Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo

Cancer Research

Volumn 62, Issue 5, 2002, Pages 1388-1393

  Decaudin, Didier ^a   Castedo, Maria ^b   Nemati, Fariba ^a   Beurdeley Thomas, Arnaud ^a   De Pinieux, Gonzague ^a   Caron, Antoine ^a   Pouillart, Pierre ^a   Wijdenes, John ^c   Rouillard, Dany ^a   Kroemer, Guido ^b   Poupon, Marie France ^a  

^a INSTITUT CURIE   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c Diaclone   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; DIAZEPAM; DNA FRAGMENT; ETOPOSIDE; FAS ANTIBODY; FAS ANTIGEN; IFOSFAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; CHEMOSENSITIVITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; LUNG SMALL CELL CANCER; MEMBRANE STEADY POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NEUROBLASTOMA; NONHUMAN; NUDE MOUSE; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL LEUKEMIA;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; BACTERIAL PROTEINS; BENZODIAZEPINONES; HUMANS; ISOQUINOLINES; JURKAT CELLS; LIGANDS; MITOCHONDRIA; NEOPLASMS; RECEPTORS, GABA-A; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0036494315     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Mitochondrial control of apoptosis
2. The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
3. The mitochondrial permeability transition
4. Subcellular localization of the Bcl-2 protein in malignant and normal lymphoid cells
5. The proto-oncogene Bcl-2 and its role in regulating apoptosis
6. The peripheral benzodiazepine receptors: A review
7. Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors
8. Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods
9. Up-regulation of peripheral benzodiazepine receptor system in hepatocellular carcinoma
10. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection
11. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
12. 3H]PK11195, by thermodynamic studies
13. Mitochondrial permeability transition triggers lymphocyte apoptosis
14. A rapid simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
15. Confluence-dependent resistance in human colon cancer cells: Role of reduced drug accumulation and low intrinsic chemosensitivity of resting cells
16. Altered glutathione metabolism in oxaliplatin resistant ovarian carcinoma cells
17. Two CD95 (APO-I/Fas) signaling pathways
18. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis
19. Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate
20. Photodynamic tumor therapy: Mitochondrial benzodiazepine receptors as a therapeutic target
21. Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment
22. Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities
23. 3H]PK11195 to cerebral cortex and peripheral tissues of various species: Species differences and heterogeneity in peripheral benzodiazepine binding sites
24. Mitochondrion as a novel target of anticancer chemotherapy