메뉴 건너뛰기




Volumn 473, Issue 2, 2016, Pages 107-121

TSPO: Kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria

Author keywords

Autophagy; Biochemistry And Mitochondrial Pharmacology; Metabolism; Peripheral Benzodiazepine Receptor (Pbr); Steroids; Translocator Protein (TSPO)

Indexed keywords

CARRIER PROTEIN; EMAPUNIL; ETIFOXINE; MIDAZOLAM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; REACTIVE OXYGEN METABOLITE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; 4 AMINOBUTYRIC ACID RECEPTOR; BZRP PROTEIN, MOUSE; CHOLESTEROL; STEROID;

EID: 84955479528     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150899     Document Type: Review
Times cited : (66)

References (188)
  • 1
    • 0000114680 scopus 로고
    • Specific benzodiazepine receptors in rat brain characterized by high-Affinity [3H]diazepam binding
    • Braestrup, C. (1977) Specific benzodiazepine receptors in rat brain characterized by high-Affinity [3H]diazepam binding. Proc. Natl. Acad. Sci. U.S.A. 74, 3805-3809
    • (1977) Proc. Natl. Acad. Sci. U.S.A , vol.74 , pp. 3805-3809
    • Braestrup, C.1
  • 2
    • 0022574416 scopus 로고
    • The peripheral-Type benzodiazepine receptor Localization to the mitochondrial outer membrane
    • Anholt, R.R., Pedersen, P.L., De Souza, E.B. and Snyder, S.H. (1986) The peripheral-Type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J. Biol. Chem. 261, 576-583
    • (1986) J. Biol. Chem , vol.261 , pp. 576-583
    • Anholt, R.R.1    Pedersen, P.L.2    De Souza, E.B.3    Snyder, S.H.4
  • 3
    • 0023713397 scopus 로고
    • Molecular characterization and mitochondrial density of a recognition site for peripheral-Type benzodiazepine ligands
    • Antkiewicz-Michaluk, L., Guidotti, A. and Krueger, K.E. (1988) Molecular characterization and mitochondrial density of a recognition site for peripheral-Type benzodiazepine ligands. Mol. Pharmacol. 34, 272-278
    • (1988) Mol. Pharmacol , vol.34 , pp. 272-278
    • Antkiewicz-Michaluk, L.1    Guidotti, A.2    Krueger, K.E.3
  • 6
    • 0021992304 scopus 로고
    • Depletion of peripheral-Type benzodiazepine receptors after hypophysectomy in rat adrenal gland and testis
    • Anholt, R.R., De Souza, E.B., Kuhar, M.J. and Snyder, S.H. (1985) Depletion of peripheral-Type benzodiazepine receptors after hypophysectomy in rat adrenal gland and testis. Eur. J. Pharmacol. 110, 41-46
    • (1985) Eur. J. Pharmacol , vol.110 , pp. 41-46
    • Anholt, R.R.1    De Souza, E.B.2    Kuhar, M.J.3    Snyder, S.H.4
  • 7
    • 0026649978 scopus 로고
    • Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: Regulation by a mitochondrial diazepam binding inhibitor receptor
    • Papadopoulos, V., Guarneri, P., Kreuger, K.E., Guidotti, A. and Costa, E. (1992) Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proc. Natl. Acad. Sci. U.S.A. 89, 5113-5117
    • (1992) Proc. Natl. Acad. Sci. U.S.A , vol.89 , pp. 5113-5117
    • Papadopoulos, V.1    Guarneri, P.2    Kreuger, K.E.3    Guidotti, A.4    Costa, E.5
  • 8
    • 0026051933 scopus 로고
    • Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors
    • Papadopoulos, V., Berkovich, A., Krueger, K.E., Costa, E. and Guidotti, A. (1991) Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology 129, 1481-1488
    • (1991) Endocrinology , vol.129 , pp. 1481-1488
    • Papadopoulos, V.1    Berkovich, A.2    Krueger, K.E.3    Costa, E.4    Guidotti, A.5
  • 9
    • 0031755752 scopus 로고    scopus 로고
    • Peripheral-Type benzodiazepine receptor function in cholesterol transport Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern
    • Li, H. and Papadopoulos, V. (1998) Peripheral-Type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139, 4991-4997
    • (1998) Endocrinology , vol.139 , pp. 4991-4997
    • Li, H.1    Papadopoulos, V.2
  • 13
    • 0021944108 scopus 로고
    • Peripheral-Type benzodiazepine receptors in endocrine organs: Autoradiographic localization in rat pituitary, adrenal, and testis
    • De Souza, E.B., Anholt, R.R., Murphy, K.M., Snyder, S.H. and Kuhar, M.J. (1985) Peripheral-Type benzodiazepine receptors in endocrine organs: Autoradiographic localization in rat pituitary, adrenal, and testis. Endocrinology 116, 567-573
    • (1985) Endocrinology , vol.116 , pp. 567-573
    • De Souza, E.B.1    Anholt, R.R.2    Murphy, K.M.3    Snyder, S.H.4    Kuhar, M.J.5
  • 14
    • 0021953954 scopus 로고
    • Peripheral-Type benzodiazepine receptors: Autoradiographic localization in whole-body sections of neonatal rats
    • Anholt, R.R., De Souza, E.B., Oster-Granite, M.L. and Snyder, S.H. (1985) Peripheral-Type benzodiazepine receptors: Autoradiographic localization in whole-body sections of neonatal rats. J. Pharmacol. Exp. Ther. 233, 517-526
    • (1985) J. Pharmacol. Exp. Ther , vol.233 , pp. 517-526
    • Anholt, R.R.1    De Souza, E.B.2    Oster-Granite, M.L.3    Snyder, S.H.4
  • 15
    • 0021949310 scopus 로고
    • Autoradiographic localization of peripheral-Type benzodiazepine binding sites in the rat brain, heart and kidney
    • Gehlert, D.R., Yamamura, H.I. and Wamsley, J.K. (1985) Autoradiographic localization of "peripheral-Type" benzodiazepine binding sites in the rat brain, heart and kidney. Naunyn Schmiedebergs Arch. Pharmacol. 328, 454-460
    • (1985) Naunyn Schmiedebergs Arch. Pharmacol , vol.328 , pp. 454-460
    • Gehlert, D.R.1    Yamamura, H.I.2    Wamsley, J.K.3
  • 16
    • 0022574416 scopus 로고
    • The peripheral-Type benzodiazepine receptor-localization to the mitochondrial outer membrane
    • Anholt, R. (1986) The peripheral-Type benzodiazepine receptor-localization to the mitochondrial outer membrane. J. Biol. Chem. 261, 576-583
    • (1986) J. Biol. Chem , vol.261 , pp. 576-583
    • Anholt, R.1
  • 17
    • 0026591024 scopus 로고
    • Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier
    • McEnery, M.W., Snowman, A.M., Trifiletti, R.R. and Snyder, S.H. (1992) Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl. Acad. Sci. U.S.A. 89, 3170-3174
    • (1992) Proc. Natl. Acad. Sci. U.S.A , vol.89 , pp. 3170-3174
    • McEnery, M.W.1    Snowman, A.M.2    Trifiletti, R.R.3    Snyder, S.H.4
  • 19
    • 0033558247 scopus 로고    scopus 로고
    • Peripheral-Type benzodiazepine receptor (PBR) in human breast cancer: Correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol
    • Hardwick, M., Fertikh, D., Culty, M., Li, H., Vidic, B. and Papadopoulos, V. (1999) Peripheral-Type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res. 59, 831-842
    • (1999) Cancer Res , vol.59 , pp. 831-842
    • Hardwick, M.1    Fertikh, D.2    Culty, M.3    Li, H.4    Vidic, B.5    Papadopoulos, V.6
  • 20
    • 0023788922 scopus 로고
    • Presence of peripheral-Type benzodiazepine binding sites on human erythrocyte membranes
    • Olson, J.M., Ciliax, B.J., Mancini, W.R. and Young, A.B. (1988) Presence of peripheral-Type benzodiazepine binding sites on human erythrocyte membranes. Eur. J. Pharmacol. 152, 47-53
    • (1988) Eur. J. Pharmacol , vol.152 , pp. 47-53
    • Olson, J.M.1    Ciliax, B.J.2    Mancini, W.R.3    Young, A.B.4
  • 22
    • 84894170581 scopus 로고    scopus 로고
    • Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity
    • Thompson, M.M., Manning, H.C. and Ellacott, K.L. (2013) Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity. PLoS One 8, e79980
    • (2013) PLoS One , vol.8 , pp. e79980
    • Thompson, M.M.1    Manning, H.C.2    Ellacott, K.L.3
  • 23
    • 0030916343 scopus 로고    scopus 로고
    • PK ('peripheral benzodiazepine')-binding sites in the CNS indicate early and discrete brain lesions: Microautoradiographic detection of [3H]PK11195 binding to activated microglia
    • Banati, R.B., Myers, R. and Kreutzberg, G.W. (1997) PK ('peripheral benzodiazepine')-binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia. J. Neurocytol. 26, 77-82
    • (1997) J. Neurocytol , vol.26 , pp. 77-82
    • Banati, R.B.1    Myers, R.2    Kreutzberg, G.W.3
