메뉴 건너뛰기




Volumn 12, Issue 4, 2012, Pages 387-397

Is there any correlation between binding and functional effects at the translocator protein (TSPO) (18 kDa)?

Author keywords

Apoptosis; Multiple binding sites; Neuroprotection; Radioligand binding; Steroidogenesis; Translocator protein (TSPO)

Indexed keywords

4' CHLORODIAZEPAM; CENTRAL NERVOUS SYSTEM AGENTS; DAA 1106; DPA 713; EMAPUNIL; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PBR 06; PBR 111; PBR 28; PROTEIN; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84860312483     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524011207040387     Document Type: Article
Times cited : (26)

References (110)
  • 1
    • 61449203017 scopus 로고    scopus 로고
    • The translocator protein (18 kDa): Central nervous system disease and drug design
    • Scarf AM, Ittner LM, Kassiou M. The translocator protein (18 kDa): Central nervous system disease and drug design. J Med Chem 2009; 52: 581-92.
    • (2009) J Med Chem , vol.52 , pp. 581-592
    • Scarf, A.M.1    Ittner, L.M.2    Kassiou, M.3
  • 2
    • 78650234355 scopus 로고    scopus 로고
    • Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state
    • Choi J, Ifuku M, Noda M, Guilarte TR. Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state. Glia 2011; 59: 219-30.
    • (2011) Glia , vol.59 , pp. 219-230
    • Choi, J.1    Ifuku, M.2    Noda, M.3    Guilarte, T.R.4
  • 3
    • 0344110538 scopus 로고    scopus 로고
    • Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease
    • Messmer K, Reynolds GP. Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease. Neurosci Lett 1998; 241: 53-6.
    • (1998) Neurosci Lett , vol.241 , pp. 53-56
    • Messmer, K.1    Reynolds, G.P.2
  • 4
    • 59049090545 scopus 로고    scopus 로고
    • A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and agematched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system
    • Gulyás B, Makkai B, Kása P, et al. A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and agematched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system. Neurochem Int 2009; 54: 28-36.
    • (2009) Neurochem Int , vol.54 , pp. 28-36
    • Gulyás, B.1    Makkai, B.2    Kása, P.3
  • 5
    • 0033768486 scopus 로고    scopus 로고
    • The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity
    • Banati R, Newcombe J, Gunn R, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000; 123: 2321-37.
    • (2000) Brain , vol.123 , pp. 2321-2337
    • Banati, R.1    Newcombe, J.2    Gunn, R.3
  • 6
    • 77954362213 scopus 로고    scopus 로고
    • The development of PET radioligands for imaging the translocator protein (18 kDa): What have we learned?
    • Luus C, Hanani R, Reynolds A, Kassiou M. The development of PET radioligands for imaging the translocator protein (18 kDa): What have we learned? J Labelled Comp Rad 2010; 53: 501-510.
    • (2010) J Labelled Comp Rad , vol.53 , pp. 501-510
    • Luus, C.1    Hanani, R.2    Reynolds, A.3    Kassiou, M.4
  • 7
    • 0038307374 scopus 로고    scopus 로고
    • Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography
    • Versijpt J, Dumont F, Van Laere K, et al. Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. Eur Neurol 2003; 50: 39-47.
    • (2003) Eur Neurol , vol.50 , pp. 39-47
    • Versijpt, J.1    Dumont, F.2    van Laere, K.3
  • 8
    • 33745637954 scopus 로고    scopus 로고
    • Microglial activation correlates with severity in Huntington disease: A clinical and PET study
    • Pavese N, Gerhard A, Tai YF, et al. Microglial activation correlates with severity in Huntington disease: A clinical and PET study. Neurology 2006; 66: 1638-43.
    • (2006) Neurology , vol.66 , pp. 1638-1643
    • Pavese, N.1    Gerhard, A.2    Tai, Y.F.3
  • 9
    • 30744472146 scopus 로고    scopus 로고
    • In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
    • Gerhard A, Pavese N, Hotton G, et al. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 2006; 21: 404-12.
    • (2006) Neurobiol Dis , vol.21 , pp. 404-412
    • Gerhard, A.1    Pavese, N.2    Hotton, G.3
  • 11
    • 70349386259 scopus 로고    scopus 로고
    • Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography
    • Dolle F, Luus C, Reynolds A, Kassiou M. Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography. Curr Med Chem 2009; 16: 2899-923.
    • (2009) Curr Med Chem , vol.16 , pp. 2899-2923
    • Dolle, F.1    Luus, C.2    Reynolds, A.3    Kassiou, M.4
  • 12
    • 79955752123 scopus 로고    scopus 로고
    • The translocator protein
    • Scarf AM, Kassiou M. The translocator protein. J Nucl Med 2011; 52: 677-80.
    • (2011) J Nucl Med , vol.52 , pp. 677-680
    • Scarf, A.M.1    Kassiou, M.2
  • 13
    • 38949137322 scopus 로고    scopus 로고
    • Platelet 18 kDa translocator protein density is reduced in depressed patients with adult separation anxiety
    • Chelli B, Pini S, Abelli M, et al. Platelet 18 kDa translocator protein density is reduced in depressed patients with adult separation anxiety. Eur Neuropsychopharmacol 2008; 18: 249-54.
