Peripheral benzodiazepine receptors and mitochondrial function

Neurochemistry International

Volumn 40, Issue 6, 2002, Pages 475-486

  Casellas, Pierre ^a,c   Galiegue, Sylvaine ^a   Basile, Anthony S ^b  

^a SANOFI   (France)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NONE   (France)

Author keywords

Mitochondria; Mitochondrial permeability transition; Neurosteroids; Peripheral benzodiazepine receptors; PK11195; Ro5 4864

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; DIAZEPAM; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NEUROSTEROID; REACTIVE OXYGEN METABOLITE; RO 54864; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BRAIN MITOCHONDRION; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; DRUG BINDING SITE; DRUG RECEPTOR BINDING; EPENDYMA CELL; GLIA; HUMAN; MEMBRANE POTENTIAL; MENTAL DISEASE; MITOCHONDRIAL MEMBRANE; MOLECULAR BIOLOGY; NEUROLOGIC DISEASE; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR SENSITIVITY; STEROIDOGENESIS; TISSUE DISTRIBUTION;

ANIMALS; HUMANS; MITOCHONDRIA; PERIPHERAL NERVES; RECEPTORS, GABA-A;

EID: 0036176076     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(01)00118-8     Document Type: Article

References (113)

1. Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor an cultured primary astrocytes and C-6 cells: Relation to cell growth
2. Depletion of peripheral-type benzodiazepine receptors after hypophysectomy in rat adrenal gland and testis
3. Peripheral-type benzodiazepine receptors: Autoradiographic localization in whole-body sections of neonatal rats
4. The peripheral-type benzodiazepine receptor-localization to the mitochondrial outer membrane
5. Mammalian peripheral-type benzodiazepine receptor is homologous to CrtK protein of Rhodobacter capsulatus, a photosynthetic bacterium
6. 11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis
7. 3H]PK11195 binding to activated microglia
8. Subcellular localization of peripheral-type binding sites for benzodiazepines in rat brain
9. Modulation of central and peripheral norepinephrine levels alters the density of peripheral-type benzodiazepine receptors in rat pineal gland, but not cardiac ventricle
10. Characterization of benzodiazepine receptors in the bovine pineal gland: Evidence for the presence of an atypical binding site
11. Regulation of renal peripheral benzodiazepine receptors by anion transport inhibitors
12. Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy
13. Maximal electroshock increases the density of peripheral-type benzodiazepine receptors in mouse cerebral cortex
14. Neurosteroids: A novel function of the brain
15. Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines
16. Imaging of human brain lesions with an site radioligand
17. Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes
18. A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport
19. Identification of des-(Gly-lle)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: Stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor
20. Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat
21. Imaging of brain tumors using peripheral benzodiazepine receptor ligands
22. Identification and purification of a 10-kilodalton protein associated with mitochondrial benzodiazepine receptors
23. Late evolutionary appearance of penpheral-type binding sites for benzodiazepines
24. Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities
25. 3H]diazepam binding
26. Peripheral-type benzodiazepine receptors in human glioblastomas: Pharmacologic characterization and photoaffinity labeling of ligand recognition site
27. Pathways of neurosteroid biosynthesis in cell lines from human brain: Regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide
28. The astrocytic (peripheral-type) benzodiazepine receptor: Role in the pathogenesis of portal-systemic encephalopathy
29. Distribution profile and properties of peripheral type benzodiazepine receptors on human hemopoetic cells
30. Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage
31. Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland
32. 3 (peripheral-type benzodiapine) binding site densities in different types of human brain tumours
33. Increased peripheral-type benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats
34. Peripheral-type benzodiazepine receptors in endocrine organs: Autoradiographic localization in rat pituitary, adrenal and testis
35. Benzodiazepine receptors
36. Peripheral benzodiazpeine binding sites in Alzheimer's disease frontal and temporal cortex
37. Inescapable stress decreases Ro5-4864 (4′-chlorodiazepam) binding in rat brain and peripheral tissues
38. Environmentally-induced changes in peripheral benzodiazepine receptors are stressor and tissue specific
39. Molecular basis for the different properties of benzodiazepines to human and bovine PBR
40. Site directed mutagenesis of the PBR: Identification of amino-acids implicated in the binding site of Ro5-4864
41. Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species
42. Benzodiazepine receptors and diazepam-binding inhibitor in human cerebral tumors
43. Cloning and characterization of PRAX-1: A new protein that specifically interacts with the Peripheral Benzodiazepine Receptor
44. In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells
45. Mitochondria: Execution central
46. Isolation, characterization and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors
47. PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease
48. A receptor complex by ammonia: Implications for the pathogenesis of hyperammonemic syndromes
49. Direct enhancement of GABA-ergic neurotransmission by ammonia
50. The mitochondrial permeability transition: Its molecular mechanism and role in reperfusion injury
51. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: Correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol
52. Neurosteroids, brain damage, and mental ilness
53. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses the induction of apoptosis and reverses Bcl-2-mediated cytoprotection
54. Regulation of PBR in cultured astrocytes by monoamine and amino-acid neurotransmitters
55. Attenuation of ammonia toxicity in mice by PK11195 and pregnenolone sulfate
56. Central and peripheral benzodiazepine receptors: Opposite chanes in human epileptogenic tissue
57. Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a five transmembrane structure
58. Increase in peripheral benzodiazepine binding sites in colonic adenocarcinoma
59. Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication
60. Altered peripheral benzodiazepine receptor binding in cardiac and liver tissues from thyroidectomized rats
61. Mitochondrial control of cell death
62. The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicity
63. Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity
64. Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics
65. Enhanced expression of the PBR and its endogenous ligand ODN in the regenerating adult rat sciatic nerve
66. Peripheral benzodiazepine binding sites: Effect of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methyl-propyl)-3-isoquinoline carboxamide
67. Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: Implications for positron emission tomography imaging
68. Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino-acid sequence and consensus pattern
69. Cholesterol binding at the cholesterol recognition/interaction amino-acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide
70. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
71. The permeability transition pore complex: A target for apoptosis regulation by caspases and Bcl-2-related proteins
72. Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria
73. Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier
74. Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease
75. Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: Relationship to cell proliferation
76. Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods
77. Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086
78. Interleukin-1 and phorbol myristate acetate modulate the PBR in lymphocytes and glial cells
79. 11C](R)-PK11195 to image focal and regional brain pathology
80. Redox regulation of cellular activation
81. The use of cultured astrocytes in the study of hepatic encephalopathy
82. Astroglial dysfunction in hepatic encephalopathy
83. Astrocyte swelling in liver failure: Role of glutamine and benzodiazepines
84. Two subcellular locations for peripheral-type benzodiazepine acceptors in rat liver
85. Presence of the peripheral-type benzodiazepine binding sites on human erythrocyte membranes
86. 3H]flunitrazepam binding in kainate-lesioned rat striatum and temporal cortex of brains from patients with senile dementia of the Alzheimer subtype
87. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis
88. Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line
89. Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein
90. 11C]PK11195 to sites in baboons: Positron emission tomography study
91. Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death and activation of astrocytes and microglia in rat thalamus
92. Monitoring by PET of macrophage accumulation in brain after ischaemic stroke
93. Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor
94. 2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: Stimulation of neurosteroid synthesis and anticonflict actions in rats
95. In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon
96. Molecular cloning and expression of cDNA encoding a peripheral type benzodiazepine receptor
97. Imaging of a glioma using peripheral benzodiazepine receptor ligands
98. Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat
99. The expression of peripheral benzodiazepine receptors in human skin: The relationship with epidermal cell differentiation
100. Characterization of benzodiazepine binding sites in cultured cells of neural origin
101. Autoradiographic study of peripheral benzodiazepine receptors in animal brain tumor models and human gliomas
102. Involvement of peripheral-type benzodiazepine receptors in the intracellular transport of heme and porphyrins
103. 2+ and oxidant stress
104. Anti-inflammatory effects of peripheral benzodiazepine receptor ligands in two mouse models of inflammation
105. Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver
106. Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor
107. PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis
108. Effect of truncated forms of the steroidogenic acute regulatory protein on intramitochondrial cholesterol transport
109. The peripheral benzodiazepine receptor ligand PK11195 inhibits arthritis in the MRL-Ipr mouse model
110. Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane
111. Peripheral-type benzodiazepine receptors in diagnostic subtypes of schizophrenic patients
112. A mammalian mitochondrial drug receptor functions as a bacterial oxygen sensor
113. Benzodiazepines, anxiety and immunity