Jin, and A.Y. Rudensky Continuous requirement for the TCR in regulatory T cell function Nat. Immunol. 15 2014 1070 1078
21. W. Liao, J.X. Lin, and W.J. Leonard Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy Immunity 38 2013 13 25
22. C. Meulenbroeks, H. van Weelden, C. Schwartz, D. Voehringer, F.A. Redegeld, V.P. Rutten, T. Willemse, A.J. Sijts, and D.M. Zaiss Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression J. Invest. Dermatol. 135 2015 222 228
23. L.A. Monticelli, G.F. Sonnenberg, M.C. Abt, T. Alenghat, C.G.K. Ziegler, T.A. Doering, J.M. Angelosanto, B.J. Laidlaw, C.Y. Yang, T. Sathaliyawala, and et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus Nat. Immunol. 12 2011 1045 1054
24. E.K. Moser, M.M. Hufford, and T.J. Braciale Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner PLoS Pathog. 10 2014 e1004315
25. Y. Qi, D.J. Operario, S.N. Georas, and T.R. Mosmann The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin PLoS ONE 7 2012 e39072
26. Y.P. Rubtsov, J.P. Rasmussen, E.Y. Chi, J. Fontenot, L. Castelli, X. Ye, P. Treuting, L. Siewe, A. Roers, W.R. Henderson Jr., and et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces Immunity 28 2008 546 558
27. S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono Regulatory T cells and immune tolerance Cell 133 2008 775 787
28. C. Schiering, T. Krausgruber, A. Chomka, A. Fröhlich, K. Adelmann, E.A. Wohlfert, J. Pott, T. Griseri, J. Bollrath, A.N. Hegazy, and et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine Nature 513 2014 564 568
29. J. Shao, and H. Sheng Amphiregulin promotes intestinal epithelial regeneration: roles of intestinal subepithelial myofibroblasts Endocrinology 151 2010 3728 3737
30. A. Vasanthakumar, K. Moro, A. Xin, Y. Liao, R. Gloury, S. Kawamoto, S. Fagarasan, L.A. Mielke, S. Afshar-Sterle, S.L. Masters, and et al. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells Nat. Immunol. 16 2015 276 285
31. T. Veiga-Parga, S. Sehrawat, and B.T. Rouse Role of regulatory T cells during virus infection Immunol. Rev. 255 2013 182 196
32. Y. Wu, M. Borde, V. Heissmeyer, M. Feuerer, A.D. Lapan, J.C. Stroud, D.L. Bates, L. Guo, A. Han, S.F. Ziegler, and et al. FOXP3 controls regulatory T cell function through cooperation with NFAT Cell 126 2006 375 387
33. D.M. Zaiss, W.C. Gause, L.C. Osborne, and D. Artis Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair Immunity 42 2015 216 226
34. D.M. Zaiss, J. van Loosdregt, A. Gorlani, C.P. Bekker, A. Gröne, M. Sibilia, P.M. van Bergen en Henegouwen, R.C. Roovers, P.J. Coffer, and A.J. Sijts Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor Immunity 38 2013 275 284
35. D.M. Zaiss, L. Yang, P.R. Shah, J.J. Kobie, J.F. Urban, and T.R. Mosmann Amphiregulin, a TH2 cytokine enhancing resistance to nematodes Science 314 2006 1746