5-aza-2′-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of Transferrin Receptor 1 (TfR1) and ferrochelatase (Fech) genes

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37196-37206

  Ning, Bo ^a,f,g   Liu, Gang ^a,g   Liu, Yuanyuan ^b   Su, Xiufen ^b   Anderson, Gregory J ^c   Zheng, Xin ^d   Chang, Yanzhong ^d   Guo, Mingzhou ^e   Liu, Yuanfang ^f   Zhao, Yuliang ^a   Nie, Guangjun ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b JILIN UNIVERSITY   (China)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d HEBEI NORMAL UNIVERSITY   (China)

^e CHINESE PLA GENERAL HOSPITAL   (China)

^f PEKING UNIVERSITY   (China)

^g UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CPG ISLANDS; ERYTHROID DIFFERENTIATION; FERROCHELATASE; HEME BIOSYNTHESIS; IRON UPTAKE; LEUKEMIA CELLS; MOLECULAR INSIGHTS; MOLECULAR MECHANISM; NUCLEAR LOCALIZATION; NUCLEAR TRANSLOCATIONS; PROMOTER ELEMENTS; TARGET GENES; TRANSFERRIN RECEPTOR 1;

ALKYLATION; BIOCHEMISTRY; BIOSYNTHESIS; GENES; METHYLATION; PORPHYRINS; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

5 AZA 2' DEOXYCYTIDINE; CD71 ANTIGEN; FERROCHELATASE; HEME; MAX PROTEIN; MYC PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CPG ISLAND; ERYTHROBLAST; FECH GENE; GENE; HEME SYNTHESIS; IRON TRANSPORT; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; TFR1 GENE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; AZACITIDINE; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CELL NUCLEUS; CPG ISLANDS; ENZYME INHIBITORS; ERYTHROID CELLS; FERROCHELATASE; HEME; HUMANS; IRON; MICE; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, TRANSFERRIN; RESPONSE ELEMENTS;

MURINAE;

EID: 80054822255     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.258129     Document Type: Article

References (43)

