-
1
-
-
13844320649
-
Aberrant DNA methylation as a cancer-inducing mechanism
-
Esteller M. Aberrant DNA methylation as a cancer-inducing mechanism. Annu Rev Pharmacol Toxicol 2005, 45: 629-656.
-
(2005)
Annu Rev Pharmacol Toxicol
, vol.45
, pp. 629-656
-
-
Esteller, M.1
-
2
-
-
0035870248
-
A gene hypermethylation profile of human cancer
-
Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001, 61: 3225-3229.
-
(2001)
Cancer Res
, vol.61
, pp. 3225-3229
-
-
Esteller, M.1
Corn, P.G.2
Baylin, S.B.3
Herman, J.G.4
-
3
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005, 37: 391-400.
-
(2005)
Nat Genet
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
Bonaldi, T.7
-
4
-
-
80054822255
-
5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes
-
Ning B, Liu G, Liu Y, Su X, Anderson GJ, Zheng X, Chang Y, et al. 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes. J Biol Chem 2011, 286: 37196-37206.
-
(2011)
J Biol Chem
, vol.286
, pp. 37196-37206
-
-
Ning, B.1
Liu, G.2
Liu, Y.3
Su, X.4
Anderson, G.J.5
Zheng, X.6
Chang, Y.7
-
5
-
-
77249087051
-
Chemical phylogenetics of histone deacetylases
-
Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. Chemical phylogenetics of histone deacetylases. Nat Chem Biol 2010, 6: 238-243.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 238-243
-
-
Bradner, J.E.1
West, N.2
Grachan, M.L.3
Greenberg, E.F.4
Haggarty, S.J.5
Warnow, T.6
Mazitschek, R.7
-
6
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
Marks PA, Breslow R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 2007, 25: 84-90.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
7
-
-
84901195692
-
Rare insights into cancer biology
-
Adam J, Yang M, Soga T, Pollard PJ. Rare insights into cancer biology. Oncogene 2014, 33: 2547-2556.
-
(2014)
Oncogene
, vol.33
, pp. 2547-2556
-
-
Adam, J.1
Yang, M.2
Soga, T.3
Pollard, P.J.4
-
9
-
-
33847065486
-
The epigenomics of cancer
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007, 128: 683-692.
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
10
-
-
22844457491
-
DNA methylation and human disease
-
Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005, 6: 597-610.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 597-610
-
-
Robertson, K.D.1
-
11
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003, 349: 2042-2054.
-
(2003)
N Engl J Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
12
-
-
34047116826
-
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
-
Weber M, Hellmann I, Stadler MB, Ramos L, Pääbo S, Rebhan M, Schübeler D. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet 2007, 39: 457-466.
-
(2007)
Nat Genet
, vol.39
, pp. 457-466
-
-
Weber, M.1
Hellmann, I.2
Stadler, M.B.3
Ramos, L.4
Pääbo, S.5
Rebhan, M.6
Schübeler, D.7
-
13
-
-
23744461983
-
Transposons reanimated in mice
-
Bestor TH. Transposons reanimated in mice. Cell 2005, 122: 322-325.
-
(2005)
Cell
, vol.122
, pp. 322-325
-
-
Bestor, T.H.1
-
14
-
-
23744457857
-
How epigenetics integrates nuclear functions. Workshop on epigenetics and chromatin: Transcriptional regulation and beyond
-
Esteller M, Almouzni G. How epigenetics integrates nuclear functions. Workshop on epigenetics and chromatin: transcriptional regulation and beyond. EMBO Rep 2005, 6: 624-628.
-
(2005)
EMBO Rep
, vol.6
, pp. 624-628
-
-
Esteller, M.1
Almouzni, G.2
-
15
-
-
1042278765
-
The history of cancer epigenetics
-
Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004, 4: 143-153.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 143-153
-
-
Feinberg, A.P.1
Tycko, B.2
-
16
-
-
80053144962
-
A decade of exploring the cancer epigenome - Biological and translational implications
-
Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 2011, 11: 726-734.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
17
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histonemodification maps
-
Esteller M. Cancer epigenomics: DNA methylomes and histonemodification maps. Nat Rev Genet 2007, 8: 286-298.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
18
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002, 3: 415-428.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
19
-
-
84866513337
-
Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
-
Taylor C, Craven RA, Harnden P, Selby PJ, Banks RE. Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma. Int J Oncol 2012, 41: 1229-1240.
-
(2012)
Int J Oncol
, vol.41
, pp. 1229-1240
-
-
Taylor, C.1
Craven, R.A.2
Harnden, P.3
Selby, P.J.4
Banks, R.E.5
-
20
-
-
73349089306
-
Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma
-
Young AC, Craven RA, Cohen D, Taylor C, Booth C, Harnden P, Cairns DA, et al. Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma. Clin Cancer Res 2009, 15: 7582-7592.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7582-7592
-
-
Young, A.C.1
Craven, R.A.2
Cohen, D.3
Taylor, C.4
Booth, C.5
Harnden, P.6
Cairns, D.A.7
-
21
-
-
0034607234
-
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
-
Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E, Bussaglia E, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 2000, 92: 564-569.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 564-569
-
-
Esteller, M.1
Silva, J.M.2
Dominguez, G.3
Bonilla, F.4
Matias-Guiu, X.5
Lerma, E.6
Bussaglia, E.7
-
22
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99: 247-257.
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
23
-
-
0000418476
-
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
-
Santi DV, Norment A, Garrett CE. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci USA 1984, 81: 6993-6997.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 6993-6997
-
-
Santi, D.V.1
Norment, A.2
Garrett, C.E.3
-
24
-
-
18944383889
-
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
-
Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, Jacob ST. 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 2005, 25: 4727-4741.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4727-4741
-
-
Ghoshal, K.1
Datta, J.2
Majumder, S.3
Bai, S.4
Kutay, H.5
Motiwala, T.6
Jacob, S.T.7
-
25
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
-
Fenaux P, Mufti GJ, Hellström-Lindberg E, Santini V, Finelli C, Giagounidis A, Schoch R, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009, 10: 223-232.
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellström-Lindberg, E.3
Santini, V.4
Finelli, C.5
Giagounidis, A.6
Schoch, R.7
-
26
-
-
77449149371
-
DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
-
Shen L, Kantarjian H, Guo Y, Lin E, Shan J, Huang X, Berry D, et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 2010, 28: 605-613.
-
(2010)
J Clin Oncol
, vol.28
, pp. 605-613
-
-
Shen, L.1
Kantarjian, H.2
Guo, Y.3
Lin, E.4
Shan, J.5
Huang, X.6
Berry, D.7
-
27
-
-
0027285909
-
A phase II study of 5, 6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma
-
Creagan ET, Schaid DJ, Hartmann LC, Loprinzi CL. A phase II study of 5, 6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma. Am J Clin Oncol 1993, 16: 243-244.
-
(1993)
Am J Clin Oncol
, vol.16
, pp. 243-244
-
-
Creagan, E.T.1
Schaid, D.J.2
Hartmann, L.C.3
Loprinzi, C.L.4
-
28
-
-
77749302093
-
A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
-
Hollenbach PW, Nguyen AN, Brady H, Williams M, Ning Y, Richard N, Krushel L, et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS One 2010, 5: e9001.