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 249-254
    • Chelli, B.1    Pini, S.2    Abelli, M.3
  • 14
    • 0141992105 scopus 로고    scopus 로고
    • Decreased platelet peripheral-type benzodiazepine receptors in persistently violent schizophrenia patients
    • Ritsner M, Modai I, Gibel A, et al. Decreased platelet peripheral-type benzodiazepine receptors in persistently violent schizophrenia patients. J Psychiatr Res 2003; 37: 549-56.
    • (2003) J Psychiatr Res , vol.37 , pp. 549-556
    • Ritsner, M.1    Modai, I.2    Gibel, A.3
  • 15
    • 0042737939 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor: Structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis
    • Lacapere J-J, Papadopoulos V. Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 2003; 68: 569-85.
    • (2003) Steroids , vol.68 , pp. 569-585
    • Lacapere, J.-J.1    Papadopoulos, V.2
  • 16
    • 0026591024 scopus 로고
    • Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier
    • McEnery M, Snowman A, Trifiletti R, Snyder S. Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 1992; 89: 3170-4.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3170-3174
    • McEnery, M.1    Snowman, A.2    Trifiletti, R.3    Snyder, S.4
  • 17
    • 0030613261 scopus 로고    scopus 로고
    • The Mr 18,000 subunit of the peripheral-type benzodiazepine receptor exhibits both benzodiazepine and isoquinoline carboxamide binding sites in the absence of the voltage-dependent anion channel or of the adenine nucleotide carrier
    • Joseph-Liauzun E, Farges R, Delmas P, Ferrara P, Loison G. The Mr 18,000 subunit of the peripheral-type benzodiazepine receptor exhibits both benzodiazepine and isoquinoline carboxamide binding sites in the absence of the voltage-dependent anion channel or of the adenine nucleotide carrier. J Biol Chem 1997; 272: 28102-28106.
    • (1997) J Biol Chem , vol.272 , pp. 28102-28106
    • Joseph-Liauzun, E.1    Farges, R.2    Delmas, P.3    Ferrara, P.4    Loison, G.5
  • 18
    • 0033613834 scopus 로고    scopus 로고
    • Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor
    • Galiegue S, Jbilo O, Combes T, et al. Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. J Biol Chem 1999; 274: 2938-2952.
    • (1999) J Biol Chem , vol.274 , pp. 2938-2952
    • Galiegue, S.1    Jbilo, O.2    Combes, T.3
  • 19
    • 20844451376 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria
    • Hauet T, Yao Z-X, Bose HS, et al. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria. Mol Endocrinol 2005; 19: 540-54.
    • (2005) Mol Endocrinol , vol.19 , pp. 540-554
    • Hauet, T.1    Yao, Z.-X.2    Bose, H.S.3
  • 20
    • 0036936614 scopus 로고    scopus 로고
    • PBR, StAR, and PKA: Partners in cholesterol transport in steroidogenic cells
    • Hauet T, Liu J, Li H, Gazouli M, Culty M, Papadopoulos V. PBR, StAR, and PKA: Partners in cholesterol transport in steroidogenic cells. Endocr Res 2002; 28: 395-401.
    • (2002) Endocr Res , vol.28 , pp. 395-401
    • Hauet, T.1    Liu, J.2    Li, H.3    Gazouli, M.4    Culty, M.5    Papadopoulos, V.6
  • 21
    • 33845977384 scopus 로고    scopus 로고
    • Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis
    • Liu J, Rone MB, Papadopoulos V. Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. J Biol Chem 2006; 281: 38879-93.
    • (2006) J Biol Chem , vol.281 , pp. 38879-38893
    • Liu, J.1    Rone, M.B.2    Papadopoulos, V.3
  • 22
    • 0035207765 scopus 로고    scopus 로고
    • Identification, localization, and function in steroidogenesis of PAP7: A peripheral-type benzodiazepine receptor-and PKA (RI{alpha})-associated protein
    • Li H, Degenhardt B, Tobin D, Yao Z-x, Tasken K, Papadopoulos V. Identification, localization, and function in steroidogenesis of PAP7: A peripheral-type benzodiazepine receptor-and PKA (RI{alpha})-associated protein. Mol Endocrinol 2001; 15: 2211-28.
    • (2001) Mol Endocrinol , vol.15 , pp. 2211-2228
    • Li, H.1    Degenhardt, B.2    Tobin, D.3    Yao, Z.4    Tasken, K.5    Papadopoulos, V.6
  • 23
    • 33746035655 scopus 로고    scopus 로고
    • Translocator protein (18kDa): New nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
    • Papadopoulos V, Baraldi M, Guilarte T, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 2006; 27: 402-9.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 402-409
    • Papadopoulos, V.1    Baraldi, M.2    Guilarte, T.3
  • 24
    • 0042319697 scopus 로고
    • Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: Stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor
    • Besman M, Yanagibashi K, Lee T, Kawamura M, Hall P, Shively J. Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor. Proc Natl Acad Sci USA 1989; 86: 4897-901.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 4897-4901
    • Besman, M.1    Yanagibashi, K.2    Lee, T.3    Kawamura, M.4    Hall, P.5    Shively, J.6
  • 25
    • 0031451871 scopus 로고    scopus 로고
    • Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line
    • Papadopoulos V, Amri H, Li H, Boujrad N, Vidic B, Garnier M. Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J Biol Chem 1997; 272: 32129-35.