  • 26
    • 66349100806 scopus 로고    scopus 로고
    • Peripheral-Type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice
    • Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S. and Tanabe, T. (2009) Peripheral-Type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice. J. Pharmacol. Sci. 110, 55-63
    • (2009) J. Pharmacol. Sci , vol.110 , pp. 55-63
    • Kondo, D.1    Saegusa, H.2    Yabe, R.3    Takasaki, I.4    Kurihara, T.5    Zong, S.6    Tanabe, T.7
  • 28
    • 0037183733 scopus 로고    scopus 로고
    • Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice
    • Bribes, E., Bourrie, B., Esclangon, M., Galiegue, S., Vidal, H. and Casellas, P. (2002) Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice. Eur. J. Pharmacol. 452, 111-122
    • (2002) Eur. J. Pharmacol , vol.452 , pp. 111-122
    • Bribes, E.1    Bourrie, B.2    Esclangon, M.3    Galiegue, S.4    Vidal, H.5    Casellas, P.6
  • 30
    • 34548861265 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization
    • Obame, F.N., Zini, R., Souktani, R., Berdeaux, A. and Morin, D. (2007) Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization. J. Pharmacol. Exp. Ther. 323, 336-345
    • (2007) J. Pharmacol. Exp. Ther , vol.323 , pp. 336-345
    • Obame, F.N.1    Zini, R.2    Souktani, R.3    Berdeaux, A.4    Morin, D.5
  • 33
    • 84901008605 scopus 로고    scopus 로고
    • Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (TSPO
    • Sileikyte, J., Blachly-Dyson, E., Sewell, R., Carpi, A., Menabo, R., Di Lisa, F., Ricchelli, F., Bernardi, P. and Forte, M. (2014) Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (TSPO). J. Biol. Chem. 289, 13769-13781
    • (2014) J. Biol. Chem , vol.289 , pp. 13769-13781
    • Sileikyte, J.1    Blachly-Dyson, E.2    Sewell, R.3    Carpi, A.4    Menabo, R.5    Di Lisa, F.6    Ricchelli, F.7    Bernardi, P.8    Forte, M.9
  • 34
    • 84907293074 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis
    • Tu, L.N., Morohaku, K., Manna, P.R., Pelton, S.H., Butler, W.R., Stocco, D.M. and Selvaraj, V. (2014) Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis. J. Biol. Chem. 289, 27444-27454
    • (2014) J. Biol. Chem , vol.289 , pp. 27444-27454
    • Tu, L.N.1    Morohaku, K.2    Manna, P.R.3    Pelton, S.H.4    Butler, W.R.5    Stocco, D.M.6    Selvaraj, V.7
  • 35
    • 84891379545 scopus 로고    scopus 로고
    • Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis
    • Morohaku, K., Pelton, S.H., Daugherty, D.J., Butler, W.R., Deng, W. and Selvaraj, V. (2014) Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology 155, 89-97
    • (2014) Endocrinology , vol.155 , pp. 89-97
    • Morohaku, K.1    Pelton, S.H.2    Daugherty, D.J.3    Butler, W.R.4    Deng, W.5    Selvaraj, V.6
  • 36
    • 84923870787 scopus 로고    scopus 로고
    • PK11195 effect on steroidogenesis is not mediated through the translocator protein (TSPO
    • Tu, L.N., Zhao, A.H., Stocco, D.M. and Selvaraj, V. (2015) PK11195 effect on steroidogenesis is not mediated through the translocator protein (TSPO). Endocrinology 156, 1033-1039
    • (2015) Endocrinology , vol.156 , pp. 1033-1039
    • Tu, L.N.1    Zhao, A.H.2    Stocco, D.M.3    Selvaraj, V.4
  • 37
    • 0025827594 scopus 로고
    • Immunohistochemistry of diazepam binding inhibitor (DBI) in the central nervous system and peripheral organs: Its possible role as an endogenous regulator of different types of benzodiazepine receptors
    • Alho, H., Harjuntausta, T., Schultz, R., Pelto-Huikko, M. and Bovolin, P. (1991) Immunohistochemistry of diazepam binding inhibitor (DBI) in the central nervous system and peripheral organs: its possible role as an endogenous regulator of different types of benzodiazepine receptors. Neuropharmacology 30, 1381-1386
    • (1991) Neuropharmacology , vol.30 , pp. 1381-1386
    • Alho, H.1    Harjuntausta, T.2    Schultz, R.3    Pelto-Huikko, M.4    Bovolin, P.5
  • 38
    • 0042319697 scopus 로고
    • Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: Stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor
    • Besman, M.J., Yanagibashi, K., Lee, T.D., Kawamura, M., Hall, P.F. and Shively, J.E. (1989) Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor. Proc. Natl. Acad. Sci. U.S.A. 86, 4897-4901
    • (1989) Proc. Natl. Acad. Sci. U.S.A , vol.86 , pp. 4897-4901
    • Besman, M.J.1    Yanagibashi, K.2    Lee, T.D.3    Kawamura, M.4    Hall, P.F.5    Shively, J.E.6
  • 39
    • 79953100002 scopus 로고    scopus 로고
    • The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism
    • Vanhee, C., Zapotoczny, G., Masquelier, D., Ghislain, M. and Batoko, H. (2011) The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism. Plant Cell 23, 785-805
    • (2011) Plant Cell , vol.23 , pp. 785-805
    • Vanhee, C.1    Zapotoczny, G.2    Masquelier, D.3    Ghislain, M.4    Batoko, H.5
  • 41
    • 84922177703 scopus 로고    scopus 로고
    • TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control
    • Gatliff, J., East, D., Crosby, J., Abeti, R., Harvey, R., Craigen, W., Parker, F. and Campanella, M. (2014) TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy 10, 2279-2296
    • (2014) Autophagy , vol.10 , pp. 2279-2296
    • Gatliff, J.1    East, D.2    Crosby, J.3    Abeti, R.4    Harvey, R.5    Craigen, W.6    Parker, F.7    Campanella, M.8
  • 42
    • 1442299155 scopus 로고    scopus 로고
    • Differential utilization of the promoter of peripheral-Type benzodiazepine receptor by steroidogenic versus nonsteroidogenic cell lines and the role of Sp1 and Sp3 in the regulation of basal activity
    • Giatzakis, C. and Papadopoulos, V. (2004) Differential utilization of the promoter of peripheral-Type benzodiazepine receptor by steroidogenic versus nonsteroidogenic cell lines and the role of Sp1 and Sp3 in the regulation of basal activity. Endocrinology 145, 1113-1123
    • (2004) Endocrinology , vol.145 , pp. 1113-1123
    • Giatzakis, C.1    Papadopoulos, V.2
  • 43
    • 81055138201 scopus 로고    scopus 로고
    • Functional characterization of the human translocator protein (18kDa) gene promoter in human breast cancer cell lines
    • Batarseh, A., Barlow, K.D., Martinez-Arguelles, D.B. and Papadopoulos, V. (2012) Functional characterization of the human translocator protein (18kDa) gene promoter in human breast cancer cell lines. Biochim. Biophys. Acta 1819, 38-56
    • (2012) Biochim. Biophys. Acta , vol.1819 , pp. 38-56
    • Batarseh, A.1    Barlow, K.D.2    Martinez-Arguelles, D.B.3    Papadopoulos, V.4
  • 44
    • 0029561954 scopus 로고
    • Identification of three transcriptional regulatory elements in the rat mitochondrial benzodiazepine receptor-encoding gene
    • Oberto, A., Longone, P. and Krueger, K.E. (1995) Identification of three transcriptional regulatory elements in the rat mitochondrial benzodiazepine receptor-encoding gene. Gene 167, 255-60
    • (1995) Gene , vol.167 , pp. 255-260
    • Oberto, A.1    Longone, P.2    Krueger, K.E.3
  • 45
    • 34247467989 scopus 로고    scopus 로고
    • The role of Ets transcription factors in the basal transcription of the translocator protein (18 kDa
    • Giatzakis, C., Batarseh, A., Dettin, L. and Papadopoulos, V. (2007) The role of Ets transcription factors in the basal transcription of the translocator protein (18 kDa). Biochemistry 46, 4763-4774
    • (2007) Biochemistry , vol.46 , pp. 4763-4774
    • Giatzakis, C.1    Batarseh, A.2    Dettin, L.3    Papadopoulos, V.4
  • 46
    • 57049093333 scopus 로고    scopus 로고
    • Phorbol-12-myristate 13-Acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression
    • Batarseh, A., Giatzakis, C. and Papadopoulos, V. (2008) Phorbol-12-myristate 13-Acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression. Biochemistry 47, 12886-12899
    • (2008) Biochemistry , vol.47 , pp. 12886-12899
    • Batarseh, A.1    Giatzakis, C.2    Papadopoulos, V.3
  • 47