-
(2010)
PLoS One
, vol.5
-
-
Hollenbach, P.W.1
Nguyen, A.N.2
Brady, H.3
Williams, M.4
Ning, Y.5
Richard, N.6
Krushel, L.7
-
29
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
-
Kantarjian H, Issa J-PJ, Rosenfeld CS, Bennett JM, Albitar M, DiPersio J, Klimek V, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006, 106: 1794-1803.
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
J-Pj, I.2
Rosenfeld, C.S.3
Bennett, J.M.4
Albitar, M.5
DiPersio, J.6
Klimek, V.7
-
30
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies
-
Issa J-PJ, Garcia-Manero G, Giles FJ, Mannari R, Thomas D, Faderl S, Bayar E, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004, 103: 1635-1640.
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
J-Pj, I.1
Garcia-Manero, G.2
Giles, F.J.3
Mannari, R.4
Thomas, D.5
Faderl, S.6
Bayar, E.7
-
31
-
-
33846011361
-
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
-
Kantarjian H, Oki Y, Garcia-Manero G, Huang X, O'Brien S, Cortes J, Faderl S, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007, 109: 52-57.
-
(2007)
Blood
, vol.109
, pp. 52-57
-
-
Kantarjian, H.1
Oki, Y.2
Garcia-Manero, G.3
Huang, X.4
O'Brien, S.5
Cortes, J.6
Faderl, S.7
-
32
-
-
68949145132
-
Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: The alternative dosing for outpatient treatment (ADOPT) trial
-
Steensma DP, Baer MR, Slack JL, Buckstein R, Godley LA, Garcia-Manero G, Albitar M, et al. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial. J Clin Oncol 2009, 27: 3842-3848.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3842-3848
-
-
Steensma, D.P.1
Baer, M.R.2
Slack, J.L.3
Buckstein, R.4
Godley, L.A.5
Garcia-Manero, G.6
Albitar, M.7
-
33
-
-
77449149374
-
Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
-
Cashen AF, Schiller GJ, O'Donnell MR, DiPersio JF. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 2010, 28: 556-561.
-
(2010)
J Clin Oncol
, vol.28
, pp. 556-561
-
-
Cashen, A.F.1
Schiller, G.J.2
O'Donnell, M.R.3
DiPersio, J.F.4
-
34
-
-
34447123203
-
Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides
-
Yoo CB, Jeong S, Egger G, Liang G, Phiasivongsa P, Tang C, Redkar S, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res 2007, 67: 6400-6408.
-
(2007)
Cancer Res
, vol.67
, pp. 6400-6408
-
-
Yoo, C.B.1
Jeong, S.2
Egger, G.3
Liang, G.4
Phiasivongsa, P.5
Tang, C.6
Redkar, S.7
-
35
-
-
77957571596
-
S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. Anubis)
-
Lavelle D, Saunthararajah Y, Vaitkus K, Singh M, Banzon V, Phiasivongsva P, Redkar S, et al. S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis). J Transl Med 2010, 8: 92.
-
(2010)
J Transl Med
, vol.8
, pp. 92
-
-
Lavelle, D.1
Saunthararajah, Y.2
Vaitkus, K.3
Singh, M.4
Banzon, V.5
Phiasivongsva, P.6
Redkar, S.7
-
36
-
-
66149123748
-
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
-
Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009, 324: 929-930.
-
(2009)
Science
, vol.324
, pp. 929-930
-
-
Kriaucionis, S.1
Heintz, N.2
-
37
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009, 324: 930-935.
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
Agarwal, S.7
-
38
-
-
82955207588
-
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
-
Wu H, Zhang Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev 2011, 25: 2436-2452.
-
(2011)
Genes Dev
, vol.25
, pp. 2436-2452
-
-
Wu, H.1
Zhang, Y.2
-
39
-
-
0037350661
-
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)
-
Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia 2003, 17: 637-641.
-
(2003)
Leukemia
, vol.17
, pp. 637-641
-
-
Lorsbach, R.B.1
Moore, J.2
Mathew, S.3
Raimondi, S.C.4
Mukatira, S.T.5
Downing, J.R.6
-
40
-
-
80052303426
-
TET family proteins and their role in stem cell differentiation and transformation
-
Cimmino L, Abdel-Wahab O, Levine RL, Aifantis I. TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell 2011, 9: 193-204.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 193-204
-
-
Cimmino, L.1
Abdel-Wahab, O.2
Levine, R.L.3
Aifantis, I.4
-
41
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Massé A, Kosmider O, et al. Mutation in TET2 in myeloid cancers. N Engl J Med 2009, 360: 2289-2301.
-
(2009)
N Engl J Med
, vol.360
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Della Valle, V.3
James, C.4
Trannoy, S.5
Massé, A.6
Kosmider, O.7
-
42
-
-
67649876132
-
Acquired mutations in TET2 are common in myelodysplastic syndromes
-
Langemeijer SMC, Kuiper RP, Berends M, Knops R, Aslanyan MG, Massop M, Stevens-Linders E, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 2009, 41: 838-842.
-
(2009)
Nat Genet
, vol.41
, pp. 838-842
-
-
Langemeijer, S.M.C.1
Kuiper, R.P.2
Berends, M.3
Knops, R.4
Aslanyan, M.G.5
Massop, M.6
Stevens-Linders, E.7
-
43
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 2011, 20: 11-24.
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
Abdel-Wahab, O.4
Ndiaye-Lobry, D.5
Lobry, C.6
Figueroa, M.E.7
-
44
-
-
79960062301
-
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
Quivoron C, Couronné L, Della Valle V, Lopez CK, Plo I, Wagner-Ballon O, Do Cruzeiro M, et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 2011, 20: 25-38.
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
Couronné, L.2
Della Valle, V.3
Lopez, C.K.4
Plo, I.5
Wagner-Ballon, O.6
Do Cruzeiro, M.7
-
45
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel JP, Gönen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, Van Vlierberghe P, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012, 366: 1079-1089.
-
(2012)
N Engl J Med
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
Gönen, M.2
Figueroa, M.E.3
Fernandez, H.4
Sun, Z.5
Racevskis, J.6
Van Vlierberghe, P.7
-
46
-
-
0035839136
-
Translating the histone code
-
Jenuwein T, Allis CD. Translating the histone code. Science 2001, 293: 1074-1080.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
47
-
-
33750596313
-
Epigenetic cancer therapy makes headway
-
Mack GS. Epigenetic cancer therapy makes headway. J Natl Cancer Inst 2006, 98: 1443-1444.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1443-1444
-
-
Mack, G.S.1
-
49
-
-
25444475765
-
Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells
-
Karpf AR, Matsui S-i. Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 2005, 65: 8635-8639.
-
(2005)
Cancer Res
, vol.65
, pp. 8635-8639
-
-
Karpf, A.R.1
S-I, M.2
-
50
-
-
0030480969
-
The CBP co-activator is a histone acetyltransferase
-
Bannister AJ, Kouzarides T. The CBP co-activator is a histone acetyltransferase. Nature 1996, 384: 641-643.