    • (1997) J Biol Chem , vol.272 , pp. 32129-32135
    • Papadopoulos, V.1    Amri, H.2    Li, H.3    Boujrad, N.4    Vidic, B.5    Garnier, M.6
  • 26
    • 0035118243 scopus 로고    scopus 로고
    • Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane
    • West LA, Horvat RD, Roess DA, Barisas BG, Juengel JL, Niswender GD. Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane. Endocrinology 2001; 142: 502-5.
    • (2001) Endocrinology , vol.142 , pp. 502-505
    • West, L.A.1    Horvat, R.D.2    Roess, D.A.3    Barisas, B.G.4    Juengel, J.L.5    Niswender, G.D.6
  • 27
    • 44149118198 scopus 로고    scopus 로고
    • DPA-714, a new translocator protein-specific ligand: Synthesis, radiofluorination, and pharmacologic characterization
    • James ML, Fulton RR, Vercoullie J, et al. DPA-714, a new translocator protein-specific ligand: Synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med 2008; 49: 814-22.
    • (2008) J Nucl Med , vol.49 , pp. 814-822
    • James, M.L.1    Fulton, R.R.2    Vercoullie, J.3
  • 28
    • 9544219672 scopus 로고    scopus 로고
    • Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific peripheral-type benzodiazepine receptor ligands
    • Campiani G, Nacci V, Fiorini I, et al. Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific peripheral-type benzodiazepine receptor ligands. J Med Chem 1996; 39: 3435-50.
    • (1996) J Med Chem , vol.39 , pp. 3435-3450
    • Campiani, G.1    Nacci, V.2    Fiorini, I.3
  • 29
    • 20644447107 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor binding properties and effects on steroid synthesis of two new phenoxyphenyl-acetamide derivatives, DAA1097 and DAA1106
    • Culty M, Silver P, Nakazato A, et al. Peripheral benzodiazepine receptor binding properties and effects on steroid synthesis of two new phenoxyphenyl-acetamide derivatives, DAA1097 and DAA1106. Drug Development Research 2001; 52: 475-84.
    • (2001) Drug Development Research , vol.52 , pp. 475-484
    • Culty, M.1    Silver, P.2    Nakazato, A.3
  • 30
    • 0033598378 scopus 로고    scopus 로고
    • Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: Synthesis, binding affinity, and in vivo studies
    • Trapani G, Franco M, Latrofa A, et al. Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: Synthesis, binding affinity, and in vivo studies. J Med Chem 1999; 42: 3934-41.
    • (1999) J Med Chem , vol.42 , pp. 3934-3941
    • Trapani, G.1    Franco, M.2    Latrofa, A.3
  • 31
    • 19944429835 scopus 로고    scopus 로고
    • Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands
    • Trapani G, Laquintana V, Denora N, et al. Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands. J Med Chem 2005; 48: 292-305.
    • (2005) J Med Chem , vol.48 , pp. 292-305
    • Trapani, G.1    Laquintana, V.2    Denora, N.3
  • 32
    • 0027443448 scopus 로고
    • Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex
    • Romeo E, Cavallaro S, Korneyev A, et al. Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex. J Pharmacol Exp Ther 1993; 267: 462-71.
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 462-471
    • Romeo, E.1    Cavallaro, S.2    Korneyev, A.3
  • 34
    • 0036176076 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptors and mitochondrial function
    • Casellas P, Galiegue S, Basile AS. Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int 2002; 40: 475-86.
    • (2002) Neurochem Int , vol.40 , pp. 475-486
    • Casellas, P.1    Galiegue, S.2    Basile, A.S.3
  • 35
    • 33845929203 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation
    • Li W, Hardwick MJ, Rosenthal D, Culty M, Papadopoulos V. Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation. Biochem Pharmacol 2007; 73: 491-503.
    • (2007) Biochem Pharmacol , vol.73 , pp. 491-503
    • Li, W.1    Hardwick, M.J.2    Rosenthal, D.3    Culty, M.4    Papadopoulos, V.5
  • 36
    • 0032526746 scopus 로고    scopus 로고
    • PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection
    • Hirsch T, Decaudin D, Susin SA, et al. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Exp Cell Res 1998; 241: 426-34.
    • (1998) Exp Cell Res , vol.241 , pp. 426-434
    • Hirsch, T.1    Decaudin, D.2    Susin, S.A.3
  • 37
    • 0029982148 scopus 로고    scopus 로고
    • The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition
    • Pastorino JG, Simbula G, Yamamoto K, Glascott PA, Jr., Rothman RJ, Farber JL. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. J Biol Chem 1996; 271: 29792-8.
    • (1996) J Biol Chem , vol.271 , pp. 29792-29798
    • Pastorino, J.G.1    Simbula, G.2    Yamamoto, K.3    Glascott Jr., P.A.4    Rothman, R.J.5    Farber, J.L.6
  • 38
    • 13844253854 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression
    • Hans G, Wislet-Gendebien S, Lallemend F, et al. Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression. Biochem Pharmacol 2005; 69: 819-30.
    • (2005) Biochem Pharmacol , vol.69 , pp. 819-830
    • Hans, G.1    Wislet-Gendebien, S.2    Lallemend, F.3
  • 40
    • 34548238745 scopus 로고    scopus 로고
    • Channel-like functions of the 18 kDa translocator protein (TSPO): Regulation of apoptosis and steroidogenesis as part of the host-defence response
    • Veenman L, Papadopoulos V, Gavish M. Channel-like functions of the 18 kDa translocator protein (TSPO): Regulation of apoptosis and steroidogenesis as part of the host-defence response. Curr Pharm Des 2007; 13: 2385-405.
