Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: A genetic polymorphism effect on in vivo Binding

Journal of Nuclear Medicine

Volumn 54, Issue 11, 2013, Pages 1915-1923

  Guo, Qi ^a,b   Colasanti, Alessandro ^a   Owen, David R ^a   Onega, Mayca ^a   Kamalakaran, Aruloly ^a   Bennacef, Idriss ^c   Matthews, Paul M ^a,c   Rabiner, Eugenii A ^a,b   Turkheimer, Federico E ^b   Gunn, Roger N ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Neuroinflammation; Rs6971 polymorphism; Specific binding; TSPO

Indexed keywords

FLUORO PERIPHERAL BENZODIAZEPINE RECEPTOR 111 F 18; RADIOLIGAND; UNCLASSIFIED DRUG; 2 (6 CHLORO 2 (4 (3 FLUOROPROPOXY)PHENYL)IMIDAZO(1,2 A)PYRIDIN 3 YL) N,N DIETHYLACETAMIDE; 2-(6-CHLORO-2-(4-(3-FLUOROPROPOXY)PHENYL)IMIDAZO(1,2-A)PYRIDIN-3-YL)-N,N-DIETHYLACETAMIDE; 4 AMINOBUTYRIC ACID RECEPTOR; DIAGNOSTIC AGENT; PYRIDINE DERIVATIVE; TSPO PROTEIN, HUMAN;

ADULT; ARTICLE; BINDING AFFINITY; BRAIN REGION; BRAIN STEM; CAUDATE NUCLEUS; CEREBELLUM; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; ISOTOPE LABELING; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOACTIVITY; SINGLE NUCLEOTIDE POLYMORPHISM; THALAMUS; 18F-PBR111; AGING; BIOLOGICAL MODEL; BLOOD; BRAIN; GENETIC POLYMORPHISM; GENETICS; KINETICS; METABOLISM; MIDDLE AGED; NERVOUS SYSTEM INFLAMMATION; RS6971 POLYMORPHISM; SCINTISCANNING; SPECIFIC BINDING; TSPO; DIAGNOSTIC USE;

18F-PBR111; NEUROINFLAMMATION; RS6971 POLYMORPHISM; SPECIFIC BINDING; TSPO;

ADULT; AGING; BRAIN; FEMALE; HEALTHY VOLUNTEERS; HUMANS; KINETICS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; POLYMORPHISM, GENETIC; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RECEPTORS, GABA;

EID: 84888327644     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.121020     Document Type: Article

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