Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [ 18F]-FEPPA

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 6, 2012, Pages 968-972

  Mizrahi, Romina ^a,b   Rusjan, Pablo M ^a   Kennedy, James ^b   Pollock, Bruce ^b   Mulsant, Benoit ^b   Suridjan, Ivonne ^a,b   De Luca, Vincenzo ^b   Wilson, Alan A ^a,b   Houle, Sylvain ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

genetics; inflammation; microglia; mitochondria; positron emission tomography

Indexed keywords

ALANINE; CARRIER PROTEIN; FEPPA F 18; PROTEIN TSPO; RADIOLIGAND; THREONINE; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANTERIOR CINGULATE; ARTICLE; BINDING AFFINITY; CAUDATE NUCLEUS; CEREBELLUM; DISTRIBUTION VOLUME; EXON; FEMALE; FRONTAL CORTEX; GENE; GENE LOCATION; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; INSULA; MALE; MEDICAL DEVICE; MICROGLIA; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PUTAMEN; QUANTITATIVE ANALYSIS; TEMPORAL CORTEX; THALAMUS; TSPO GENE;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANILIDES; EXONS; FEMALE; HUMANS; MALE; MICROGLIA; MIDDLE AGED; POLYMORPHISM, GENETIC; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRIDINES; RECEPTORS, GABA;

EID: 84861846497     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.46     Document Type: Article

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