-
(1996)
Nature
, vol.384
, pp. 641-643
-
-
Bannister, A.J.1
Kouzarides, T.2
-
51
-
-
13444311619
-
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
-
Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, et al. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 2005, 24: 368-381.
-
(2005)
EMBO J
, vol.24
, pp. 368-381
-
-
Wang, J.1
Iwasaki, H.2
Krivtsov, A.3
Febbo, P.G.4
Thorner, A.R.5
Ernst, P.6
Anastasiadou, E.7
-
52
-
-
19944385935
-
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
-
Huntly BJP, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N, Rowan R, et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 2004, 6: 587-596.
-
(2004)
Cancer Cell
, vol.6
, pp. 587-596
-
-
Huntly, B.J.P.1
Shigematsu, H.2
Deguchi, K.3
Lee, B.H.4
Mizuno, S.5
Duclos, N.6
Rowan, R.7
-
54
-
-
79952430906
-
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
-
Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 2011, 471: 189-195.
-
(2011)
Nature
, vol.471
, pp. 189-195
-
-
Pasqualucci, L.1
Dominguez-Sola, D.2
Chiarenza, A.3
Fabbri, G.4
Grunn, A.5
Trifonov, V.6
Kasper, L.H.7
-
55
-
-
51949111451
-
Chemical probes for histone-modifying enzymes
-
Cole PA. Chemical probes for histone-modifying enzymes. Nat Chem Biol 2008, 4: 590-597.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 590-597
-
-
Cole, P.A.1
-
56
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325: 834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
Olsen, J.V.7
-
57
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006, 6: 38-51.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
58
-
-
0041347519
-
Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
-
Johnstone RW, Licht JD. Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 2003, 4: 13-18.
-
(2003)
Cancer Cell
, vol.4
, pp. 13-18
-
-
Johnstone, R.W.1
Licht, J.D.2
-
59
-
-
79251541733
-
Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors
-
Federico M, Bagella L. Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors. J Biomed Biotechnol 2011, 2011: 475641.
-
(2011)
J Biomed Biotechnol
, vol.2011
-
-
Federico, M.1
Bagella, L.2
-
60
-
-
34547683194
-
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
-
Olsen EA, Kim YH, Kuzel TM, Pacheco TR, Foss FM, Parker S, Frankel SR, et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 2007, 25: 3109-3115.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3109-3115
-
-
Olsen, E.A.1
Kim, Y.H.2
Kuzel, T.M.3
Pacheco, T.R.4
Foss, F.M.5
Parker, S.6
Frankel, S.R.7
-
61
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
-
Piekarz RL, Frye R, Turner M, Wright JJ, Allen SL, Kirschbaum MH, Zain J, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009, 27: 5410-5417.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5410-5417
-
-
Piekarz, R.L.1
Frye, R.2
Turner, M.3
Wright, J.J.4
Allen, S.L.5
Kirschbaum, M.H.6
Zain, J.7
-
62
-
-
0142179154
-
Identification of novel isoform-selective inhibitors within class i histone deacetylases
-
Hu E, Dul E, Sung C-M, Chen Z, Kirkpatrick R, Zhang G-F, Johanson K, et al. Identification of novel isoform-selective inhibitors within class I histone deacetylases. J Pharmacol Exp Ther 2003, 307: 720-728.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 720-728
-
-
Hu, E.1
Dul, E.2
Sung, C.-M.3
Chen, Z.4
Kirkpatrick, R.5
Zhang, G.-F.6
Johanson, K.7
-
63
-
-
42249084230
-
MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
-
Fournel M, Bonfils C, Hou Y, Yan PT, Trachy-Bourget M-C, Kalita A, Liu J, et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther 2008, 7: 759-768.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 759-768
-
-
Fournel, M.1
Bonfils, C.2
Hou, Y.3
Yan, P.T.4
Trachy-Bourget, M.-C.5
Kalita, A.6
Liu, J.7
-
64
-
-
82555187781
-
Mocetinostat for relapsed classical Hodgkin's lymphoma: An open-label, single-arm, phase 2 trial
-
Younes A, Oki Y, Bociek RG, Kuruvilla J, Fanale M, Neelapu S, Copeland A, et al. Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial. Lancet Oncol 2011, 12: 1222-1228.
-
(2011)
Lancet Oncol
, vol.12
, pp. 1222-1228
-
-
Younes, A.1
Oki, Y.2
Bociek, R.G.3
Kuruvilla, J.4
Fanale, M.5
Neelapu, S.6
Copeland, A.7
-
65
-
-
77951685547
-
The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells
-
Mandl-Weber S, Meinel FG, Jankowsky R, Oduncu F, Schmidmaier R, Baumann P. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol 2010, 149: 518-528.
-
(2010)
Br J Haematol
, vol.149
, pp. 518-528
-
-
Mandl-Weber, S.1
Meinel, F.G.2
Jankowsky, R.3
Oduncu, F.4
Schmidmaier, R.5
Baumann, P.6
-
66
-
-
84926359534
-
HDAC inhibitors still need a home run, despite recent approval
-
Guha M. HDAC inhibitors still need a home run, despite recent approval. Nat Rev Drug Discov 2015, 14: 225-226.
-
(2015)
Nat Rev Drug Discov
, vol.14
, pp. 225-226
-
-
Guha, M.1
-
67
-
-
79957933972
-
Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat)
-
Furlan A, Monzani V, Reznikov LL, Leoni F, Fossati G, Modena D, Mascagni P, et al. Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol Med 2011, 17: 353-362.
-
(2011)
Mol Med
, vol.17
, pp. 353-362
-
-
Furlan, A.1
Monzani, V.2
Reznikov, L.L.3
Leoni, F.4
Fossati, G.5
Modena, D.6
Mascagni, P.7
-
68
-
-
79960163508
-
Discovery of (2E)-3-2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol- 5-yl-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile
-
Wang H, Yu N, Chen D, Lee KCL, Lye PL, Chang JWW, Deng W, et al. Discovery of (2E)-3-2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol- 5-yl-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J Med Chem 2011, 54: 4694-4720.
-
(2011)
J Med Chem
, vol.54
, pp. 4694-4720
-
-
Wang, H.1
Yu, N.2
Chen, D.3
Lee, K.C.L.4
Lye, P.L.5
Chang, J.W.W.6
Deng, W.7
-
69
-
-
77949714263
-
SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer
-
Novotny-Diermayr V, Sangthongpitag K, Hu CY, Wu X, Sausgruber N, Yeo P, Greicius G, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther 2010, 9: 642-652.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 642-652
-
-
Novotny-Diermayr, V.1
Sangthongpitag, K.2
Hu, C.Y.3
Wu, X.4
Sausgruber, N.5
Yeo, P.6
Greicius, G.7
-
70
-
-
77951708371
-
CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity
-
Lai C-J, Bao R, Tao X, Wang J, Atoyan R, Qu H, Wang D-G, et al. CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity. Cancer Res 2010, 70: 3647-3656.
