Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency

Science Translational Medicine

Volumn 5, Issue 167, 2013, Pages

  Yu, Liang ^a   Vogel, Jodi L ^a   Arbuckle, Jesse H ^a   Rai, Ganesha ^b   Jadhav, Ajit ^b   Simeonov, Anton ^b   Maloney, David J ^b   Kristie, Thomas M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; DIMETHYLOXALYLGLYCINE; HISTONE DEMETHYLASE; JMJD2 HISTONE DEMETHYLASE; MESSENGER RNA; ML 324; N [3 (DIMETHYLAMINO)PROPYL] 4 (8 HYDROXYQUINOLIN 6 YL)BENZAMIDE; OXYGENASE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CHROMATIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; ENZYME INHIBITION; EPIGENETICS; GENE REPRESSION; HERPES SIMPLEX; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; IC 50; IMMEDIATE EARLY GENE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FAMILY; PROTEIN TARGETING; SENSORY NERVE CELL; TRANSCRIPTION INITIATION; TRIGEMINUS GANGLION; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS LATENCY; VIRUS REACTIVATION;

CATALYSIS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, VIRAL; GENES, IMMEDIATE-EARLY; HERPES SIMPLEX; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; PROMOTER REGIONS, GENETIC; SIMPLEXVIRUS; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 84872330923     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3005145     Document Type: Article

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