Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice

Journal of Pharmacological Sciences

Volumn 110, Issue 1, 2009, Pages 55-63

  Kondo, Daisuke ^a   Saegusa, Hironao ^a   Yabe, Ritsuko ^a   Takasaki, Ichiro ^a   Kurihara, Takashi ^a   Zong, Shuqin ^a   Tanabe, Tsutomu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

GABAA receptor; Neuropathic pain; Peripheral type benzodiazepine receptor; PK11195; Spinal nerve injury

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PERIPHERAL BENZODIAZEPINE RECEPTOR; PERIPHERAL BENZODIAZEPINE RECEPTOR ANTAGONIST; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HYPERALGESIA; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY;

EID: 66349100806     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09028FP     Document Type: Article

References (29)

1. Gavish M, Bachman I, Shoukrun R, Katz Y, Veenman L, Weisinger G, et al. Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev. 1999;51:629-650.
2. Papadopoulos V, Lecanu L, Brown RC, Han Z, Yao ZX. Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders. Neuroscience. 2006;138:749-756. (Pubitemid 43306813)
3. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, et al. Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006;27:402-409. (Pubitemid 44069585)
4. Lacapere JJ, Papadopoulos V. Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids. 2003;68:569-585. (Pubitemid 37075920)
5. Costigan M, Befort K, Karchewski L, Griffin RS, D'Urso D, Allchorne A, et al. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. 2002;3:16. (Pubitemid 38729131)
6. Wang H, Sun H, Della Penna K, Benz RJ, Xu J, Gerhold DL, et al. Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases. Neuroscience. 2002;114:529-546. (Pubitemid 35247642)
7. Xiao HS, Huang QH, Zhang FX, Bao L, Lu YJ, Guo C, et al. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci U S A. 2002;99:8360-8365. (Pubitemid 34651057)
8. Mills CD, Bitler JL, Woolf CJ. Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mol Cell Neurosci. 2005;30:228-237. (Pubitemid 41316565)
9. Kondo D, Yabe R, Kurihara T, Saegusa H, Zong S, Tanabe T. Progesterone receptor antagonist is effective in relieving neuropathic pain. Eur J Pharmacol. 2006;541:44-48. (Pubitemid 43903478)
10. Baulieu EE. Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res. 1997;52:1-32. (Pubitemid 127470204)
11. Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003;424:778-783. (Pubitemid 37021707)
12. Ryu JK, Choi HB, McLarnon JG. Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. Neurobiol Dis. 2005;20:550-561. (Pubitemid 41476281)
13. Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sik A, et al. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature. 2003;424:938-942. (Pubitemid 37051684)
14. Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005;438:1017-1021. (Pubitemid 43093974)
15. Belelli D, Lambert JJ. Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci. 2005;6:565-575.
16. Schlichter R, Keller AF, De Roo M, Breton JD, Inquimbert P, Poisbeau P. Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways. J Mol Neurosci. 2006;28:33-51. (Pubitemid 43780335)
17. Zimmermann M. Ethical guidelines for the investigations of experimental pain in conscious animals. Pain. 1983;16:109-110.
18. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 1992;50:355-363.
19. 2+ channel. EMBO J. 2001;20:2349-2356.
20. Takasaki I, Kurihara T, Saegusa H, Zong S, Tanabe T. Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain. Eur J Pharmacol. 2005;524:80-83. (Pubitemid 41606817)
21. Hylden JLK, Wilcox GL. Intrathecal morphine in mice: a new technique. Eur J Pharmacol. 1980;67: 313-316. (Pubitemid 10007057)
22. 2+ channel enhanced morphine analgesia and reduced morphine tolerance. Eur J Neurosci. 2004;20:3516-3519.
23. Karchewski LA, Bloechlinger S, Woolf CJ. Axonal injurydependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons. Eur J Neurosci. 2004;20:671-683. (Pubitemid 39043647)
24. B receptor pharmacology in a rat model of neuropathic pain. Anesthesiology. 2002;96:1161-1167.
25. Meyer L, Venard C, Schaeffer V, Patte-Mensah C, Mensah- Nyagan AG.The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury. Neurobiol Dis. 2008;30:30-41.
26. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33:87-107. (Pubitemid 18107427)
27. Poisbeau P, Patte-Mensah C, Keller AF, Barrot M, Breton JD, Luis-Delgado OE, et al. Inflammatory pain upregulates spinal inhibition via endogenous neurosteroid production. J Neurosci. 2005;25:11768-11776. (Pubitemid 43098469)
28. Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5 alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 2005;117:326-339. (Pubitemid 41383528)
29. Ossipov MH, Lai J, Porreca, F. Mechanisms of experimental neuropathic pain: integration from animal models. In: McMahon SB, Koltzenburg, M, editors. Wall and Melzack's textbook of pain. 5th ed. Churchhill Livingstone: Elsevier Limited; 2006. p. 929-946.