ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells

Journal of Immunology

Volumn 189, Issue 11, 2012, Pages 5240-5249

  Enders, Anselm ^a   Stankovic, Sanda ^b   Teh, Charis ^a   Uldrich, Adam P ^b   Yabas, Mehmet ^a   Juelich, Torsten ^a   Altin, John A ^a   Frankenreiter, Sandra ^a   Bergmann, Hannes ^a   Roots, Carla M ^a   Kyparissoudis, Konstantinos ^b   Goodnow, Chris C ^a   Godfrey, Dale I ^b  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD1D ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL RECEPTOR; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 17; RETINOIC ACID RELATED ORPHAN RECEPTOR GAMMA T; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZBTB7B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HELPLESS MOUSE; HETEROZYGOTE; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPOIESIS; MALE; MISSENSE MUTATION; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; THYMUS;

ANIMALS; ANTIGENS, CD1D; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA-BINDING PROTEINS; GENE EXPRESSION; INTERFERON-GAMMA; INTERLEUKIN-17; MALE; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; NATURAL KILLER T-CELLS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROTEIN STRUCTURE, TERTIARY; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 84869767226     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201486     Document Type: Article

References (46)

1. Bendelac, A., P. B. Savage, and L. Teyton. 2007. The biology of NKT cells. Annu. Rev. Immunol. 25: 297-336. (Pubitemid 46697911)
2. Godfrey, D. I., and M. Kronenberg. 2004. Going both ways: immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 114: 1379-1388. (Pubitemid 40385565)
3. Godfrey, D. I., H. R. MacDonald, M. Kronenberg, M. J. Smyth, and L. Van Kaer. 2004. NKT cells: what's in a name? Nat. Rev. Immunol. 4: 231-237. (Pubitemid 38339089)
4. Coquet, J. M., S. Chakravarti, K. Kyparissoudis, F. W. McNab, L. A. Pitt, B. S. McKenzie, S. P. Berzins, M. J. Smyth, and D. I. Godfrey. 2008. Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc. Natl. Acad. Sci. USA 105: 11287-11292.
5. Gumperz, J. E., S. Miyake, T. Yamamura, and M. B. Brenner. 2002. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J. Exp. Med. 195: 625-636. (Pubitemid 34461507)
6. Lee, P. T., K. Benlagha, L. Teyton, and A. Bendelac. 2002. Distinct functional lineages of human V(alpha)24 natural killer T cells. J. Exp. Med. 195: 637-641. (Pubitemid 34461508)
7. Michel, M.-L., A. C. Keller, C. Paget, M. Fujio, F. Trottein, P. B. Savage, C.-H. Wong, E. Schneider, M. Dy, and M. C. Leite-de-Moraes. 2007. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J. Exp. Med. 204: 995-1001. (Pubitemid 46798144)
8. Lee, P. T., A. Putnam, K. Benlagha, L. Teyton, P. A. Gottlieb, and A. Bendelac. 2002. Testing the NKT cell hypothesis of human IDDM pathogenesis. J. Clin. Invest. 110: 793-800.
9. van der Vliet, H. J., B. M. von Blomberg, N. Nishi, M. Reijm, A. E. Voskuyl, A. A. van Bodegraven, C. H. Polman, T. Rustemeyer, P. Lips, A. J. van den Eertwegh, et al. 2001. Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin. Immunol. 100: 144-148.
10. Berzins, S. P., A. D. Cochrane, D. G. Pellicci, M. J. Smyth, and D. I. Godfrey. 2005. Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples. Eur. J. Immunol. 35: 1399-1407. (Pubitemid 40691421)
11. Godfrey, D. I., S. Stankovic, and A. G. Baxter. 2010. Raising the NKT cell family. Nat. Immunol. 11: 197-206.
12. Kim, P. J., S.-Y. Pai, M. Brigl, G. S. Besra, J. Gumperz, and I.-C. Ho. 2006. GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177: 6650-6659. (Pubitemid 44715028)
13. He, X., X. He, V. P. Dave, Y. Zhang, X. Hua, E. Nicolas, W. Xu, B. A. Roe, and D. J. Kappes. 2005. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433: 826-833. (Pubitemid 40314886)
14. Sun, G., X. Liu, P. Mercado, S. R. Jenkinson, M. Kypriotou, L. Feigenbaum, P. Galéra, and R. Bosselut. 2005. The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat. Immunol. 6: 373-381. (Pubitemid 41716777)
15. Wildt, K. F., G. Sun, B. Grueter, M. Fischer, M. Zamisch, M. Ehlers, and R. Bosselut. 2007. The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer. J. Immunol. 179: 4405-4414.
16. Engel, I., K. Hammond, B. A. Sullivan, X. He, I. Taniuchi, D. Kappes, and M. Kronenberg. 2010. Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J. Exp. Med. 207: 1015-1029.
17. Wang, L., T. Carr, Y. Xiong, K. F. Wildt, J. Zhu, L. Feigenbaum, A. Bendelac, and R. Bosselut. 2010. The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40: 2385-2390.
18. Matsuda, J. L., O. V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C. R. Wang, Y. Koezuka, and M. Kronenberg. 2000. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192: 741-754.
19. Nelms, K. A., and C. C. Goodnow. 2001. Genome-wide ENU mutagenesis to reveal immune regulators. Immunity 15: 409-418. (Pubitemid 32907388)