    • (2007) Curr Pharm Des , vol.13 , pp. 2385-2405
    • Veenman, L.1    Papadopoulos, V.2    Gavish, M.3
  • 41
    • 78649687576 scopus 로고    scopus 로고
    • Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
    • Rupprecht R, Papadopoulos V, Rammes G, et al. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov 2010; 9: 971-88.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 971-988
    • Rupprecht, R.1    Papadopoulos, V.2    Rammes, G.3
  • 42
    • 0036888292 scopus 로고    scopus 로고
    • Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells
    • Sutter A, Maaser K, Höpfner M, et al. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells. Int J Cancer 2002; 102: 318-27.
    • (2002) Int J Cancer , vol.102 , pp. 318-327
    • Sutter, A.1    Maaser, K.2    Höpfner, M.3
  • 43
    • 0033810610 scopus 로고    scopus 로고
    • Cell cyclerelated expression and ligand binding of peripheral benzodiazepine receptor in human breast cancer cell lines
    • Sänger N, Strohmeier R, Kaufmann M, Kuhl H. Cell cyclerelated expression and ligand binding of peripheral benzodiazepine receptor in human breast cancer cell lines. Eur J Cancer 2000; 36: 2157-63.
    • (2000) Eur J Cancer , vol.36 , pp. 2157-2163
    • Sänger, N.1    Strohmeier, R.2    Kaufmann, M.3    Kuhl, H.4
  • 44
    • 0035977186 scopus 로고    scopus 로고
    • Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells
    • Maaser K, Hopfner M, Jansen A, et al. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer 2001; 85: 1771-80.
    • (2001) Br J Cancer , vol.85 , pp. 1771-1780
    • Maaser, K.1    Hopfner, M.2    Jansen, A.3
  • 45
    • 0033558247 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: Correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol
    • Hardwick M, Fertikh D, Culty M, Li H, Vidic B, Papadopoulos V. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: Correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res 1999; 59: 831-42.
    • (1999) Cancer Res , vol.59 , pp. 831-842
    • Hardwick, M.1    Fertikh, D.2    Culty, M.3    Li, H.4    Vidic, B.5    Papadopoulos, V.6
  • 46
    • 0025021503 scopus 로고
    • Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine
    • Ikezaki K, Black KL. Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine. Cancer Lett 1990; 49: 115-20.
    • (1990) Cancer Lett , vol.49 , pp. 115-120
    • Ikezaki, K.1    Black, K.L.2
  • 47
    • 70649091117 scopus 로고    scopus 로고
    • Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo
    • Sakai M, Ferraz-de-Paula V, Pinheiro ML, et al. Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol 2010; 626: 131-8.
    • (2010) Eur J Pharmacol , vol.626 , pp. 131-138
    • Sakai, M.1    Ferraz-de-Paula, V.2    Pinheiro, M.L.3
  • 48
    • 0025202078 scopus 로고
    • In vivo treatment with benzodiazepines inhibits murine phagocyte oxidative metabolism and production of interleukin 1, tumor necrosis factor and interleukin-6
    • Zavala F, Taupin V, Descamps-Latscha B. In vivo treatment with benzodiazepines inhibits murine phagocyte oxidative metabolism and production of interleukin 1, tumor necrosis factor and interleukin-6. J Pharmacol Exp Ther 1990; 255: 442-50.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 442-450
    • Zavala, F.1    Taupin, V.2    Descamps-Latscha, B.3
  • 49
    • 0026657226 scopus 로고
    • A physiological role for the peripheral benzodiazepine receptor on human neutrophils
    • Zavala F, Veber F, Taupin V, Nguyen A, Descamps-Latscha B. A physiological role for the peripheral benzodiazepine receptor on human neutrophils. Ann N Y Acad Sci 1992; 650: 229-33.
    • (1992) Ann N Y Acad Sci , vol.650 , pp. 229-233
    • Zavala, F.1    Veber, F.2    Taupin, V.3    Nguyen, A.4    Descamps-Latscha, B.5
  • 50
    • 0032726123 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model
    • Waterfield JD, McGeer EG, McGeer PL. The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model. Rheumatology 1999; 38: 1068-73.
    • (1999) Rheumatology , vol.38 , pp. 1068-1073
    • Waterfield, J.D.1    McGeer, E.G.2    McGeer, P.L.3
  • 51
    • 0034657024 scopus 로고    scopus 로고
    • Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions
    • Klegeris A, McGeer EG, McGeer PL. Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions. Biochem Pharmacol 2000; 59: 1305-14.
    • (2000) Biochem Pharmacol , vol.59 , pp. 1305-1314
    • Klegeris, A.1    McGeer, E.G.2    McGeer, P.L.3
  • 53
    • 17744386969 scopus 로고    scopus 로고
    • Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity
    • Veiga S, Azcoitia I, Garcia-Segura LM. Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. J Neurosci Res 2005; 80: 129-37.
    • (2005) J Neurosci Res , vol.80 , pp. 129-137
    • Veiga, S.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 54
    • 34648828256 scopus 로고    scopus 로고
    • Translocator protein (18 kDa) is involved in the regulation of reactive gliosis
    • Veiga S, Carrero P, Pernia S, Azcoitia I, Garcia-Segura L. Translocator protein (18 kDa) is involved in the regulation of reactive gliosis. Glia 2007; 55: 1426-36.