-
(2010)
Cancer Res
, vol.70
, pp. 3647-3656
-
-
Lai, C.-J.1
Bao, R.2
Tao, X.3
Wang, J.4
Atoyan, R.5
Qu, H.6
Wang, D.-G.7
-
71
-
-
77955960586
-
PCI-24781, a novel hydroxamic acid HDAC inhibitor, exerts cytotoxicity and histone alterations via caspase-8 and FADD in leukemia cells
-
Rivera-Del Valle N, Gao S, Miller CP, Fulbright J, Gonzales C, Sirisawad M, Steggerda S, et al. PCI-24781, a novel hydroxamic acid HDAC inhibitor, exerts cytotoxicity and histone alterations via caspase-8 and FADD in leukemia cells. Int J Cell Biol 2010, 2010: 207420.
-
(2010)
Int J Cell Biol
, vol.2010
-
-
Rivera-Del Valle, N.1
Gao, S.2
Miller, C.P.3
Fulbright, J.4
Gonzales, C.5
Sirisawad, M.6
Steggerda, S.7
-
72
-
-
77956194142
-
The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo
-
Lucas DM, Alinari L, West DA, Davis ME, Edwards RB, Johnson AJ, Blum KA, et al. The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo. PLoS One 2010, 5: e10941.
-
(2010)
PLoS One
, vol.5
-
-
Lucas, D.M.1
Alinari, L.2
West, D.A.3
Davis, M.E.4
Edwards, R.B.5
Johnson, A.J.6
Blum, K.A.7
-
73
-
-
84860381721
-
A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL
-
Hwang JJ, Kim YS, Kim T, Kim MJ, Jeong IG, Lee J-H, Choi J, et al. A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL. Invest New Drugs 2012, 30: 1434-1442.
-
(2012)
Invest New Drugs
, vol.30
, pp. 1434-1442
-
-
Hwang, J.J.1
Kim, Y.S.2
Kim, T.3
Kim, M.J.4
Jeong, I.G.5
Lee, J.-H.6
Choi, J.7
-
74
-
-
84924942755
-
Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells
-
Chun S-M, Lee J-Y, Choi J, Lee J-H, Hwang JJ, Kim C-S, Suh Y-A, et al. Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells. PLoS One 2015, 10: e0119379.
-
(2015)
PLoS One
, vol.10
-
-
Chun, S.-M.1
Lee, J.-Y.2
Choi, J.3
Lee, J.-H.4
Hwang, J.J.5
Kim, C.-S.6
Suh, Y.-A.7
-
75
-
-
0036898253
-
Acetylation inactivates the transcriptional repressor BCL6
-
Bereshchenko OR, Gu W, Dalla-Favera R. Acetylation inactivates the transcriptional repressor BCL6. Nat Genet 2002, 32: 606-613.
-
(2002)
Nat Genet
, vol.32
, pp. 606-613
-
-
Bereshchenko, O.R.1
Gu, W.2
Dalla-Favera, R.3
-
76
-
-
84897022815
-
Comprehensive molecular characterization of urothelial bladder carcinoma
-
Network TCGAR. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 2014, 507: 315-322.
-
(2014)
Nature
, vol.507
, pp. 315-322
-
-
Network, T.C.G.A.R.1
-
77
-
-
84881059186
-
Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms
-
Ali A, Bluteau O, Messaoudi K, Palazzo A, Boukour S, Lordier L, Lecluse Y, et al. Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms. Cell Death Dis 2013, 4: e738.
-
(2013)
Cell Death Dis
, vol.4
-
-
Ali, A.1
Bluteau, O.2
Messaoudi, K.3
Palazzo, A.4
Boukour, S.5
Lordier, L.6
Lecluse, Y.7
-
78
-
-
79952262759
-
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
-
Wagner JM, Hackanson B, Lübbert M, Jung M. Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clin Epigenet 2010, 1: 117-136.
-
(2010)
Clin Epigenet
, vol.1
, pp. 117-136
-
-
Wagner, J.M.1
Hackanson, B.2
Lübbert, M.3
Jung, M.4
-
79
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
Barski A, Cuddapah S, Cui K, Roh T-Y, Schones DE, Wang Z, Wei G, et al. High-resolution profiling of histone methylations in the human genome. Cell 2007, 129: 823-837.
-
(2007)
Cell
, vol.129
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
Roh, T.-Y.4
Schones, D.E.5
Wang, Z.6
Wei, G.7
-
80
-
-
65549104157
-
Histone modifications at human enhancers reflect global cell-type-specific gene expression
-
Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 2009, 459: 108-112.
-
(2009)
Nature
, vol.459
, pp. 108-112
-
-
Heintzman, N.D.1
Hon, G.C.2
Hawkins, R.D.3
Kheradpour, P.4
Stark, A.5
Harp, L.F.6
Ye, Z.7
-
81
-
-
78751662908
-
The polycomb complex PRC2 and its mark in life
-
Margueron R, Reinberg D. The polycomb complex PRC2 and its mark in life. Nature 2011, 469: 343-349.
-
(2011)
Nature
, vol.469
, pp. 343-349
-
-
Margueron, R.1
Reinberg, D.2
-
82
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, Paul JE, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010, 42: 181-185.
-
(2010)
Nat Genet
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
Mungall, A.J.4
An, J.5
Goya, R.6
Paul, J.E.7
-
83
-
-
78650454078
-
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
-
Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM, Copeland RA. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci USA 2010, 107: 20980-20985.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20980-20985
-
-
Sneeringer, C.J.1
Scott, M.P.2
Kuntz, K.W.3
Knutson, S.K.4
Pollock, R.M.5
Richon, V.M.6
Copeland, R.A.7
-
84
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, Waghorn K, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010, 42: 722-726.
-
(2010)
Nat Genet
, vol.42
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
Hidalgo-Curtis, C.E.4
Bryant, C.5
Jones, A.V.6
Waghorn, K.7
-
85
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
Nikoloski G, Langemeijer SMC, Kuiper RP, Knops R, Massop M, Tönnissen ERLTM, van der Heijden A, et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 2010, 42: 665-667.
-
(2010)
Nat Genet
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
Langemeijer, S.M.C.2
Kuiper, R.P.3
Knops, R.4
Massop, M.5
Tönnissen, E.R.L.T.M.6
Van Der Heijden, A.7
-
86
-
-
79960058024
-
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
-
Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J, Johnston LD, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 2011, 20: 53-65.
-
(2011)
Cancer Cell
, vol.20
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Majer, C.R.4
Sneeringer, C.J.5
Song, J.6
Johnston, L.D.7
-
87
-
-
84871737742
-
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
-
Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 2012, 3: 1288.
-
(2012)
Nat Commun
, vol.3
, pp. 1288
-
-
Yu, W.1
Chory, E.J.2
Wernimont, A.K.3
Tempel, W.4
Scopton, A.5
Federation, A.6
Marineau, J.J.7
-
88
-
-
34247625135
-
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
-
Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RKM, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 2007, 21: 1050-1063.
-
(2007)
Genes Dev
, vol.21
, pp. 1050-1063
-
-
Tan, J.1
Yang, X.2
Zhuang, L.3
Jiang, X.4
Chen, W.5
Lee, P.L.6
Karuturi, R.K.M.7
-
89
-
-
84870573126
-
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
-
McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, Liu Y, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012, 492: 108-112.