20. Dave, V. P., D. Allman, R. Keefe, R. R. Hardy, and D. J. Kappes. 1998. HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc. Natl. Acad. Sci. USA 95: 8187-8192. (Pubitemid 28326088)
21. Egawa, T., and D. R. Littman. 2008. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat. Immunol. 9: 1131-1139.
22. Bilic, I., and W. Ellmeier. 2007. The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol. Lett. 108: 1-9. (Pubitemid 44959055)
23. Li, X., H. Peng, D. C. Schultz, J. M. Lopez-Guisa, F. J. Rauscher, III, and R. Marmorstein. 1999. Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. Cancer Res. 59: 5275-5282. (Pubitemid 29503994)
24. Kappes, D. J., X. He, and X. He. 2006. Role of the transcription factor Th-POK in CD4:CD8 lineage commitment. Immunol. Rev. 209: 237-252.
25. Galéra, P., R. W. Park, P. Ducy, M. G. Mattéi, and G. Karsenty. 1996. c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis. J. Biol. Chem. 271: 21331-21339. (Pubitemid 26292994)
26. Benlagha, K., T. Kyin, A. Beavis, L. Teyton, and A. Bendelac. 2002. A thymic precursor to the NK T cell lineage. Science 296: 553-555. (Pubitemid 34408679)
27. Pellicci, D. G., K. J. L. Hammond, A. P. Uldrich, A. G. Baxter, M. J. Smyth, and D. I. Godfrey. 2002. A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J. Exp. Med. 195: 835-844. (Pubitemid 34286755)
28. Ivanov, I. I., B. S. McKenzie, L. Zhou, C. E. Tadokoro, A. Lepelley, J. J. Lafaille, D. J. Cua, and D. R. Littman. 2006. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133. (Pubitemid 44380299)
29. Rachitskaya, A. V., A. M. Hansen, R. Horai, Z. Li, R. Villasmil, D. Luger, R. B. Nussenblatt, and R. R. Caspi. 2008. Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J. Immunol. 180: 5167-5171.
30. Collins, A., D. R. Littman, and I. Taniuchi. 2009. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat. Rev. Immunol. 9: 106-115.
31. Townsend, M. J., A. S. Weinmann, J. L. Matsuda, R. Salomon, P. J. Farnham, C. A. Biron, L. Gapin, and L. H. Glimcher. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20: 477-494. (Pubitemid 38482125)
32. Doisne, J.-M., C. Becourt, L. Amniai, N. Duarte, J.-B. Le Luduec, G. Eberl, and K. Benlagha. 2009. Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions. J. Immunol. 183: 2142-2149.
33. Godfrey, D. I., and S. P. Berzins. 2007. Control points in NKT-cell development. Nat. Rev. Immunol. 7: 505-518. (Pubitemid 46987785)
34. Takahashi, T., S. Chiba, M. Nieda, T. Azuma, S. Ishihara, Y. Shibata, T. Juji, and H. Hirai. 2002. Cutting edge: analysis of human V alpha 24+CD8+ NK T cells activated by alpha-galactosylceramide-pulsed monocyte-derived dendritic cells. J. Immunol. 168: 3140-3144. (Pubitemid 34250371)
35. Lee, K.-A., M.-H. Kang, Y.-S. Lee, Y.-J. Kim, D.-H. Kim, H.-J. Ko, and C.-Y. Kang. 2008. A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity. Cell. Immunol. 251: 50-55.
36. Pichavant, M., S. Goya, E. H. Meyer, R. A. Johnston, H. Y. Kim, P. Matangkasombut, M. Zhu, Y. Iwakura, P. B. Savage, R. H. DeKruyff, et al. 2008. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J. Exp. Med. 205: 385-393. (Pubitemid 351281604)
37. Yoshiga, Y., D. Goto, S. Segawa, Y. Ohnishi, I. Matsumoto, S. Ito, A. Tsutsumi, M. Taniguchi, and T. Sumida. 2008. Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritis. Int. J. Mol. Med. 22: 369-374.
38. Weaver, C. T., R. D. Hatton, P. R. Mangan, and L. E. Harrington. 2007. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852. (Pubitemid 46697925)
39. Yang, X. O., A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong. 2007. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282: 9358-9363. (Pubitemid 47104613)
40. Bendelac, A., N. Killeen, D. R. Littman, and R. H. Schwartz. 1994. A subset of CD4+ thymocytes selected by MHC class I molecules. Science 263: 1774-1778. (Pubitemid 24131588)
41. Egawa, T., G. Eberl, I. Taniuchi, K. Benlagha, F. Geissmann, L. Hennighausen, A. Bendelac, and D. R. Littman. 2005. Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22: 705-716. (Pubitemid 40814501)
42. Hager, E., A. Hawwari, J. L. Matsuda, M. S. Krangel, and L. Gapin. 2007. Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J. Immunol. 179: 2228-2234.
43. D'Cruz, L. M., J. Knell, J. K. Fujimoto, and A. W. Goldrath. 2010. An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells. Nat. Immunol. 11: 240-249.
44. Chan, A. C., S. P. Berzins, and D. I. Godfrey. 2010. Transcriptional regulation of lymphocyte development. Developing NKT cells need their (E) protein. Immunol. Cell Biol. 88: 507-509.
45. Taniuchi, I., M. Osato, T. Egawa, M. J. Sunshine, S. C. Bae, T. Komori, Y. Ito, and D. R. Littman. 2002. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111: 621-633. (Pubitemid 35441245)
46. Setoguchi, R., M. Tachibana, Y. Naoe, S. Muroi, K. Akiyama, C. Tezuka, T. Okuda, and I. Taniuchi. 2008. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319: 822-825. (Pubitemid 351225874)