    • (2007) Glia , vol.55 , pp. 1426-1436
    • Veiga, S.1    Carrero, P.2    Pernia, S.3    Azcoitia, I.4    Garcia-Segura, L.5
  • 55
    • 26944485506 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum
    • Ryu JK, Choi HB, McLarnon JG. Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. Neurobiol Dis 2005; 20: 550-61.
    • (2005) Neurobiol Dis , vol.20 , pp. 550-561
    • Ryu, J.K.1    Choi, H.B.2    McLarnon, J.G.3
  • 56
    • 0348109489 scopus 로고    scopus 로고
    • Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: Evidence from activated microglial cells in vitro
    • Wilms H, Claasen J, Rohl C, Sievers J, Deuschl G, Lucius R. Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro. Neurobiol Dis 2003; 14: 417-24.
    • (2003) Neurobiol Dis , vol.14 , pp. 417-424
    • Wilms, H.1    Claasen, J.2    Rohl, C.3    Sievers, J.4    Deuschl, G.5    Lucius, R.6
  • 57
    • 70349742796 scopus 로고    scopus 로고
    • Neuroprotective effects of a ligand of translocator protein-18kDa (Ro5-4864) in experimental diabetic neuropathy
    • Giatti S, Pesaresi M, Cavaletti G, et al. Neuroprotective effects of a ligand of translocator protein-18kDa (Ro5-4864) in experimental diabetic neuropathy. Neuroscience 2009; 164: 520-9.
    • (2009) Neuroscience , vol.164 , pp. 520-529
    • Giatti, S.1    Pesaresi, M.2    Cavaletti, G.3
  • 58
    • 0036264571 scopus 로고    scopus 로고
    • SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4Hpyridazino[ 4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair
    • Ferzaz B, Brault E, Bourliaud G, et al. SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4Hpyridazino[ 4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J Pharmacol Exp Ther 2002; 301: 1067-78.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 1067-1078
    • Ferzaz, B.1    Brault, E.2    Bourliaud, G.3
  • 59
    • 67651117272 scopus 로고    scopus 로고
    • Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects
    • Rupprecht R, Rammes G, Eser D, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science 2009; 325: 490-3.
    • (2009) Science , vol.325 , pp. 490-493
    • Rupprecht, R.1    Rammes, G.2    Eser, D.3
  • 60
    • 0034846643 scopus 로고    scopus 로고
    • 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands
    • Selleri S, Bruni F, Costagli C, et al. 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands. Bioorg Med Chem 2001; 9: 2661-71.
    • (2001) Bioorg Med Chem , vol.9 , pp. 2661-2671
    • Selleri, S.1    Bruni, F.2    Costagli, C.3
  • 61
    • 21744438122 scopus 로고    scopus 로고
    • Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation
    • Selleri S, Gratteri P, Costagli C, et al. Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation. Bioorg Med Chem 2005; 13: 4821-34.
    • (2005) Bioorg Med Chem , vol.13 , pp. 4821-4834
    • Selleri, S.1    Gratteri, P.2    Costagli, C.3
  • 62
    • 77957577508 scopus 로고    scopus 로고
    • Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO)
    • Reynolds A, Hanani R, Hibbs D, et al. Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). Bioorg Med Chem Lett 2010; 20: 5799-802.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 5799-5802
    • Reynolds, A.1    Hanani, R.2    Hibbs, D.3
  • 63
    • 52449100136 scopus 로고    scopus 로고
    • Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis
    • Da Settimo F, Simorini F, Taliani S, et al. Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. J Med Chem 2008; 51: 5789-97.
    • (2008) J Med Chem , vol.51 , pp. 5789-5797
    • da Settimo, F.1    Simorini, F.2    Taliani, S.3
  • 64
    • 0037068436 scopus 로고    scopus 로고
    • Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR)
    • Campiani G, Ramunno A, Fiorini I, et al. Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR). J Med Chem 2002; 45: 4276-81.
    • (2002) J Med Chem , vol.45 , pp. 4276-4281
    • Campiani, G.1    Ramunno, A.2    Fiorini, I.3
  • 65
    • 0028585940 scopus 로고
    • Site-directed mutagenesis of the peripheral benzodiazepine receptor: Identification of amino acids implicated in the binding site of Ro5-4864
    • Farges R, Joseph-Liauzun E, Shire D, Caput D, Le FurG, Ferrara P. Site-directed mutagenesis of the peripheral benzodiazepine receptor: identification of amino acids implicated in the binding site of Ro5-4864. Mol Pharmacol 1994; 46: 1160-7.
    • (1994) Mol Pharmacol , vol.46 , pp. 1160-1167
    • Farges, R.1    Joseph-Liauzun, E.2    Shire, D.3    Caput, D.4    Le Fur, G.5    Ferrara, P.6
  • 66
    • 0023162093 scopus 로고
    • 3H]PK 11195 to cerebral cortex and peripheral tissues of various species: Species differences and heterogeneity in peripheral benzodiazepine binding sites
    • 3H]PK 11195 to cerebral cortex and peripheral tissues of various species: Species differences and heterogeneity in peripheral benzodiazepine binding sites. J Neurochem 1987; 49: 1407-14.
    • (1987) J Neurochem , vol.49 , pp. 1407-1414
    • Awad, M.1    Gavish, M.2
  • 67
    • 0026032902 scopus 로고
    • The bovine peripheral-type benzodiazepine receptor: A receptor with low affinity for benzodiazepines
    • Parola AL, Laird HE. The bovine peripheral-type benzodiazepine receptor: A receptor with low affinity for benzodiazepines. Life Sci 1991; 48: 757-64.