-
(2012)
Nature
, vol.492
, pp. 108-112
-
-
McCabe, M.T.1
Ott, H.M.2
Ganji, G.3
Korenchuk, S.4
Thompson, C.5
Van Aller, G.S.6
Liu, Y.7
-
90
-
-
84879773777
-
Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition
-
Amatangelo MD, Garipov A, Li H, Conejo-Garcia JR, Speicher DW, Zhang R. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle 2013, 12: 2113-2119.
-
(2013)
Cell Cycle
, vol.12
, pp. 2113-2119
-
-
Amatangelo, M.D.1
Garipov, A.2
Li, H.3
Conejo-Garcia, J.R.4
Speicher, D.W.5
Zhang, R.6
-
91
-
-
84867632489
-
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
-
Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, Sacks JD, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol 2012, 8: 890-896.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 890-896
-
-
Knutson, S.K.1
Wigle, T.J.2
Warholic, N.M.3
Sneeringer, C.J.4
Allain, C.J.5
Klaus, C.R.6
Sacks, J.D.7
-
92
-
-
77954291438
-
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors
-
Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, et al. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 2010, 18: 23-38.
-
(2010)
Cancer Cell
, vol.18
, pp. 23-38
-
-
Qi, J.1
Nakayama, K.2
Cardiff, R.D.3
Borowsky, A.D.4
Kaul, K.5
Williams, R.6
Krajewski, S.7
-
93
-
-
84916881910
-
Synergistic anti-tumor activity of EZH2 inhibitors and glucocorticoid receptor agonists in models of germinal center non-Hodgkin lymphomas
-
Knutson SK, Warholic NM, Johnston LD, Klaus CR, Wigle TJ, Iwanowicz D, Littlefield BA, et al. Synergistic anti-tumor activity of EZH2 inhibitors and glucocorticoid receptor agonists in models of germinal center non-Hodgkin lymphomas. PLoS One 2014, 9: e111840.
-
(2014)
PLoS One
, vol.9
-
-
Knutson, S.K.1
Warholic, N.M.2
Johnston, L.D.3
Klaus, C.R.4
Wigle, T.J.5
Iwanowicz, D.6
Littlefield, B.A.7
-
94
-
-
84877324084
-
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
-
Knutson SK, Warholic NM, Wigle TJ. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci USA 2013, 110: 7922-7927.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 7922-7927
-
-
Knutson, S.K.1
Warholic, N.M.2
Wigle, T.J.3
-
95
-
-
84879750981
-
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
-
Konze KD, Ma A, Li F, Barsyte-Lovejoy D. An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chem Biol 2013, 8: 1324-1334.
-
(2013)
ACS Chem Biol
, vol.8
, pp. 1324-1334
-
-
Konze, K.D.1
Ma, A.2
Li, F.3
Barsyte-Lovejoy, D.4
-
96
-
-
84859643953
-
Anti-leukemia activity of chaetocin via death receptordependent apoptosis and dual modulation of the histone methyltransferase SUV39H1
-
Chaib H, Nebbioso A, Prebet T, Castellano R, Garbit S, Restouin A, Vey N, et al. Anti-leukemia activity of chaetocin via death receptordependent apoptosis and dual modulation of the histone methyltransferase SUV39H1. Leukemia 2012, 26: 662-674.
-
(2012)
Leukemia
, vol.26
, pp. 662-674
-
-
Chaib, H.1
Nebbioso, A.2
Prebet, T.3
Castellano, R.4
Garbit, S.5
Restouin, A.6
Vey, N.7
-
97
-
-
84989315935
-
The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells
-
Lai Y-S, Chen J-Y, Tsai H-J, Chen T-Y, Hung W-C. The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells. Blood Cancer J 2015, 5: e313.
-
(2015)
Blood Cancer J
, vol.5
-
-
Lai, Y.-S.1
Chen, J.-Y.2
Tsai, H.-J.3
Chen, T.-Y.4
Hung, W.-C.5
-
98
-
-
84875853532
-
Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells
-
Lu Z, Tian Y, Salwen HR, Chlenski A, Godley LA, Raj JU, Yang Q. Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells. Anti-Cancer Drugs 2013, 24: 484-493.
-
(2013)
Anti-Cancer Drugs
, vol.24
, pp. 484-493
-
-
Lu, Z.1
Tian, Y.2
Salwen, H.R.3
Chlenski, A.4
Godley, L.A.5
Raj, J.U.6
Yang, Q.7
-
99
-
-
79960493567
-
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
-
Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol 2011, 7: 566-574.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 566-574
-
-
Vedadi, M.1
Barsyte-Lovejoy, D.2
Liu, F.3
Rival-Gervier, S.4
Allali-Hassani, A.5
Labrie, V.6
Wigle, T.J.7
-
100
-
-
84864140929
-
A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma
-
Yuan Y, Wang Q, Paulk J, Kubicek S, Kemp MM, Adams DJ, Shamji AF, et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol 2012, 7: 1152-1157.
-
(2012)
ACS Chem Biol
, vol.7
, pp. 1152-1157
-
-
Yuan, Y.1
Wang, Q.2
Paulk, J.3
Kubicek, S.4
Kemp, M.M.5
Adams, D.J.6
Shamji, A.F.7
-
101
-
-
84901508481
-
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis
-
Rodriguez-Paredes M, Martinez de Paz A, Simó-Riudalbas L, Sayols S, Moutinho C, Moran S, Villanueva A, et al. Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Oncogene 2013, 33: 2807-2813.
-
(2013)
Oncogene
, vol.33
, pp. 2807-2813
-
-
Rodriguez-Paredes, M.1
Martinez De Paz, A.2
Simó-Riudalbas, L.3
Sayols, S.4
Moutinho, C.5
Moran, S.6
Villanueva, A.7
-
102
-
-
84862777766
-
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
-
Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein H-U, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 2012, 18: 605-611.
-
(2012)
Nat Med
, vol.18
, pp. 605-611
-
-
Schenk, T.1
Chen, W.C.2
Göllner, S.3
Howell, L.4
Jin, L.5
Hebestreit, K.6
Klein, H.-U.7
-
103
-
-
84886808679
-
Chromatin proteins and modifications as drug targets
-
Helin K, Dhanak D. Chromatin proteins and modifications as drug targets. Nature 2013, 502: 480-488.
-
(2013)
Nature
, vol.502
, pp. 480-488
-
-
Helin, K.1
Dhanak, D.2
-
104
-
-
79955035374
-
Inhibition of histone demethylases by 4-carboxy-2, 2'-bipyridyl compounds
-
Chang K-H, King ONF, Tumber A, Woon ECY, Heightman TD, McDonough MA, Schofield CJ, et al. Inhibition of histone demethylases by 4-carboxy-2, 2'-bipyridyl compounds. ChemMedChem 2011, 6: 759-764.
-
(2011)
ChemMedChem
, vol.6
, pp. 759-764
-
-
Chang, K.-H.1
King, O.N.F.2
Tumber, A.3
Woon, E.C.Y.4
Heightman, T.D.5
McDonough, M.A.6
Schofield, C.J.7
-
105
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012, 488: 404-408.
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
Liddle, J.4
Che, K.5
Joberty, G.6
Bantscheff, M.7
-
106
-
-
84961291627
-
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
-
Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med 2014, 20: 1394-1396.