    • 77953283910 scopus 로고    scopus 로고
    • Protein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors
    • Batarseh, A., Li, J. and Papadopoulos, V. (2010) Protein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors. Biochemistry 49, 4766-4778
    • (2011) Biochemistry , vol.49 , pp. 4766-4778
    • Batarseh, A.1    Li, J.2    Papadopoulos, V.3
  • 48
    • 77955415606 scopus 로고    scopus 로고
    • Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states
    • Batarseh, A. and Papadopoulos, V. (2010) Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol. Cell. Endocrinol. 327, 1-12
    • (2011) Mol. Cell. Endocrinol , vol.327 , pp. 1-12
    • Batarseh, A.1    Papadopoulos, V.2
  • 52
    • 83755225151 scopus 로고    scopus 로고
    • The endocrine disruptor mono-(2-ethylhexyl phthalate affects the differentiation of human liposarcoma cells (SW 872)
    • Campioli, E., Batarseh, A., Li, J. and Papadopoulos, V. (2011) The endocrine disruptor mono-(2-ethylhexyl) phthalate affects the differentiation of human liposarcoma cells (SW 872). PLoS One 6, e28750
    • (2011) PLoS One , vol.6 , pp. e28750
    • Campioli, E.1    Batarseh, A.2    Li, J.3    Papadopoulos, V.4
  • 53
    • 84938819770 scopus 로고    scopus 로고
    • TSPO is a REDOX regulator of cell mitophagy
    • Gatliff, J. and Campanella, M. (2015) TSPO is a REDOX regulator of cell mitophagy. Biochem. Soc. Trans. 43, 543-552
    • (2015) Biochem. Soc. Trans , vol.43 , pp. 543-552
    • Gatliff, J.1    Campanella, M.2
  • 54
    • 0023106449 scopus 로고
    • Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy
    • Basile, A.S., Ostrowski, N.L. and Skolnick, P. (1987) Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy. J. Pharmacol. Exp. Ther. 240, 1006-1013
    • (1987) J. Pharmacol. Exp. Ther , vol.240 , pp. 1006-1013
    • Basile, A.S.1    Ostrowski, N.L.2    Skolnick, P.3
  • 56
    • 0032553623 scopus 로고    scopus 로고
    • Ovarian steroids and stress produce changes in peripheral benzodiazepine receptor density
    • Bitran, D., Carlson, D., Leschiner, S. and Gavish, M. (1998) Ovarian steroids and stress produce changes in peripheral benzodiazepine receptor density. Eur. J. Pharmacol. 361, 235-242
    • (1998) Eur. J. Pharmacol , vol.361 , pp. 235-242
    • Bitran, D.1    Carlson, D.2    Leschiner, S.3    Gavish, M.4
  • 57
    • 0028282754 scopus 로고
    • Modulation of peripheral benzodiazepine receptors in female rat genital organs by various gonadal steroids
    • Bar-Ami, S., Amiri, Z., Fares, F. and Gavish, M. (1994) Modulation of peripheral benzodiazepine receptors in female rat genital organs by various gonadal steroids. Life Sci. 54, 1965-1975
    • (1994) Life Sci , vol.54 , pp. 1965-1975
    • Bar-Ami, S.1    Amiri, Z.2    Fares, F.3    Gavish, M.4
  • 58
    • 0022538863 scopus 로고
    • Modulation of peripheral benzodiazepine binding sites following chronic estradiol treatment
    • Gavish, M., Okun, F., Weizman, A. and Youdim, M.B. (1986) Modulation of peripheral benzodiazepine binding sites following chronic estradiol treatment. Eur. J. Pharmacol. 127, 147-151
    • (1986) Eur. J. Pharmacol , vol.127 , pp. 147-151
    • Gavish, M.1    Okun, F.2    Weizman, A.3    Youdim, M.B.4
  • 59
    • 0027981072 scopus 로고
    • Acute action of choriogonadotropin on Leydig tumor cells: Induction of a higher affinity benzodiazepine-binding site related to steroid biosynthesis
    • Boujrad, N., Gaillard, J.L., Garnier, M. and Papadopoulos, V. (1994) Acute action of choriogonadotropin on Leydig tumor cells: induction of a higher affinity benzodiazepine-binding site related to steroid biosynthesis. Endocrinology 135, 1576-1583
    • (1994) Endocrinology , vol.135 , pp. 1576-1583
    • Boujrad, N.1    Gaillard, J.L.2    Garnier, M.3    Papadopoulos, V.4
  • 60
    • 0028224695 scopus 로고
    • Studies on the phosphorylation of the 18 kDa mitochondrial benzodiazepine receptor protein
    • Whalin, M.E., Boujrad, N., Papadopoulos, V. and Krueger, K.E. (1994) Studies on the phosphorylation of the 18 kDa mitochondrial benzodiazepine receptor protein. J. Recept. Res. 14, 217-228
    • (1994) J. Recept. Res , vol.14 , pp. 217-228
    • Whalin, M.E.1    Boujrad, N.2    Papadopoulos, V.3    Krueger, K.E.4
  • 61
    • 77952105024 scopus 로고    scopus 로고
    • Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): An emerging signaling molecule
    • Fan, J., Liu, J., Culty, M. and Papadopoulos, V. (2010) Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): An emerging signaling molecule. Prog. Lipid Res. 49, 218-234
    • (2011) Prog. Lipid Res , vol.49 , pp. 218-234
    • Fan, J.1    Liu, J.2    Culty, M.3    Papadopoulos, V.4
  • 62
    • 33845977384 scopus 로고    scopus 로고
    • Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis
    • Liu, J., Rone, M.B. and Papadopoulos, V. (2006) Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. J. Biol. Chem. 281, 38879-38893
    • (2006) J. Biol. Chem , vol.281 , pp. 38879-38893
    • Liu, J.1    Rone, M.B.2    Papadopoulos, V.3
  • 63
    • 84905040926 scopus 로고    scopus 로고
    • Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein StAR via protein kinase A (PKA) signaling in hypothalamic astrocytes
    • Chen, C., Kuo, J., Wong, A. and Micevych, P. (2014) Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes. Endocrinology 155, 2976-2985
    • (2014) Endocrinology , vol.155 , pp. 2976-2985
    • Chen, C.1    Kuo, J.2    Wong, A.3    Micevych, P.4
  • 64
    • 84887995915 scopus 로고    scopus 로고
    • Gene regulation by antisense transcription
    • Pelechano, V. and Steinmetz, L.M. (2013) Gene regulation by antisense transcription. Nat. Rev. Genet. 14, 880-893
    • (2013) Nat. Rev. Genet , vol.14 , pp. 880-893
    • Pelechano, V.1    Steinmetz, L.M.2
  • 65
    • 84864015137 scopus 로고    scopus 로고
    • Transcriptional regulation of translocator protein (Tspo) via a SINE B2-mediated natural antisense transcript in MA-10 Leydig cells
    • Fan, J. and Papadopoulos, V. (2012) Transcriptional regulation of translocator protein (Tspo) via a SINE B2-mediated natural antisense transcript in MA-10 Leydig cells. Biol. Reprod. 86, 1-15
    • (2012) Biol. Reprod , vol.86 , pp. 1-15
    • Fan, J.1    Papadopoulos, V.2
  • 66
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-Activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega, R.B., Huss, J.M. and Kelly, D.P. (2000) The coactivator PGC-1 cooperates with peroxisome proliferator-Activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20, 1868-1876
    • (2000) Mol. Cell. Biol , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 67
    • 0035501659 scopus 로고    scopus 로고
    • Peripheral-Type benzodiazepine receptor levels correlate with the ability of human breast cancer MDA-MB-231 cell line to grow in SCID mice
    • Hardwick, M., Rone, J., Han, Z., Haddad, B. and Papadopoulos, V. (2001) Peripheral-Type benzodiazepine receptor levels correlate with the ability of human breast cancer MDA-MB-231 cell line to grow in SCID mice. Int. J. Cancer 94, 322-327
    • (2001) Int. J. Cancer , vol.94 , pp. 322-327
    • Hardwick, M.1    Rone, J.2    Han, Z.3    Haddad, B.4    Papadopoulos, V.5
  • 68
    • 0036286837 scopus 로고    scopus 로고
    • Effect of peroxisome proliferators on Leydig cell peripheral-Type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: Role of the peroxisome proliferator-Activator receptor alpha
    • Gazouli, M., Yao, Z.X., Boujrad, N., Corton, J.C., Culty, M. and Papadopoulos, V. (2002) Effect of peroxisome proliferators on Leydig cell peripheral-Type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: role of the peroxisome proliferator-Activator receptor alpha. Endocrinology 143, 2571-2583
    • (2002) Endocrinology , vol.143 , pp. 2571-2583
    • Gazouli, M.1    Yao, Z.X.2    Boujrad, N.3    Corton, J.C.4    Culty, M.5    Papadopoulos, V.6
  • 69
    • 0034457745 scopus 로고    scopus 로고