    • (1991) Life Sci , vol.48 , pp. 757-764
    • Parola, A.L.1    Laird, H.E.2
  • 68
    • 70350112559 scopus 로고    scopus 로고
    • Distribution, pharmacological characterization and function of the 18 kDa translocator protein in rat small intestine
    • Ostuni MA, Péranzi G, Ducroc RA, et al. Distribution, pharmacological characterization and function of the 18 kDa translocator protein in rat small intestine. Biol Cell 2009; 101: 573-86.
    • (2009) Biol Cell , vol.101 , pp. 573-586
    • Ostuni, M.A.1    Péranzi, G.2    Ducroc, R.A.3
  • 69
    • 0037461325 scopus 로고    scopus 로고
    • In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: Functional significance in drug ligand and cholesterol binding
    • Delavoie F, Li H, Hardwick M, et al. In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: Functional significance in drug ligand and cholesterol binding. Biochemistry (Mosc) 2003; 42: 4506-19.
    • (2003) Biochemistry (Mosc) , vol.42 , pp. 4506-4519
    • Delavoie, F.1    Li, H.2    Hardwick, M.3
  • 70
    • 0029793981 scopus 로고    scopus 로고
    • Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to Alpidem
    • Anzini M, Cappelli A, Vomero S, et al. Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to Alpidem. J Med Chem 1996; 39: 4275-84.
    • (1996) J Med Chem , vol.39 , pp. 4275-4284
    • Anzini, M.1    Cappelli, A.2    Vomero, S.3
  • 72
    • 0020533010 scopus 로고
    • Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies
    • Le FurG, Guilloux F, Rufat P, et al. Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies. Life Sci 1983; 32: 1849-56.
    • (1983) Life Sci , vol.32 , pp. 1849-1856
    • Le Fur, G.1    Guilloux, F.2    Rufat, P.3
  • 73
    • 77953560009 scopus 로고    scopus 로고
    • Threedimensional structure of TspO by electron cryomicroscopy of helical crystals
    • Korkhov VM, Sachse C, Short JM, Tate CG. Threedimensional structure of TspO by electron cryomicroscopy of helical crystals. Structure 2010; 18: 677-87.
    • (2010) Structure , vol.18 , pp. 677-687
    • Korkhov, V.M.1    Sachse, C.2    Short, J.M.3    Tate, C.G.4
  • 74
    • 0034008139 scopus 로고    scopus 로고
    • TspO of rhodobacter sphaeroides. A structural and functional model for the mammalian peripheral benzodiazepine receptor
    • Yeliseev AA, Kaplan S. TspO of rhodobacter sphaeroides. A structural and functional model for the mammalian peripheral benzodiazepine receptor. J Biol Chem 2000; 275: 5657-67.
    • (2000) J Biol Chem , vol.275 , pp. 5657-5667
    • Yeliseev, A.A.1    Kaplan, S.2
  • 75
    • 0031893596 scopus 로고    scopus 로고
    • Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a fivetransmembrane structure
    • Joseph-Liauzun E, Delmas P, Shire D, Ferrara P. Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a fivetransmembrane structure. J Biol Chem 1998; 273: 2146-52.
    • (1998) J Biol Chem , vol.273 , pp. 2146-2152
    • Joseph-Liauzun, E.1    Delmas, P.2    Shire, D.3    Ferrara, P.4
  • 76
    • 0027333450 scopus 로고
    • A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport
    • Bernassau J, Reversat J, Ferrara P, Caput D, Le Fur G. A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport. J Mol Graph 1993; 11: 236-44.
    • (1993) J Mol Graph , vol.11 , pp. 236-244
    • Bernassau, J.1    Reversat, J.2    Ferrara, P.3    Caput, D.4    Le Fur, G.5
  • 77
    • 43849100475 scopus 로고    scopus 로고
    • Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding
    • Murail S, Robert J-C, Coïc Y-M, et al. Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding. Biochim Biophys Acta 2008; 1778: 1375-81.
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 1375-1381
    • Murail, S.1    Robert, J.-C.2    Coïc, Y.-M.3
  • 79
    • 0030445907 scopus 로고    scopus 로고
    • Acute action of choriogonadotropin on Leydig tumor cells: Changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor
    • Boujrad N, Vidic B, Papadopoulos V. Acute action of choriogonadotropin on Leydig tumor cells: changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor. Endocrinology 1996; 137: 5727-30.
    • (1996) Endocrinology , vol.137 , pp. 5727-5730
    • Boujrad, N.1    Vidic, B.2    Papadopoulos, V.3
  • 80
    • 0026073663 scopus 로고
    • Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor
    • Riond J, Mattei M, Kaghad M, et al. Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. Eur J Biochem 1991; 195: 305-11.
    • (1991) Eur J Biochem , vol.195 , pp. 305-311
    • Riond, J.1    Mattei, M.2    Kaghad, M.3
  • 81
    • 0035848570 scopus 로고    scopus 로고
    • Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling
    • Anzini M, Cappelli A, Vomero S, et al. Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling J Med Chem 2001; 44: 1134-50.
