Novel androstenetriol interacts with the mitochondrial translocator protein and controls steroidogenesis

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 9875-9887

  Midzak, Andrew ^a,b   Akula, Nagaraju ^a   Lecanu, Laurent ^a,b   Papadopoulos, Vassilios ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL TRANSPORT; CRAC MOTIF; CYTOCHROME P450; ENZYMATIC TRANSFORMATION; INTEGRAL PART; INTRACELLULAR CHOLESTEROL; INTRACELLULAR STORES; MICROMOLAR CONCENTRATION; MITOCHONDRIAL IMPORT; MITOCHONDRIAL MATRIX; MOLECULAR MODELING STUDIES; NANOMOLAR RANGE; NOVEL LIGANDS; POTENT INHIBITOR; PROTEIN LEVEL; STEROID HORMONE; STEROIDOGENIC ACUTE REGULATORY PROTEINS; THERAPEUTIC CONTROL; TRANSLOCATORS; TUMOR CELLS;

AMINO ACIDS; CHOLESTEROL; DISEASE CONTROL; ENZYME INHIBITION; ENZYMES; HORMONES; MITOCHONDRIA; TUMORS;

ENZYME ACTIVITY;

ANDROGEN; ANDROSTENETRIOL; CARRIER PROTEIN; MITOCHONDRIAL TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GROWTH REGULATION; LEYDIG CELL; MATHEMATICAL COMPUTING; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; STEROIDOGENESIS;

AMINO ACID MOTIFS; ANDROSTENOLS; ANIMALS; CARRIER PROTEINS; CELL LINE, TUMOR; CHOLESTEROL; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MITOCHONDRIA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, GABA; RECEPTORS, GABA-A;

RATTUS;

EID: 79953180013     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.203216     Document Type: Article

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