    • The peroxisome proliferator perfluorodecanoic acid inhibits the peripheral-Type benzodiazepine receptor (PBR) expression and hormone-stimulated mitochondrial cholesterol transport and steroid formation in Leydig cells
    • Boujrad, N., Vidic, B., Gazouli, M., Culty, M. and Papadopoulos, V. (2000) The peroxisome proliferator perfluorodecanoic acid inhibits the peripheral-Type benzodiazepine receptor (PBR) expression and hormone-stimulated mitochondrial cholesterol transport and steroid formation in Leydig cells. Endocrinology 141, 3137-3148
    • (2000) Endocrinology , vol.141 , pp. 3137-3148
    • Boujrad, N.1    Vidic, B.2    Gazouli, M.3    Culty, M.4    Papadopoulos, V.5
  • 70
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-Talk with transcription factors NF-kappaB and AP-1
    • Delerive, P., Bosscher, K., Besnard, S., Berghe, W., Peters, J.M., Gonzalez, F.J., Fruchart, J.C., Tedgui, A., Haegeman, G. and Staels, B. (1999) Peroxisome proliferator-Activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-Talk with transcription factors NF-kappaB and AP-1. J. Biol. Chem. 274, 32048-32054
    • (1999) J. Biol. Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    Bosscher, K.2    Besnard, S.3    Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6    Fruchart, J.C.7    Tedgui, A.8    Haegeman, G.9    Staels, B.10
  • 71
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    • Poynter, M.E. and Daynes, R.A. (1998) Peroxisome proliferator-Activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273, 32833-32841
    • (1998) J. Biol. Chem , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 73
    • 84867519027 scopus 로고    scopus 로고
    • PPARalpha as a therapeutic target in inflammation-Associated diseases
    • Gervois, P. and Mansouri, R.M. (2012) PPARalpha as a therapeutic target in inflammation-Associated diseases. Expert Opin. Ther. Targets 16, 1113-1125
    • (2012) Expert Opin. Ther. Targets , vol.16 , pp. 1113-1125
    • Gervois, P.1    Mansouri, R.M.2
  • 74
    • 0027333450 scopus 로고
    • A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport
    • Bernassau, J.M., Reversat, J.L., Ferrara, P., Caput, D. and Lefur, G. (1993) A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport. J. Mol. Graph. 11, 236-244
    • (1993) J. Mol. Graph , vol.11 , pp. 236-244
    • Bernassau, J.M.1    Reversat, J.L.2    Ferrara, P.3    Caput, D.4    Lefur, G.5
  • 75
    • 0031893596 scopus 로고    scopus 로고
    • Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a five-Transmembrane structure
    • Joseph-Liauzun, E., Delmas, P., Shire, D. and Ferrara, P. (1998) Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a five-Transmembrane structure. J. Biol. Chem. 273, 2146-2152
    • (1998) J. Biol. Chem , vol.273 , pp. 2146-2152
    • Joseph-Liauzun, E.1    Delmas, P.2    Shire, D.3    Ferrara, P.4
  • 76
    • 43849100475 scopus 로고    scopus 로고
    • Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding
    • Murail, S., Robert, J.C., Coic, Y.M., Neumann, J.M., Ostuni, M.A., Yao, Z.X., Papadopoulos, V., Jamin, N. and Lacapere, J.J. (2008) Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding. Biochim. Biophys. Acta 1778, 1375-1381
    • (2008) Biochim. Biophys. Acta , vol.1778 , pp. 1375-1381
    • Murail, S.1    Robert, J.C.2    Coic, Y.M.3    Neumann, J.M.4    Ostuni, M.A.5    Yao, Z.X.6    Papadopoulos, V.7    Jamin, N.8    Lacapere, J.J.9
  • 77
    • 0034008139 scopus 로고    scopus 로고
    • TspO of rhodobacter sphaeroides A structural and functional model for the mammalian peripheral benzodiazepine receptor
    • Yeliseev, A.A. and Kaplan, S. (2000) TspO of rhodobacter sphaeroides. A structural and functional model for the mammalian peripheral benzodiazepine receptor. J. Biol. Chem. 275, 5657-5667
    • (2000) J. Biol. Chem , vol.275 , pp. 5657-5667
    • Yeliseev, A.A.1    Kaplan, S.2
  • 78
    • 77953560009 scopus 로고    scopus 로고
    • Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals
    • Korkhov, V.M. (2010) Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals. Structure 18, 677
    • (2011) Structure , vol.18 , pp. 677
    • Korkhov, V.M.1
  • 80
    • 84896998596 scopus 로고    scopus 로고
    • Structure of the mitochondrial translocator protein in complex with a diagnostic ligand
    • Jaremko, L., Jaremko, M., Giller, K., Becker, S. and Zweckstetter, M. (2014) Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science 343, 1363-1366
    • (2014) Science , vol.343 , pp. 1363-1366
    • Jaremko, L.1    Jaremko, M.2    Giller, K.3    Becker, S.4    Zweckstetter, M.5
  • 81
    • 84883234112 scopus 로고    scopus 로고
    • Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides
    • Li, F., Xia, Y., Meiler, J. and Ferguson-Miller, S. (2013) Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides. Biochemistry 52, 5884-5899
    • (2013) Biochemistry , vol.52 , pp. 5884-5899
    • Li, F.1    Xia, Y.2    Meiler, J.3    Ferguson-Miller, S.4
  • 82
    • 84860312483 scopus 로고    scopus 로고
    • Is there any correlation between binding and functional effects at the translocator protein (TSPO) (18 kDa)?
    • Scarf, A.M., Auman, K.M. and Kassiou, M. (2012) Is there any correlation between binding and functional effects at the translocator protein (TSPO) (18 kDa)? Curr. Mol. Med. 12, 387-397
    • (2012) Curr. Mol. Med , vol.12 , pp. 387-397
    • Scarf, A.M.1    Auman, K.M.2    Kassiou, M.3
  • 83
    • 0035970108 scopus 로고    scopus 로고
    • Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-Type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide
    • Li, H., Yao, Z., Degenhardt, B., Teper, G. and Papadopoulos, V. (2001) Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-Type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proc. Natl. Acad. Sci. U.S.A. 98, 1267-1272
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 1267-1272
    • Li, H.1    Yao, Z.2    Degenhardt, B.3    Teper, G.4    Papadopoulos, V.5
  • 86
    • 0042737939 scopus 로고    scopus 로고
    • Peripheral-Type benzodiazepine receptor: Structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis
    • Lacapere, J.J. and Papadopoulos, V. (2003) Peripheral-Type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 68, 569-585
    • (2003) Steroids , vol.68 , pp. 569-585
    • Lacapere, J.J.1    Papadopoulos, V.2
  • 87
    • 63149093649 scopus 로고    scopus 로고
    • Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression
    • Costa, B., Pini, S., Martini, C., Abelli, M., Gabelloni, P., Landi, S., Muti, M., Gesi, C., Lari, L., Cardini, A. et al. (2009) Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Psychiatr. Genet. 19, 110-111
    • (2009) Psychiatr. Genet , vol.19 , pp. 110-111
    • Costa, B.1    Pini, S.2    Martini, C.3    Abelli, M.4    Gabelloni, P.5    Landi, S.6    Muti, M.7    Gesi, C.8    Lari, L.9    Cardini, A.10
  • 89
  • 90
    • 71949088753 scopus 로고    scopus 로고
    • The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals
    • Costa, B., Pini, S., Gabelloni, P., Da Pozzo, E., Abelli, M., Lari, L., Preve, M., Lucacchini, A., Cassano, G.B. and Martini, C. (2009) The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Endocrinology 150, 5438-5445
    • (2009) Endocrinology , vol.150 , pp. 5438-5445
    • Costa, B.1    Pini, S.2    Gabelloni, P.3    Da Pozzo, E.4    Abelli, M.5    Lari, L.6    Preve, M.7    Lucacchini, A.8    Cassano, G.B.9    Martini, C.10
  • 91
    • 84923349128 scopus 로고    scopus 로고
    • Identification of a key cholesterol binding enhancement motif in translocator protein 18 kDa
    • Li, F., Liu, J., Valls, L., Hiser, C. and Ferguson-Miller, S. (2015) Identification of a key cholesterol binding enhancement motif in translocator protein 18 kDa. Biochemistry 54, 1441-1443
    • (2015) Biochemistry , vol.54 , pp. 1441-1443
    • Li, F.1    Liu, J.2    Valls, L.3    Hiser, C.4    Ferguson-Miller, S.5
  • 92