    • (2001) J Med Chem , vol.44 , pp. 1134-1150
    • Anzini, M.1    Cappelli, A.2    Vomero, S.3
  • 82
    • 0021179690 scopus 로고
    • Histidine modification with diethylpyrocarbonate induces a decrease in the binding of an antagonist, PK 11195, but not of an agonist, Ro5-4864, of the peripheral benzodiazepine receptors
    • Benavides J, Begassat F, Phan T, et al. Histidine modification with diethylpyrocarbonate induces a decrease in the binding of an antagonist, PK 11195, but not of an agonist, Ro5-4864, of the peripheral benzodiazepine receptors. Life Sci 1984; 35: 1249-56.
    • (1984) Life Sci , vol.35 , pp. 1249-1256
    • Benavides, J.1    Begassat, F.2    Phan, T.3
  • 84
    • 0023611636 scopus 로고
    • Modification of the peripheral-type benzodiazepine receptor by arachidonate, diethylpyrocarbonate and thiol reagents
    • Skowronski R, Beaumont K, Fanestil DD. Modification of the peripheral-type benzodiazepine receptor by arachidonate, diethylpyrocarbonate and thiol reagents. Eur J Pharmacol 1987; 143: 305-14.
    • (1987) Eur J Pharmacol , vol.143 , pp. 305-314
    • Skowronski, R.1    Beaumont, K.2    Fanestil, D.D.3
  • 86
    • 0024408795 scopus 로고
    • Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor
    • Sprengel R, Werner P, Seeburg PH, et al. Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. J Biol Chem 1989; 264: 20415-21.
    • (1989) J Biol Chem , vol.264 , pp. 20415-20421
    • Sprengel, R.1    Werner, P.2    Seeburg, P.H.3
  • 87
    • 0021923465 scopus 로고
    • Characterization of solubilized peripheral type benzodiazepine binding sites from rat adrenals by using [3H]PK 11195, an isoquinoline carboxamide derivative
    • Benavides J, Menager J, Burgevin M, et al. Characterization of solubilized peripheral type benzodiazepine binding sites from rat adrenals by using [3H]PK 11195, an isoquinoline carboxamide derivative. Biochem Pharmacol 1985; 34: 167-70.
    • (1985) Biochem Pharmacol , vol.34 , pp. 167-170
    • Benavides, J.1    Menager, J.2    Burgevin, M.3
  • 88
    • 0027362976 scopus 로고
    • Molecular basis for the different binding properties of benzodiazepines to human and bovine peripheral-type benzodiazepine receptors
    • Farges R, Joseph-Liauzun E, Shire D, et al. Molecular basis for the different binding properties of benzodiazepines to human and bovine peripheral-type benzodiazepine receptors. FEBS Lett 1993; 335: 305-8.
    • (1993) FEBS Lett , vol.335 , pp. 305-308
    • Farges, R.1    Joseph-Liauzun, E.2    Shire, D.3
  • 89
    • 0028031729 scopus 로고
    • In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells
    • Garnier M, Dimchev AB, Boujrad N, Price JM, Musto NA, Papadopoulos V. In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol Pharmacol 1994; 45: 201-11.
    • (1994) Mol Pharmacol , vol.45 , pp. 201-211
    • Garnier, M.1    Dimchev, A.B.2    Boujrad, N.3    Price, J.M.4    Musto, N.A.5    Papadopoulos, V.6
  • 90
    • 20044376658 scopus 로고    scopus 로고
    • Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor
    • Jamin N, Neumann J-M, Ostuni MA, et al. Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor. Mol Endocrinol 2005; 19: 588-94.
    • (2005) Mol Endocrinol , vol.19 , pp. 588-594
    • Jamin, N.1    Neumann, J.-M.2    Ostuni, M.A.3
  • 91
    • 0030203123 scopus 로고    scopus 로고
    • Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: Implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse
    • Masonis AET, McCarthy MP. Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: Implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse. J Steroid Biochem Mol Biol 1996; 58: 551-5.
    • (1996) J Steroid Biochem Mol Biol , vol.58 , pp. 551-555
    • Masonis, A.E.T.1    McCarthy, M.P.2
  • 92
    • 0027981072 scopus 로고
    • Acute action of choriogonadotropin on Leydig tumor cells: Induction of a higher affinity benzodiazepine-binding site related to steroid biosynthesis
    • Boujrad N, Gaillard JL, Garnier M, Papadopoulos V. Acute action of choriogonadotropin on Leydig tumor cells: induction of a higher affinity benzodiazepine-binding site related to steroid biosynthesis. Endocrinology 1994; 135: 1576-83.
    • (1994) Endocrinology , vol.135 , pp. 1576-1583
    • Boujrad, N.1    Gaillard, J.L.2    Garnier, M.3    Papadopoulos, V.4
  • 93
    • 0029026911 scopus 로고
    • Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis
    • Papadopoulos V, Brown AS. Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis. J Steroid Biochem Mol Biol 1995; 53: 103-10.
    • (1995) J Steroid Biochem Mol Biol , vol.53 , pp. 103-110
    • Papadopoulos, V.1    Brown, A.S.2
  • 94
    • 73749087636 scopus 로고    scopus 로고
    • 11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker
    • 11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker. Neuroimage 2010; 49: 2924-32.
    • (2010) Neuroimage , vol.49 , pp. 2924-2932
    • Kreisl, W.C.1    Fujita, M.2    Fujimura, Y.3
  • 95
    • 77956263860 scopus 로고    scopus 로고
    • Two binding sites for [3H]PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation
    • Owen DR, Howell OW, Tang S-P, et al. Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation. J Cereb Blood Flow Metab 2010; 30: 1608-18.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1608-1618
    • Owen, D.R.1    Howell, O.W.2    Tang, S.-P.3
  • 96
    • 37849018674 scopus 로고    scopus 로고
    • 11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors
    • 11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors. Neuroimage 2008; 39: 1289-98.