-
(2014)
Nat Med
, vol.20
, pp. 1394-1396
-
-
Hashizume, R.1
Andor, N.2
Ihara, Y.3
Lerner, R.4
Gan, H.5
Chen, X.6
Fang, D.7
-
107
-
-
70350494322
-
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
-
Fiskus W, Wang Y, Sreekumar A, Buckley KM, Shi H, Jillella A, Ustun C, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 2009, 114: 2733-2743.
-
(2009)
Blood
, vol.114
, pp. 2733-2743
-
-
Fiskus, W.1
Wang, Y.2
Sreekumar, A.3
Buckley, K.M.4
Shi, H.5
Jillella, A.6
Ustun, C.7
-
108
-
-
84960334079
-
Targeted EZH2 inhibitors in diffuse large B-cell lymphoma (DLBCL): Immunohistochemical and mutational profiles of patients may determine candidates for treatment
-
Dubois S, Mareschal S, Cornic M, Picquenot J-M, Bertrand P, Bohers E, Maingonnat C, et al. Targeted EZH2 inhibitors in diffuse large B-cell lymphoma (DLBCL): immunohistochemical and mutational profiles of patients may determine candidates for treatment. ASH Annual Meeting and Exposition 2014, 124: 1656.
-
(2014)
ASH Annual Meeting and Exposition
, vol.124
, pp. 1656
-
-
Dubois, S.1
Mareschal, S.2
Cornic, M.3
Picquenot, J.-M.4
Bertrand, P.5
Bohers, E.6
Maingonnat, C.7
-
109
-
-
77953644347
-
Reversal of histone methylation: Biochemical and molecular mechanisms of histone demethylases
-
Mosammaparast N, Shi Y. Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases. Annu Rev Biochem 2010, 79: 155-179.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 155-179
-
-
Mosammaparast, N.1
Shi, Y.2
-
110
-
-
84859169877
-
The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, et al. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012, 483: 603-607.
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
Wilson, C.J.7
-
111
-
-
84862123313
-
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
-
Harris WJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, Li Y, Ciceri F, et al. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 2012, 21: 473-487.
-
(2012)
Cancer Cell
, vol.21
, pp. 473-487
-
-
Harris, W.J.1
Huang, X.2
Lynch, J.T.3
Spencer, G.J.4
Hitchin, J.R.5
Li, Y.6
Ciceri, F.7
-
112
-
-
78649815150
-
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
-
Hayami S, Kelly JD, Cho H-S, Yoshimatsu M, Unoki M, Tsunoda T, Field HI, et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 2011, 128: 574-586.
-
(2011)
Int J Cancer
, vol.128
, pp. 574-586
-
-
Hayami, S.1
Kelly, J.D.2
Cho, H.-S.3
Yoshimatsu, M.4
Unoki, M.5
Tsunoda, T.6
Field, H.I.7
-
113
-
-
80255137124
-
Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer
-
Kauffman EC, Robinson BD, Downes MJ, Powell LG, Lee MM, Scherr DS, Gudas LJ, et al. Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. Mol Carcinog 2011, 50: 931-944.
-
(2011)
Mol Carcinog
, vol.50
, pp. 931-944
-
-
Kauffman, E.C.1
Robinson, B.D.2
Downes, M.J.3
Powell, L.G.4
Lee, M.M.5
Scherr, D.S.6
Gudas, L.J.7
-
114
-
-
56749151276
-
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases
-
Rose NR, Ng SS, Mecinović J, Liénard BMR, Bello SH, Sun Z, McDonough MA, et al. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem 2008, 51: 7053-7056.
-
(2008)
J Med Chem
, vol.51
, pp. 7053-7056
-
-
Rose, N.R.1
Ng, S.S.2
Mecinović, J.3
Liénard, B.M.R.4
Bello, S.H.5
Sun, Z.6
McDonough, M.A.7
-
115
-
-
79958273993
-
Inhibitors of histone demethylases
-
Lohse B, Kristensen JL, Kristensen LH, Agger K, Helin K, Gajhede M, Clausen RP. Inhibitors of histone demethylases. Bioorg Med Chem 2011, 19: 3625-3636.
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 3625-3636
-
-
Lohse, B.1
Kristensen, J.L.2
Kristensen, L.H.3
Agger, K.4
Helin, K.5
Gajhede, M.6
Clausen, R.P.7
-
116
-
-
78649528262
-
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
-
King ONF, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One 2010, 5: e15535.
-
(2010)
PLoS One
, vol.5
-
-
King, O.N.F.1
Li, X.S.2
Sakurai, M.3
Kawamura, A.4
Rose, N.R.5
Ng, S.S.6
Quinn, A.M.7
-
117
-
-
84872330923
-
Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency
-
Liang Y, Vogel JL, Arbuckle JH, Rai G, Jadhav A, Simeonov A, Maloney DJ, et al. Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. Sci Transl Med 2013, 5: 167ra5.
-
(2013)
Sci Transl Med
, vol.5
, pp. 167ra5
-
-
Liang, Y.1
Vogel, J.L.2
Arbuckle, J.H.3
Rai, G.4
Jadhav, A.5
Simeonov, A.6
Maloney, D.J.7
-
118
-
-
84874789264
-
Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination
-
Zhao W, Li Q, Ayers S, Gu Y, Shi Z, Zhu Q, Chen Y, et al. Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Cell 2013, 152: 1037-1050.
-
(2013)
Cell
, vol.152
, pp. 1037-1050
-
-
Zhao, W.1
Li, Q.2
Ayers, S.3
Gu, Y.4
Shi, Z.5
Zhu, Q.6
Chen, Y.7
-
119
-
-
84960343669
-
Regulatory factors of induced pluripotency: Current status
-
Zhao W, Ning B, Qian C. Regulatory factors of induced pluripotency: current status. Stem Cell Investigation 2014, 1: 7.
-
(2014)
Stem Cell Investigation
, vol.1
, pp. 7
-
-
Zhao, W.1
Ning, B.2
Qian, C.3
-
120
-
-
35348826654
-
JMJD3 is a histone H3K27 demethylase
-
Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD. JMJD3 is a histone H3K27 demethylase. Cell Res 2007, 17: 850-857.
-
(2007)
Cell Res
, vol.17
, pp. 850-857
-
-
Xiang, Y.1
Zhu, Z.2
Han, G.3
Lin, H.4
Xu, L.5
Chen, C.D.6
-
121
-
-
84908029332
-
Inhibition of demethylases by GSK-J1/J4
-
Heinemann B, Nielsen JM, Hudlebusch HR, Lees MJ, Larsen DV, Boesen T, Labelle M, et al. Inhibition of demethylases by GSK-J1/J4. Nature 2014, 514: E1-E2.
-
(2014)
Nature
, vol.514
, pp. E1-E2
-
-
Heinemann, B.1
Nielsen, J.M.2
Hudlebusch, H.R.3
Lees, M.J.4
Larsen, D.V.5
Boesen, T.6
Labelle, M.7
-
122
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012, 482: 226-231.
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
Korshunov, A.2
Liu, X.Y.3
Jones, D.T.4
Pfaff, E.5
Jacob, K.6
Sturm, D.7
-
123
-
-
84877785024
-
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
-
Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 2013, 340: 857-861.