    • 84921829870 scopus 로고    scopus 로고
    • Protein structure Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism
    • Li, F., Liu, J., Zheng, Y., Garavito, R.M. and Ferguson-Miller, S. (2015) Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism. Science 347, 555-558
    • (2015) Science , vol.347 , pp. 555-558
    • Li, F.1    Liu, J.2    Zheng, Y.3    Garavito, R.M.4    Ferguson-Miller, S.5
  • 95
    • 84881426292 scopus 로고    scopus 로고
    • Influence of TSPO genotype on 11C-PBR28 standardized uptake values
    • Yoder, K.K., Nho, K., Risacher, S.L., Kim, S., Shen, L. and Saykin, A.J. (2013) Influence of TSPO genotype on 11C-PBR28 standardized uptake values. J. Nucl. Med. 54, 1320-1322
    • (2013) J. Nucl. Med , vol.54 , pp. 1320-1322
    • Yoder, K.K.1    Nho, K.2    Risacher, S.L.3    Kim, S.4    Shen, L.5    Saykin, A.J.6
  • 97
  • 98
    • 79951665862 scopus 로고    scopus 로고
    • The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
    • Miller, W.L. and Auchus, R.J. (2011) The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr. Rev. 32, 81-151
    • (2011) Endocr. Rev , vol.32 , pp. 81-151
    • Miller, W.L.1    Auchus, R.J.2
  • 99
    • 0025996448 scopus 로고
    • Regulation of steroid hormone biosynthesis Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells
    • Epstein, L.F. and Orme-Johnson, N.R. (1991) Regulation of steroid hormone biosynthesis. Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells. J. Biol. Chem. 266, 19739-19745
    • (1991) J. Biol. Chem , vol.266 , pp. 19739-19745
    • Epstein, L.F.1    Orme-Johnson, N.R.2
  • 100
    • 0028104418 scopus 로고
    • The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells Characterization of the steroidogenic acute regulatory protein StAR
    • Clark, B.J., Wells, J., King, S.R. and Stocco, D.M. (1994) The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J. Biol. Chem. 269, 28314-28322
    • (1994) J. Biol. Chem , vol.269 , pp. 28314-28322
    • Clark, B.J.1    Wells, J.2    King, S.R.3    Stocco, D.M.4
  • 101
    • 0037007628 scopus 로고    scopus 로고
    • Rapid regulation of steroidogenesis by mitochondrial protein import
    • Bose, H.S., Lingappa, V.R. and Miller, W.L. (2002) Rapid regulation of steroidogenesis by mitochondrial protein import. Nature 417, 87-91
    • (2002) Nature , vol.417 , pp. 87-91
    • Bose, H.S.1    Lingappa, V.R.2    Miller, W.L.3
  • 102
    • 0035813102 scopus 로고    scopus 로고
    • Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics
    • Petrescu, A.D., Gallegos, A.M., Okamura, Y., Strauss, III and Schroeder, F. (2001) Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics. J. Biol. Chem. 276, 36970-36982
    • (2001) J. Biol. Chem , vol.276 , pp. 36970-36982
    • Petrescu, A.D.1    Gallegos, A.M.2    Okamura, Y.3    Strauss4    Schroeder, F.5
  • 103
    • 20844451376 scopus 로고    scopus 로고
    • Peripheral-Type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria
    • Hauet, T., Liu, J., Li, H., Gazouli, M., Culty, M. and Papadopoulos, V. (2005) Peripheral-Type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. Mol. Endocrinol. 19, 540-554
    • (2005) Mol. Endocrinol , vol.19 , pp. 540-554
    • Hauet, T.1    Liu, J.2    Li, H.3    Gazouli, M.4    Culty, M.5    Papadopoulos, V.6
  • 104
    • 0027447948 scopus 로고
    • Peripheral-Type benzodiazepine/diazepam binding inhibitor receptor: Biological role in steroidogenic cell function
    • Papadopoulos, V. (1993) Peripheral-Type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr. Rev. 14, 222-240
    • (1993) Endocr. Rev , vol.14 , pp. 222-240
    • Papadopoulos, V.1
  • 105
    • 0036936614 scopus 로고    scopus 로고
    • PBR StAR and PKA: Partners in cholesterol transport in steroidogenic cells
    • Hauet, T., Liu, J., Li, H., Gazouli, M., Culty, M. and Papadopoulos, V. (2002) PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells. Endocr. Res. 28, 395-401
    • (2002) Endocr. Res , vol.28 , pp. 395-401
    • Hauet, T.1    Liu, J.2    Li, H.3    Gazouli, M.4    Culty, M.5    Papadopoulos, V.6
  • 107
    • 79953180013 scopus 로고    scopus 로고
    • Novel androstenetriol interacts with the mitochondrial translocator protein and controls steroidogenesis
    • Midzak, A., Akula, N., Lecanu, L. and Papadopoulos, V. (2011) Novel androstenetriol interacts with the mitochondrial translocator protein and controls steroidogenesis. J. Biol. Chem. 286, 9875-9887
    • (2011) J. Biol. Chem , vol.286 , pp. 9875-9887
    • Midzak, A.1    Akula, N.2    Lecanu, L.3    Papadopoulos, V.4
  • 108
    • 84940721792 scopus 로고    scopus 로고
    • Computational modeling and biological validation of novel non-steroidal ligands for the cholesterol recognition/interaction amino acid consensus (CRAC) motif of the mitochondrial translocator protein (TSPO)
    • Midzak, A.S., Akula, N., Rone, M.B. and Papadopoulos, V. (2015) Computational modeling and biological validation of novel non-steroidal ligands for the cholesterol recognition/interaction amino acid consensus (CRAC) motif of the mitochondrial translocator protein (TSPO) Pharmacol. Res. 99, 393-403
    • (2015) Pharmacol Res , vol.99 , pp. 393-403
    • Midzak, A.S.1    Akula, N.2    Rone, M.B.3    Papadopoulos, V.4
  • 109
    • 67649288976 scopus 로고    scopus 로고
    • Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states
    • Rone, M.B., Fan, J. and Papadopoulos, V. (2009) Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim. Biophys. Acta 1791, 646-658
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 646-658
    • Rone, M.B.1    Fan, J.2    Papadopoulos, V.3
  • 110
    • 84907293074 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor/translocator protein global knockout mice are viable with no effects on steroid hormone biosynthesis
    • Tu, L.N., Morohaku, K., Manna, P.R., Pelton, S.H., Butler, W.R., Stocco, D.M. and Selvaraj, V. (2014) Peripheral benzodiazepine receptor/translocator protein global knockout mice are viable with no effects on steroid hormone biosynthesis. J. Biol. Chem. 289, 27444-27454
    • (2014) J. Biol. Chem , vol.289 , pp. 27444-27454
    • Tu, L.N.1    Morohaku, K.2    Manna, P.R.3    Pelton, S.H.4    Butler, W.R.5    Stocco, D.M.6    Selvaraj, V.7
  • 111
    • 84931274608 scopus 로고    scopus 로고
    • Conditional steroidogenic cell-Targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation
    • Fan, J., Campioli, E., Midzak, A., Culty, M. and Papadopoulos, V. (2015) Conditional steroidogenic cell-Targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proc. Natl. Acad. Sci. U.S.A. 112, 7261-7266
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. 7261-7266
    • Fan, J.1    Campioli, E.2    Midzak, A.3    Culty, M.4    Papadopoulos, V.5
  • 113
    • 84905668746 scopus 로고    scopus 로고
    • Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype
    • Taylor, J.M., Allen, A.M. and Graham, A. (2014) Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype. Clin. Sci. 127, 603-613
    • (2014) Clin. Sci , vol.127 , pp. 603-613
    • Taylor, J.M.1    Allen, A.M.2    Graham, A.3
  • 114
    • 84955441486 scopus 로고    scopus 로고
    • Tmem178 is a negative regulator of bone homeostasis and osteoclast activation in mice and humans via a novel negative feedback loop targeting endoplasmic reticulum Ca2+ mobilization
    • Las Vegas, NV, U.S.A., 27-28 March 2015, Abstract 556
    • Decker, C. and Faccio, R. (2015) Tmem178 is a negative regulator of bone homeostasis and osteoclast activation in mice and humans via a novel negative feedback loop targeting endoplasmic reticulum Ca2+ mobilization. Orthopaedic Research Society (ORS) Annual Meeting 2015, Las Vegas, NV, U.S.A., 27-28 March 2015, Abstract 556
    • (2015) Orthopaedic Research Society (ORS) Annual Meeting 2015
    • Decker, C.1    Faccio, R.2
  • 115
    • 57449108862 scopus 로고    scopus 로고
    • The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
