An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 1, 2012, Pages 1-5

  Owen, David R ^a   Yeo, Astrid J ^b   Gunn, Roger N ^a,d   Song, Kijoung ^b   Wadsworth, Graham ^a   Lewis, Andrew ^a   Rhodes, Chris ^a   Pulford, David J ^b   Bennacef, Idriss ^a   Parker, Christine A ^a,c   Stjean, Pamela L ^b   Cardon, Lon R ^b   Mooser, Vincent E ^b   Matthews, Paul M ^a,c   Rabiner, Eugenii A ^a,c   Rubio, Justin P ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c University of Oxford ^*

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Ala147Thr; PBR28; polymorphism; radioligand binding; TSPO

Indexed keywords

CARRIER PROTEIN; PBR 28 C 11; RADIOLIGAND; TSPO PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BINDING AFFINITY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; THROMBOCYTE;

ACETAMIDES; ADULT; AMINO ACID SUBSTITUTION; BINDING, COMPETITIVE; BLOOD PLATELETS; CELL MEMBRANE; DNA; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; ISOQUINOLINES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRIDINES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, GABA; TRITIUM;

EID: 84855340957     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.147     Document Type: Article

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