1. Nimer, S. D. (2008) Blood 111, 4841-4851
2. Tefferi, A., and Vardiman, J. W. (2009) N. Engl. J. Med. 361, 1872-1885
3. Aul, C., Bowen, D. T., and Yoshida, Y. (1998) Haematologica 83, 71-86
4. Hofmann, W. K., and Koeffler, H. P. (2005) Annu. Rev. Med. 56, 1-16
5. Jädersten, M., and Hellström-Lindberg, E. (2010) Exp. Cell Res. 316, 1390-1396
6. Quintás-Cardama, A., Santos, F. P., and Garcia-Manero, G. (2010) Nat. Rev. Clin. Oncol. 7, 433-444
7. Daskalakis, M., Nguyen, T. T., Nguyen, C., Guldberg, P., Köhler, G., Wijermans, P., Jones, P. A., and Lübbert, M. (2002) Blood 100, 2957-2964
8. Fandy, T. E., Herman, J. G., Kerns, P., Jiemjit, A., Sugar, E. A., Choi, S. H., Yang, A. S., Aucott, T., Dauses, T., Odchimar-Reissig, R., Licht, J., McConnell, M. J., Nasrallah, C., Kim, M. K., Zhang, W., Sun, Y., Murgo, A., Espinoza-Delgado, I., Oteiza, K., Owoeye, I., Silverman, L. R., Gore, S. D., and Carraway, H. E. (2009) Blood 114, 2764-2773
9. Schmelz, K., Sattler, N., Wagner, M., Lübbert, M., Dörken, B., and Tamm, I. (2005) Leukemia 19, 103-111
10. Creusot, F., Acs, G., and Christman, J. K. (1982) J. Biol. Chem. 257, 2041-2048
11. Pinto, A., Attadia, V., Fusco, A., Ferrara, F., Spada, O. A., and Di Fiore, P. P. (1984) Blood 64, 922-929
12. Valdez, B. C., Li, Y., Murray, D., Corn, P., Champlin, R. E., and Andersson, B. S. (2010) Leuk. Res. 34, 364-372
13. Kotkow, K. J., and Orkin, S. H. (1995) Mol. Cell. Biol. 15, 4640-4647
14. Weiss, M. J., and Orkin, S. H. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 9623-9627
15. Crossley, M., Tsang, A. P., Bieker, J. J., and Orkin, S. H. (1994) J. Biol. Chem. 269, 15440-15444
16. Perkins, A. C., Sharpe, A. H., and Orkin, S. H. (1995) Nature 375, 318-322
17. Dang, C. V. (1999) Mol. Cell. Biol. 19, 1-11
18. O'Donnell, K. A., Yu, D., Zeller, K. I., Kim, J. W., Racke, F., Thomas- Tikhonenko, A., and Dang, C. V. (2006) Mol. Cell. Biol. 26, 2373-2386
19. Okazaki, F., Matsunaga, N., Okazaki, H., Utoguchi, N., Suzuki, R., Maruyama, K., Koyanagi, S., and Ohdo, S. (2010) Cancer Res. 70, 6238-6246
20. Wu, K. J., Polack, A., and Dalla-Favera, R. (1999) Science 283, 676-679
21. Sridhar, K., Ross, D. T., Tibshirani, R., Butte, A. J., and Greenberg, P. L. (2009) Blood 114, 4847-4858
22. Mills, K. I., Kohlmann, A., Williams, P. M., Wieczorek, L., Liu, W. M., Li, R., Wei, W., Bowen, D. T., Loeffler, H., Hernandez, J. M., Hofmann, W. K., and Haferlach, T. (2009) Blood 114, 1063-1072
23. Livak, K. J., and Schmittgen, T. D. (2001) Methods 25, 402-408
24. Ponka, P., and Schulman, H. M. (1985) J. Biol. Chem. 260, 14717-14721
25. Oshiro, S., Nakamura, Y., Ishige, R., Hori, M., Nakajima, H., and Gahl, W. A. (1994) J. Biochem. 115, 849-852
26. Sinclair, P. R., Gorman, N., and Jacobs, J. M. (2001) in Current Protocols in Toxicology, pp. 8.3.1-8.3.7, John Wiley & Sons, Inc., New York
27. Perini, G., Diolaiti, D., Porro, A., and Della Valle, G. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 12117-12122
28. Christman, J. K., Weich, N., Schoenbrun, B., Schneiderman, N., and Acs, G. (1980) J. Cell Biol. 86, 366-370
29. Ponka, P. (1997) Blood 89, 1-25
30. Bird, A. P. (1986) Nature 321, 209-213
31. Jaenisch, R., and Bird, A. (2003) Nat. Genet. 33, 245-254
32. Suzuki, M. M., and Bird, A. (2008) Nat. Rev. Genet. 9, 465-476
33. Welch, J. J., Watts, J. A., Vakoc, C. R., Yao, Y., Wang, H., Hardison, R. C., Blobel, G. A., Chodosh, L. A., and Weiss, M. J. (2004) Blood 104, 3136-3147
34. Tallack, M. R., Whitington, T., Yuen, W. S., Wainwright, E. N., Keys, J. R., Gardiner, B. B., Nourbakhsh, E., Cloonan, N., Grimmond, S. M., Bailey, T. L., and Perkins, A. C. (2010) Genome Res. 20, 1052-1063
35. Pelengaris, S., Khan, M., and Evan, G. (2002) Nat. Rev. Cancer 2, 764-776
36. Gusella, J. F., Weil, S. C., Tsiftsoglou, A. S., Volloch, V., Neumann, J. R., Keys, C., and Housman, D. E. (1980) Blood 56, 481-487
37. Humphries, R. K., Dover, G., Young, N. S., Moore, J. G., Charache, S., Ley, T., and Nienhuis, A. W. (1985) J. Clin. Invest. 75, 547-557
38. Angst, E., Dawson, D. W., Nguyen, A., Park, J., Go, V. L., Reber, H. A., Hines, O. J., and Eibl, G. (2010) Pancreas 39, 675-679
39. Fenaux, P., Mufti, G. J., Hellstrom-Lindberg, E., Santini, V., Finelli, C., Giagounidis, A., Schoch, R., Gattermann, N., Sanz, G., List, A., Gore, S. D., Seymour, J. F., Bennett, J. M., Byrd, J., Backstrom, J., Zimmerman, L., McKenzie, D., Beach, C., and Silverman, L. R. (2009) Lancet Oncol. 10, 223-232
40. Bowen, H., Biggs, T. E., Phillips, E., Baker, S. T., Perry, V. H., Mann, D. A., and Barton, C. H. (2002) J. Biol. Chem. 277, 34997-35006
41. Soriano, A. O., Yang, H., Faderl, S., Estrov, Z., Giles, F., Ravandi, F., Cortes, J., Wierda, W. G., Ouzounian, S., Quezada, A., Pierce, S., Estey, E. H., Issa, J. P., Kantarjian, H. M., and Garcia-Manero, G. (2007) Blood 110, 2302-2308
42. Laskey, J. D., Ponka, P., and Schulman, H. M. (1986) J. Cell. Physiol. 129, 185-192
43. Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J., Cocito, A., and Amati, B. (2003) Gene Dev. 17, 1115-1129