    • Wang, L., Wildt, K.F., Castro, E., Xiong, Y., Feigenbaum, L., Tessarollo, L. and Bosselut, R. (2008) The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity 29, 876-887
    • (2008) Immunity , vol.29 , pp. 876-887
    • Wang, L.1    Wildt, K.F.2    Castro, E.3    Xiong, Y.4    Feigenbaum, L.5    Tessarollo, L.6    Bosselut, R.7
  • 117
    • 84894546025 scopus 로고    scopus 로고
    • The mitochondrial translocator protein, TSPO, inhibits HIV-1 envelope glycoprotein biosynthesis via the endoplasmic reticulum-Associated protein degradation pathway
    • Zhou, T., Dang, Y. and Zheng, Y.H. (2014) The mitochondrial translocator protein, TSPO, inhibits HIV-1 envelope glycoprotein biosynthesis via the endoplasmic reticulum-Associated protein degradation pathway. J. Virol. 88, 3474-3784
    • (2014) J. Virol , vol.88 , pp. 3474-3784
    • Zhou, T.1    Dang, Y.2    Zheng, Y.H.3
  • 118
  • 119
    • 84896289942 scopus 로고    scopus 로고
    • PPARs integrate the mammalian clock and energy metabolism
    • Chen, L. and Yang, G. (2014) PPARs integrate the mammalian clock and energy metabolism. PPAR Res. 2014, 653017
    • (2014) PPAR Res , pp. 653017
    • Chen, L.1    Yang, G.2
  • 120
    • 66749084577 scopus 로고    scopus 로고
    • Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock
    • Yang, X., Zhang, Y.K., Esterly, N., Klaassen, C.D. and Wan, Y.J. (2009) Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock. J. Biochem. 145, 609-623
    • (2009) J. Biochem , vol.145 , pp. 609-623
    • Yang, X.1    Zhang, Y.K.2    Esterly, N.3    Klaassen, C.D.4    Wan, Y.J.5
  • 121
    • 77649138576 scopus 로고    scopus 로고
    • Circadian rhythms and metabolic syndrome: From experimental genetics to human disease
    • Maury, E., Ramsey, K.M. and Bass, J. (2010) Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ. Res. 106, 447-462
    • (2011) Circ. Res , vol.106 , pp. 447-462
    • Maury, E.1    Ramsey, K.M.2    Bass, J.3
  • 124
    • 84926173452 scopus 로고    scopus 로고
    • Induction of androgen formation in the male by a TAT-VDAC1 fusion peptide blocking 14-3-3varepsilon protein adaptor and mitochondrial VDAC1 interactions
    • Aghazadeh, Y., Martinez-Arguelles, D.B., Fan, J., Culty, M. and Papadopoulos, V. (2014) Induction of androgen formation in the male by a TAT-VDAC1 fusion peptide blocking 14-3-3varepsilon protein adaptor and mitochondrial VDAC1 interactions. Mol. Ther. 22, 1779-1791
    • (2014) Mol. Ther , vol.22 , pp. 1779-1791
    • Aghazadeh, Y.1    Martinez-Arguelles, D.B.2    Fan, J.3    Culty, M.4    Papadopoulos, V.5
  • 125
    • 84926032958 scopus 로고    scopus 로고
    • Peptide targeting of mitochondria elicits testosterone formation
    • Campanella, M. (2014) Peptide targeting of mitochondria elicits testosterone formation. Mol. Ther. 22, 1727-1729
    • (2014) Mol. Ther , vol.22 , pp. 1727-1729
    • Campanella, M.1
  • 126
    • 79959866757 scopus 로고    scopus 로고
    • Cloning and expression of the translocator protein (18 kDa), voltage-dependent anion channel, and diazepam binding inhibitor in the gonad of largemouth bass (Micropterus salmoides) across the reproductive cycle
    • Doperalski, N.J., Martyniuk, C.J., Prucha, M.S., Kroll, K.J., Denslow, N.D. and Barber, D.S. (2011) Cloning and expression of the translocator protein (18 kDa), voltage-dependent anion channel, and diazepam binding inhibitor in the gonad of largemouth bass (Micropterus salmoides) across the reproductive cycle. Gen. Comp. Endocrinol. 173, 86-95
    • (2011) Gen. Comp. Endocrinol , vol.173 , pp. 86-95
    • Doperalski, N.J.1    Martyniuk, C.J.2    Prucha, M.S.3    Kroll, K.J.4    Denslow, N.D.5    Barber, D.S.6
  • 127
    • 84860866704 scopus 로고    scopus 로고
    • Hormone-induced 14-3-3gamma adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells
    • Aghazadeh, Y., Rone, M.B., Blonder, J., Ye, X., Veenstra, T.D., Hales, D.B., Culty, M. and Papadopoulos, V. (2012) Hormone-induced 14-3-3gamma adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells. J. Biol. Chem. 287, 15380-15394
    • (2012) J. Biol. Chem , vol.287 , pp. 15380-15394
    • Aghazadeh, Y.1    Rone, M.B.2    Blonder, J.3    Ye, X.4    Veenstra, T.D.5    Hales, D.B.6    Culty, M.7    Papadopoulos, V.8
  • 128
    • 84903521989 scopus 로고    scopus 로고
    • Vitro effect of FGIN-1-27, a ligand to 18 kDa mitochondrial translocator protein, in human osteoblast-like cells
    • Rosenberg, N., Rosenberg, O., Weizman, A., Veenman, L. and Gavish, M. (2014) In vitro effect of FGIN-1-27, a ligand to 18 kDa mitochondrial translocator protein, in human osteoblast-like cells. J. Bioenerg. Biomembr. 46, 197-204
    • (2014) J. Bioenerg. Biomembr , vol.46 , pp. 197-204
    • Rosenberg, N.1    Rosenberg, O.2    Weizman, A.3    Veenman, L.4    Gavish, M.5
  • 129
    • 84881318539 scopus 로고    scopus 로고
    • Vitro catabolic effect of protoporphyrin IX in human osteoblast-like cells: Possible role of the 18 kDa mitochondrial translocator protein
    • Rosenberg, N., Rosenberg, O., Weizman, A., Veenman, L. and Gavish, M. (2013) In vitro catabolic effect of protoporphyrin IX in human osteoblast-like cells: possible role of the 18 kDa mitochondrial translocator protein. J. Bioenerg. Biomembr. 45, 333-341
    • (2013) J. Bioenerg. Biomembr , vol.45 , pp. 333-341
    • Rosenberg, N.1    Rosenberg, O.2    Weizman, A.3    Veenman, L.4    Gavish, M.5
  • 131
    • 40549107751 scopus 로고    scopus 로고
    • Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain
    • Amitani, M., Ohashi, A., Hatazawa, J., Gee, A. and Inoue, O. (2008) Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain. Synapse 62, 253-258
    • (2008) Synapse , vol.62 , pp. 253-258
    • Amitani, M.1    Ohashi, A.2    Hatazawa, J.3    Gee, A.4    Inoue, O.5
  • 132
    • 84860341342 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1
    • Joo, H.K., Lee, Y.R., Lim, S.Y., Lee, E.J., Choi, S., Cho, E.J., Park, M.S., Ryoo, S., Park, J.B. and Jeon, B.H. (2012) Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1. FEBS Lett. 586, 1349-1355
    • (2012) FEBS Lett , vol.586 , pp. 1349-1355
    • Joo, H.K.1    Lee, Y.R.2    Lim, S.Y.3    Lee, E.J.4    Choi, S.5    Cho, E.J.6    Park, M.S.7    Ryoo, S.8    Park, J.B.9    Jeon, B.H.10
  • 134
    • 84859747227 scopus 로고    scopus 로고
    • Voltage-dependant anion channels: Novel insights into isoform function through genetic models
    • Raghavan, A., Sheiko, T., Graham, B.H. and Craigen, W.J. (2012) Voltage-dependant anion channels: novel insights into isoform function through genetic models. Biochim. Biophys. Acta 1818, 1477-1485
    • (2012) Biochim. Biophys. Acta , vol.1818 , pp. 1477-1485
    • Raghavan, A.1    Sheiko, T.2    Graham, B.H.3    Craigen, W.J.4
  • 135
    • 0029001681 scopus 로고
    • Expression of peripheral-Type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: Relationship to cell proliferation
    • Miettinen, H., Kononen, J., Haapasalo, H., Helen, P., Sallinen, P., Harjuntausta, T., Helin, H. and Alho, H. (1995) Expression of peripheral-Type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation. Cancer Res. 55, 2691-2695
    • (1995) Cancer Res , vol.55 , pp. 2691-2695
    • Miettinen, H.1    Kononen, J.2    Haapasalo, H.3    Helen, P.4    Sallinen, P.5    Harjuntausta, T.6    Helin, H.7    Alho, H.8
  • 139
    • 0034257080 scopus 로고    scopus 로고
    • Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines
    • Beinlich, A., Strohmeier, R., Kaufmann, M. and Kuhl, H. (2000) Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines. Biochem. Pharmacol. 60, 397-402
    • (2000) Biochem. Pharmacol , vol.60 , pp. 397-402
    • Beinlich, A.1    Strohmeier, R.2    Kaufmann, M.3    Kuhl, H.4
  • 140
    • 1642334068 scopus 로고    scopus 로고
    • Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival
    • Galiegue, S., Casellas, P., Kramar, A., Tinel, N. and Simony-Lafontaine, J. (2004) Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival. Clin. Cancer Res. 10, 2058-2064