-
(2013)
Science
, vol.340
, pp. 857-861
-
-
Lewis, P.W.1
Müller, M.M.2
Koletsky, M.S.3
Cordero, F.4
Lin, S.5
Banaszynski, L.A.6
Garcia, B.A.7
-
124
-
-
34250739960
-
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis
-
Wilkinson RW, Odedra R, Heaton SP, Wedge SR, Keen NJ, Crafter C, Foster JR, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res 2007, 13: 3682-3688.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3682-3688
-
-
Wilkinson, R.W.1
Odedra, R.2
Heaton, S.P.3
Wedge, S.R.4
Keen, N.J.5
Crafter, C.6
Foster, J.R.7
-
125
-
-
28844475262
-
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin
-
Hirota T, Lipp JJ, Toh B-H, Peters J-M. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 2005, 438: 1176-1180.
-
(2005)
Nature
, vol.438
, pp. 1176-1180
-
-
Hirota, T.1
Lipp, J.J.2
Toh, B.-H.3
Peters, J.-M.4
-
126
-
-
10344236486
-
Aurora-kinase inhibitors as anticancer agents
-
Keen N, Taylor S. Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 2004, 4: 927-936.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 927-936
-
-
Keen, N.1
Taylor, S.2
-
128
-
-
77956696835
-
Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in myelofibrosis
-
Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, Estrov Z, et al. Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in myelofibrosis. N Engl J Med 2010, 363: 1117-1127.
-
(2010)
N Engl J Med
, vol.363
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
Pardanani, A.D.4
Cortes-Franco, J.5
Thomas, D.A.6
Estrov, Z.7
-
129
-
-
76949083372
-
Lestaurtinib, a multitargeted tyrosinse kinase inhibitor: From bench to bedside
-
Shabbir M, Stuart R. Lestaurtinib, a multitargeted tyrosinse kinase inhibitor: from bench to bedside. Expert Opin Investig Drugs 2010, 19: 427-436.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 427-436
-
-
Shabbir, M.1
Stuart, R.2
-
130
-
-
80755140046
-
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
-
Hart S, Goh KC, Novotny-Diermayr V, Hu CY, Hentze H, Tan YC, Madan B, et al. SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies. Leukemia 2011, 25: 1751-1759.
-
(2011)
Leukemia
, vol.25
, pp. 1751-1759
-
-
Hart, S.1
Goh, K.C.2
Novotny-Diermayr, V.3
Hu, C.Y.4
Hentze, H.5
Tan, Y.C.6
Madan, B.7
-
131
-
-
84884201421
-
A small molecule inhibitor of Polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks
-
Ismail IH, McDonald D, Strickfaden H, Xu Z, Hendzel MJ. A small molecule inhibitor of Polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem 2013, 288: 26944-26954.
-
(2013)
J Biol Chem
, vol.288
, pp. 26944-26954
-
-
Ismail, I.H.1
McDonald, D.2
Strickfaden, H.3
Xu, Z.4
Hendzel, M.J.5
-
132
-
-
35848961668
-
How chromatinbinding modules interpret histone modifications: Lessons from professional pocket pickers
-
Taverna SD, Li H, Ruthenburg AJ, Allis CD, Patel DJ. How chromatinbinding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol 2007, 14: 1025-1040.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 1025-1040
-
-
Taverna, S.D.1
Li, H.2
Ruthenburg, A.J.3
Allis, C.D.4
Patel, D.J.5
-
133
-
-
84874771985
-
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
-
Spruijt CG, Gnerlich F, Smits AH, Pfaffeneder T, Jansen PWTC, Bauer C, Münzel M, et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 2013, 152: 1146-1159.
-
(2013)
Cell
, vol.152
, pp. 1146-1159
-
-
Spruijt, C.G.1
Gnerlich, F.2
Smits, A.H.3
Pfaffeneder, T.4
Jansen, P.W.T.C.5
Bauer, C.6
Münzel, M.7
-
134
-
-
34547793043
-
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression
-
Lan F, Collins RE, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, et al. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature 2007, 448: 718-722.
-
(2007)
Nature
, vol.448
, pp. 718-722
-
-
Lan, F.1
Collins, R.E.2
De Cegli, R.3
Alpatov, R.4
Horton, J.R.5
Shi, X.6
Gozani, O.7
-
135
-
-
34547725157
-
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
-
Ooi SKT, Qiu C, Bernstein E, Li K, Jia D, Yang Z, Erdjument-Bromage H, et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 2007, 448: 714-717.
-
(2007)
Nature
, vol.448
, pp. 714-717
-
-
Ooi, S.K.T.1
Qiu, C.2
Bernstein, E.3
Li, K.4
Jia, D.5
Yang, Z.6
Erdjument-Bromage, H.7
-
136
-
-
33745818717
-
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2
-
Peña PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, et al. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature 2006, 442: 100-103.
-
(2006)
Nature
, vol.442
, pp. 100-103
-
-
Peña, P.V.1
Davrazou, F.2
Shi, X.3
Walter, K.L.4
Verkhusha, V.V.5
Gozani, O.6
Zhao, R.7
-
137
-
-
0033519641
-
Structure and ligand of a histone acetyltransferase bromodomain
-
Dhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM. Structure and ligand of a histone acetyltransferase bromodomain. Nature 1999, 399: 491-496.
-
(1999)
Nature
, vol.399
, pp. 491-496
-
-
Dhalluin, C.1
Carlson, J.E.2
Zeng, L.3
He, C.4
Aggarwal, A.K.5
Zhou, M.M.6
-
138
-
-
36448949026
-
Multivalent engagement of chromatin modifications by linked binding modules
-
Ruthenburg AJ, Li H, Patel DJ, Allis CD. Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol 2007, 8: 983-994.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 983-994
-
-
Ruthenburg, A.J.1
Li, H.2
Patel, D.J.3
Allis, C.D.4
-
139
-
-
77953995002
-
Covalent histone modifications - Miswritten, misinterpreted and mis-erased in human cancers
-
Chi P, Allis CD, Wang GG. Covalent histone modifications - miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer 2010, 10: 457-469.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 457-469
-
-
Chi, P.1
Allis, C.D.2
Wang, G.G.3
-
140
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan W-I, Robson SC, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 2011, 478: 529-533.
-
(2011)
Nature
, vol.478
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.-I.6
Robson, S.C.7
-
141
-
-
84856397832
-
Fragment-based discovery of bromodomain inhibitors part 1: Inhibitor binding modes and implications for lead discovery
-
Chung C-w, Dean AW, Woolven JM, Bamborough P. Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery. J Med Chem 2012, 55: 576-586.
-
(2012)
J Med Chem
, vol.55
, pp. 576-586
-
-
C-W, C.1
Dean, A.W.2
Woolven, J.M.3
Bamborough, P.4
-
142
-
-
0004788326
-
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
-
Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc Natl Acad Sci USA 1998, 95: 8538-8543.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8538-8543
-
-
Jiang, Y.W.1
Veschambre, P.2
Erdjument-Bromage, H.3
Tempst, P.4
Conaway, J.W.5
Conaway, R.C.6
Kornberg, R.D.7
-
143
-
-
77958111633
-
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
-
Malik S, Roeder RG. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 2010, 11: 761-772.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 761-772
-
-
Malik, S.1
Roeder, R.G.2
-
144
-
-
23744467035
-
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
-
Yang Z, Yik JHN, Chen R, He N, Jang MK, Ozato K, Zhou Q. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell 2005, 19: 535-545.
