Induction of androgen formation in the male by a TAT-VDAC1 fusion peptide blocking 14-3-3ε protein adaptor and mitochondrial VDAC1 interactions

Molecular Therapy

Volumn 22, Issue 10, 2014, Pages 1779-1791

  Aghazadeh, Yasaman ^a,b   Martinez Arguelles, Daniel B ^a,b   Fan, Jinjiang ^a,b   Culty, Martine ^a,b   Papadopoulos, Vassilios ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CHOLESTEROL; LUTEINIZING HORMONE; PEPTIDE DERIVATIVE; PROTEIN 14 3 3 EPSILON; TAT VOLTAGE DEPENDENT ANION CHANNEL 1 FUSION PEPTIDE; TESTOSTERONE; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 1; ANDROGEN; HYBRID PROTEIN; PEPTIDE; PROTEIN 14 3 3; PROTEIN BINDING; STEROID; TRANSACTIVATOR PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG SPECIFICITY; EX VIVO STUDY; IN VITRO STUDY; IN VIVO STUDY; INTRATESTICULAR DRUG ADMINISTRATION; LUTEINIZING HORMONE RELEASE; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; RAT; STEROIDOGENESIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PROTEIN CONFORMATION; PROTEIN TRANSPORT; TESTIS;

RATTUS;

14-3-3 PROTEINS; ANDROGENS; ANIMALS; CELL LINE; LUTEINIZING HORMONE; MALE; MICE; MITOCHONDRIA; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RATS; RECOMBINANT FUSION PROTEINS; STEROIDS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TESTIS; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 84926173452     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2014.116     Document Type: Article

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