    • (2004) Clin. Cancer Res , vol.10 , pp. 2058-2064
    • Galiegue, S.1    Casellas, P.2    Kramar, A.3    Tinel, N.4    Simony-Lafontaine, J.5
  • 141
    • 0036888292 scopus 로고    scopus 로고
    • Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells
    • Sutter, A.P., Maaser, K., Hopfner, M., Barthel, B., Grabowski, P., Faiss, S., Carayon, P., Zeitz, M. and Scherubl, H. (2002) Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells. Int. J. Cancer 102, 318-327
    • (2002) Int. J. Cancer , vol.102 , pp. 318-327
    • Sutter, A.P.1    Maaser, K.2    Hopfner, M.3    Barthel, B.4    Grabowski, P.5    Faiss, S.6    Carayon, P.7    Zeitz, M.8    Scherubl, H.9
  • 142
    • 0034027974 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor in human endometrium and endometrial carcinoma
    • Batra, S. and Iosif, C.S. (2000) Peripheral benzodiazepine receptor in human endometrium and endometrial carcinoma. Anticancer Res. 20, 463-466
    • (2000) Anticancer Res , vol.20 , pp. 463-466
    • Batra, S.1    Iosif, C.S.2
  • 144
    • 80055083184 scopus 로고    scopus 로고
    • Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands
    • Owen, D.R. and Matthews, P.M. (2011) Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands. Int. Rev. Neurobiol. 101, 19-39
    • (2011) Int. Rev. Neurobiol , vol.101 , pp. 19-39
    • Owen, D.R.1    Matthews, P.M.2
  • 145
    • 84902192302 scopus 로고    scopus 로고
    • Inflammation and its resolution as determinants of acute coronary syndromes
    • Libby, P., Tabas, I., Fredman, G. and Fisher, E.A. (2014) Inflammation and its resolution as determinants of acute coronary syndromes. Circ. Res. 114, 1867-1879
    • (2014) Circ. Res , vol.114 , pp. 1867-1879
    • Libby, P.1    Tabas, I.2    Fredman, G.3    Fisher, E.A.4
  • 146
    • 84866947090 scopus 로고    scopus 로고
    • Evaluation of age-related changes in translocator protein (TSPO human brain using 11)C-[R]-PK11195 PET
    • Kumar, A., Muzik, O., Shandal, V., Chugani, D., Chakraborty, P. and Chugani, H.T. (2012) Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET. J. Neuroinflammation 9, 232
    • (2012) J. Neuroinflammation , vol.9 , pp. 232
    • Kumar, A.1    Muzik, O.2    Shandal, V.3    Chugani, D.4    Chakraborty, P.5    Chugani, H.T.6
  • 148
    • 84866291187 scopus 로고    scopus 로고
    • Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [1 1)C]DAA1106
    • Yasuno, F., Kosaka, J., Ota, M., Higuchi, M., Ito, H., Fujimura, Y., Nozaki, S., Takahashi, S., Mizukami, K., Asada, T. and Suhara, T. (2012) Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [(1)(1)C]DAA1106. Psychiatry Res. 203, 67-74
    • (2012) Psychiatry Res , vol.203 , pp. 67-74
    • Yasuno, F.1    Kosaka, J.2    Ota, M.3    Higuchi, M.4    Ito, H.5    Fujimura, Y.6    Nozaki, S.7    Takahashi, S.8    Mizukami, K.9    Asada, T.10    Suhara, T.11
  • 151
    • 84860882049 scopus 로고    scopus 로고
    • Longitudinal and parallel monitoring of neuroinflammation and neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease
    • Maia, S., Arlicot, N., Vierron, E., Bodard, S., Vergote, J., Guilloteau, D. and Chalon, S. (2012) Longitudinal and parallel monitoring of neuroinflammation and neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease. Synapse 66, 573-583
    • (2012) Synapse , vol.66 , pp. 573-583
    • Maia, S.1    Arlicot, N.2    Vierron, E.3    Bodard, S.4    Vergote, J.5    Guilloteau, D.6    Chalon, S.7
  • 154
    • 84864582802 scopus 로고    scopus 로고
    • Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [11 C]vinpocetine
    • Gulyas, B., Toth, M., Schain, M., Airaksinen, A., Vas, A., Kostulas, K., Lindstrom, P., Hillert, J. and Halldin, C. (2012) Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [((11))C]vinpocetine. J. Neurol. Sci. 320, 110-117
    • (2012) J. Neurol. Sci , vol.320 , pp. 110-117
    • Gulyas, B.1    Toth, M.2    Schain, M.3    Airaksinen, A.4    Vas, A.5    Kostulas, K.6    Lindstrom, P.7    Hillert, J.8    Halldin, C.9
  • 158
    • 84871318150 scopus 로고    scopus 로고
    • TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation
    • Zhao, Y.Y., Yu, J.Z., Li, Q.Y., Ma, C.G., Lu, C.Z. and Xiao, B.G. (2011) TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation. Neuron. Glia Biol. 7, 187-197
    • (2011) Neuron. Glia Biol , vol.7 , pp. 187-197
    • Zhao, Y.Y.1    Yu, J.Z.2    Li, Q.Y.3    Ma, C.G.4    Lu, C.Z.5    Xiao, B.G.6
  • 160
    • 0042074645 scopus 로고
    • Porphyrins are endogenous ligands for the mitochondrial (peripheral-Type) benzodiazepine receptor
    • Verma, A., Nye, J.S. and Snyder, S.H. (1987) Porphyrins are endogenous ligands for the mitochondrial (peripheral-Type) benzodiazepine receptor. Proc. Natl. Acad. Sci. U.S.A. 84, 2256-2260
    • (1987) Proc. Natl. Acad. Sci. U.S.A , vol.84 , pp. 2256-2260
    • Verma, A.1    Nye, J.S.2    Snyder, S.H.3
  • 161
    • 0027960574 scopus 로고
    • An endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone
    • Pastorino, J.G., Simbula, G., Gilfor, E., Hoek, J.B., Farber, J.L. and Protoporphyrin, I.X. (1994) An endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone. J. Biol. Chem. 269, 31041-31046
    • (1994) J. Biol. Chem , vol.269 , pp. 31041-31046
    • Pastorino, J.G.1    Simbula, G.2    Gilfor, E.3    Hoek, J.B.4    Farber, J.L.5    Protoporphyrin, I.X.6
  • 163
    • 77955343273 scopus 로고    scopus 로고
    • Ca2+-dependent autophagy is enhanced by the pharmacological agent PK: Pharmacological tools in autophagy
    • Gastaldello, A., Callaghan, H., Gami, P. and Campanella, M. (2010) Ca2+-dependent autophagy is enhanced by the pharmacological agent PK: pharmacological tools in autophagy. Autophagy 6, 607-613
    • (2011) Autophagy , vol.6 , pp. 607-613
    • Gastaldello, A.1    Callaghan, H.2    Gami, P.3    Campanella, M.4
  • 164
    • 0020533010 scopus 로고
    • Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide II vivo studies
    • Fur, G., Guilloux, F., Rufat, P., Benavides, J., Uzan, A., Renault, C., Dubroeucq, M.C. and Gueremy, C. (1983) Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies. Life Sci. 32, 1849-1856
    • (1983) Life Sci , vol.32 , pp. 1849-1856
    • Fur, G.1    Guilloux, F.2    Rufat, P.3    Benavides, J.4    Uzan, A.5    Renault, C.6    Dubroeucq, M.C.7    Gueremy, C.8
  • 165
    • 0036176076 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptors and mitochondrial function
    • Casellas, P., Galiegue, S. and Basile, A.S. (2002) Peripheral benzodiazepine receptors and mitochondrial function. Neurochem. Int. 40, 475-486
    • (2002) Neurochem. Int , vol.40 , pp. 475-486
    • Casellas, P.1    Galiegue, S.2    Basile, A.S.3
  • 166
    • 0026806389 scopus 로고
    • 2-Aryl-3-indoleacetamides (FGIN-1): A new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)
    • Romeo, E., Auta, J., Kozikowski, A.P., Ma, D., Papadopoulos, V., Puia, G., Costa, E. and Guidotti, A. (1992) 2-Aryl-3-indoleacetamides (FGIN-1): A new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J. Pharmacol. Exp. Ther. 262, 971-978
    • (1992) J. Pharmacol. Exp. Ther , vol.262 , pp. 971-978
    • Romeo, E.1    Auta, J.2    Kozikowski, A.P.3    Ma, D.4    Papadopoulos, V.5    Puia, G.6    Costa, E.7    Guidotti, A.8
  • 167
    • 0035164240 scopus 로고    scopus 로고
    • Synthesis and preliminary behavioural evaluation in mice of new 3-Aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43
    • Guillon, J., Boulouard, M., Lelong, V., Dallemagne, P., Rault, S. and Jarry, C. (2001) Synthesis and preliminary behavioural evaluation in mice of new 3-Aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43. J. Pharm. Pharmacol. 53, 1561-1568
    • (2001) J. Pharm. Pharmacol , vol.53 , pp. 1561-1568
    • Guillon, J.1    Boulouard, M.2    Lelong, V.3    Dallemagne, P.4    Rault, S.5    Jarry, C.6
  • 169
