TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

Autophagy

Volumn 10, Issue 12, 2014, Pages 2279-2296

  Gatliff, Jemma ^a   East, Daniel ^a   Crosby, James ^a   Abeti, Rosella ^c   Harvey, Robert ^d   Craigen, William ^e   Parker, Peter ^f,g   Campanella, Michelangelo ^a,b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF LONDON   (United Kingdom)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^g KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Mitochondria; Mitophagy; PARK2; ROS; TSPO; Ubiquitin

Indexed keywords

BAFILOMYCIN; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CARRIER PROTEIN; CHOLESTEROL; COMPLEMENTARY DNA; PARK2 PROTEIN; PINK1 PROTEIN; POLYUBIQUITIN; PROTEIN AGGREGATE; PROTEIN P62; REACTIVE OXYGEN METABOLITE; RED FLUORESCENT PROTEIN; SMALL INTERFERING RNA; TSPO PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 1; 4 AMINOBUTYRIC ACID RECEPTOR; BZRP PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE; VDAC1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST EPITHELIUM; CELL ORGANELLE; CELL SURFACE; CELLS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; EMBRYO; FIBROBLAST; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MACROAUTOPHAGY; MAMMAL CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN GEL BLOT ANALYSIS; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; METABOLISM; MITOCHONDRIAL MEMBRANE; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; AUTOPHAGY; BIOLOGICAL TRANSPORT; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; REACTIVE OXYGEN SPECIES; RECEPTORS, GABA; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 84922177703     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/15548627.2014.991665     Document Type: Article

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