    • (2008) Neuroimage , vol.39 , pp. 1289-1298
    • Imaizumi, M.1    Briard, E.2    Zoghbi, S.S.3
  • 97
    • 30044447326 scopus 로고    scopus 로고
    • Peripheral benzodiazepine receptor: Characterization in human T-lymphoma Jurkat cells
    • Costa B, Salvetti A, Rossi L, et al. Peripheral benzodiazepine receptor: Characterization in human T-lymphoma Jurkat cells. Mol Pharmacol 2006; 69: 37-44.
    • (2006) Mol Pharmacol , vol.69 , pp. 37-44
    • Costa, B.1    Salvetti, A.2    Rossi, L.3
  • 98
    • 79851473610 scopus 로고    scopus 로고
    • Mixed-affinity binding in humans with 18-kDa translocator protein ligands
    • Owen DRJ, Gunn RN, Rabiner EA, et al. Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med 2011; 52: 24-32.
    • (2011) J Nucl Med , vol.52 , pp. 24-32
    • Owen, D.R.J.1    Gunn, R.N.2    Rabiner, E.A.3
  • 99
    • 78650656892 scopus 로고    scopus 로고
    • Variation in binding affinity of the novel anxiolytic XBD173 for the 18 kDa translocator protein in human brain
    • Owen DRJ, Lewis AJM, Reynolds R, et al. Variation in binding affinity of the novel anxiolytic XBD173 for the 18 kDa translocator protein in human brain. Synapse 2011; 65: 257-9.
    • (2011) Synapse , vol.65 , pp. 257-259
    • Owen, D.R.J.1    Lewis, A.J.M.2    Reynolds, R.3
  • 100
    • 0025773662 scopus 로고
    • Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon
    • Awad M, Gavish M. Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon. Life Sci 1991; 49: 1155-61.
    • (1991) Life Sci , vol.49 , pp. 1155-1161
    • Awad, M.1    Gavish, M.2
  • 101
    • 4143123246 scopus 로고    scopus 로고
    • Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand
    • Kita A, Kohayakawa H, Kinoshita T, et al. Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br J Pharmacol 2004; 142: 1059-72.
    • (2004) Br J Pharmacol , vol.142 , pp. 1059-1072
    • Kita, A.1    Kohayakawa, H.2    Kinoshita, T.3
  • 102
    • 37849053628 scopus 로고    scopus 로고
    • 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo
    • 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem 2007; 51: 17-30.
    • (2007) J Med Chem , vol.51 , pp. 17-30
    • Briard, E.1    Zoghbi, S.S.2    Imaizumi, M.3
  • 104
    • 61449112099 scopus 로고    scopus 로고
    • 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET
    • 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. J Med Chem 2009; 52: 688-99.
    • (2009) J Med Chem , vol.52 , pp. 688-699
    • Briard, E.1    Zoghbi, S.S.2    Simeìon, F.G.3
  • 105
    • 79851499878 scopus 로고    scopus 로고
    • 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline
    • 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline. J Nucl Med 2011; 52: 107-14.
    • (2011) J Nucl Med , vol.52 , pp. 107-114
    • Buck, J.R.1    McKinley, E.T.2    Hight, M.R.3
  • 106
    • 46849086547 scopus 로고    scopus 로고
    • 18F]Pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography
    • 18F]Pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography. J Med Chem 2008; 51: 3700-12.
    • (2008) J Med Chem , vol.51 , pp. 3700-3712
    • Fookes, C.J.R.1    Pham, T.Q.2    Mattner, F.3
  • 107
    • 0032586711 scopus 로고    scopus 로고
    • 3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors
    • 3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors. Eur J Pharmacol 1999; 371: 197-204.
    • (1999) Eur J Pharmacol , vol.371 , pp. 197-204
    • Chaki, S.1    Funakoshi, T.2    Yoshikawa, R.3
  • 108
    • 34548260271 scopus 로고    scopus 로고
    • A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: Implications for PET imaging of microglial activation
    • Venneti S, Lopresti BJ, Wang G, et al. A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation. J Neurochem 2007; 102: 2118-31.
    • (2007) J Neurochem , vol.102 , pp. 2118-2131
    • Venneti, S.1    Lopresti, B.J.2    Wang, G.3
  • 109
    • 54449090610 scopus 로고    scopus 로고
    • The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders
    • Venneti S, Wang G, Nguyen J, Wiley C. The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders. J Neuropathol Exp Neurol 2008; 67: 1001-10.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1001-1010
    • Venneti, S.1    Wang, G.2    Nguyen, J.3    Wiley, C.4
  • 110
    • 62049083382 scopus 로고    scopus 로고
    • Autoradiographical imaging of PPAR[gamma] agonist effects on PBR/TSPO binding in TASTPM mice
    • Roberts JC, Friel SL, Roman S, et al. Autoradiographical imaging of PPAR[gamma] agonist effects on PBR/TSPO binding in TASTPM mice. Exp Neurol 2009; 216: 459-70.
    • (2009) Exp Neurol , vol.216 , pp. 459-470
    • Roberts, J.C.1    Friel, S.L.2    Roman, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.