    • 84911960848 scopus 로고    scopus 로고
    • Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-diethyl-2-(4-(2-[F]fluoroethoxy)phenyl)pyrazolo[1,5-A]pyrimidin-3-yl)-N,N-diethylacetamide ([F]VUIIS1008 glioma
    • Tang, D., Nickels, M.L., Tantawy, M.N., Buck, J.R. and Manning, H.C. (2014) Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-diethyl-2-(4-(2-[F]fluoroethoxy)phenyl)pyrazolo[1,5-A]pyrimidin-3-yl)-N,N-diethylacetamide ([F]VUIIS1008) in glioma. Mol. Imaging Biol. 16, 813-820
    • (2014) Mol. Imaging Biol , vol.16 , pp. 813-820
    • Tang, D.1    Nickels, M.L.2    Tantawy, M.N.3    Buck, J.R.4    Manning, H.C.5
  • 170
    • 84937524245 scopus 로고    scopus 로고
    • The changing landscape in translocator protein (TSPO) function
    • Selvaraj, V. and Stocco, D.M. (2015) The changing landscape in translocator protein (TSPO) function. Trends Endocrinol. Metab. 26, 341-348
    • (2015) Trends Endocrinol. Metab , vol.26 , pp. 341-348
    • Selvaraj, V.1    Stocco, D.M.2
  • 171
    • 84941549562 scopus 로고    scopus 로고
    • Neuroprotective effects of a novel translocator protein (18 kDa) ligand, ZBD-2, against focal cerebral ischemia in vivo and NMDA-induced neurotoxicity in vitro
    • Li, X.B., Guo, H.L., Shi, T.Y., Yang, L., Wang, M., Zhang, K., Guo, Y.Y., Wu, Y.M., Liu, S.B. and Zhao, M.G. (2015) Neuroprotective effects of a novel translocator protein (18 kDa) ligand, ZBD-2, against focal cerebral ischemia in vivo and NMDA-induced neurotoxicity in vitro. Clin. Exp. Pharmacol. Physiol. 42, 1068-1074
    • (2015) Clin. Exp. Pharmacol. Physiol , vol.42 , pp. 1068-1074
    • Li, X.B.1    Guo, H.L.2    Shi, T.Y.3    Yang, L.4    Wang, M.5    Zhang, K.6    Guo, Y.Y.7    Wu, Y.M.8    Liu, S.B.9    Zhao, M.G.10
  • 172
    • 84938333516 scopus 로고    scopus 로고
    • Therapeutic actions of translocator protein (18kDa) ligands in experimental models of psychiatric disorders and neurodegenerative diseases
    • Arbo, B.D., Benetti, F., Garcia-Segura, L.M. and Ribeiro, M.F. (2015) Therapeutic actions of translocator protein (18kDa) ligands in experimental models of psychiatric disorders and neurodegenerative diseases. J. Steroid Biochem. Mol. Biol. 154, 68-74
    • (2015) J. Steroid Biochem. Mol. Biol , vol.154 , pp. 68-74
    • Arbo, B.D.1    Benetti, F.2    Garcia-Segura, L.M.3    Ribeiro, M.F.4
  • 174
    • 77951646609 scopus 로고    scopus 로고
    • 4'-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats
    • Xiao, J., Liang, D., Zhang, H., Liu, Y., Li, F. and Chen, Y.H. (2010) 4'-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats. Exp. Biol. Med. 235, 478-486
    • (2011) Exp. Biol. Med , vol.235 , pp. 478-486
    • Xiao, J.1    Liang, D.2    Zhang, H.3    Liu, Y.4    Li, F.5    Chen, Y.H.6
  • 176
    • 84926671031 scopus 로고    scopus 로고
    • Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain
    • Wang, D.S., Tian, Z., Guo, Y.Y., Guo, H.L., Kang, W.B., Li, S., Den, Y.T., Li, X.B., Feng, B., Feng, D. et al. (2015) Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain. Mol. pain 11, 16
    • (2015) Mol. Pain , vol.11 , pp. 16
    • Wang, D.S.1    Tian, Z.2    Guo, Y.Y.3    Guo, H.L.4    Kang, W.B.5    Li, S.6    Den, Y.T.7    Li, X.B.8    Feng, B.9    Feng, D.10
  • 177
    • 84903780264 scopus 로고    scopus 로고
    • Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis
    • Miao, Y.L., Guo, W.Z., Shi, W.Z., Fang, W.W., Liu, Y., Liu, J., Li, B.W., Wu, W. and Li, Y.F. (2014) Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis. PLoS One 9, e101450
    • (2014) PLoS One , vol.9 , pp. e101450
    • Miao, Y.L.1    Guo, W.Z.2    Shi, W.Z.3    Fang, W.W.4    Liu, Y.5    Liu, J.6    Li, B.W.7    Wu, W.8    Li, Y.F.9
  • 178
    • 84930252571 scopus 로고    scopus 로고
    • Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-Traumatic stress disorder
    • Zhang, L.M., Qiu, Z.K., Zhao, N., Chen, H.X., Liu, Y.Q., Xu, J.P., Zhang, Y.Z., Yang, R.F. and Li, Y.F. (2014) Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-Traumatic stress disorder. Int. J. Neuropsychopharmacol. 17, 1659-1669
    • (2014) Int. J. Neuropsychopharmacol , vol.17 , pp. 1659-1669
    • Zhang, L.M.1    Qiu, Z.K.2    Zhao, N.3    Chen, H.X.4    Liu, Y.Q.5    Xu, J.P.6    Zhang, Y.Z.7    Yang, R.F.8    Li, Y.F.9
  • 179
  • 180
    • 56149111067 scopus 로고    scopus 로고
    • The effect of oxygenation level on cerebral post-Traumatic apoptotsis is modulated by the 18-kDa translocator protein (also known as peripheral-Type benzodiazepine receptor) in a rat model of cortical contusion
    • Soustiel, J.F., Palzur, E., Vlodavsky, E., Veenman, L. and Gavish, M. (2008) The effect of oxygenation level on cerebral post-Traumatic apoptotsis is modulated by the 18-kDa translocator protein (also known as peripheral-Type benzodiazepine receptor) in a rat model of cortical contusion. Neuropathol. Appl. Neurobiol. 34, 412-423
    • (2008) Neuropathol. Appl. Neurobiol , vol.34 , pp. 412-423
    • Soustiel, J.F.1    Palzur, E.2    Vlodavsky, E.3    Veenman, L.4    Gavish, M.5
  • 181
    • 84877937811 scopus 로고    scopus 로고
    • Cardioprotection by the TSPO ligand 4'-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion
    • Paradis, S., Leoni, V., Caccia, C., Berdeaux, A. and Morin, D. (2013) Cardioprotection by the TSPO ligand 4'-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion. Cardiovasc. Res. 98, 420-427
    • (2013) Cardiovasc. Res , vol.98 , pp. 420-427
    • Paradis, S.1    Leoni, V.2    Caccia, C.3    Berdeaux, A.4    Morin, D.5
  • 185
    • 56149099254 scopus 로고    scopus 로고
    • The 18-kDa translocator protein, formerly known as the peripheral-Type benzodiazepine receptor, confers proapoptotic and antineoplastic effects in a human colorectal cancer cell line
    • Shoukrun, R., Veenman, L., Shandalov, Y., Leschiner, S., Spanier, I., Karry, R., Katz, Y., Weisinger, G., Weizman, A. and Gavish, M. (2008) The 18-kDa translocator protein, formerly known as the peripheral-Type benzodiazepine receptor, confers proapoptotic and antineoplastic effects in a human colorectal cancer cell line. Pharmacogenet. Genomics 18, 977-988
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 977-988
    • Shoukrun, R.1    Veenman, L.2    Shandalov, Y.3    Leschiner, S.4    Spanier, I.5    Karry, R.6    Katz, Y.7    Weisinger, G.8    Weizman, A.9    Gavish, M.10
  • 186
    • 84872694582 scopus 로고    scopus 로고
    • The upregulation of translocator protein (18 kDa) promotes recovery from neuropathic pain in rats
    • Wei, X.H., Wei, X., Chen, F.Y., Zang, Y., Xin, W.J., Pang, R.P., Chen, Y., Wang, J., Li, Y.Y., Shen, K.F. et al. (2013) The upregulation of translocator protein (18 kDa) promotes recovery from neuropathic pain in rats. J. Neurosci. 33, 1540-1551
    • (2013) J. Neurosci , vol.33 , pp. 1540-1551
    • Wei, X.H.1    Wei, X.2    Chen, F.Y.3    Zang, Y.4    Xin, W.J.5    Pang, R.P.6    Chen, Y.7    Wang, J.8    Li, Y.Y.9    Shen, K.F.10
  • 187
    • 0042020058 scopus 로고    scopus 로고
    • Ligands of the peripheral benzodiazepine receptor have therapeutic effects in pneumopathies in vivo
    • Bribes, E., Bourrie, B. and Casellas, P. (2003) Ligands of the peripheral benzodiazepine receptor have therapeutic effects in pneumopathies in vivo. Immunol. Lett. 88, 241-247
    • (2003) Immunol. Lett , vol.88 , pp. 241-247
    • Bribes, E.1    Bourrie, B.2    Casellas, P.3
  • 188
    • 4143123246 scopus 로고    scopus 로고
    • Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand
    • Kita, A., Kohayakawa, H., Kinoshita, T., Ochi, Y., Nakamichi, K., Kurumiya, S., Furukawa, K. and Oka, M. (2004) Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br. J. Pharmacol. 142, 1059-1072
    • (2004) Br. J. Pharmacol , vol.142 , pp. 1059-1072
    • Kita, A.1    Kohayakawa, H.2    Kinoshita, T.3    Ochi, Y.4    Nakamichi, K.5    Kurumiya, S.6    Furukawa, K.7    Oka, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.