In vivo imaging of neuroinflammation in the rodent brain with [ 11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 38, Issue 3, 2011, Pages 509-514

  Chauveau, Fabien ^a,b,e   Boutin, Hervé ^a,b,f   Van Camp, Nadja ^a,b   Thominiaux, Cyrille ^a   Hantraye, Philippe ^c   Rivron, Luc ^d   Marguet, Frank ^d   Castel, Marie Noëlle ^d   Rooney, Thomas ^d   Benavides, Jesus ^d   Dollé, Frédéric ^a   Tavitian, Bertrand ^a,b  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c Molecular Imaging Research Center   (France)

^d SANOFI   (France)

^e UNIVERSITÉ DE LYON   (France)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

11C PK11195; 11C SSR180575; Neuroinflammation; Peripheral benzodiazepine receptor; Translocator protein (18 kDa)

Indexed keywords

7 CHLORO N,N 5 TRIMETHYL 4 OXO 3 PHENYL 3,5 DIHYDRO 4H PYRIDAZINO[4,5 B]INDOLE 1 ACETAMIDE C 11; ACETAMIDE DERIVATIVE; CARBON 11; CARRIER PROTEIN; ISOQUINOLINE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; RADIOPHARMACEUTICAL AGENT; SSR 180575; TRANSLOCATOR PROTEIN (18 KDA); UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN; CONTROLLED STUDY; DRUG UPTAKE; IMAGE QUALITY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NEUROIMAGING; NEUROINFLAMMATION; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RODENT; SENSITIVITY AND SPECIFICITY;

ACETAMIDES; ANIMALS; AUTORADIOGRAPHY; BRAIN; CARBON RADIOISOTOPES; CARRIER PROTEINS; INDOLES; INFLAMMATION; LIGANDS; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RATS; RECEPTORS, GABA-A;

EID: 79953737531     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-010-1628-5     Document Type: Article

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