-
(2005)
Mol Cell
, vol.19
, pp. 535-545
-
-
Yang, Z.1
Yik, J.H.N.2
Chen, R.3
He, N.4
Jang, M.K.5
Ozato, K.6
Zhou, Q.7
-
145
-
-
63849121338
-
Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse
-
Shang E, Wang X, Wen D, Greenberg DA, Wolgemuth DJ. Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse. Dev Dyn 2009, 238: 908-917.
-
(2009)
Dev Dyn
, vol.238
, pp. 908-917
-
-
Shang, E.1
Wang, X.2
Wen, D.3
Greenberg, D.A.4
Wolgemuth, D.J.5
-
146
-
-
0036091456
-
Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4
-
Houzelstein D, Bullock SL, Lynch DE, Grigorieva EF, Wilson VA, Beddington RSP. Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Mol Cell Biol 2002, 22: 3794-3802.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3794-3802
-
-
Houzelstein, D.1
Bullock, S.L.2
Lynch, D.E.3
Grigorieva, E.F.4
Wilson, V.A.5
Beddington, R.S.P.6
-
147
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, et al. Selective inhibition of BET bromodomains. Nature 2010, 468: 1067-1073.
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
-
148
-
-
84932634729
-
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation
-
Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, Bradner JE. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 2015, 348: 1376-1381.
-
(2015)
Science
, vol.348
, pp. 1376-1381
-
-
Winter, G.E.1
Buckley, D.L.2
Paulk, J.3
Roberts, J.M.4
Souza, A.5
Dhe-Paganon, S.6
Bradner, J.E.7
-
149
-
-
84897024898
-
Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
-
Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry MS, Rotolo A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood 2014, 123: 697-705.
-
(2014)
Blood
, vol.123
, pp. 697-705
-
-
Chaidos, A.1
Caputo, V.2
Gouvedenou, K.3
Liu, B.4
Marigo, I.5
Chaudhry, M.S.6
Rotolo, A.7
-
150
-
-
84936818798
-
The bromodomain protein BRD4 controlsHOTAIR, a long noncoding RNA essential for glioblastoma proliferation
-
Pastori C, Kapranov P, Penas C, Peschansky V, Volmar C-H, Sarkaria JN, Bregy A, et al. The bromodomain protein BRD4 controlsHOTAIR, a long noncoding RNA essential for glioblastoma proliferation. Proc Natl Acad Sci USA 2015, 112: 8326-8331.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 8326-8331
-
-
Pastori, C.1
Kapranov, P.2
Penas, C.3
Peschansky, V.4
Volmar, C.-H.5
Sarkaria, J.N.6
Bregy, A.7
-
151
-
-
79953783228
-
Small-molecule ligands of methyl-lysine binding proteins
-
Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, et al. Small-molecule ligands of methyl-lysine binding proteins. J Med Chem 2011, 54: 2504-2511.
-
(2011)
J Med Chem
, vol.54
, pp. 2504-2511
-
-
Herold, J.M.1
Wigle, T.J.2
Norris, J.L.3
Lam, R.4
Korboukh, V.K.5
Gao, C.6
Ingerman, L.A.7
-
152
-
-
84884993346
-
Small-molecule ligands of methyl-lysine binding proteins: Optimization of selectivity for L3MBTL3
-
James LI, Korboukh VK, Krichevsky L, Baughman BM, Herold JM, Norris JL, Jin J, et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem 2013, 56: 7358-7371.
-
(2013)
J Med Chem
, vol.56
, pp. 7358-7371
-
-
James, L.I.1
Korboukh, V.K.2
Krichevsky, L.3
Baughman, B.M.4
Herold, J.M.5
Norris, J.L.6
Jin, J.7
-
153
-
-
84902334205
-
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
-
Asangani IA, Dommeti VL, Wang X, Malik R, Cieslik M, Yang R, Escara-Wilke J, et al. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer. Nature 2014, 510: 278-282.
-
(2014)
Nature
, vol.510
, pp. 278-282
-
-
Asangani, I.A.1
Dommeti, V.L.2
Wang, X.3
Malik, R.4
Cieslik, M.5
Yang, R.6
Escara-Wilke, J.7
-
154
-
-
80455131079
-
Drug discovery toward antagonists of methyl-lysine binding proteins
-
Herold JM, Ingerman LA, Gao C, Frye SV.Drug discovery toward antagonists of methyl-lysine binding proteins. Curr Chem Genomics 2011, 5: 51-61.
-
(2011)
Curr Chem Genomics
, vol.5
, pp. 51-61
-
-
Herold, J.M.1
Ingerman, L.A.2
Gao, C.3
Frye, S.V.4
-
155
-
-
84885848767
-
Tudor: A versatile family of histone methylation 'readers
-
Lu R, Wang GG. Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci 2013, 38: 546-555.
-
(2013)
Trends Biochem Sci
, vol.38
, pp. 546-555
-
-
Lu, R.1
Wang, G.G.2
-
156
-
-
80053132089
-
Deciphering arginine methylation: Tudor tells the tale
-
Chen C, Nott TJ, Jin J, Pawson T. Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol 2011, 12: 629-642.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 629-642
-
-
Chen, C.1
Nott, T.J.2
Jin, J.3
Pawson, T.4
-
157
-
-
84875509226
-
ERG induces epigenetic activation of Tudor domaincontaining protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer
-
Kacprzyk LA, Laible M, Andrasiuk T, Brase JC, Börno ST, Fälth M, Kuner R, et al. ERG induces epigenetic activation of Tudor domaincontaining protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer. PLoS One 2013, 8: e59976.
-
(2013)
PLoS One
, vol.8
-
-
Kacprzyk, L.A.1
Laible, M.2
Andrasiuk, T.3
Brase, J.C.4
Börno, S.T.5
Fälth, M.6
Kuner, R.7
-
158
-
-
78651107405
-
L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability
-
Gurvich N, Perna F, Farina A, Voza F, Menendez S, Hurwitz J, Nimer SD. L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Proc Natl Acad Sci USA 2010, 107: 22552-22557.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 22552-22557
-
-
Gurvich, N.1
Perna, F.2
Farina, A.3
Voza, F.4
Menendez, S.5
Hurwitz, J.6
Nimer, S.D.7
-
159
-
-
84874116695
-
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
-
James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol 2013, 9: 184-191.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 184-191
-
-
James, L.I.1
Barsyte-Lovejoy, D.2
Zhong, N.3
Krichevsky, L.4
Korboukh, V.K.5
Herold, J.M.6
MacNevin, C.J.7
-
160
-
-
84892919442
-
Cancer epigenetics drug discovery and development: The challenge of hitting the mark
-
Campbell RM, Tummino PJ. Cancer epigenetics drug discovery and development: the challenge of hitting the mark. J Clin Invest 2014, 124: 64-69.
-
(2014)
J Clin Invest
, vol.124
, pp. 64-69
-
-
Campbell, R.M.1
Tummino, P.J.2
|